LU91381I2 - OPTAFLU-Définition du produit: Vaccin grippal préparé à partir du virus de la grippe dans une culture celluluaire ou les cellules sont cultivées à unetempérature comprise entre 30°C et 36°C pour la r éplication des virus - Google Patents
OPTAFLU-Définition du produit: Vaccin grippal préparé à partir du virus de la grippe dans une culture celluluaire ou les cellules sont cultivées à unetempérature comprise entre 30°C et 36°C pour la r éplication des virusInfo
- Publication number
- LU91381I2 LU91381I2 LU91381C LU91381C LU91381I2 LU 91381 I2 LU91381 I2 LU 91381I2 LU 91381 C LU91381 C LU 91381C LU 91381 C LU91381 C LU 91381C LU 91381 I2 LU91381 I2 LU 91381I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- replication
- cell culture
- viruses
- optaflu
- cultured
- Prior art date
Links
- 241000712461 unidentified influenza virus Species 0.000 title abstract 3
- 238000004113 cell culture Methods 0.000 title abstract 2
- 230000010076 replication Effects 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 229960003971 influenza vaccine Drugs 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19612967A DE19612967A1 (de) | 1996-04-01 | 1996-04-01 | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| PCT/IB1997/000404 WO1997037001A1 (fr) | 1996-04-01 | 1997-04-01 | Procedes de replication des virus de la grippe dans une culture cellulaire, et virus de la grippe obtenus selon ce procede |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU91381I2 true LU91381I2 (fr) | 2008-01-30 |
Family
ID=7790127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU91381C LU91381I2 (fr) | 1996-04-01 | 2007-11-30 | OPTAFLU-Définition du produit: Vaccin grippal préparé à partir du virus de la grippe dans une culture celluluaire ou les cellules sont cultivées à unetempérature comprise entre 30°C et 36°C pour la r éplication des virus |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20030119183A1 (fr) |
| EP (3) | EP0891420B2 (fr) |
| JP (6) | JP4447054B2 (fr) |
| AT (2) | ATE288479T1 (fr) |
| CA (1) | CA2250078C (fr) |
| DE (3) | DE19612967A1 (fr) |
| DK (2) | DK1526172T3 (fr) |
| ES (3) | ES2236799T5 (fr) |
| LU (1) | LU91381I2 (fr) |
| NL (1) | NL300307I1 (fr) |
| PT (2) | PT891420E (fr) |
| WO (1) | WO1997037001A1 (fr) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| AU737705B2 (en) * | 1997-10-31 | 2001-08-30 | Merck Sharp & Dohme Corp. | A method of improved mixing in roller bottles |
| WO1999023206A1 (fr) * | 1997-10-31 | 1999-05-14 | Merck & Co., Inc. | Procede de melange ameliore d'une culture cellulaire infectee par la varicelle dans une bouteille pour agitateur rotatif |
| FR2775601B1 (fr) * | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
| AU2001236042B9 (en) | 2000-03-03 | 2006-06-29 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell |
| DE10144906B4 (de) * | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
| EP1458362A4 (fr) * | 2001-11-19 | 2006-01-18 | Becton Dickinson Co | Compositions pharmaceutiques sous forme particulaire |
| WO2004033615A1 (fr) | 2002-09-16 | 2004-04-22 | Pan-Biotech Gmbh | Procede de mise en culture de cellules, notamment de cellules humaines ou animales |
| US20060019375A1 (en) * | 2002-09-16 | 2006-01-26 | Josef Seidl | Device for culturing cells, particularly human or animal cells |
| WO2004113518A1 (fr) | 2003-06-20 | 2004-12-29 | Microbix Biosystems Inc. | Perfectionnements dans la production de virus |
| US20080254065A1 (en) | 2004-03-09 | 2008-10-16 | Chiron Corporation | Influenza Virus Vaccines |
| EP1747268A1 (fr) * | 2004-05-20 | 2007-01-31 | ID Biomedical Corporation | Procédé pour la fabrication d'un vaccin contre la grippe |
| US20090104226A1 (en) | 2004-05-21 | 2009-04-23 | Novartis Vaccines And Diagnostics Inc. | Alphavirus Vectors for Respiratory Pathogen Vaccines |
| CA2890962A1 (fr) * | 2004-09-09 | 2006-03-16 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | Reduction de risques iatrogenes potentiels associes aux vaccins contre la grippe |
| PT1824990E (pt) | 2004-12-08 | 2015-06-11 | Medimmune Llc | Métodos de produção de composições de vacinas contra a gripe |
| EP2368975B1 (fr) | 2004-12-23 | 2014-09-17 | MedImmune, LLC | Lignée cellulaire MDCK non tumorigène pour la propagation de virus |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| JP5602366B2 (ja) | 2005-11-01 | 2014-10-08 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | β−プロピオラクトン処理による低レベルの残存細胞DNAを含む細胞由来のウイルスワクチン |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| EP3714900A1 (fr) * | 2005-11-04 | 2020-09-30 | Seqirus UK Limited | Vaccins avec adjuvants dotés d'antigènes non virions préparés à partir de virus de la grippe cultivés dans une culture cellulaire |
| NZ567979A (en) | 2005-11-04 | 2012-02-24 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents which is an agonist of Toll-Like Receptor 7 |
| EP1951302A2 (fr) | 2005-11-04 | 2008-08-06 | Novartis Vaccines and Diagnostics S.r.l. | Vaccins antigrippaux présentant un taux réduit d'adjuvants de type émulsion |
| DE06808434T1 (de) | 2005-11-04 | 2009-12-17 | Novartis Vaccines And Diagnostics S.R.L. | Emulsionen mit freiem wässrigen phasen tensid als adjuvans für spalt-grippeimpfstoffe |
| PL1951299T3 (pl) | 2005-11-04 | 2012-07-31 | Novartis Ag | Szczepionki przeciw grypie zawierające kombinacje adiuwantów cząsteczkowych i czynników wzmacniających immunogenność |
| KR20110110853A (ko) | 2006-01-27 | 2011-10-07 | 노파르티스 파르마 아게 | 적혈구응집소 및 기질 단백질을 함유한 인플루엔자 백신 |
| CA2646349A1 (fr) | 2006-03-24 | 2007-10-04 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Stockage de vaccins antigrippaux sans refrigeration |
| EP2010557B1 (fr) | 2006-03-31 | 2014-02-26 | Wisconsin Alumni Research Foundation | Virus de la grippe recombinants à haut titre pour vaccins |
| JP5322636B2 (ja) * | 2006-05-11 | 2013-10-23 | 一般財団法人化学及血清療法研究所 | インフルエンザウイルスの増殖方法 |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| KR20090057015A (ko) | 2006-09-11 | 2009-06-03 | 노파르티스 아게 | 난을 사용하지 않는 인플루엔자 바이러스 백신의 제조 |
| CN101627113B (zh) | 2006-09-15 | 2013-04-24 | 米迪缪尼有限公司 | 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法 |
| EP2679240A1 (fr) | 2006-12-06 | 2014-01-01 | Novartis AG | Vaccins comprenant un antigène issu de quatre souches du virus grippal |
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| US8883481B2 (en) | 2009-10-20 | 2014-11-11 | Novartis Ag | Reverse genetics methods for virus rescue |
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| US11739303B2 (en) | 2020-01-24 | 2023-08-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized NA |
| WO2021195410A1 (fr) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Virus de la grippe multivalents recombinants |
| KR102444684B1 (ko) * | 2020-04-29 | 2022-09-16 | 에스케이바이오사이언스(주) | 일회용 배양 공정 시스템을 이용한 인플루엔자 바이러스 생산 방법 |
| WO2023154043A1 (fr) | 2022-02-09 | 2023-08-17 | Takeda Vaccines, Inc. | Vaccins contre le zika et compositions immunogènes, et procédés d'utilisation associés |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1278075B (de) * | 1964-06-22 | 1968-09-19 | Norden Lab Inc | Verwendung von Gewebekulturen zur Zuechtung von Viren fuer die Gewinnung von Impfstoffen |
| US4064232A (en) * | 1974-01-14 | 1977-12-20 | Sandoz Ltd. | Process for isolating the immunogenic components of influenza viruses |
| USRE33164E (en) * | 1979-05-15 | 1990-02-13 | Mobay Corporation | Influenza vaccine production in liquid cell culture |
| CA1122527A (fr) * | 1979-05-15 | 1982-04-27 | Karen K. Brown | Production d'un vaccin contre l'influenza par culture de cellules en milieu liquide |
| US4500513A (en) * | 1979-05-15 | 1985-02-19 | Miles Laboratories, Inc. | Influenza vaccine production in liquid cell culture |
| US5013663A (en) * | 1983-06-15 | 1991-05-07 | American Home Products Corporation | Canine corona virus vaccine |
| US4783411A (en) * | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
| US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| US5824536A (en) * | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| US5756341A (en) * | 1994-11-10 | 1998-05-26 | Immuno Ag | Method for controlling the infectivity of viruses |
| US5753489A (en) * | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| US5646033A (en) * | 1994-11-30 | 1997-07-08 | Dyncorp | African green monkey kidney cell lines useful for maintaining viruses and for preparation of viral vaccines |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| US6514502B1 (en) * | 1999-01-26 | 2003-02-04 | Schering-Plough Veterinary Corporation | Propagation of bovine cononavirus in chinese hamster ovary cells |
-
1996
- 1996-04-01 DE DE19612967A patent/DE19612967A1/de not_active Withdrawn
-
1997
- 1997-04-01 DK DK05075182.5T patent/DK1526172T3/da active
- 1997-04-01 DE DE69732407.9T patent/DE69732407T3/de not_active Expired - Lifetime
- 1997-04-01 AT AT97915628T patent/ATE288479T1/de active
- 1997-04-01 ES ES97915628T patent/ES2236799T5/es not_active Expired - Lifetime
- 1997-04-01 DE DE122007000082C patent/DE122007000082I1/de active Pending
- 1997-04-01 WO PCT/IB1997/000404 patent/WO1997037001A1/fr not_active Ceased
- 1997-04-01 ES ES09011476T patent/ES2435726T3/es not_active Expired - Lifetime
- 1997-04-01 DK DK97915628.8T patent/DK0891420T4/da active
- 1997-04-01 EP EP97915628.8A patent/EP0891420B2/fr not_active Expired - Lifetime
- 1997-04-01 EP EP05075182A patent/EP1526172B1/fr not_active Expired - Lifetime
- 1997-04-01 JP JP53509097A patent/JP4447054B2/ja not_active Expired - Fee Related
- 1997-04-01 CA CA002250078A patent/CA2250078C/fr not_active Expired - Lifetime
- 1997-04-01 AT AT05075182T patent/ATE513905T1/de active
- 1997-04-01 ES ES05075182T patent/ES2367081T3/es not_active Expired - Lifetime
- 1997-04-01 EP EP09011476.0A patent/EP2172543B1/fr not_active Revoked
- 1997-04-01 PT PT97915628T patent/PT891420E/pt unknown
- 1997-04-01 PT PT05075182T patent/PT1526172E/pt unknown
-
2002
- 2002-09-16 US US10/245,037 patent/US20030119183A1/en not_active Abandoned
-
2006
- 2006-07-10 JP JP2006189769A patent/JP2006296437A/ja not_active Withdrawn
- 2006-11-03 US US11/592,336 patent/US20070117131A1/en not_active Abandoned
-
2007
- 2007-11-28 NL NL300307C patent/NL300307I1/nl unknown
- 2007-11-30 LU LU91381C patent/LU91381I2/fr unknown
-
2008
- 2008-06-27 JP JP2008169656A patent/JP2008245659A/ja not_active Withdrawn
-
2010
- 2010-09-03 JP JP2010198362A patent/JP5264843B2/ja not_active Expired - Lifetime
-
2011
- 2011-07-15 JP JP2011157202A patent/JP2011212020A/ja not_active Withdrawn
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2013
- 2013-02-28 JP JP2013039239A patent/JP2013116124A/ja not_active Withdrawn
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