ATE288479T1 - Verfahren fuer die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren - Google Patents
Verfahren fuer die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-virenInfo
- Publication number
- ATE288479T1 ATE288479T1 AT97915628T AT97915628T ATE288479T1 AT E288479 T1 ATE288479 T1 AT E288479T1 AT 97915628 T AT97915628 T AT 97915628T AT 97915628 T AT97915628 T AT 97915628T AT E288479 T1 ATE288479 T1 AT E288479T1
- Authority
- AT
- Austria
- Prior art keywords
- influenza
- replication
- cell culture
- influenza viruses
- viruses produced
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000004113 cell culture Methods 0.000 title abstract 2
- 230000010076 replication Effects 0.000 title abstract 2
- 206010022000 influenza Diseases 0.000 title 2
- 241000700605 Viruses Species 0.000 title 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19612967A DE19612967A1 (de) | 1996-04-01 | 1996-04-01 | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| PCT/IB1997/000404 WO1997037001A1 (en) | 1996-04-01 | 1997-04-01 | Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288479T1 true ATE288479T1 (de) | 2005-02-15 |
Family
ID=7790127
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97915628T ATE288479T1 (de) | 1996-04-01 | 1997-04-01 | Verfahren fuer die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren |
| AT05075182T ATE513905T1 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die replikation von influenza in zellkultur, und die bei diesem verfahren hergestellten influenza viren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05075182T ATE513905T1 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die replikation von influenza in zellkultur, und die bei diesem verfahren hergestellten influenza viren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20030119183A1 (de) |
| EP (3) | EP0891420B2 (de) |
| JP (6) | JP4447054B2 (de) |
| AT (2) | ATE288479T1 (de) |
| CA (1) | CA2250078C (de) |
| DE (3) | DE19612967A1 (de) |
| DK (2) | DK1526172T3 (de) |
| ES (3) | ES2236799T5 (de) |
| LU (1) | LU91381I2 (de) |
| NL (1) | NL300307I1 (de) |
| PT (2) | PT891420E (de) |
| WO (1) | WO1997037001A1 (de) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| AU737705B2 (en) * | 1997-10-31 | 2001-08-30 | Merck Sharp & Dohme Corp. | A method of improved mixing in roller bottles |
| WO1999023206A1 (en) * | 1997-10-31 | 1999-05-14 | Merck & Co., Inc. | A method of improved mixing of a varicella-infected cell culture in roller bottles |
| FR2775601B1 (fr) * | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
| AU2001236042B9 (en) | 2000-03-03 | 2006-06-29 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell |
| DE10144906B4 (de) * | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
| EP1458362A4 (de) * | 2001-11-19 | 2006-01-18 | Becton Dickinson Co | Pharmazeutische zusammensetzungen in teilchenform |
| WO2004033615A1 (de) | 2002-09-16 | 2004-04-22 | Pan-Biotech Gmbh | Verfahren zur kultivierung von zellen, insbesondere menschlicher oder tierischer zellen |
| US20060019375A1 (en) * | 2002-09-16 | 2006-01-26 | Josef Seidl | Device for culturing cells, particularly human or animal cells |
| WO2004113518A1 (en) | 2003-06-20 | 2004-12-29 | Microbix Biosystems Inc. | Improvements in virus production |
| US20080254065A1 (en) | 2004-03-09 | 2008-10-16 | Chiron Corporation | Influenza Virus Vaccines |
| EP1747268A1 (de) * | 2004-05-20 | 2007-01-31 | ID Biomedical Corporation | Verfahren zur herstellung einer influenzavakzine |
| US20090104226A1 (en) | 2004-05-21 | 2009-04-23 | Novartis Vaccines And Diagnostics Inc. | Alphavirus Vectors for Respiratory Pathogen Vaccines |
| CA2890962A1 (en) * | 2004-09-09 | 2006-03-16 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | Decreasing potential iatrogenic risks associated with influenza vaccines |
| PT1824990E (pt) | 2004-12-08 | 2015-06-11 | Medimmune Llc | Métodos de produção de composições de vacinas contra a gripe |
| EP2368975B1 (de) | 2004-12-23 | 2014-09-17 | MedImmune, LLC | Nicht-tumorerzeugende MDCK-Zelllinie zur Ausbreitung von Viren |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| JP5602366B2 (ja) | 2005-11-01 | 2014-10-08 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | β−プロピオラクトン処理による低レベルの残存細胞DNAを含む細胞由来のウイルスワクチン |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| EP3714900A1 (de) * | 2005-11-04 | 2020-09-30 | Seqirus UK Limited | Adjuvierte impfstoffe mit nichtvirenähnlichen antigenen aus influenza-viren, die in einer zellkultur gezüchtet wurden |
| NZ567979A (en) | 2005-11-04 | 2012-02-24 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents which is an agonist of Toll-Like Receptor 7 |
| EP1951302A2 (de) | 2005-11-04 | 2008-08-06 | Novartis Vaccines and Diagnostics S.r.l. | Grippe-impfstoffe mit verringerter menge einer öl-in-wasser-emulsion als adjuvans |
| DE06808434T1 (de) | 2005-11-04 | 2009-12-17 | Novartis Vaccines And Diagnostics S.R.L. | Emulsionen mit freiem wässrigen phasen tensid als adjuvans für spalt-grippeimpfstoffe |
| PL1951299T3 (pl) | 2005-11-04 | 2012-07-31 | Novartis Ag | Szczepionki przeciw grypie zawierające kombinacje adiuwantów cząsteczkowych i czynników wzmacniających immunogenność |
| KR20110110853A (ko) | 2006-01-27 | 2011-10-07 | 노파르티스 파르마 아게 | 적혈구응집소 및 기질 단백질을 함유한 인플루엔자 백신 |
| CA2646349A1 (en) | 2006-03-24 | 2007-10-04 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Storage of influenza vaccines without refrigeration |
| EP2010557B1 (de) | 2006-03-31 | 2014-02-26 | Wisconsin Alumni Research Foundation | Hochtitrige rekombinante influenzaviren für impfstoffe |
| JP5322636B2 (ja) * | 2006-05-11 | 2013-10-23 | 一般財団法人化学及血清療法研究所 | インフルエンザウイルスの増殖方法 |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| KR20090057015A (ko) | 2006-09-11 | 2009-06-03 | 노파르티스 아게 | 난을 사용하지 않는 인플루엔자 바이러스 백신의 제조 |
| CN101627113B (zh) | 2006-09-15 | 2013-04-24 | 米迪缪尼有限公司 | 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法 |
| EP2679240A1 (de) | 2006-12-06 | 2014-01-01 | Novartis AG | Impfstoffe mit Antigen aus vier Stämmen des Influenzavirus |
| JP5352578B2 (ja) * | 2007-05-04 | 2013-11-27 | バクスター・インターナショナル・インコーポレイテッド | ウイルスの増殖のための二段階温度プロフィール |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| HRP20120790T1 (hr) | 2007-06-27 | 2013-01-31 | Novartis Ag | Cjepiva protiv influence sa niskom koliäśinom aditiva |
| EP3459563B1 (de) | 2008-03-18 | 2025-12-17 | Seqirus UK Limited | Verbesserungen bei der herstellung von influenzavirusimpfstoffantigenen |
| BRPI0919252A2 (pt) | 2008-09-24 | 2015-08-11 | Medimmune Llc | Métodos para cultivar células, propagação e purificação de vírus |
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| EA023662B1 (ru) | 2009-02-10 | 2016-06-30 | Новартис Аг | Вакцины против гриппа со сниженным количеством сквалена |
| EP2396031A1 (de) | 2009-02-10 | 2011-12-21 | Novartis AG | Grippeimpfstoffe mit erhöhten h3-antigen-mengen |
| BE1019643A3 (fr) | 2009-04-27 | 2012-09-04 | Novartis Ag | Vaccins de protection contre la grippe. |
| NZ596432A (en) | 2009-05-21 | 2013-05-31 | Novartis Ag | Reverse genetics using non-endogenous pol i promoters |
| WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
| CN104862335A (zh) | 2009-07-31 | 2015-08-26 | 诺华股份有限公司 | 反向遗传系统 |
| CA2773637A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| US8883481B2 (en) | 2009-10-20 | 2014-11-11 | Novartis Ag | Reverse genetics methods for virus rescue |
| ES2813347T3 (es) | 2009-10-26 | 2021-03-23 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero |
| EP2531592A1 (de) | 2010-02-04 | 2012-12-12 | Vivalis | Fed-batch-verfahren mit konzentriertem zellkulturmedium zur effizienten produktion von biologischen wirkstoffen bei eb66-zellen |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| EP2563909A1 (de) | 2010-04-26 | 2013-03-06 | Novartis AG | Verbesserte herstellung von virusreplikonpartikeln bei verpackungszellen |
| CN103025350A (zh) | 2010-05-21 | 2013-04-03 | 诺华有限公司 | 流感病毒的重配方法 |
| CA2801151A1 (en) | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens with lyophilization |
| US20130224245A1 (en) | 2010-06-01 | 2013-08-29 | Novartis Ag | Concentration of vaccine antigens without lyophilization |
| AU2011290471B2 (en) | 2010-08-20 | 2015-08-20 | Novartis Ag | Soluble needle arrays for delivery of influenza vaccines |
| ES2716243T3 (es) | 2010-10-11 | 2019-06-11 | Glaxosmithkline Biologicals Sa | Plataformas de suministro de antígenos |
| EP4144368B1 (de) | 2011-01-26 | 2025-02-26 | GlaxoSmithKline Biologicals S.A. | Rsv-immunisierungstherapie |
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| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
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| WO2013054199A2 (en) | 2011-10-12 | 2013-04-18 | Novartis Ag | Cmv antigens and uses thereof |
| CA2852857A1 (en) | 2011-10-20 | 2013-04-25 | Novartis Ag | Adjuvanted influenza b virus vaccines for pediatric priming |
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| JP5918870B2 (ja) | 2012-03-06 | 2016-05-18 | クルセル ホランド ベー ヴェー | インフルエンザに対する改善されたワクチン接種 |
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| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| BR112015012380A2 (pt) | 2012-12-03 | 2017-09-12 | Novartis Ag | vírus influenza recombinante |
| CA2905612A1 (en) | 2013-03-13 | 2014-09-18 | Novartis Ag | Influenza virus reassortment |
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| DE202013005130U1 (de) | 2013-06-05 | 2013-09-10 | Novartis Ag | Influenza Virus Reassortierung |
| DE202013005100U1 (de) | 2013-06-05 | 2013-08-26 | Novartis Ag | Influenza Virus Reassortierung |
| HK1222882A1 (zh) | 2013-06-06 | 2017-07-14 | Novartis Ag | 流感病毒重配 |
| JP2016524915A (ja) | 2013-07-15 | 2016-08-22 | ウィスコンシン アルムニ リサーチ ファンデイション | Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| MA40920A (fr) | 2014-11-07 | 2017-09-12 | Takeda Vaccines Inc | Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci |
| AR102548A1 (es) | 2014-11-07 | 2017-03-08 | Takeda Vaccines Inc | Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y uso |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| KR20180035807A (ko) | 2015-06-26 | 2018-04-06 | 세퀴러스 유케이 리미티드 | 항원적으로 매치된 인플루엔자 백신 |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| EP3320343B1 (de) | 2015-07-07 | 2020-09-02 | Seqirus UK Limited | Verfahren zur quantifizierung von immunogenem hämagglutinin |
| EP3417056A1 (de) | 2016-02-19 | 2018-12-26 | Wisconsin Alumni Research Foundation (WARF) | Verbesserte influenza-b-virus-replikation für impfstoffentwicklung |
| JP2021500891A (ja) | 2017-10-25 | 2021-01-14 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス |
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| WO2020033527A2 (en) | 2018-08-07 | 2020-02-13 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
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| EP3914295A2 (de) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutationen zur verleihung von genetischer stabilität gegenüber zusätzlichen genen bei grippeviren |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| SG11202110975XA (en) | 2019-05-08 | 2021-10-28 | Takeda Vaccines Inc | Inactivated virus compositions and zika vaccine formulations |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
| MX2022006005A (es) | 2019-11-18 | 2022-10-27 | Seqirus Pty Ltd | Metodo para producir virus de la influenza reagrupados. |
| US11739303B2 (en) | 2020-01-24 | 2023-08-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized NA |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| KR102444684B1 (ko) * | 2020-04-29 | 2022-09-16 | 에스케이바이오사이언스(주) | 일회용 배양 공정 시스템을 이용한 인플루엔자 바이러스 생산 방법 |
| WO2023154043A1 (en) | 2022-02-09 | 2023-08-17 | Takeda Vaccines, Inc. | Zika vaccines and immunogenic compositions, and methods of using the same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1278075B (de) * | 1964-06-22 | 1968-09-19 | Norden Lab Inc | Verwendung von Gewebekulturen zur Zuechtung von Viren fuer die Gewinnung von Impfstoffen |
| US4064232A (en) * | 1974-01-14 | 1977-12-20 | Sandoz Ltd. | Process for isolating the immunogenic components of influenza viruses |
| USRE33164E (en) * | 1979-05-15 | 1990-02-13 | Mobay Corporation | Influenza vaccine production in liquid cell culture |
| CA1122527A (en) * | 1979-05-15 | 1982-04-27 | Karen K. Brown | Influenza vaccine production in liquid cell culture |
| US4500513A (en) * | 1979-05-15 | 1985-02-19 | Miles Laboratories, Inc. | Influenza vaccine production in liquid cell culture |
| US5013663A (en) * | 1983-06-15 | 1991-05-07 | American Home Products Corporation | Canine corona virus vaccine |
| US4783411A (en) * | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
| US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| US5824536A (en) * | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| US5756341A (en) * | 1994-11-10 | 1998-05-26 | Immuno Ag | Method for controlling the infectivity of viruses |
| US5753489A (en) * | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| US5646033A (en) * | 1994-11-30 | 1997-07-08 | Dyncorp | African green monkey kidney cell lines useful for maintaining viruses and for preparation of viral vaccines |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| US6514502B1 (en) * | 1999-01-26 | 2003-02-04 | Schering-Plough Veterinary Corporation | Propagation of bovine cononavirus in chinese hamster ovary cells |
-
1996
- 1996-04-01 DE DE19612967A patent/DE19612967A1/de not_active Withdrawn
-
1997
- 1997-04-01 DK DK05075182.5T patent/DK1526172T3/da active
- 1997-04-01 DE DE69732407.9T patent/DE69732407T3/de not_active Expired - Lifetime
- 1997-04-01 AT AT97915628T patent/ATE288479T1/de active
- 1997-04-01 ES ES97915628T patent/ES2236799T5/es not_active Expired - Lifetime
- 1997-04-01 DE DE122007000082C patent/DE122007000082I1/de active Pending
- 1997-04-01 WO PCT/IB1997/000404 patent/WO1997037001A1/en not_active Ceased
- 1997-04-01 ES ES09011476T patent/ES2435726T3/es not_active Expired - Lifetime
- 1997-04-01 DK DK97915628.8T patent/DK0891420T4/da active
- 1997-04-01 EP EP97915628.8A patent/EP0891420B2/de not_active Expired - Lifetime
- 1997-04-01 EP EP05075182A patent/EP1526172B1/de not_active Expired - Lifetime
- 1997-04-01 JP JP53509097A patent/JP4447054B2/ja not_active Expired - Fee Related
- 1997-04-01 CA CA002250078A patent/CA2250078C/en not_active Expired - Lifetime
- 1997-04-01 AT AT05075182T patent/ATE513905T1/de active
- 1997-04-01 ES ES05075182T patent/ES2367081T3/es not_active Expired - Lifetime
- 1997-04-01 EP EP09011476.0A patent/EP2172543B1/de not_active Revoked
- 1997-04-01 PT PT97915628T patent/PT891420E/pt unknown
- 1997-04-01 PT PT05075182T patent/PT1526172E/pt unknown
-
2002
- 2002-09-16 US US10/245,037 patent/US20030119183A1/en not_active Abandoned
-
2006
- 2006-07-10 JP JP2006189769A patent/JP2006296437A/ja not_active Withdrawn
- 2006-11-03 US US11/592,336 patent/US20070117131A1/en not_active Abandoned
-
2007
- 2007-11-28 NL NL300307C patent/NL300307I1/nl unknown
- 2007-11-30 LU LU91381C patent/LU91381I2/fr unknown
-
2008
- 2008-06-27 JP JP2008169656A patent/JP2008245659A/ja not_active Withdrawn
-
2010
- 2010-09-03 JP JP2010198362A patent/JP5264843B2/ja not_active Expired - Lifetime
-
2011
- 2011-07-15 JP JP2011157202A patent/JP2011212020A/ja not_active Withdrawn
-
2013
- 2013-02-28 JP JP2013039239A patent/JP2013116124A/ja not_active Withdrawn
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