LU91398I2 - "La protéine L1 recombinante du papillomavirus humain de type 11" Gardasil-Silgard - Google Patents
"La protéine L1 recombinante du papillomavirus humain de type 11" Gardasil-SilgardInfo
- Publication number
- LU91398I2 LU91398I2 LU91398C LU91398C LU91398I2 LU 91398 I2 LU91398 I2 LU 91398I2 LU 91398 C LU91398 C LU 91398C LU 91398 C LU91398 C LU 91398C LU 91398 I2 LU91398 I2 LU 91398I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- recombinant
- protein
- silgard
- gardasil
- human papillomavirus
- Prior art date
Links
- 241000701828 Human papillomavirus type 11 Species 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 2
- 101710121996 Hexon protein p72 Proteins 0.000 abstract 1
- 101710125418 Major capsid protein Proteins 0.000 abstract 1
- 208000009608 Papillomavirus Infections Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 208000003154 papilloma Diseases 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
- 210000002845 virion Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90310992A | 1992-06-25 | 1992-06-25 | |
| PCT/US1993/006109 WO1994000152A1 (fr) | 1992-06-25 | 1993-06-24 | Vaccin contre le papillomavirus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU91398I2 true LU91398I2 (fr) | 2008-02-14 |
Family
ID=25416951
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU91395C LU91395I2 (fr) | 1992-06-25 | 2005-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 18"-Cervarix |
| LU91397C LU91397I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 6" Gardasil-Silgard |
| LU91399C LU91399I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 16" Gardasil-Silgard |
| LU91394C LU91394I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 16"-Cervarix |
| LU91393C LU91393I2 (fr) | 1992-06-25 | 2007-12-14 | "La combinaison de la protéine L1 recombinante du papillomavirus humain de types 16 et 18" - Cervarix |
| LU91398C LU91398I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 11" Gardasil-Silgard |
| LU91396C LU91396I2 (fr) | 1992-06-25 | 2007-12-14 | "La combinaison de la protéine L1 recombinante du papillomavirus humain de types 6,11,16 et 18" -Gardasil/Silgard |
| LU91400C LU91400I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 18" Gardasil-Silgard |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU91395C LU91395I2 (fr) | 1992-06-25 | 2005-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 18"-Cervarix |
| LU91397C LU91397I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 6" Gardasil-Silgard |
| LU91399C LU91399I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 16" Gardasil-Silgard |
| LU91394C LU91394I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 16"-Cervarix |
| LU91393C LU91393I2 (fr) | 1992-06-25 | 2007-12-14 | "La combinaison de la protéine L1 recombinante du papillomavirus humain de types 16 et 18" - Cervarix |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU91396C LU91396I2 (fr) | 1992-06-25 | 2007-12-14 | "La combinaison de la protéine L1 recombinante du papillomavirus humain de types 6,11,16 et 18" -Gardasil/Silgard |
| LU91400C LU91400I2 (fr) | 1992-06-25 | 2007-12-14 | "La protéine L1 recombinante du papillomavirus humain de type 18" Gardasil-Silgard |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20020068326A1 (fr) |
| EP (2) | EP1835029A1 (fr) |
| AT (1) | ATE380871T1 (fr) |
| AU (1) | AU697743C (fr) |
| DE (9) | DE122007000094I1 (fr) |
| DK (1) | DK0647140T3 (fr) |
| ES (1) | ES2294778T3 (fr) |
| FR (1) | FR07C0073I2 (fr) |
| LU (8) | LU91395I2 (fr) |
| NL (8) | NL300316I1 (fr) |
| PT (1) | PT647140E (fr) |
| WO (1) | WO1994000152A1 (fr) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122007000085I1 (de) | 1991-07-19 | 2008-03-27 | Univ Queensland St Lucia | Polynukleotidabschnitt des HPV16-Genoms |
| US5437951A (en) * | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
| US8062642B1 (en) | 1993-03-09 | 2011-11-22 | University Of Rochester | Production of papillomavirus capsid protein and virus-like particles |
| US6153201A (en) * | 1993-03-09 | 2000-11-28 | University Of Rochester | Oral immunization with papillomavirus virus-like particles |
| DE4415743C2 (de) * | 1994-05-04 | 1996-10-10 | Deutsches Krebsforsch | Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen |
| BR9507657A (pt) * | 1994-05-16 | 1997-09-09 | Merck & Co Inc | Proteina isolada e purificada de papilomavirus recombinante capsideos particulas semelhantes a virus processos a virus processos para produzir a proteina para tratar ou prevenir a infecçao por papilomavirus para produzir uma proteina de capsideo de papilomavirus recombinante montada em um capsideo ou particula semelhante a virus e para induzir uma resposta imune em um animal vertebrado composiçoes farmacêuticas kit para a detecçao de papilomavirus ou anticorpos para papilomavirus e sistema sinte |
| US5888516A (en) * | 1994-05-16 | 1999-03-30 | Merck & Co. Inc. | Recombinant papillomavirus vaccines |
| AU683564B2 (en) * | 1994-05-17 | 1997-11-13 | University Of Queensland, The | Recombinant papilloma virus L1 |
| AUPM566794A0 (en) * | 1994-05-17 | 1994-06-09 | University Of Queensland, The | Process and product |
| JPH10506014A (ja) * | 1994-09-22 | 1998-06-16 | メルク エンド カンパニー インコーポレーテッド | ヒトパピローマウイルス6a型をコードするDNA |
| DE122007000093I1 (de) | 1994-10-07 | 2008-03-27 | Univ Loyola Chicago | Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung |
| IL117459A (en) * | 1995-03-22 | 2005-11-20 | Merck & Co Inc | Dna encoding human papillomavirus type 18 |
| US5820870A (en) * | 1995-03-22 | 1998-10-13 | Merck & Co., Inc. | Recombinant human papillomavirus type 18 vaccine |
| US5840306A (en) * | 1995-03-22 | 1998-11-24 | Merck & Co., Inc. | DNA encoding human papillomavirus type 18 |
| US6908615B1 (en) | 1996-03-18 | 2005-06-21 | Merck & Co., Inc. | DNA encoding human papilloma virus type 18 |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| AU755679B2 (en) * | 1997-07-03 | 2002-12-19 | Medimmune, Llc | Homogeneous human papilloma virus capsomere containing compositions, methods for manufacture,and the use thereof as diagnostic, prophylactic or therapy |
| US6228368B1 (en) | 1997-10-06 | 2001-05-08 | Loyola University Of Chicago | Papilloma virus capsomere formulations and method of use |
| CA2229955C (fr) | 1998-02-20 | 2003-12-09 | Medigene Gmbh | Formulations de vaccins contenant des capsomeres de papillomavirus; methodes d'utilisation |
| US20020039584A1 (en) | 1998-02-20 | 2002-04-04 | Medigene Ag | Papilloma virus capsomere vaccine formulations and methods of use |
| US7494658B2 (en) | 1998-02-20 | 2009-02-24 | Medigene Ag | Papilloma virus truncated L1 protein and fusion protein constructs |
| US7182947B2 (en) | 1998-02-20 | 2007-02-27 | Medigene Ag | Papillomavirus truncated L1 protein and fusion protein constructs |
| US6926897B1 (en) | 1998-03-24 | 2005-08-09 | Medigene Aktiengesellschaft | Medicament for the avoidance or treatment of papillomavirus-specific tumour |
| EP1104442A1 (fr) | 1998-07-13 | 2001-06-06 | Loyola University Of Chicago | Recepteur cellulaire du papillomavirus |
| US6692752B1 (en) | 1999-09-08 | 2004-02-17 | Smithkline Beecham Biologicals S.A. | Methods of treating human females susceptible to HSV infection |
| DE122007000087I1 (de) * | 1998-10-16 | 2008-03-27 | Glaxosmithkline Biolog Sa | Adjuvanzsysteme und impfstoffe |
| GB0109297D0 (en) | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
| DE60236806D1 (de) | 2001-08-13 | 2010-08-05 | Univ Rochester | Transkutane immunisierung gegen papillomavirus mit virusähnlichen papillomaviruspartikeln |
| GB0206360D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| ATE500267T1 (de) | 2003-07-21 | 2011-03-15 | Transgene Sa | Multifunktionelle cytokine |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| HUE036180T2 (hu) | 2006-09-26 | 2018-06-28 | Infectious Disease Res Inst | Szintetikus adjuvánst tartalmazó vakcina készítmény |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| HUE031411T2 (en) | 2007-03-02 | 2017-07-28 | Glaxosmithkline Biologicals Sa | New Methods and Preparations |
| WO2010079505A2 (fr) | 2008-05-26 | 2010-07-15 | Cadila Healthcare Limited | Vaccin combine rougeole-papillome humain |
| GB0815872D0 (en) | 2008-09-01 | 2008-10-08 | Pasteur Institut | Novel method and compositions |
| GB0820822D0 (en) | 2008-11-13 | 2008-12-24 | Inst Catala D Oncologia | Novel product and processes |
| WO2010112533A1 (fr) * | 2009-04-03 | 2010-10-07 | Deutsches Krebsforschungszentrum | Augmentation de la production de particules analogues au papillomavirus avec un système d'expression de baculovirus modifié |
| HUE031051T2 (en) | 2009-06-05 | 2017-06-28 | Infectious Disease Res Inst | Synthetic glycopyranosyl lipid adjuvant and vaccine compositions containing it |
| WO2011026111A1 (fr) | 2009-08-31 | 2011-03-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Distribution par voie orale d'un vaccin au gros intestin pour induire une immunité mucosale |
| EP3242135B1 (fr) | 2010-04-08 | 2020-07-01 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Analyse de cellules présentatrices d'antigène des lymphocytes b |
| EP3632463A1 (fr) | 2011-04-08 | 2020-04-08 | Immune Design Corp. | Compositions immunogènes et leurs procédés d'utilisation pour induire des réponses immunitaires humorales et cellulaires |
| WO2013119856A1 (fr) | 2012-02-07 | 2013-08-15 | Infectious Disease Research Institute | Formulations d'adjuvant amélioré comprenant des agonistes de tlr4 et leurs procédés d'utilisation |
| SI2850431T1 (en) | 2012-05-16 | 2018-08-31 | Immune Design Corp. | Vaccines for hsv-2 |
| WO2014066443A1 (fr) | 2012-10-23 | 2014-05-01 | Emory University | Conjugués de gm-csf et d'il-4, compositions et procédés associés |
| EP2986303B1 (fr) | 2013-04-18 | 2020-02-26 | Immune Design Corp. | Monothérapie par gla pour une utilisation dans le traitement du cancer |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| IL246456B2 (en) | 2013-12-31 | 2024-06-01 | Access To Advanced Health Inst | Formulations will be assembled into a single vial |
| CN108885212B (zh) | 2016-02-22 | 2022-05-31 | 勃林格殷格翰维特梅迪卡有限公司 | 固定生物分子的方法 |
| BR112018073676B1 (pt) | 2016-05-16 | 2023-10-03 | University Of Virginia Patent Foundation | Lipossomas peguilados e métodos de uso |
| MX2018014086A (es) | 2016-05-16 | 2019-09-18 | Infectious Disease Res Inst | Formulacion que contiene agonista tlr y metodos de uso. |
| CA3023271A1 (fr) | 2016-06-01 | 2017-12-07 | Infectious Disease Research Institute | Nanoparticules d'alun contenant un agent d'encollage |
| US11141377B2 (en) | 2017-06-15 | 2021-10-12 | Infectious Disease Research Institute | Nanostructured lipid carriers and stable emulsions and uses thereof |
| CA3078223A1 (fr) | 2017-09-08 | 2019-03-14 | Infectious Disease Research Institute | Formulations liposomales comprenant de la saponine et procedes d'utilisation |
| WO2020243115A1 (fr) | 2019-05-25 | 2020-12-03 | Infectious Disease Research Institute | Composition et procédé de séchage par atomisation d'une émulsion de vaccin et d'adjuvant |
| WO2022051022A1 (fr) | 2020-09-04 | 2022-03-10 | Infectious Disease Research Institute | Arn co-lyophilisé et support lipidique nanostructuré |
| EP4583841A1 (fr) | 2022-09-09 | 2025-07-16 | Access to Advanced Health Institute | Composition de vaccin immunogène incorporant une saponine |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57106626A (en) * | 1980-12-22 | 1982-07-02 | Teijin Ltd | Cytotoxic protein complex and its preparation |
| US4455296A (en) * | 1982-02-02 | 1984-06-19 | Board Of Regents, The University Of Texas System | Hybrid cell lines producing monoclonal antibodies directed against Haemophilus influenzae |
| US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| FR2524487B1 (fr) * | 1982-04-05 | 1985-11-22 | Pasteur Institut | Fragments d'adn codant pour des polypeptides contenant au moins un determinant antigenique des papillomavirus, notamment du type hpv 1a et polypeptides correspondants |
| US4596674A (en) * | 1984-09-11 | 1986-06-24 | Merck & Co., Inc. | Immunogenic HAV peptides |
| DE3625257A1 (de) * | 1986-07-23 | 1988-02-04 | Behringwerke Ag | Expressionsprodukte der menschlichen papillomviren typ 16 und 18, fuer diese proteine spezifische antikoerper und diese antikoerper bzw. entsprechende dna enthaltende diagnostika |
| NZ223009A (en) * | 1986-12-31 | 1990-06-26 | Nl Rivm Of Thoven | Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens |
| EP0320942A3 (fr) * | 1987-12-18 | 1989-10-04 | American Cyanamid Company | Polysaccharides et composés macromoléculaires contenant ces polysaccharides |
| AU650868B2 (en) * | 1990-03-20 | 1994-07-07 | Behringwerke Aktiengesellschaft | Seroreactive epitopes of human papillomavirus (HPV) 16 proteins |
| DE122007000085I1 (de) * | 1991-07-19 | 2008-03-27 | Univ Queensland St Lucia | Polynukleotidabschnitt des HPV16-Genoms |
-
1993
- 1993-06-24 EP EP07013259A patent/EP1835029A1/fr not_active Withdrawn
- 1993-06-24 DE DE122007000094C patent/DE122007000094I1/de active Pending
- 1993-06-24 PT PT93916789T patent/PT647140E/pt unknown
- 1993-06-24 DK DK93916789T patent/DK0647140T3/da active
- 1993-06-24 WO PCT/US1993/006109 patent/WO1994000152A1/fr not_active Ceased
- 1993-06-24 DE DE122007000099C patent/DE122007000099I1/de active Pending
- 1993-06-24 DE DE122007000097C patent/DE122007000097I1/de active Pending
- 1993-06-24 DE DE69334192T patent/DE69334192T2/de not_active Expired - Lifetime
- 1993-06-24 DE DE122007000095C patent/DE122007000095I1/de active Pending
- 1993-06-24 DE DE122007000101C patent/DE122007000101I1/de active Pending
- 1993-06-24 DE DE122007000096C patent/DE122007000096I1/de active Pending
- 1993-06-24 DE DE122007000100C patent/DE122007000100I1/de active Pending
- 1993-06-24 ES ES93916789T patent/ES2294778T3/es not_active Expired - Lifetime
- 1993-06-24 DE DE122007000098C patent/DE122007000098I1/de active Pending
- 1993-06-24 EP EP93916789A patent/EP0647140B1/fr not_active Expired - Lifetime
- 1993-06-24 AT AT93916789T patent/ATE380871T1/de active
-
1995
- 1995-01-24 AU AU11352/95A patent/AU697743C/en not_active Expired
- 1995-06-07 US US08/473,228 patent/US20020068326A1/en not_active Abandoned
-
1996
- 1996-12-16 US US08/764,926 patent/US8012679B1/en not_active Expired - Fee Related
-
2005
- 2005-12-14 LU LU91395C patent/LU91395I2/fr unknown
-
2007
- 2007-12-14 NL NL300316C patent/NL300316I1/nl unknown
- 2007-12-14 NL NL300322C patent/NL300322I1/nl unknown
- 2007-12-14 LU LU91397C patent/LU91397I2/fr unknown
- 2007-12-14 LU LU91399C patent/LU91399I2/fr unknown
- 2007-12-14 NL NL300315C patent/NL300315I2/nl unknown
- 2007-12-14 NL NL300321C patent/NL300321I1/nl unknown
- 2007-12-14 NL NL300318C patent/NL300318I2/nl unknown
- 2007-12-14 NL NL300317C patent/NL300317I1/nl unknown
- 2007-12-14 LU LU91394C patent/LU91394I2/fr unknown
- 2007-12-14 LU LU91393C patent/LU91393I2/fr unknown
- 2007-12-14 NL NL300319C patent/NL300319I1/nl unknown
- 2007-12-14 NL NL300320C patent/NL300320I1/nl unknown
- 2007-12-14 LU LU91398C patent/LU91398I2/fr unknown
- 2007-12-14 LU LU91396C patent/LU91396I2/fr unknown
- 2007-12-14 LU LU91400C patent/LU91400I2/fr unknown
- 2007-12-21 FR FR07C0073C patent/FR07C0073I2/fr active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LU91397I2 (fr) | "La protéine L1 recombinante du papillomavirus humain de type 6" Gardasil-Silgard | |
| DE122008000010I1 (de) | Sich selbst-zusammenbauende rekombinante hpv16 papillomavirus-hüllproteine |