LU92915I2 - Ivermectine pour son usage dans le traitement de la rosacée - Google Patents
Ivermectine pour son usage dans le traitement de la rosacée Download PDFInfo
- Publication number
- LU92915I2 LU92915I2 LU92915C LU92915C LU92915I2 LU 92915 I2 LU92915 I2 LU 92915I2 LU 92915 C LU92915 C LU 92915C LU 92915 C LU92915 C LU 92915C LU 92915 I2 LU92915 I2 LU 92915I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- rosaceae
- ivermectin
- treatment
- Prior art date
Links
- AZSNMRSAGSSBNP-XPNPUAGNSA-N 22,23-dihydroavermectin B1a Chemical compound C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 AZSNMRSAGSSBNP-XPNPUAGNSA-N 0.000 title 1
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 title 1
- 235000004789 Rosa xanthina Nutrition 0.000 title 1
- 241000220222 Rosaceae Species 0.000 title 1
- 229960002418 ivermectin Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0305048A FR2854074B1 (fr) | 2003-04-24 | 2003-04-24 | Utilisation de l'ivermectine pour le traitement de desordres dermatologiques |
| US46899403P | 2003-05-09 | 2003-05-09 | |
| PCT/EP2004/004950 WO2004093886A1 (fr) | 2003-04-24 | 2004-04-22 | Formulation a usage topique d'ivermectine pour le traitement de conditions dermatologiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU92915I2 true LU92915I2 (fr) | 2016-02-17 |
Family
ID=33312271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU92915C LU92915I2 (fr) | 2003-04-24 | 2015-12-17 | Ivermectine pour son usage dans le traitement de la rosacée |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US7550440B2 (fr) |
| EP (1) | EP1620113B1 (fr) |
| JP (2) | JP5711867B2 (fr) |
| KR (1) | KR101187231B1 (fr) |
| AU (1) | AU2004231323C1 (fr) |
| BR (1) | BRPI0410503B8 (fr) |
| CA (1) | CA2522579C (fr) |
| CY (2) | CY1111797T1 (fr) |
| FR (1) | FR15C0069I2 (fr) |
| HU (1) | HUS1500048I1 (fr) |
| LT (1) | LTC1620113I2 (fr) |
| LU (1) | LU92915I2 (fr) |
| MX (1) | MXPA05011208A (fr) |
| PL (2) | PL378932A1 (fr) |
| RU (1) | RU2350333C3 (fr) |
| WO (1) | WO2004093886A1 (fr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2854074B1 (fr) | 2003-04-24 | 2007-11-23 | Galderma Res & Dev | Utilisation de l'ivermectine pour le traitement de desordres dermatologiques |
| WO2004093886A1 (fr) * | 2003-04-24 | 2004-11-04 | Galderma S.A. | Formulation a usage topique d'ivermectine pour le traitement de conditions dermatologiques |
| US7648711B2 (en) * | 2003-05-25 | 2010-01-19 | Yuwan Wang | Dimethicone-containing sustained release injection formulation |
| DE602005020912D1 (de) | 2004-03-18 | 2010-06-10 | Galderma Sa | Ivermectin enthaltende creme |
| FR2867684B1 (fr) * | 2004-03-18 | 2006-05-05 | Galderma Sa | Gel creme contenant de l'ivermectine |
| FR2883181B1 (fr) | 2005-03-17 | 2007-05-18 | Galderma Sa | Composition a base d'une avermectine et d'acide azelaique notamment pour le traitement de la rosacee |
| FR2886852B1 (fr) * | 2005-06-10 | 2007-11-23 | Galderma Sa | Composition a base d'une avermectine et d'hydrocortisone notamment pour le traitement de la rosacee |
| FR2886851B1 (fr) * | 2005-06-10 | 2007-10-05 | Galderma Sa | Composition a base d'une avermectine et de metronidazole notamment pour le traitement de la rosacee |
| FR2886850B1 (fr) * | 2005-06-10 | 2007-10-05 | Galderma Sa | Composition a base d'une avermectine et de peroxyde de benzoyle notamment pour le traitement de la rosacee |
| FR2894823B1 (fr) | 2005-12-20 | 2008-02-29 | Galderma Sa | Composition de type emulsion inverse comprenant de l'ivermectine, et ses utilisations en cosmetique et en dermatologie |
| FR2900052B1 (fr) * | 2006-04-19 | 2011-02-18 | Galderma Sa | Composition comprenant au moins une phase aqueuse et au moins une phase grasse comprenant de l'ivermectine |
| FR2906468B1 (fr) * | 2006-09-28 | 2012-09-21 | Galderma Sa | Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques |
| FR2907013B1 (fr) * | 2006-10-12 | 2012-09-21 | Galderma Sa | Produits de soin cutane a double compartiment comprenant de l'ivermectine, et leurs utilisations |
| FR2907012B1 (fr) | 2006-10-12 | 2012-09-21 | Galderma Sa | Composition dermatologique comprenant des nanocapsules d'avermectine, son procede de preparation et son utilisation |
| EP2091325B1 (fr) | 2006-10-12 | 2014-08-06 | Topaz Pharmaceuticals Inc. | Formulation shampooing-après-shampooing comprenant un avermectine pour l'élimination et la prophylaxie contre les souches de poux sensibles et résistantes aux traitements |
| US8901163B2 (en) * | 2007-01-03 | 2014-12-02 | Galderma S.A. | Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound |
| DE102007056424A1 (de) * | 2007-11-23 | 2009-05-28 | Neopharmacie Gmbh | Pharmazeutische Zusammensetzung, enthaltend eine Öl/Wasser-Emulsion |
| JP5694944B2 (ja) * | 2008-10-29 | 2015-04-01 | トパズ ファーマシューティカルズ インコーポレイティド | エマルション系局所治療用製剤の保存方式 |
| JP2012513387A (ja) * | 2008-12-23 | 2012-06-14 | ガルデルマ・ソシエテ・アノニム | 感水性の活性成分を含む、局所用医薬組成物 |
| ES2658897T3 (es) | 2011-08-24 | 2018-03-12 | Novan, Inc. | Macromoléculas de liberación de óxido nítrico ajustables que tienen múltiples estructuras donantes de óxido nítrico |
| US8642665B2 (en) | 2011-12-16 | 2014-02-04 | Conopco, Inc. | Environmentally friendly, low whitening compositions |
| JP5717034B2 (ja) * | 2012-08-27 | 2015-05-13 | 丸和バイオケミカル株式会社 | マクロライド系化合物を含有する土壌線虫防除用薬剤 |
| FR3000397A1 (fr) * | 2012-12-31 | 2014-07-04 | Galderma Res & Dev | Combinaison de laropiprant et d'ivermectine pour le traitement de la rosacee |
| CN103356687B (zh) | 2012-10-19 | 2016-06-01 | 厦门大学 | 一种伊维菌素及其衍生物的用途 |
| FR3003761B1 (fr) * | 2013-03-29 | 2016-01-01 | Galderma Sa | Utilisation d'une lactone macrocyclique pour le traitement d'une infection par un papillomavirus |
| US9782425B2 (en) | 2013-07-08 | 2017-10-10 | Galderma S.A. | Treatment of papulopustular rosacea with ivermectin |
| US9233117B2 (en) * | 2013-07-08 | 2016-01-12 | Galderma S. A. | Treatment of inflammatory lesions of rosacea with ivermectin |
| US11813284B2 (en) | 2013-08-08 | 2023-11-14 | Novan, Inc. | Topical compositions and methods of using the same |
| WO2015079016A1 (fr) | 2013-11-29 | 2015-06-04 | Galderma Sa | Compose de la famille des avermectines ou de la famille des milbemycines pour le traitement et/ou la prevention de dermatite atopique |
| CN104706584A (zh) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | 一种伊维菌素脂肪乳浓缩液、其制备方法及用途 |
| US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
| WO2016022066A1 (fr) * | 2014-08-04 | 2016-02-11 | Jerry Tan Eye Surgery Pte Ltd | Compositions pharmaceutiques pour blépharite et encroûtement des paupières liés à demodex |
| FR3026010B1 (fr) * | 2014-09-18 | 2016-11-04 | Galderma Sa | Compositions comprenant un compose de la famille des avermectines et de la doxycycline pour le traitement de la rosacee |
| WO2016096797A1 (fr) | 2014-12-15 | 2016-06-23 | Galderma Sa | Composé de la famille des avermectines associé à un autre composé actif en vue du traitement et/ou de la prévention des dermatoses inflammatoires |
| WO2016096795A1 (fr) * | 2014-12-15 | 2016-06-23 | Galderma Sa | Composé de la famille des avermectines utilisable en vue du traitement et/ou de la prévention de dermatoses inflammatoires |
| EP3362045B1 (fr) | 2015-10-13 | 2019-10-09 | Galderma S.A. | Procédé de préparation d'une composition ayant une concentration élevée des avermectins |
| WO2017064205A1 (fr) | 2015-10-13 | 2017-04-20 | Galderma Sa | Procédé de préparation d'une émulsion stable comprenant une ou de plusieurs avermectines |
| EP3493795A1 (fr) | 2016-08-04 | 2019-06-12 | Nestlé Skin Health SA | Formule de traitement ou de prévention de la couperose. |
| US11160780B2 (en) * | 2016-09-30 | 2021-11-02 | Aurobindo Pharma Ltd. | Pharmaceutical composition of ivermectin and process for preparation thereof |
| US11234959B2 (en) | 2016-11-03 | 2022-02-01 | Galderma Holding SA | Compositions comprising a compound of the avermectin family for the treatment and/or prevention of hand eczema |
| EP3326614A1 (fr) | 2016-11-24 | 2018-05-30 | Nestlé Skin Health SA | Composition comprenant des composés d'avermectine sans solvants et agents pro-pénétrants de composés d'avermectine |
| EP3326609A1 (fr) | 2016-11-24 | 2018-05-30 | Nestlé Skin Health SA | Composition comprenant des composés d'avermectine sans agents de gélification |
| EP3326608A1 (fr) | 2016-11-24 | 2018-05-30 | Nestlé Skin Health SA | Composition comprenant des composés d'avermectine sans matières grasses solides |
| KR20260035292A (ko) * | 2017-06-12 | 2026-03-12 | 레이크우드 아메덱스, 인크. | 비스포스포신 겔 제제 및 이의 용도 |
| AU2018385766B2 (en) | 2017-12-15 | 2022-12-01 | Tarsus Pharmaceuticals, Inc. | Isoxazoline parasiticide formulations and methods for treating blepharitis |
| WO2019241498A1 (fr) | 2018-06-15 | 2019-12-19 | W. R. Grace & Co.-Conn | Agent antimousse actif, son procédé de fabrication et formulation de démoussage |
| SG11202102783QA (en) * | 2018-09-28 | 2021-04-29 | Galderma Res & Dev | Pharmaceutical composition in the form of a water-in-oil emulsion (w/o) and its uses |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| WO2020210784A1 (fr) | 2019-04-12 | 2020-10-15 | Ecolab Usa Inc. | Nettoyant antimicrobien multi-usages et procédés de fabrication et d'utilisation de celui-ci |
| US12161752B2 (en) | 2019-08-20 | 2024-12-10 | Vishwanath Padmanabhan | Compositions and methods for the treatment of anterior blepharitis and posterior blepharitis |
| CN115379824A (zh) * | 2019-08-21 | 2022-11-22 | 生物制药股份有限公司 | 用于局部递送活性剂的溶剂递送系统 |
| KR20220052474A (ko) | 2020-10-21 | 2022-04-28 | 순천향대학교 산학협력단 | 주사증 진단을 위한 마이크로RNA-21-3p 및 이의 용도 |
| KR102480430B1 (ko) | 2020-10-21 | 2022-12-21 | 순천향대학교 산학협력단 | 주사증 진단을 위한 마이크로RNA-31-5p 및 이의 용도 |
| US11291679B1 (en) * | 2021-03-22 | 2022-04-05 | Mountain Valley Md Inc. | Injectable, infusable, instillable ivermectin adjuvant for cancer therapies |
| EP4062907A1 (fr) | 2021-03-23 | 2022-09-28 | Substipharm | Formulation par voie orale d'ivermectine et utilisations |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5332577A (en) | 1988-12-27 | 1994-07-26 | Dermamed | Transdermal administration to humans and animals |
| GB9422306D0 (en) * | 1994-11-04 | 1994-12-21 | Sandoz Ltd | Organic compounds |
| US5952371A (en) * | 1996-10-16 | 1999-09-14 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
| RU2138268C1 (ru) * | 1997-09-22 | 1999-09-27 | Мосин Владимир Александрович | Средство, подавляющее пролиферацию и вызывающее гибель опухолевых клеток, при этом защищающее нормальные клетки |
| US5952372A (en) * | 1998-09-17 | 1999-09-14 | Mcdaniel; William Robert | Method for treating rosacea using oral or topical ivermectin |
| US6310968B1 (en) * | 1998-11-24 | 2001-10-30 | Picker International, Inc. | Source-assisted attenuation correction for emission computed tomography |
| IL144561A0 (en) * | 1999-01-25 | 2002-05-23 | Optime Therapeutics Inc | Liposome compositions and methods for treating pests utilizing the same |
| US6133310A (en) * | 1999-08-26 | 2000-10-17 | Parks; L. Dean | Method of treatment of rosacea |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| US6399652B1 (en) * | 2000-06-29 | 2002-06-04 | L. Dean Parks | Method of treating acne vulgaris using avermectin compound |
| US6319945B1 (en) | 2000-06-29 | 2001-11-20 | L. Dean Parks | Method of treatment of seborrheic dermatitis |
| US6399651B1 (en) | 2000-06-29 | 2002-06-04 | L. Dean Parks | Method of treating dermatoses using avermectin compound |
| US20030064940A1 (en) * | 2001-10-02 | 2003-04-03 | Parks L. Dean | Kit for treating acne vulgaris using avermectin compound |
| DE10063946A1 (de) * | 2000-12-20 | 2002-07-04 | Basf Ag | Verwendung von Lichtschutzmittelkombinationen, die als wesentlichen Bestandteil 2,2'-p-Phenylen-bis(3,1-benzoxazin-4-on) enthalten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen |
| EP1476121A4 (fr) * | 2002-02-08 | 2010-10-27 | Merck Sharp & Dohme | Composition topique d'ivermectine |
| CN1649578A (zh) * | 2002-03-04 | 2005-08-03 | 戴弗根斯公司 | 杀线虫的脂肪酸和脂肪酸酯相关化合物 |
| WO2004093886A1 (fr) * | 2003-04-24 | 2004-11-04 | Galderma S.A. | Formulation a usage topique d'ivermectine pour le traitement de conditions dermatologiques |
| DE602005020912D1 (de) | 2004-03-18 | 2010-06-10 | Galderma Sa | Ivermectin enthaltende creme |
| FR2867684B1 (fr) | 2004-03-18 | 2006-05-05 | Galderma Sa | Gel creme contenant de l'ivermectine |
-
2004
- 2004-04-22 WO PCT/EP2004/004950 patent/WO2004093886A1/fr not_active Ceased
- 2004-04-22 PL PL378932A patent/PL378932A1/pl not_active Application Discontinuation
- 2004-04-22 PL PL04728811T patent/PL1620113T3/pl unknown
- 2004-04-22 RU RU2005136438A patent/RU2350333C3/ru active Protection Beyond IP Right Term
- 2004-04-22 JP JP2006505405A patent/JP5711867B2/ja not_active Expired - Lifetime
- 2004-04-22 KR KR1020057019402A patent/KR101187231B1/ko not_active Expired - Lifetime
- 2004-04-22 CA CA2522579A patent/CA2522579C/fr not_active Expired - Fee Related
- 2004-04-22 BR BRPI0410503A patent/BRPI0410503B8/pt not_active IP Right Cessation
- 2004-04-22 EP EP04728811A patent/EP1620113B1/fr not_active Expired - Lifetime
- 2004-04-22 MX MXPA05011208A patent/MXPA05011208A/es active IP Right Grant
- 2004-04-22 AU AU2004231323A patent/AU2004231323C1/en active Active
-
2005
- 2005-10-24 US US11/255,910 patent/US7550440B2/en not_active Expired - Lifetime
-
2009
- 2009-05-19 US US12/468,287 patent/US8080530B2/en not_active Expired - Lifetime
- 2009-06-12 US US12/483,604 patent/US8093219B2/en not_active Expired - Lifetime
-
2011
- 2011-09-07 CY CY20111100856T patent/CY1111797T1/el unknown
- 2011-12-02 US US13/310,633 patent/US8415311B2/en not_active Expired - Fee Related
-
2012
- 2012-03-22 JP JP2012065724A patent/JP5538461B2/ja not_active Expired - Lifetime
- 2012-06-21 US US13/529,971 patent/US8470788B2/en not_active Expired - Fee Related
-
2013
- 2013-03-27 US US13/851,816 patent/US8598129B2/en not_active Expired - Fee Related
-
2015
- 2015-09-22 HU HUS1500048C patent/HUS1500048I1/hu unknown
- 2015-09-24 LT LTPA2015033C patent/LTC1620113I2/lt unknown
- 2015-10-14 FR FR15C0069C patent/FR15C0069I2/fr active Active
- 2015-12-17 LU LU92915C patent/LU92915I2/fr unknown
-
2016
- 2016-09-09 CY CY2016031C patent/CY2016031I2/el unknown
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