LU93160I2 - Methode de traitement du cancer resistant au gefitinib - Google Patents

Methode de traitement du cancer resistant au gefitinib Download PDF

Info

Publication number
LU93160I2
LU93160I2 LU93160C LU93160C LU93160I2 LU 93160 I2 LU93160 I2 LU 93160I2 LU 93160 C LU93160 C LU 93160C LU 93160 C LU93160 C LU 93160C LU 93160 I2 LU93160 I2 LU 93160I2
Authority
LU
Luxembourg
Prior art keywords
cancer
gefitinib
erlotinib
progression
methode
Prior art date
Application number
LU93160C
Other languages
English (en)
Original Assignee
Gen Hospital Corp
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36777922&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU93160(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Hospital Corp, Wyeth Llc filed Critical Gen Hospital Corp
Publication of LU93160I2 publication Critical patent/LU93160I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LU93160C 2005-02-03 2016-07-26 Methode de traitement du cancer resistant au gefitinib LU93160I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64948305P 2005-02-03 2005-02-03
US67198905P 2005-04-15 2005-04-15
PCT/US2006/003717 WO2006084058A2 (fr) 2005-02-03 2006-02-02 Methode de traitement du cancer resistant au gefitinib

Publications (1)

Publication Number Publication Date
LU93160I2 true LU93160I2 (en) 2016-09-26

Family

ID=36777922

Family Applications (1)

Application Number Title Priority Date Filing Date
LU93160C LU93160I2 (en) 2005-02-03 2016-07-26 Methode de traitement du cancer resistant au gefitinib

Country Status (27)

Country Link
US (3) US10603314B2 (fr)
EP (1) EP1848414B1 (fr)
JP (1) JP2008528695A (fr)
KR (1) KR101313702B1 (fr)
CN (8) CN108743588A (fr)
AT (1) ATE504299T1 (fr)
AU (1) AU2006210572B2 (fr)
BR (1) BRPI0606839B8 (fr)
CA (1) CA2596714C (fr)
CY (2) CY1111676T1 (fr)
DE (1) DE602006021142D1 (fr)
DK (1) DK1848414T3 (fr)
ES (1) ES2364495T3 (fr)
FR (1) FR16C1004I1 (fr)
HU (1) HUS1600033I1 (fr)
IL (3) IL184791A (fr)
LU (1) LU93160I2 (fr)
MX (1) MX2007009317A (fr)
NI (1) NI200700185A (fr)
NO (1) NO20074366L (fr)
NZ (1) NZ556673A (fr)
PL (1) PL1848414T3 (fr)
PT (1) PT1848414E (fr)
RU (2) RU2405566C2 (fr)
SI (1) SI1848414T1 (fr)
WO (1) WO2006084058A2 (fr)
ZA (1) ZA200706804B (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101313702B1 (ko) 2005-02-03 2013-10-04 와이어쓰 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물
EP2505591A1 (fr) 2005-02-11 2012-10-03 Memorial Sloan-Kettering Cancer Center Procédés et compositions pour détecter un mutant d'EGFR résistant aux médicaments
CA2646257A1 (fr) * 2005-04-14 2006-10-26 Wyeth Utilisation d'un inhibiteur kinase du recepteur du facteur de croissance epidermique (egfr) chez des patients resistant a la gefitinib
EP1942937A1 (fr) 2005-11-04 2008-07-16 Wyeth Combinaisons antineoplasiques a base d'inhibiteur de mtop, d'herceptine et/ou de khi-272
PT1948180E (pt) * 2005-11-11 2013-05-10 Boehringer Ingelheim Int Tratamento de combinação de cancro compreendendo inibidores de egfr/her2
JP5688877B2 (ja) * 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌疾患の治療用キナゾリン誘導体
CN101516376A (zh) * 2006-09-18 2009-08-26 贝林格尔.英格海姆国际有限公司 用于治疗携带egfr突变的癌症的方法
AU2007299080B2 (en) 2006-09-18 2013-04-18 Boehringer Ingelheim International Gmbh Method for treating cancer harboring EGFR mutations
WO2008121467A2 (fr) * 2007-02-28 2008-10-09 Dana-Farber Cancer Institute, Inc. Polythérapie pour le traitement du cancer
CA2679757A1 (fr) * 2007-03-02 2008-09-12 Mdrna, Inc. Composes d'acide nucleique permettant d'inhiber l'expression de gene de la famille erbb et utilisations de ceux-ci
AU2008239594B2 (en) 2007-04-13 2013-10-24 Beth Israel Deaconess Medical Center Methods for treating cancer resistant to ErbB therapeutics
AU2013203111B2 (en) * 2007-04-13 2015-10-08 Beth Israel Deaconess Medical Center, Inc. Methods for treating cancer resistant to erbb therapeutics
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
BRPI0914790A2 (pt) 2008-06-17 2015-10-20 Wyeth Llc uso de um composto de vinorelbina e um composto de hki-272, composição farmacêutica e produto e kit para o tratamento de neoplasma
CA2730930C (fr) 2008-07-16 2015-01-13 Pharmacyclics, Inc. Inhibiteurs de tyrosine kinase de bruton pour le traitement de tumeurs solides
US8669273B2 (en) 2008-08-04 2014-03-11 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
DK3000467T3 (da) 2009-04-06 2023-03-27 Wyeth Llc Behandling med neratinib mod brystkræft
US9908884B2 (en) 2009-05-05 2018-03-06 Dana-Farber Cancer Institute, Inc. EGFR inhibitors and methods of treating disorders
PT2451445T (pt) 2009-07-06 2019-07-10 Boehringer Ingelheim Int Processo para secagem de bibw2992, dos seus sais e de formulações farmacêuticas sólidas compreendendo este ingrediente ativo
US9556426B2 (en) 2009-09-16 2017-01-31 Celgene Avilomics Research, Inc. Protein kinase conjugates and inhibitors
WO2011069962A1 (fr) 2009-12-07 2011-06-16 Boehringer Ingelheim International Gmbh Bibw 2992 pour utilisation dans le traitement du cancer du sein triple négatif
WO2011079231A1 (fr) * 2009-12-23 2011-06-30 Gatekeeper Pharmaceutical, Inc. Composés qui modulent l'activité egfr et des procédés pour traiter ou prévenir des affections avec ceux-ci
JP2013516422A (ja) 2009-12-30 2013-05-13 アビラ セラピューティクス， インコーポレイテッド タンパク質のリガンド−指向性共有的修飾
CA3007787C (fr) 2010-06-03 2020-03-10 Pharmacyclics Llc Utilisation d'inhibiteurs de la tyrosine kinase de bruton (btk)
JP2014520863A (ja) 2011-07-13 2014-08-25 ファーマサイクリックス，インク． Ｂｒｕｔｏｎ型チロシンキナーゼの阻害剤
EP4119551A1 (fr) 2011-07-27 2023-01-18 Astrazeneca AB Composés de 2-(anilino 2,4,5-substitué)pyrimidine
EP2751285B2 (fr) * 2011-08-31 2020-04-01 Genentech, Inc. Procédé d'analyse de la sensibilité d'une tumeur à des inhibiteurs de la egfr kinase
WO2013152186A1 (fr) * 2012-04-04 2013-10-10 Beth Israel Deaconess Medical Center, Inc. Procédés et compositions pour la 6-phosphogluconate déshydrogénase (6-pgd) en tant que cible pour la thérapie du cancer du poumon
CN104704129A (zh) 2012-07-24 2015-06-10 药品循环公司 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
US20140308274A1 (en) * 2013-03-15 2014-10-16 Mirna Therapeutics, Inc. Combination cancer treatments utilizing synthetic oligonucleotides and egfr-tki inhibitors
KR101384686B1 (ko) 2013-05-28 2014-04-21 주식회사 바이오인프라 Egfr 표적 치료제에 대한 폐암의 치료 반응성을 예측하는 방법
US9415050B2 (en) 2013-08-12 2016-08-16 Pharmacyclics Llc Methods for the treatment of HER2 amplified cancer
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
US9885086B2 (en) 2014-03-20 2018-02-06 Pharmacyclics Llc Phospholipase C gamma 2 and resistance associated mutations
KR101751371B1 (ko) 2014-06-25 2017-06-27 연세대학교 원주산학협력단 3,4,5-트리하이드록시벤조산, 이의 유도체 또는 이의 염을 유효성분으로 포함하는 수용체 티로신 키나아제 저해제 내성 항암제 조성물
WO2016029175A1 (fr) * 2014-08-21 2016-02-25 Pharmacyclics Llc Méthodes de traitement de troubles associés à des formes mutantes de l'egfr
CN105085489B (zh) 2014-11-05 2019-03-01 益方生物科技（上海）有限公司 嘧啶或吡啶类化合物、其制备方法和医药用途
US9364469B1 (en) * 2015-08-26 2016-06-14 Macau University Of Science And Technology Identification of a new AMPK activator for treatment of lung cancer
GB201516905D0 (en) * 2015-09-24 2015-11-11 Stratified Medical Ltd Treatment of Neurodegenerative diseases
WO2017117474A1 (fr) * 2015-12-30 2017-07-06 Dana-Farber Cancer Institute, Inc. Composés bifonctionnels destinés à la dégradation d'her3 et procédés d'utilisation
CN105816437B (zh) 2016-03-29 2018-08-03 深圳市药欣生物科技有限公司 一种帕布昔利布的药物制剂及其制备方法
US12098428B2 (en) * 2017-02-26 2024-09-24 Institute For Cancer Research Frequent EGFR and NTRK somatic mutations in colorectal cancer (CRC) with microsatellite instability (MSI)
WO2019178239A1 (fr) * 2018-03-13 2019-09-19 Board Of Regents, The University Of Texas System Procédés de traitement de cancers à l'aide de mutations activant l'egfr
CA3133766A1 (fr) 2019-03-29 2020-10-08 Astrazeneca Ab Osimertinib destine a etre utilise dans le traitement du cancer du poumon non a petites cellules
AU2020328598A1 (en) 2019-08-15 2022-03-03 Black Diamond Therapeutics, Inc. Alkynyl quinazoline compounds
CN114761006A (zh) * 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
US12174172B2 (en) * 2019-12-19 2024-12-24 Johnson & Johnson Consumer Inc. Method for evaluating the efficacy of a composition in reducing the effects of cancer therapeutics on skin
TWI776584B (zh) * 2020-07-10 2022-09-01 長庚醫療財團法人林口長庚紀念醫院 β-1腎上腺素受體拮抗劑用於製備減少表皮生長因子受體抑制劑誘導的上皮細胞損傷以及抑制癌細胞的組合物之用途
CN114306245A (zh) 2020-09-29 2022-04-12 深圳市药欣生物科技有限公司 无定形固体分散体的药物组合物及其制备方法
CN113234832B (zh) * 2021-06-30 2022-06-03 深圳市狂风生命科技有限公司 人类egfr基因错义突变分子标志物及其在预测靶向抑制剂抗药性中的应用
CN114569617B (zh) * 2022-05-06 2022-07-29 中国农业大学 甲基硒酸作为吉非替尼治疗吉非替尼耐药的非小细胞肺癌增敏剂的新用途
TW202535922A (zh) * 2023-12-18 2025-09-16 美商思進公司 治療ｅｇｆｒ突變癌症之方法
CN119899201B (zh) * 2024-12-27 2025-11-25 深圳大学 一种生物素化吉非替尼探针及其制备方法和应用

Family Cites Families (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1327358C (fr) 1987-11-17 1994-03-01 Morio Fujiu Derives fluorocytidine
JP3040121B2 (ja) * 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
CA2045231A1 (fr) * 1990-07-19 1992-01-20 Victor Ling Glycoproteine de membrane cellulaire ayant une resistance aux agents antineoplasiques contenant du platine
EP1400536A1 (fr) 1991-06-14 2004-03-24 Genentech Inc. Procédé pour fabriquer des anticorps humanisés
AU671491B2 (en) 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (fr) 1992-12-18 1995-08-21 Hoffmann La Roche
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
PL181304B1 (pl) 1994-07-22 2001-07-31 Lilly Co Eli Preparat farmaceutyczny do hamowania zmniejszania masy kosci PL PL PL PL PL PL PL PL PL PL
US5476932A (en) 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
JP3437685B2 (ja) * 1995-09-12 2003-08-18 株式会社東芝 交直変換装置の制御保護システム
EP0860433B1 (fr) 1995-11-07 2002-07-03 Kirin Beer Kabushiki Kaisha Derives de quinoline et derives de quinazoline inhibant l'autophosphorylation d'un recepteur de facteur de croissance originaire de plaquettes, et compositions pharmaceutiques les contenant
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6426383B1 (en) * 1997-05-28 2002-07-30 Nalco Chemical Company Preparation of water soluble polymer dispersions from vinylamide monomers
US6251912B1 (en) 1997-08-01 2001-06-26 American Cyanamid Company Substituted quinazoline derivatives
SE9704545D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
US20010051628A1 (en) * 1998-05-04 2001-12-13 H.-J. Su Huang Methods to modulate the resistance of cells to apoptosis mediated by mutant epidermal growth factor receptors
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
ATE255575T1 (de) 1998-09-29 2003-12-15 Wyeth Corp Substituierte 3-cyanochinoline als protein tyrosine kinase inhibitoren
US6297258B1 (en) * 1998-09-29 2001-10-02 American Cyanamid Company Substituted 3-cyanoquinolines
US20030203956A1 (en) * 1998-12-23 2003-10-30 Masterrer Jaime L. Method of using a cyclooxygenase-2 inhibitor and one or more ornithine decarboxylase inhibitors as a combination therapy in the treatment of neoplasia
US6432979B1 (en) * 1999-08-12 2002-08-13 American Cyanamid Company Method of treating or inhibiting colonic polyps and colorectal cancer
TWI256395B (en) 1999-09-29 2006-06-11 Wyeth Corp Regioselective synthesis of rapamycin derivatives
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
EP1248869A2 (fr) 2000-01-07 2002-10-16 Transform Pharmaceuticals, Inc. Formation, identification et analyse a productivites elevees de formes solides diverses
US6384051B1 (en) 2000-03-13 2002-05-07 American Cyanamid Company Method of treating or inhibiting colonic polyps
TWI310684B (en) * 2000-03-27 2009-06-11 Bristol Myers Squibb Co Synergistic pharmaceutical kits for treating cancer
GB0008368D0 (en) * 2000-04-06 2000-05-24 Astrazeneca Ab Combination product
US7306801B2 (en) * 2000-05-15 2007-12-11 Health Research, Inc. Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein
JP2004507465A (ja) * 2000-08-11 2004-03-11 ワイス エストロゲン受容体陽性癌腫の治療方法
TWI286074B (en) * 2000-11-15 2007-09-01 Wyeth Corp Pharmaceutical composition containing CCI-779 as an antineoplastic agent
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
TWI233359B (en) * 2001-04-06 2005-06-01 Wyeth Corp Pharmaceutical composition for treating neoplasm
EA010184B1 (ru) 2001-04-06 2008-06-30 Уайт Применение противоопухолевых комбинаций рапамицина с гемцитабином или 5-фторурацилом
TWI296196B (en) * 2001-04-06 2008-05-01 Wyeth Corp Antineoplastic combinations
PL367267A1 (en) 2001-06-01 2005-02-21 Wyeth Antineoplastic combinations
ZA200603888B (en) * 2001-06-01 2007-05-30 Wyeth Corp Antineoplastic combinations
DE60232370D1 (de) 2001-06-14 2009-06-25 Univ California Mutationen in der mit der resistenz gegenüber sti-
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
AR037438A1 (es) 2001-11-27 2004-11-10 Wyeth Corp 3-cianoquinolinas como inhibidores de egf-r y her2 quinasas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos
PT1478648E (pt) * 2002-02-01 2014-07-15 Ariad Pharma Inc Compostos contendo fósforo e suas utilizações
TWI275390B (en) 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles
WO2003106622A2 (fr) * 2002-05-30 2003-12-24 The Children's Hospital Of Philadelphia Procedes de traitement de la leucemie lymphoide aigue
DE60310922T2 (de) * 2002-06-05 2007-10-11 Cedars-Sinai Medical Center, Los Angeles Gefitinib (iressa) zur behandlung von krebs
WO2004004644A2 (fr) 2002-07-05 2004-01-15 Beth Israel Deaconess Medical Center Association d'un inhibiteur de cible mammalienne de rapamycine (mtor) et d'un inhibiteur de la tyrosine kinase aux fins du de traitement de neoplasmes
AU2003251875A1 (en) * 2002-07-15 2004-02-02 Combinatorx, Incorporated Combination therapy for the treatment of neoplasms
WO2004010937A2 (fr) * 2002-07-26 2004-02-05 Advanced Research & Technology Institute At Indiana University Methode de traitement du cancer
AU2003258061A1 (en) * 2002-08-02 2004-02-23 Salmedix, Inc. Therapeutic inhibitionof protein kinases in cancer cells
US20040209930A1 (en) * 2002-10-02 2004-10-21 Carboni Joan M. Synergistic methods and compositions for treating cancer
AU2003278383B2 (en) * 2002-11-04 2007-06-14 Astrazeneca Ab Quinazoline derivatives as Src tyrosine kinase inhibitors
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
CA2514479A1 (fr) * 2003-01-23 2004-08-05 T.K. Signal Ltd. Nouveaux inhibiteurs irreversibles de la tyrosine kinase du recepteur du facteur de croissance epidermique et utilisations de ces derniers dans la therapie et le diagnostic
CN1437942A (zh) 2003-02-08 2003-08-27 杭州华卫制药技术开发有限公司 注射用长春瑞滨粉针剂及制备方法
UA83484C2 (uk) * 2003-03-05 2008-07-25 Уайт Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
DE602004004520T2 (de) * 2003-04-22 2007-11-08 Wyeth Antineoplastische zusammensetzungen
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
EP1663978B1 (fr) 2003-07-23 2007-11-28 Bayer Pharmaceuticals Corporation Omega-carboxyaryldiphenyluree fluoro-subtituee pour le traitement et la prevention de maladies et d'etats pathologiques
US20050025825A1 (en) 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
WO2005018677A2 (fr) 2003-08-01 2005-03-03 Wyeth Holdings Corporation Utilisation d'un melange d'un inhibiteur de la kinase du recepteur de facteur de croissance epidermique et d'agents cytotoxiques dans le traitement et l'inhibition de cancer
CN1835923A (zh) 2003-08-19 2006-09-20 惠氏控股公司 制备4－氨基－3－喹啉腈的方法
US7399865B2 (en) * 2003-09-15 2008-07-15 Wyeth Protein tyrosine kinase enzyme inhibitors
BR0318503A (pt) 2003-09-15 2006-09-12 Wyeth Corp quinolinas substituìdas como inibidores de enzima proteìna tirosina cinase
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
US20050142192A1 (en) 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
WO2005049021A1 (fr) 2003-11-03 2005-06-02 Oy Helsinki Transplantation R & D Ltd Substances et procedes pour inhiber l'hyperplasie neointime
US7981618B2 (en) 2003-11-05 2011-07-19 Board Of Regents Of The University Of Texas System Diagnostic and therapeutic methods and compositions involving PTEN and breast cancer
TW200526684A (en) 2003-11-21 2005-08-16 Schering Corp Anti-IGFR1 antibody therapeutic combinations
EP1694330A4 (fr) * 2003-12-04 2009-06-24 Amr Technology Inc Derives de la vinorelbine
US9016221B2 (en) 2004-02-17 2015-04-28 University Of Florida Research Foundation, Inc. Surface topographies for non-toxic bioadhesion control
AR047988A1 (es) * 2004-03-11 2006-03-15 Wyeth Corp Combinaciones antineoplásicas de cci-779 y rituximab
ES2425749T3 (es) * 2004-03-31 2013-10-17 The General Hospital Corporation Método para determinar la respuesta del cáncer a tratamientos dirigidos al receptor del factor de crecimiento epidérmico
DE602004025386D1 (de) 2004-05-28 2010-03-18 Hetero Drugs Ltd Neue stereoselektive synthese von benzimidazolsulfoxiden
EP3042964A1 (fr) * 2004-06-04 2016-07-13 Genentech, Inc. Mutations egfr
US20080286771A1 (en) 2004-07-23 2008-11-20 Kevin Hudson Method of Predicting the Responsiveness of a Tumour to Erbb Receptor Drugs
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
TW200616612A (en) 2004-10-08 2006-06-01 Wyeth Corp Method for the teatment of polycystic kidney disease field of invention
EP1799699A1 (fr) 2004-10-13 2007-06-27 Wyeth Analogues de la 17-hydroxywortmannine employés en tant qu inhibiteurs de pi3k
WO2006044748A2 (fr) 2004-10-15 2006-04-27 Monogram Biosciences, Inc. Predicteurs de reponse pour medicaments specifiques de la voie erbb
US20060084666A1 (en) * 2004-10-18 2006-04-20 Harari Paul M Combined treatment with radiation and an epidermal growth factor receptor kinase inhibitor
WO2006085168A2 (fr) 2005-01-07 2006-08-17 Ranbaxy Laboratories Limited Formes de dosage orales solides de ziprasidone
GB0501999D0 (en) 2005-02-01 2005-03-09 Sentinel Oncology Ltd Pharmaceutical compounds
KR101313702B1 (ko) * 2005-02-03 2013-10-04 와이어쓰 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물
WO2006081985A1 (fr) 2005-02-04 2006-08-10 F. Hoffmann-La Roche Ag Traitement combine par un derive de n4-(oxycarbonyl substitue)-5'-desoxy-5-fluorocytidine et un inhibiteur de l'activite kinase du recepteur du facteur de croissance epidermique
MX2007009963A (es) 2005-02-24 2007-09-26 Amgen Inc Mutaciones del receptor del factor de crecimiento epidermico.
SI1859793T1 (sl) 2005-02-28 2011-08-31 Eisai R&D Man Co Ltd Nova kombinirana uporaba sulfonamidne spojine za zdravljenje raka
EP1854463A4 (fr) 2005-03-03 2011-03-23 Takeda Pharmaceutical Composition a liberation controlee
US8105768B2 (en) 2005-03-09 2012-01-31 Abbott Laboratories Methods of identifying patients for treatment with HER-2/neu inhibitors based on detection of HER-2/neu and TOP2A gene copy number
GB0504994D0 (en) 2005-03-11 2005-04-20 Biotica Tech Ltd Novel compounds
US20060235006A1 (en) 2005-04-13 2006-10-19 Lee Francis Y Combinations, methods and compositions for treating cancer
CA2646257A1 (fr) 2005-04-14 2006-10-26 Wyeth Utilisation d'un inhibiteur kinase du recepteur du facteur de croissance epidermique (egfr) chez des patients resistant a la gefitinib
WO2006116016A2 (fr) 2005-04-21 2006-11-02 The Regents Of The University Of California Determinants moleculaires de la reponse de l'inhibiteur d'egfr kinase dans le glioblastome
SI1896034T1 (sl) 2005-04-28 2010-07-30 Wyeth Llc Mikronizirani sestavki tanaprogeta in postopki priprave le-tega
AU2006245421A1 (en) 2005-05-12 2006-11-16 Pfizer Inc. Anticancer combination therapy using sunitinib malate
CA2608394A1 (fr) * 2005-05-25 2006-11-30 Wyeth Procedes de preparation de 3-cyano-quinoleines et intermediaires concus au moyen de ceux-ci
CN101203494A (zh) * 2005-05-25 2008-06-18 惠氏公司 合成经取代3-氰基喹啉和其中间物的方法
DE102005053679A1 (de) 2005-06-24 2006-12-28 Bayer Healthcare Ag Therapeutischer Einsatz von Moxifloxacin zur Rekonstruktion von Funktionsstörungen des Immunsystems
US20070014859A1 (en) 2005-07-15 2007-01-18 Wyeth Highly bioavailable oral delayed release dosage forms of O-desmethylvenlafaxine succinate
WO2007015569A1 (fr) 2005-08-01 2007-02-08 Eisai R & D Management Co., Ltd. Procédé de prédiction de l’efficacité d’un inhibiteur de vascularisation
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
WO2007039705A1 (fr) 2005-10-05 2007-04-12 Astrazeneca Uk Limited Méthode pour prédire ou surveiller la réponse d'un patient à un médicament de récepteur erbb
WO2007050495A2 (fr) 2005-10-26 2007-05-03 Children's Medical Center Corporation Methode permettant de pronostiquer une reponse a un anti-egfr
EP1942937A1 (fr) * 2005-11-04 2008-07-16 Wyeth Combinaisons antineoplasiques a base d'inhibiteur de mtop, d'herceptine et/ou de khi-272
US20070105887A1 (en) * 2005-11-04 2007-05-10 Wyeth Antineoplastic combinations of temsirolimus and sunitinib malate
PT1948180E (pt) 2005-11-11 2013-05-10 Boehringer Ingelheim Int Tratamento de combinação de cancro compreendendo inibidores de egfr/her2
ATE450266T1 (de) 2005-11-24 2009-12-15 Aicuris Gmbh & Co Kg Parapocken-viren in kombination mit klassischen zytotoxischen chemotherapeutika als biochemotherapie zur behandlung von krebs
JP2007145745A (ja) 2005-11-25 2007-06-14 Osaka Univ 変異型ＥＧＦＲ下流シグナルを抑制するＳｒｃファミリーチロシンキナーゼ阻害剤を含む肺癌治療剤およびその利用
WO2007075794A2 (fr) 2005-12-22 2007-07-05 Wyeth Formulations orales contenant de la tigecycline
WO2007095038A2 (fr) 2006-02-09 2007-08-23 Novartis Ag Mutations et polymorphismes du gène erbb2
KR101292508B1 (ko) 2006-04-07 2013-08-01 노파르티스 아게 백혈병의 치료를 위한, 피리미딜아미노벤즈아미드 화합물과 조합된 ｃ-ｓｒｃ 억제제의 용도
TW200806282A (en) 2006-05-05 2008-02-01 Wyeth Corp Solid dosage formulations
CN103424541B (zh) 2006-05-18 2018-01-30 分子压型学会股份有限公司 确定针对病状的个性化医疗介入的系统和方法
TW200808728A (en) 2006-05-23 2008-02-16 Wyeth Corp Method of preparing 4-halogenated quinoline intermediates
WO2008005469A2 (fr) 2006-06-30 2008-01-10 Schering Corporation Biomarqueur igfbp2
AU2007299080B2 (en) 2006-09-18 2013-04-18 Boehringer Ingelheim International Gmbh Method for treating cancer harboring EGFR mutations
JP2010504974A (ja) 2006-09-28 2010-02-18 フォリカ，インコーポレーテッド 新しい毛嚢を生成させ毛髪を成長させる方法、キット、及び組成物
EP2073823A1 (fr) 2006-10-13 2009-07-01 Medigene AG Utilisation de virus oncolytiques et d'agents anti-angiogéniques dans le traitement du cancer
EP2104501B1 (fr) 2006-12-13 2014-03-12 Merck Sharp & Dohme Corp. Methodes de traitement du cancer avec des inhibiteurs igf1r
EP2121018A2 (fr) 2006-12-13 2009-11-25 Schering Corporation Procédés et compositions pour traiter le cancer
PL2101759T3 (pl) 2006-12-14 2019-05-31 Exelixis Inc Sposoby stosowania inhibitorów MEK
WO2008076143A1 (fr) 2006-12-18 2008-06-26 Osi Pharmaceuticals, Inc. Combinaison d'un inhibiteur de l'igfr et d'un agent anticancéreux
CN101678022A (zh) 2006-12-21 2010-03-24 弗特克斯药品有限公司 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物
CN101631536A (zh) 2007-01-12 2010-01-20 惠氏公司 片中片组合物
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
AR065096A1 (es) 2007-02-01 2009-05-13 Takeda Pharmaceutical Preparacion solida
WO2008121467A2 (fr) 2007-02-28 2008-10-09 Dana-Farber Cancer Institute, Inc. Polythérapie pour le traitement du cancer
GB0706633D0 (en) 2007-04-04 2007-05-16 Cyclacel Ltd Combination
EP1978106A1 (fr) 2007-04-07 2008-10-08 Universitätsklinikum Hamburg-Eppendorf Amplificateur ayant une protection de sortie, en particulier un amplificateur opérationnel pour une application audio
AU2008239594B2 (en) 2007-04-13 2013-10-24 Beth Israel Deaconess Medical Center Methods for treating cancer resistant to ErbB therapeutics
CA2684265A1 (fr) 2007-04-19 2008-10-30 Wellstat Biologics Corporation Detection d'une proteine her-2-neu de cellules cancereuses en circulation non isolees et traitement
WO2008136838A1 (fr) 2007-05-04 2008-11-13 Trustees Of Dartmouth College Nouveaux dérivés d'amide de cddo et leurs procédés d'utilisation
US20110014117A1 (en) 2007-06-28 2011-01-20 Schering Corporation Anti-igf1r
HRP20160625T1 (hr) 2007-09-10 2016-08-12 Boston Biomedical, Inc. Novi inhibitori stat3 signalnog puta i inhibitori matičnih stanica raka
EP2205076A4 (fr) 2007-09-24 2010-12-29 Tragara Pharmaceuticals Inc Polythérapie pour le traitement de cancer au moyen d'inhibiteurs de la cox-2 et d'inhibiteurs doubles de l'egfr ýerbb1¨et de l'her-2 ýerbb2¨
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
JP2011500086A (ja) 2007-10-22 2011-01-06 シェーリング コーポレイション 完全ヒト抗ｖｅｇｆ抗体および使用方法
US20100298760A1 (en) 2007-11-05 2010-11-25 Bernat Olle Methods, kits, and compositions for administering pharmaceutical compounds
CN101185633A (zh) 2007-12-14 2008-05-28 山东蓝金生物工程有限公司 一种治疗实体肿瘤的尼拉替尼缓释植入剂
JP2011505873A (ja) 2007-12-18 2011-03-03 シェーリング コーポレイション 抗ｉｇｆ１ｒ療法に対する感受性のバイオマーカー
US20100297118A1 (en) 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
WO2009100176A2 (fr) 2008-02-07 2009-08-13 Abbott Laboratories Forme pharmaceutique pour administration orale d’un inhibiteur de tyrosine kinase
WO2009105234A2 (fr) 2008-02-19 2009-08-27 Combinatorx, Incorporated Procédés et compositions pour le traitement de troubles associés à des défauts du gène ou de la protéine du régulateur de la conductance transmembranaire d'une fibrose kystique
AU2009219437B2 (en) 2008-02-25 2014-10-16 Nestec S.A. Drug selection for breast cancer therapy using antibody-based arrays
WO2009111073A2 (fr) 2008-03-06 2009-09-11 Odyssey Thera, Inc. Dosages haute densité et haut rendement permettant d’identifier les voies de régulation lipidique et nouveaux agents thérapeutiques pour les troubles lipidiques
US20110104256A1 (en) 2008-03-25 2011-05-05 Yaolin Wang Methods for treating or preventing colorectal cancer
WO2009121031A1 (fr) 2008-03-27 2009-10-01 Vascular Biosciences, Inc. Procédé d'identification de nouveaux candidats thérapeutiques via l'analyse d'expression génique dans les maladies d'origine vasculaire
WO2009146034A2 (fr) 2008-03-31 2009-12-03 Takeda Pharmaceutical Company Limited Inhibiteurs de kinases mapk/erk et procédés d’utilisation de ceux-ci
CA2725390C (fr) 2008-04-08 2014-09-23 Syndax Pharmaceuticals, Inc. Administration d'un inhibiteur de hdac, d'un inhibiteur de her-2, et d'un modulateur du recepteur de l'oestrogene selectif
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
MX2010011439A (es) 2008-04-18 2011-01-25 Reata Pharmaceuticals Inc Moduladores de inflamacion antioxidantes: derivados del acido oleanolico homologacion c-17.
JP5529851B2 (ja) 2008-04-18 2014-06-25 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体
KR101713140B1 (ko) 2008-04-18 2017-03-08 리타 파마슈티컬스 잉크. Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체
WO2009146218A2 (fr) 2008-04-18 2009-12-03 Reata Pharmaceuticals, Inc. Composés comprenant un pharmacore anti-inflammatoire et procédés d'utilisation
US20110129456A1 (en) 2008-05-05 2011-06-02 Yaolin Wang Sequential Administration of Chemotherapeutic Agents for Treatment of Cancer
WO2009151910A2 (fr) 2008-05-25 2009-12-17 Wyeth Produit de combinaison d'un inhibiteur de tyrosine kinase de récepteur et d'un inhibiteur d'acide gras synthase pour le traitement du cancer
BRPI0914790A2 (pt) 2008-06-17 2015-10-20 Wyeth Llc uso de um composto de vinorelbina e um composto de hki-272, composição farmacêutica e produto e kit para o tratamento de neoplasma
EP2309860B1 (fr) 2008-07-22 2014-01-08 Trustees of Dartmouth College Cyanoénones monocycliques et leurs procédés d'utilisation
US8669273B2 (en) 2008-08-04 2014-03-11 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
US20100069340A1 (en) 2008-09-11 2010-03-18 Wyeth Pharmaceutical compositions of an src kinase inhibitor and an aromatase inhibitor
WO2010045318A2 (fr) 2008-10-14 2010-04-22 Caris Mpi, Inc. Cibles géniques et protéiques exprimées par des gènes représentant des profils de biomarqueurs et des jeux de signatures par type de tumeurs
WO2010048477A2 (fr) 2008-10-24 2010-04-29 Wyeth Llc Procede ameliore de preparation de produits couples a partir de 4-amino-3-cyanoquinoleines utilisant des intermediaires stabilises
JP2012508244A (ja) 2008-11-07 2012-04-05 エンゾン ファーマシューティカルズ，インコーポレーテッド ＥｒｂＢ−３（ＨＥＲ３）選択的併用療法
WO2010085845A1 (fr) 2009-01-28 2010-08-05 The University Of Queensland Diagnostic du cancer et/ou thérapie contre celui-ci
CN102307475A (zh) 2009-02-04 2012-01-04 彼帕科学公司 用与生长因子抑制剂组合的parp抑制剂治疗肺癌
WO2010098627A2 (fr) 2009-02-27 2010-09-02 한올바이오파마주식회사 Préparation pharmaceutique
WO2010104406A1 (fr) 2009-03-11 2010-09-16 Auckland Uniservices Limited Formes promédicaments d'inhibiteurs de kinase et leur utilisation en thérapie
DK3000467T3 (da) 2009-04-06 2023-03-27 Wyeth Llc Behandling med neratinib mod brystkræft
AR076053A1 (es) 2009-04-14 2011-05-18 Schering Corp Derivados de pirazolo[1,5-a]pirimidina como inhibidores de mtor
WO2010124009A2 (fr) 2009-04-21 2010-10-28 Schering Corporation Anticorps anti-vegf entièrement humains et méthodes d'utilisation de ceux-ci
US9908884B2 (en) 2009-05-05 2018-03-06 Dana-Farber Cancer Institute, Inc. EGFR inhibitors and methods of treating disorders
CN102470109A (zh) 2009-07-02 2012-05-23 惠氏有限责任公司 3-氰基喹啉片剂制剂及其应用
WO2011008054A2 (fr) 2009-07-17 2011-01-20 한올바이오파마주식회사 Sel d'acide butyrique de n,n-diméthyl diamide imidocarbonimidique, son procédé de préparation, ainsi que compositions et combinaisons pharmaceutiques le contenant
KR20110007984A (ko) 2009-07-17 2011-01-25 한올바이오파마주식회사 Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제
WO2011025267A2 (fr) 2009-08-25 2011-03-03 한올바이오파마주식회사 Méthanesulfonate de metformine, procédé de préparation correspondant, composition pharmaceutique le comprenant et formulation combinée le comprenant
KR101190953B1 (ko) 2009-08-25 2012-10-12 한올바이오파마주식회사 메트포르민 타우린염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제
KR101211227B1 (ko) 2009-08-25 2012-12-11 한올바이오파마주식회사 메트포르민 아스코르브산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제
US20110055838A1 (en) 2009-08-28 2011-03-03 Moyes William A Optimized thread scheduling via hardware performance monitoring
EP2470212A4 (fr) 2009-10-01 2013-12-04 Csl Ltd Procédé de traitement de la leucémie à chromosome philadelphie positive
AU2010316683B2 (en) 2009-11-09 2015-10-08 Wyeth Llc Tablet formulations of neratinib maleate
CA2780332C (fr) 2009-11-09 2018-01-30 Wyeth Llc Spheroides de medicament enrobes et utilisations de ceux-ci pour eliminer ou reduire des affections telles que le vomissement et la diarrhee
EP2896632B1 (fr) 2009-11-13 2017-10-25 Daiichi Sankyo Europe GmbH Matériau et procédés de traitement ou de prévention de maladies associées à des HER-3
WO2011069962A1 (fr) 2009-12-07 2011-06-16 Boehringer Ingelheim International Gmbh Bibw 2992 pour utilisation dans le traitement du cancer du sein triple négatif
CA2783743C (fr) 2009-12-11 2022-10-04 Wyeth Llc Biomarqueurs de la voie de la phosphatidylinotisol-3-kinase
US8338456B2 (en) 2010-01-13 2012-12-25 Wyeth Llc Cut-point in PTEN protein expression that accurately identifies tumors and is predictive of drug response to a pan-ErbB inhibitor

Also Published As

Publication number Publication date
NZ556673A (en) 2010-03-26
PL1848414T3 (pl) 2011-10-31
CY2016026I1 (el) 2017-04-05
EP1848414A2 (fr) 2007-10-31
US20230226039A1 (en) 2023-07-20
RU2007132902A (ru) 2009-03-10
AU2006210572A1 (en) 2006-08-10
CN113952338A (zh) 2022-01-21
BRPI0606839B8 (pt) 2021-12-14
RU2405566C9 (ru) 2012-04-27
IL259741A (en) 2018-07-31
FR16C1004I1 (fr) 2016-09-23
IL247165A0 (en) 2016-09-29
BRPI0606839B1 (pt) 2021-11-30
CY2016026I2 (el) 2017-04-05
CN113952459A (zh) 2022-01-21
IL184791A0 (en) 2008-12-29
DK1848414T3 (da) 2011-07-25
NI200700185A (es) 2008-05-06
CN102886045A (zh) 2013-01-23
BRPI0606839A2 (pt) 2010-03-09
CN101155579B (zh) 2012-10-31
KR101313702B1 (ko) 2013-10-04
HK1105285A1 (en) 2008-02-06
ES2364495T3 (es) 2011-09-05
CN113975393A (zh) 2022-01-28
ATE504299T1 (de) 2011-04-15
HUS1600033I1 (hu) 2016-09-28
MX2007009317A (es) 2008-01-30
EP1848414A4 (fr) 2008-11-26
US10596162B2 (en) 2020-03-24
WO2006084058A3 (fr) 2006-12-14
US20160310482A1 (en) 2016-10-27
CN120022370A (zh) 2025-05-23
WO2006084058A2 (fr) 2006-08-10
AU2006210572A2 (en) 2006-08-10
CN108421044A (zh) 2018-08-21
CN108743588A (zh) 2018-11-06
CA2596714C (fr) 2014-06-17
EP1848414B1 (fr) 2011-04-06
CY1111676T1 (el) 2015-10-07
IL184791A (en) 2017-05-29
CN101155579A (zh) 2008-04-02
AU2006210572B2 (en) 2011-08-04
CN113952459B (zh) 2025-02-11
DE602006021142D1 (de) 2011-05-19
CA2596714A1 (fr) 2006-08-10
KR20070107693A (ko) 2007-11-07
US20100087482A1 (en) 2010-04-08
JP2008528695A (ja) 2008-07-31
SI1848414T1 (sl) 2011-08-31
ZA200706804B (en) 2008-10-29
PT1848414E (pt) 2011-05-25
US10603314B2 (en) 2020-03-31
NO20074366L (no) 2007-11-05
RU2405566C2 (ru) 2010-12-10

Similar Documents

Publication Publication Date Title
LU93160I2 (en) Methode de traitement du cancer resistant au gefitinib
EA201491371A1 (ru) Соединение пиразинкарбоксамида
EA200901442A1 (ru) Комбинированная терапия соединением, проявляющим активность ингибитора рецептора адф на тромбоцитах
IS2855B (is) 4-anilínókínasólínafleiður sem andfjölgunarefni
EP3311818A3 (fr) Inhibiteurs de tyrosine-kinase de bruton pour le traitement de tumeurs solides
MXPA05010711A (es) Compuestos y composiciones novedosos como inhibidores de proteina-quinasa.
WO2007013950A3 (fr) Polytherapie de tumeurs exprimant her
MX338185B (es) Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
BRPI0908635A8 (pt) composto, composição farmacêutica e método de tratamento de câncer
MX2012004258A (es) Inhibidores de la tirosina quinasa de bruton.
MX2009002585A (es) Inhibidores e egfr a base de quinolina que contienen porcion de enlace de zinc.
NO20060398L (no) Anvendelse av en kombinasjon av en epidermal vekstfaktor reseptor kinase inhibitor og cytotoksiske midler for behandling og hemming av kreft
NO20074722L (no) Anvendelse av en epidermal vekstfaktor reseptor kinase inhibitor (EGRR) i gefitinib resistente pasienter
TW200716598A (en) Aminoquinoline and aminoquinazoline kinase modulators
MX2024005107A (es) Nuevo uso de compuesto de quinazolinona para el tratamiento de cancer.
MXPA05011858A (es) Agentes terapeuticos que comprenden un agente antiagiongenico en combinacion con un inhibidor src y su uso terapeutico.
MX2010004259A (es) Tratamientos antitumorales mejorados.
TW200638937A (en) Use of EGFR tyrosinekinase inhibitors for treatment of chronic rhinosinusitis
EA200702201A1 (ru) Рофлумиласт для лечения лёгочной гипертензии
WO2008036254A3 (fr) Composés autophagiques et inhibiteurs de la tyrosine kinase pour le traitement du cancer
ATE496899T1 (de) Tetrahydro- und dihydrochinazolinone
ATE465165T1 (de) Pyrimidothienindazole als tyrosinkinasehemmer des epidermalen wachstumsfaktors
PL1843771T3 (pl) Zastosowanie pirymidyloaminobenzamidów do leczenia chorób odpowiadających na modulację aktywności kinazy Tie-2
UA40977U (ru) Способ определения показаний к хирургическому лечению рецидивного холедохолитиаза
UA102114U (uk) Спосіб диференційованої гіпотензивної терапії у хворих на гіпертонічну хворобу