LV10085B - N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran)carboxamide derivatives - Google Patents

N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran)carboxamide derivatives Download PDF

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Publication number
LV10085B
LV10085B LVP-92-232A LV920232A LV10085B LV 10085 B LV10085 B LV 10085B LV 920232 A LV920232 A LV 920232A LV 10085 B LV10085 B LV 10085B
Authority
LV
Latvia
Prior art keywords
formula
alkyl
aryl
hydrogen
amino
Prior art date
Application number
LVP-92-232A
Other languages
English (en)
Latvian (lv)
Other versions
LV10085A (lv
Inventor
Georges Henri Paul Van Daele
Jean-Paul Rene Marie Bosmans
Michel Anna Jozef De Cleyn
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of LV10085A publication Critical patent/LV10085A/xx
Publication of LV10085B publication Critical patent/LV10085B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
LVP-92-232A 1990-03-06 1992-11-27 N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran)carboxamide derivatives LV10085B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909005014A GB9005014D0 (en) 1990-03-06 1990-03-06 N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Publications (2)

Publication Number Publication Date
LV10085A LV10085A (lv) 1994-05-10
LV10085B true LV10085B (en) 1995-02-20

Family

ID=10672103

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-92-232A LV10085B (en) 1990-03-06 1992-11-27 N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran)carboxamide derivatives

Country Status (38)

Country Link
US (2) US5185335A (fr)
EP (1) EP0445862B1 (fr)
JP (1) JP2601566B2 (fr)
KR (1) KR0177521B1 (fr)
CN (1) CN1038936C (fr)
AT (1) ATE191912T1 (fr)
AU (1) AU636012B2 (fr)
BG (1) BG60381B1 (fr)
CA (1) CA2037575C (fr)
CY (1) CY2235B1 (fr)
CZ (1) CZ286617B6 (fr)
DE (1) DE69132119T2 (fr)
DK (1) DK0445862T3 (fr)
ES (1) ES2147175T3 (fr)
FI (1) FI101622B1 (fr)
GB (1) GB9005014D0 (fr)
GR (1) GR3033461T3 (fr)
HR (1) HRP930483B1 (fr)
HU (2) HU221627B1 (fr)
IE (1) IE910710A1 (fr)
IL (1) IL97018A (fr)
LT (1) LT3708B (fr)
LV (1) LV10085B (fr)
MA (1) MA22076A1 (fr)
MY (1) MY108831A (fr)
NO (1) NO177424C (fr)
NZ (1) NZ237189A (fr)
PL (6) PL168384B1 (fr)
PT (1) PT96937B (fr)
RU (1) RU2070884C1 (fr)
SG (1) SG47482A1 (fr)
SI (1) SI9110396B (fr)
SK (2) SK282406B6 (fr)
TN (1) TNSN91010A1 (fr)
UA (1) UA25969A1 (fr)
YU (1) YU48854B (fr)
ZA (1) ZA911611B (fr)
ZW (1) ZW2391A1 (fr)

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WO1994008994A1 (fr) * 1992-10-13 1994-04-28 Smithkline Beecham Plc Esters ou amides heterocycliques utilises comme antagonistes de recepteur de 5-ht¿4?
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
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JPH0820586A (ja) 1994-07-05 1996-01-23 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
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JPH0873463A (ja) 1994-07-05 1996-03-19 Sanwa Kagaku Kenkyusho Co Ltd ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途
ATE178064T1 (de) * 1994-09-27 1999-04-15 Janssen Pharmaceutica Nv Phenyl-oxo-alkyl-(4-piperidinyl) benzoatderivate
WO1996010027A1 (fr) * 1994-09-27 1996-04-04 Janssen Pharmaceutica N.V. Derives benzoates bicycliques de piperidinyle n-substitue
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US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
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HUP0101511A3 (en) 1998-04-28 2002-12-28 Dainippon Pharmaceutical Co 1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
EP1077973A2 (fr) * 1998-05-14 2001-02-28 Egis Gyogyszergyar Rt. Derives de benzofuranne, composition pharmaceutique renfermant ces derives et procede de preparation du principe actif
CA2340952C (fr) * 1998-09-10 2009-12-08 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide et derives de cetone utilises comme antagonistes du recepteur 5-ht4
JP2002530334A (ja) * 1998-11-23 2002-09-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 消化不良の処置用医薬の製造のためのプルカロプリドの使用
JO2181B1 (en) * 1999-04-29 2003-04-23 شركة جانسين فارماسوتيكا ان. في Procalopride solution is taken by mouth
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CN1288730A (zh) * 1999-09-07 2001-03-28 麦克内尔-Ppc股份有限公司 轻泻组合物
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CN1330646C (zh) 2002-01-16 2007-08-08 詹森药业有限公司 普卢卡必利－n－氧化物
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DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
EP2270004A1 (fr) * 2004-02-27 2011-01-05 Vertex Pharmceuticals Incorporated Inhibiteurs de caspase et leur utilisation
GB0525661D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
NZ596889A (en) * 2006-04-07 2013-06-28 Vertex Pharma Use of amide indole derivatives as modulators of ATP-binding cassette transporters
CN102477002B (zh) * 2010-11-26 2015-04-15 苏州凯达生物医药技术有限公司 3-氨基-2,2-双甲基丙酰胺的制备方法
DK2678332T3 (en) 2011-02-25 2016-08-15 Yuhan Corp Diaminopyrimidine derivatives and process for their preparation
GB201103397D0 (fr) 2011-02-28 2011-04-13 Shire Movetis N V
KR101256908B1 (ko) * 2011-04-28 2013-04-23 (주)에이치비메디컬스 주름제거용 충전체
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
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KR101657616B1 (ko) 2013-05-24 2016-09-19 주식회사유한양행 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
EP3413891B1 (fr) * 2016-02-11 2024-01-03 Symed Labs Limited Procédés pour la préparation de succinate de prucalopride très pur
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Also Published As

Publication number Publication date
RU2070884C1 (ru) 1996-12-27
DE69132119T2 (de) 2000-12-21
ES2147175T3 (es) 2000-09-01
EP0445862A2 (fr) 1991-09-11
LT3708B (en) 1996-02-26
HU211350A9 (en) 1995-11-28
NO177424B (no) 1995-06-06
SI9110396B (sl) 2000-06-30
NO177424C (no) 1995-09-13
BG93979A (bg) 1993-12-24
PL289323A1 (en) 1992-03-09
LTIP846A (en) 1995-02-27
KR0177521B1 (ko) 1999-03-20
JPH04211685A (ja) 1992-08-03
EP0445862A3 (en) 1992-05-20
HRP930483A2 (en) 1995-12-31
ATE191912T1 (de) 2000-05-15
CN1054598A (zh) 1991-09-18
PL169238B1 (pl) 1996-06-28
CS46091A3 (en) 1991-10-15
CY2235B1 (en) 2003-07-04
HU910706D0 (en) 1991-09-30
PL168384B1 (en) 1996-02-29
JP2601566B2 (ja) 1997-04-16
UA25969A1 (uk) 1999-02-26
CA2037575C (fr) 2003-09-16
AU7207991A (en) 1991-09-12
IL97018A0 (en) 1992-03-29
FI911096A0 (fi) 1991-03-05
FI101622B (fi) 1998-07-31
DK0445862T3 (da) 2000-09-04
PL168356B1 (pl) 1996-02-29
YU48854B (sh) 2002-06-19
NO910863L (no) 1991-09-09
SK282407B6 (sk) 2002-01-07
PT96937A (pt) 1991-10-31
GR3033461T3 (en) 2000-09-29
HUT60733A (en) 1992-10-28
YU39691A (sh) 1994-06-10
LV10085A (lv) 1994-05-10
HRP930483B1 (en) 2001-04-30
MY108831A (en) 1996-11-30
PT96937B (pt) 1998-07-31
ZA911611B (en) 1992-11-25
PL168686B1 (pl) 1996-03-29
IE910710A1 (en) 1991-09-11
AU636012B2 (en) 1993-04-08
NZ237189A (en) 1992-11-25
SG47482A1 (en) 1998-04-17
EP0445862B1 (fr) 2000-04-19
IL97018A (en) 1995-11-27
SI9110396A (en) 1997-12-31
PL168811B1 (pl) 1996-04-30
HK1010727A1 (en) 1999-06-25
PL168693B1 (pl) 1996-03-29
MA22076A1 (fr) 1991-10-01
BG60381B1 (bg) 1995-01-31
FI101622B1 (fi) 1998-07-31
SK282406B6 (sk) 2002-01-07
FI911096A7 (fi) 1991-09-07
TNSN91010A1 (fr) 1992-10-25
KR910016744A (ko) 1991-11-05
CA2037575A1 (fr) 1991-09-07
NO910863D0 (no) 1991-03-05
ZW2391A1 (en) 1992-09-07
HU221627B1 (hu) 2002-12-28
CN1038936C (zh) 1998-07-01
US5262418A (en) 1993-11-16
CZ286617B6 (cs) 2000-05-17
US5185335A (en) 1993-02-09
GB9005014D0 (en) 1990-05-02
DE69132119D1 (de) 2000-05-25

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