LV12825B - Hiv proteāzes inhibitora iegūšana - Google Patents

Hiv proteāzes inhibitora iegūšana

Info

Publication number: LV12825B
Authority: LV; Latvia
Prior art keywords: hiv; prostate; inhibitor; obtaining; amide
Prior art date: 1993-07-16

Application number

LVP-02-39A

Other languages

English (en)

Other versions

LV12825A (en

Inventor

David Asikn

Ralph P. VOLANTE

Kan K. Eng

Original Assignee

Merck & Co. Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

2002-03-15

Publication date

2002-09-20

1994-01-26 Priority claimed from US08/187,664 external-priority patent/US5463067A/en

2002-03-15 Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.

2002-05-20 Publication of LV12825A publication Critical patent/LV12825A/en

2002-09-20 Publication of LV12825B publication Critical patent/LV12825B/lv

Links

239000003112 inhibitor Substances 0.000 title 1
210000002307 prostate Anatomy 0.000 title 1
150000001408 amides Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical class OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 abstract 1
229940122440 HIV protease inhibitor Drugs 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
239000004030 hiv protease inhibitor Substances 0.000 abstract 1
150000002924 oxiranes Chemical class 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Epoxy Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

LVP-02-39A 1993-07-16 2002-03-15 Hiv proteāzes inhibitora iegūšana LV12825B (lv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9322593A	1993-07-16	1993-07-16
US08/187,664 US5463067A (en)	1993-07-16	1994-01-26	Process for making HIV protease inhibitors

Publications (2)

Publication Number	Publication Date
LV12825A LV12825A (en)	2002-05-20
LV12825B true LV12825B (lv)	2002-09-20

Family

ID=26787287

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-02-39A LV12825B (lv)	1993-07-16	2002-03-15	Hiv proteāzes inhibitora iegūšana

Country Status (22)

Country	Link
US (2)	US5491238A (lv)
EP (1)	EP0708762B1 (lv)
JP (1)	JP3547136B2 (lv)
CN (2)	CN1066723C (lv)
AT (1)	ATE200079T1 (lv)
AU (1)	AU676079B2 (lv)
CZ (1)	CZ293953B6 (lv)
DE (1)	DE69426979T2 (lv)
DK (1)	DK0708762T3 (lv)
ES (1)	ES2155091T3 (lv)
FI (1)	FI119473B (lv)
GR (1)	GR3035645T3 (lv)
HU (1)	HUT74583A (lv)
IL (1)	IL110342A (lv)
LV (1)	LV12825B (lv)
NO (1)	NO306297B1 (lv)
NZ (1)	NZ269904A (lv)
PL (1)	PL179039B1 (lv)
PT (1)	PT708762E (lv)
RU (1)	RU2125561C1 (lv)
SK (1)	SK282616B6 (lv)
WO (1)	WO1995002584A2 (lv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110255A (en) *	1993-07-16	1998-12-06	Merck & Co Inc	Formation and resolution of 2-tert-butylcarboxamido-piperazine
IL111584A0 (en) *	1993-11-18	1995-01-24	Merck & Co Inc	Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
ES2116029T3 (es) *	1994-11-04	1998-07-01	Yamakawa Chemical Ind	Procedimiento para preparar derivados de piperazina opticamente activos e intermedios para prepararlos.
DE4446025A1 (de) *	1994-12-22	1996-06-27	Basf Ag	2-Caroxamido-1,4,5,6-tetrahydropyrazine
EP1125930A1 (de) *	1995-05-23	2001-08-22	Lonza Ag	Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung
ES2164187T3 (es) *	1995-05-23	2002-02-16	Lonza Ag	Procedimiento para la preparacion de derivados de acidos 2-piperazina-carboxilicos opticamente activos.
CA2201218C (en) *	1996-04-23	2004-09-28	Rudolf Fuchs	Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
US6645961B1 (en)	1997-03-07	2003-11-11	Merck & Co., Inc.	Dry granulation formulation for an HIV protease inhibitor
US6482952B2 (en)	2000-06-20	2002-11-19	Merck & Co., Inc.	Process for preparing acetonides
US7218837B2 (en)	2000-09-25	2007-05-15	Victor Company Of Japan, Ltd.	Program-signal recording and reproducing apparatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2052907A1 (en) *	1990-10-11	1992-04-12	Joseph P. Vacca	Hiv protease inhibitors having symmetrical structure
US5169952A (en) *	1991-07-02	1992-12-08	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides

1994
- 1994-07-11 NZ NZ269904A patent/NZ269904A/en not_active IP Right Cessation
- 1994-07-11 AU AU73588/94A patent/AU676079B2/en not_active Ceased
- 1994-07-11 EP EP94922511A patent/EP0708762B1/en not_active Expired - Lifetime
- 1994-07-11 AT AT94922511T patent/ATE200079T1/de not_active IP Right Cessation
- 1994-07-11 PT PT94922511T patent/PT708762E/pt unknown
- 1994-07-11 PL PL94312613A patent/PL179039B1/pl not_active IP Right Cessation
- 1994-07-11 DK DK94922511T patent/DK0708762T3/da active
- 1994-07-11 DE DE69426979T patent/DE69426979T2/de not_active Expired - Lifetime
- 1994-07-11 JP JP50463295A patent/JP3547136B2/ja not_active Expired - Fee Related
- 1994-07-11 CN CN94193304A patent/CN1066723C/zh not_active Expired - Fee Related
- 1994-07-11 SK SK55-96A patent/SK282616B6/sk not_active IP Right Cessation
- 1994-07-11 CZ CZ1996131A patent/CZ293953B6/cs not_active IP Right Cessation
- 1994-07-11 HU HU9600077A patent/HUT74583A/hu unknown
- 1994-07-11 WO PCT/US1994/007706 patent/WO1995002584A2/en not_active Ceased
- 1994-07-11 RU RU96103642A patent/RU2125561C1/ru not_active IP Right Cessation
- 1994-07-11 ES ES94922511T patent/ES2155091T3/es not_active Expired - Lifetime
- 1994-07-17 IL IL11034294A patent/IL110342A/en not_active IP Right Cessation
1995
- 1995-06-02 US US08/458,379 patent/US5491238A/en not_active Expired - Lifetime
- 1995-06-21 US US08/459,069 patent/US5496948A/en not_active Expired - Lifetime
1996
- 1996-01-15 NO NO960168A patent/NO306297B1/no not_active IP Right Cessation
- 1996-01-15 FI FI960184A patent/FI119473B/fi active IP Right Grant
1999
- 1999-08-10 CN CNB991117905A patent/CN1192014C/zh not_active Expired - Fee Related
2001
- 2001-03-29 GR GR20010400119T patent/GR3035645T3/el unknown
2002
- 2002-03-15 LV LVP-02-39A patent/LV12825B/lv unknown

Also Published As

Publication number	Publication date
CZ13196A3 (en)	1996-04-17
JPH08509985A (ja)	1996-10-22
AU676079B2 (en)	1997-02-27
DE69426979D1 (de)	2001-05-03
DE69426979T2 (de)	2001-09-20
CN1252402A (zh)	2000-05-10
CN1130380A (zh)	1996-09-04
WO1995002584A3 (en)	1995-03-09
ES2155091T3 (es)	2001-05-01
PL179039B1 (pl)	2000-07-31
FI119473B (fi)	2008-11-28
SK5596A3 (en)	1997-01-08
DK0708762T3 (da)	2001-04-30
EP0708762A1 (en)	1996-05-01
AU7358894A (en)	1995-02-13
LV12825A (en)	2002-05-20
PT708762E (pt)	2001-07-31
NZ269904A (en)	1997-11-24
WO1995002584A2 (en)	1995-01-26
ATE200079T1 (de)	2001-04-15
NO960168L (no)	1996-03-15
NO960168D0 (no)	1996-01-15
IL110342A0 (en)	1994-10-21
GR3035645T3 (en)	2001-06-29
FI960184A0 (fi)	1996-01-15
CN1066723C (zh)	2001-06-06
CZ293953B6 (cs)	2004-08-18
US5491238A (en)	1996-02-13
SK282616B6 (sk)	2002-10-08
FI960184L (fi)	1996-03-14
IL110342A (en)	1998-12-27
EP0708762B1 (en)	2001-03-28
US5496948A (en)	1996-03-05
JP3547136B2 (ja)	2004-07-28
HU9600077D0 (en)	1996-03-28
CN1192014C (zh)	2005-03-09
RU2125561C1 (ru)	1999-01-27
NO306297B1 (no)	1999-10-18
HUT74583A (en)	1997-01-28
PL312613A1 (en)	1996-04-29

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FI941632A7 (fi)	1994-04-08	Parannettu menetelmä (5R)-1,1-dimetyylietyyli-6-syano-5-hydroksi-3-oksoheksanoaatin valmistamiseksi
TW255890B (lv)	1995-09-01
DK0915866T3 (da)	2002-06-10	Forbedret fremgangsmåde til syntese af beskyttende estere af (S)-3,4-dihydroxysmørsyre
ATE21896T1 (de)	1986-09-15	Verfahren zur epoxidierung von olefinischen verbindungen.
AU5932300A (en)	2001-01-30	Synthesis of zsm-5 and zsm-11
MY106624A (en)	1995-06-30	Preparation of monoepoxides
NO20004739L (no)	2000-10-03	FremgangsmÕte for fremstilling av et oksiran
DK0748319T3 (da)	2002-03-18	Fremgangsmåde til fremstilling af et epoxid
MY116862A (en)	2004-04-30	New processes for preparing pesticidal intermediates
TW339326B (en)	1998-09-01	Process for the prepration of lactams
Kulinkovich et al.	2001	Synthesis of α, β-Epoxy Ketones from Alkyl-and Arylsubstituted Cyclopropanols
WO1995002584A3 (en)	1995-03-09	Process for making hiv protease inhibitors
DK0619305T3 (da)	1997-07-07	Lactonforbindelse og fremgangsmåde til fremstilling deraf
FI862557A0 (fi)	1986-06-16	Foerfarande foer framstaellning av en dibromnitrofoerening.
AU2603797A (en)	1997-11-26	Process to prepare taxol
IL110255A0 (en)	1994-10-21	Process and intermediate for synthesizing hiv protease inhibitors
AU1083395A (en)	1995-06-13	Method for making intermediates useful in synthesis of retroviral protease inhibitors
IT1309601B1 (it)	2002-01-24	Processo per la preparazione di 1,4,7,10 tetraazaciclododecano.
BR9608070A (pt)	1999-01-26	Epóxidos assímetricos sua síntese e utilização
TW336230B (en)	1998-07-11	Process for the production of olefinic unsaturated compounds
MD970270A (en)	1999-05-31	Process for obtaining the acid chloride compounds
GB2369356B (en)	2004-02-04	Process
DE69915081T2 (de)	2004-10-21	Verfahren zur herstellung von c-4-deacetyltaxanen
CHINI et al.	1995	Regiochemical Control of the Ring Opening of 1, 2‐Epoxides by Means of Chelating Processes. Part 7. Synthesis and Ring‐Opening Reactions of cis‐and trans‐Oxides Derived from 2‐(Benzyloxy)‐3, 6‐dihydro‐2H‐pyran.
ATE244217T1 (de)	2003-07-15	Herstellung von beta-mehtylcarbapenem- zwischenprodukten