LV12825B - Hiv proteāzes inhibitora iegūšana - Google Patents

Hiv proteāzes inhibitora iegūšana

Info

Publication number: LV12825B
Authority: LV; Latvia
Prior art keywords: hiv; prostate; inhibitor; obtaining; amide
Prior art date: 1993-07-16

Application number

LVP-02-39A

Other languages

English (en)

Other versions

LV12825A (en

Inventor

David Asikn

Ralph P. VOLANTE

Kan K. Eng

Original Assignee

Merck & Co. Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

2002-03-15

Publication date

2002-09-20

1994-01-26 Priority claimed from US08/187,664 external-priority patent/US5463067A/en

2002-03-15 Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.

2002-05-20 Publication of LV12825A publication Critical patent/LV12825A/en

2002-09-20 Publication of LV12825B publication Critical patent/LV12825B/lv

Links

239000003112 inhibitor Substances 0.000 title 1
210000002307 prostate Anatomy 0.000 title 1
150000001408 amides Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical class OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 abstract 1
229940122440 HIV protease inhibitor Drugs 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
239000004030 hiv protease inhibitor Substances 0.000 abstract 1
150000002924 oxiranes Chemical class 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Epoxy Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

LVP-02-39A 1993-07-16 2002-03-15 Hiv proteāzes inhibitora iegūšana LV12825B (lv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9322593A	1993-07-16	1993-07-16
US08/187,664 US5463067A (en)	1993-07-16	1994-01-26	Process for making HIV protease inhibitors

Publications (2)

Publication Number	Publication Date
LV12825A LV12825A (en)	2002-05-20
LV12825B true LV12825B (lv)	2002-09-20

Family

ID=26787287

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-02-39A LV12825B (lv)	1993-07-16	2002-03-15	Hiv proteāzes inhibitora iegūšana

Country Status (22)

Country	Link
US (2)	US5491238A (lv)
EP (1)	EP0708762B1 (lv)
JP (1)	JP3547136B2 (lv)
CN (2)	CN1066723C (lv)
AT (1)	ATE200079T1 (lv)
AU (1)	AU676079B2 (lv)
CZ (1)	CZ293953B6 (lv)
DE (1)	DE69426979T2 (lv)
DK (1)	DK0708762T3 (lv)
ES (1)	ES2155091T3 (lv)
FI (1)	FI119473B (lv)
GR (1)	GR3035645T3 (lv)
HU (1)	HUT74583A (lv)
IL (1)	IL110342A (lv)
LV (1)	LV12825B (lv)
NO (1)	NO306297B1 (lv)
NZ (1)	NZ269904A (lv)
PL (1)	PL179039B1 (lv)
PT (1)	PT708762E (lv)
RU (1)	RU2125561C1 (lv)
SK (1)	SK282616B6 (lv)
WO (1)	WO1995002584A2 (lv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110255A (en) *	1993-07-16	1998-12-06	Merck & Co Inc	Formation and resolution of 2-tert-butylcarboxamido-piperazine
IL111584A0 (en) *	1993-11-18	1995-01-24	Merck & Co Inc	Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
EP0710652B1 (en) *	1994-11-04	1998-03-04	Yamakawa Chemical Industry Co., Ltd.	Process for preparing optically active piperazine derivatives and intermediates for preparation
DE4446025A1 (de) *	1994-12-22	1996-06-27	Basf Ag	2-Caroxamido-1,4,5,6-tetrahydropyrazine
EP1125930A1 (de) *	1995-05-23	2001-08-22	Lonza Ag	Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung
PT744401E (pt) *	1995-05-23	2002-05-31	Lonza Ag	Processo para a producao de derivados de acido 2-piperazinocarboxilico opticamente activos
CA2201218C (en) *	1996-04-23	2004-09-28	Rudolf Fuchs	Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
US6645961B1 (en)	1997-03-07	2003-11-11	Merck & Co., Inc.	Dry granulation formulation for an HIV protease inhibitor
US6482952B2 (en)	2000-06-20	2002-11-19	Merck & Co., Inc.	Process for preparing acetonides
US7218837B2 (en)	2000-09-25	2007-05-15	Victor Company Of Japan, Ltd.	Program-signal recording and reproducing apparatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2052907A1 (en) *	1990-10-11	1992-04-12	Joseph P. Vacca	Hiv protease inhibitors having symmetrical structure
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides
US5169952A (en) *	1991-07-02	1992-12-08	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides

1994
- 1994-07-11 DE DE69426979T patent/DE69426979T2/de not_active Expired - Lifetime
- 1994-07-11 EP EP94922511A patent/EP0708762B1/en not_active Expired - Lifetime
- 1994-07-11 RU RU96103642A patent/RU2125561C1/ru not_active IP Right Cessation
- 1994-07-11 CZ CZ1996131A patent/CZ293953B6/cs not_active IP Right Cessation
- 1994-07-11 SK SK55-96A patent/SK282616B6/sk not_active IP Right Cessation
- 1994-07-11 JP JP50463295A patent/JP3547136B2/ja not_active Expired - Fee Related
- 1994-07-11 PL PL94312613A patent/PL179039B1/pl not_active IP Right Cessation
- 1994-07-11 HU HU9600077A patent/HUT74583A/hu unknown
- 1994-07-11 DK DK94922511T patent/DK0708762T3/da active
- 1994-07-11 PT PT94922511T patent/PT708762E/pt unknown
- 1994-07-11 AT AT94922511T patent/ATE200079T1/de not_active IP Right Cessation
- 1994-07-11 WO PCT/US1994/007706 patent/WO1995002584A2/en not_active Ceased
- 1994-07-11 NZ NZ269904A patent/NZ269904A/en not_active IP Right Cessation
- 1994-07-11 AU AU73588/94A patent/AU676079B2/en not_active Ceased
- 1994-07-11 ES ES94922511T patent/ES2155091T3/es not_active Expired - Lifetime
- 1994-07-11 CN CN94193304A patent/CN1066723C/zh not_active Expired - Fee Related
- 1994-07-17 IL IL11034294A patent/IL110342A/en not_active IP Right Cessation
1995
- 1995-06-02 US US08/458,379 patent/US5491238A/en not_active Expired - Lifetime
- 1995-06-21 US US08/459,069 patent/US5496948A/en not_active Expired - Lifetime
1996
- 1996-01-15 FI FI960184A patent/FI119473B/fi active IP Right Grant
- 1996-01-15 NO NO960168A patent/NO306297B1/no not_active IP Right Cessation
1999
- 1999-08-10 CN CNB991117905A patent/CN1192014C/zh not_active Expired - Fee Related
2001
- 2001-03-29 GR GR20010400119T patent/GR3035645T3/el unknown
2002
- 2002-03-15 LV LVP-02-39A patent/LV12825B/lv unknown

Also Published As

Publication number	Publication date
SK282616B6 (sk)	2002-10-08
RU2125561C1 (ru)	1999-01-27
NO306297B1 (no)	1999-10-18
AU676079B2 (en)	1997-02-27
HU9600077D0 (en)	1996-03-28
WO1995002584A3 (en)	1995-03-09
CN1130380A (zh)	1996-09-04
NO960168L (no)	1996-03-15
EP0708762A1 (en)	1996-05-01
FI960184L (fi)	1996-03-14
HUT74583A (en)	1997-01-28
CZ13196A3 (en)	1996-04-17
DE69426979T2 (de)	2001-09-20
CN1066723C (zh)	2001-06-06
IL110342A0 (en)	1994-10-21
PL312613A1 (en)	1996-04-29
CN1192014C (zh)	2005-03-09
GR3035645T3 (en)	2001-06-29
FI119473B (fi)	2008-11-28
AU7358894A (en)	1995-02-13
CN1252402A (zh)	2000-05-10
ATE200079T1 (de)	2001-04-15
SK5596A3 (en)	1997-01-08
EP0708762B1 (en)	2001-03-28
JPH08509985A (ja)	1996-10-22
JP3547136B2 (ja)	2004-07-28
NO960168D0 (no)	1996-01-15
IL110342A (en)	1998-12-27
FI960184A0 (fi)	1996-01-15
ES2155091T3 (es)	2001-05-01
US5496948A (en)	1996-03-05
PT708762E (pt)	2001-07-31
US5491238A (en)	1996-02-13
DK0708762T3 (da)	2001-04-30
NZ269904A (en)	1997-11-24
PL179039B1 (pl)	2000-07-31
LV12825A (en)	2002-05-20
WO1995002584A2 (en)	1995-01-26
DE69426979D1 (de)	2001-05-03
CZ293953B6 (cs)	2004-08-18

Publication	Publication Date	Title
LV12825B (lv)	2002-09-20	Hiv proteāzes inhibitora iegūšana
ZA937313B (en)	1994-04-25	Process for obtaining 10-deacetylbaccatin III
DK0915866T3 (da)	2002-06-10	Forbedret fremgangsmåde til syntese af beskyttende estere af (S)-3,4-dihydroxysmørsyre
AU591860B2 (en)	1989-12-14	Pyrolidineamide derivative having anti-prolyl endopeptidase
AU5932300A (en)	2001-01-30	Synthesis of zsm-5 and zsm-11
MY106624A (en)	1995-06-30	Preparation of monoepoxides
NO20004739L (no)	2000-10-03	FremgangsmÕte for fremstilling av et oksiran
DK0748319T3 (da)	2002-03-18	Fremgangsmåde til fremstilling af et epoxid
TW339326B (en)	1998-09-01	Process for the prepration of lactams
DK0619305T3 (da)	1997-07-07	Lactonforbindelse og fremgangsmåde til fremstilling deraf
ATE233249T1 (de)	2003-03-15	Verfahren zur herstellung von hiv protease inhibitoren
AU2603797A (en)	1997-11-26	Process to prepare taxol
EP0366041A3 (en)	1991-10-23	Imido-percarboxylic acids
ZA943994B (en)	1995-02-03	Process for the preparation of an oxazolidinecarboxylic acid which is useful for preparing therapeutically active taxoids
GR3033429T3 (en)	2000-09-29	Method for making intermediates useful in synthesis of retroviral protease inhibitors
EA199700395A1 (ru)	1998-08-27	Способ получения ингибиторов протеазы вируса иммунодефицита человека
IT1309601B1 (it)	2002-01-24	Processo per la preparazione di 1,4,7,10 tetraazaciclododecano.
BR9608070A (pt)	1999-01-26	Epóxidos assímetricos sua síntese e utilização
GB2369356B (en)	2004-02-04	Process
Armstrong et al.	2004	Aminative rearrangement of 2-alkoxy-3, 4-dihydro-2 H-pyrans: a novel stereocontrolled route to substituted pyrrolidines
DE69915081D1 (de)	2004-04-01	Verfahren zur herstellung von c-4-deacetyltaxanen
ATE244217T1 (de)	2003-07-15	Herstellung von beta-mehtylcarbapenem- zwischenprodukten
NO965222L (no)	1998-06-08	Reduksjon av umettede karbonylforbindelser og karboksylsyresalter