LV15544A - Jauni borskābi saturoši peptidomimētiķi kā malārijas serīna proteāzes inhibitori - Google Patents

Jauni borskābi saturoši peptidomimētiķi kā malārijas serīna proteāzes inhibitori

Info

Publication number
LV15544A
LV15544A LVP-19-32A LV190032A LV15544A LV 15544 A LV15544 A LV 15544A LV 190032 A LV190032 A LV 190032A LV 15544 A LV15544 A LV 15544A
Authority
LV
Latvia
Prior art keywords
malaria
inhibitors
boric acid
peptidomimetics
serine protease
Prior art date
Application number
LVP-19-32A
Other languages
English (en)
Inventor
Aigars Jirgensons
Elīna LĪDUMNIECE
Chrislaine Withers-Martinez
Michael BLACKMAN
Paul William Finn
Original Assignee
Latvijas Organiskās Sintēzes Institūts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Latvijas Organiskās Sintēzes Institūts filed Critical Latvijas Organiskās Sintēzes Institūts
Priority to LVP-19-32A priority Critical patent/LV15544A/lv
Priority to CA3144846A priority patent/CA3144846A1/en
Priority to PCT/IB2020/053392 priority patent/WO2021001697A1/en
Priority to DE112020003182.9T priority patent/DE112020003182T5/de
Publication of LV15544A publication Critical patent/LV15544A/lv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Izgudrojums attiecas uz jauniem borskābi saturošiem peptidomimētiķiem I:kas darbojas kā malārijas subtilizīnam radniecīgās serīna proteāzes (SUB) inhibitori. Tie ir izmantojami kā medicīniskie preparāti vai kā to sastāvdaļas malārijas ārstēšanai.
LVP-19-32A 2019-07-01 2019-07-01 Jauni borskābi saturoši peptidomimētiķi kā malārijas serīna proteāzes inhibitori LV15544A (lv)

Priority Applications (4)

Application Number Priority Date Filing Date Title
LVP-19-32A LV15544A (lv) 2019-07-01 2019-07-01 Jauni borskābi saturoši peptidomimētiķi kā malārijas serīna proteāzes inhibitori
CA3144846A CA3144846A1 (en) 2019-07-01 2020-04-09 Novel boronic acid containing peptidomimetics as malarial serine protease inhibitors
PCT/IB2020/053392 WO2021001697A1 (en) 2019-07-01 2020-04-09 Novel boronic acid containing peptidomimetics as malarial serine protease inhibitors
DE112020003182.9T DE112020003182T5 (de) 2019-07-01 2020-04-09 Neuartige Borsäure-haltige Peptidomimetika als Malaria-Serinprotease Inhibitoren

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-19-32A LV15544A (lv) 2019-07-01 2019-07-01 Jauni borskābi saturoši peptidomimētiķi kā malārijas serīna proteāzes inhibitori

Publications (1)

Publication Number Publication Date
LV15544A true LV15544A (lv) 2021-01-20

Family

ID=67551401

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-19-32A LV15544A (lv) 2019-07-01 2019-07-01 Jauni borskābi saturoši peptidomimētiķi kā malārijas serīna proteāzes inhibitori

Country Status (4)

Country Link
CA (1) CA3144846A1 (lv)
DE (1) DE112020003182T5 (lv)
LV (1) LV15544A (lv)
WO (1) WO2021001697A1 (lv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025125851A1 (en) * 2023-12-11 2025-06-19 Latvian Institute Of Organic Synthesis 3-(acylamidomethyl)phenylboronic acid derivatives as malarial serine protease inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2791651C (en) * 2010-03-01 2019-08-20 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
CA2905237A1 (en) * 2013-03-15 2014-09-18 Adaerata, Limited Partnership Small molecule modulators of pcsk9 and methods of use thereof

Also Published As

Publication number Publication date
WO2021001697A1 (en) 2021-01-07
CA3144846A1 (en) 2021-01-07
DE112020003182T5 (de) 2022-04-14

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