MA47736B1 - Pyrimidopyrimidinones utiles en tant qu'inhibiteurs de la kinase wee-1 - Google Patents
Pyrimidopyrimidinones utiles en tant qu'inhibiteurs de la kinase wee-1Info
- Publication number
- MA47736B1 MA47736B1 MA47736A MA47736A MA47736B1 MA 47736 B1 MA47736 B1 MA 47736B1 MA 47736 A MA47736 A MA 47736A MA 47736 A MA47736 A MA 47736A MA 47736 B1 MA47736 B1 MA 47736B1
- Authority
- MA
- Morocco
- Prior art keywords
- wee
- useful
- pyrimidopyrimidinones
- kinase inhibitors
- compound
- Prior art date
Links
- RLJCWYYOGHGGBV-UHFFFAOYSA-N 1h-pyrimido[5,4-d]pyrimidin-2-one Chemical class C1=NC=C2NC(=O)N=CC2=N1 RLJCWYYOGHGGBV-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne un composé utile en tant qu'inhibiteur de l'activité de la kinase wee-1. La présente invention concerne également des compositions pharmaceutiques comprenant ce composé, des méthodes d'utilisation de ce composé dans le traitement du cancer, ainsi que des méthodes de traitement du cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1703881.1A GB201703881D0 (en) | 2017-03-10 | 2017-03-10 | Pharmaceutical compounds |
| PCT/GB2018/050620 WO2018162932A1 (fr) | 2017-03-10 | 2018-03-12 | Pyrimidopyrimidinones utiles en tant qu'inhibiteurs de la kinase wee-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA47736A MA47736A (fr) | 2021-04-21 |
| MA47736B1 true MA47736B1 (fr) | 2021-10-29 |
Family
ID=58605309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA47736A MA47736B1 (fr) | 2017-03-10 | 2018-03-12 | Pyrimidopyrimidinones utiles en tant qu'inhibiteurs de la kinase wee-1 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US11208413B2 (fr) |
| EP (1) | EP3592745B1 (fr) |
| JP (1) | JP7244430B2 (fr) |
| KR (1) | KR102605546B1 (fr) |
| CN (1) | CN110603256B (fr) |
| AU (1) | AU2018231671B2 (fr) |
| CA (1) | CA3055874A1 (fr) |
| CL (1) | CL2019002557A1 (fr) |
| CY (1) | CY1124613T1 (fr) |
| DK (1) | DK3592745T3 (fr) |
| EA (1) | EA201992137A1 (fr) |
| ES (1) | ES2895365T3 (fr) |
| GB (1) | GB201703881D0 (fr) |
| HR (1) | HRP20211652T1 (fr) |
| HU (1) | HUE056220T2 (fr) |
| IL (1) | IL269063B (fr) |
| LT (1) | LT3592745T (fr) |
| MA (1) | MA47736B1 (fr) |
| MX (1) | MX386565B (fr) |
| MY (1) | MY195580A (fr) |
| NZ (1) | NZ756945A (fr) |
| PH (1) | PH12019502049A1 (fr) |
| PL (1) | PL3592745T3 (fr) |
| PT (1) | PT3592745T (fr) |
| RS (1) | RS62464B1 (fr) |
| SA (1) | SA519410093B1 (fr) |
| SG (1) | SG11201908114UA (fr) |
| SI (1) | SI3592745T1 (fr) |
| SM (1) | SMT202100596T1 (fr) |
| UA (1) | UA125093C2 (fr) |
| WO (1) | WO2018162932A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201703881D0 (en) * | 2017-03-10 | 2017-04-26 | Almac Discovery Ltd | Pharmaceutical compounds |
| WO2019074979A1 (fr) | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | Composés hétérocycliques et leurs utilisations |
| WO2019074981A1 (fr) | 2017-10-09 | 2019-04-18 | GiraFpharma LLC | Composés hétérocycliques et leurs utilisations |
| US20220162229A1 (en) * | 2019-04-09 | 2022-05-26 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| WO2020210375A1 (fr) | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Composés hétérocycliques et leurs utilisations |
| EP3952878A4 (fr) * | 2019-04-09 | 2023-01-04 | Nuvation Bio Inc. | Composés hétérocycliques et leurs utilisations |
| JP2024543405A (ja) * | 2021-11-09 | 2024-11-21 | ハンジョウ グルバイオ ファーマシューティカル カンパニー リミテッド | Ｗｅｅ１プロテインキナーゼ分解剤及びその使用 |
| IL315441A (en) * | 2022-03-07 | 2024-11-01 | Debiopharm Int Sa | Treatment methods for small cell lung cancer |
| WO2023217201A2 (fr) * | 2022-05-10 | 2023-11-16 | 杭州德睿智药科技有限公司 | Nouveau composé pyrimido-hétérocyclique servant d'inhibiteur de wee1 et son application |
| WO2025101691A1 (fr) | 2023-11-08 | 2025-05-15 | Exelixis, Inc. | Méthodes de traitement du cancer à l'aide de composés inhibant pkmyt1 |
| WO2025186213A1 (fr) * | 2024-03-04 | 2025-09-12 | Debiopharm International S.A. | Combinaison d'un inhibiteur de wee1 et d'un inhibiteur de topoisomérase 1 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| PE20080695A1 (es) * | 2006-04-27 | 2008-06-28 | Banyu Pharma Co Ltd | Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel |
| US8575179B2 (en) * | 2008-12-12 | 2013-11-05 | Msd K.K. | Dihydropyrazolopyrimidinone derivatives |
| MX2014010176A (es) | 2012-02-23 | 2014-11-10 | Abbvie Inc | Inhibidores de cinasas de piridopirimidinona. |
| GB201306610D0 (en) * | 2013-04-11 | 2013-05-29 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB201322602D0 (en) * | 2013-12-19 | 2014-02-05 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB201703881D0 (en) * | 2017-03-10 | 2017-04-26 | Almac Discovery Ltd | Pharmaceutical compounds |
-
2017
- 2017-03-10 GB GBGB1703881.1A patent/GB201703881D0/en not_active Ceased
-
2018
- 2018-03-12 AU AU2018231671A patent/AU2018231671B2/en active Active
- 2018-03-12 KR KR1020197029457A patent/KR102605546B1/ko active Active
- 2018-03-12 SI SI201830430T patent/SI3592745T1/sl unknown
- 2018-03-12 JP JP2019548963A patent/JP7244430B2/ja active Active
- 2018-03-12 WO PCT/GB2018/050620 patent/WO2018162932A1/fr not_active Ceased
- 2018-03-12 MA MA47736A patent/MA47736B1/fr unknown
- 2018-03-12 PL PL18711666T patent/PL3592745T3/pl unknown
- 2018-03-12 LT LTEPPCT/GB2018/050620T patent/LT3592745T/lt unknown
- 2018-03-12 CA CA3055874A patent/CA3055874A1/fr active Pending
- 2018-03-12 EP EP18711666.0A patent/EP3592745B1/fr active Active
- 2018-03-12 NZ NZ756945A patent/NZ756945A/en unknown
- 2018-03-12 SG SG11201908114U patent/SG11201908114UA/en unknown
- 2018-03-12 US US16/492,292 patent/US11208413B2/en active Active
- 2018-03-12 HU HUE18711666A patent/HUE056220T2/hu unknown
- 2018-03-12 MX MX2019010554A patent/MX386565B/es unknown
- 2018-03-12 MY MYPI2019005160A patent/MY195580A/en unknown
- 2018-03-12 SM SM20210596T patent/SMT202100596T1/it unknown
- 2018-03-12 HR HRP20211652TT patent/HRP20211652T1/hr unknown
- 2018-03-12 EA EA201992137A patent/EA201992137A1/ru unknown
- 2018-03-12 ES ES18711666T patent/ES2895365T3/es active Active
- 2018-03-12 UA UAA201910268A patent/UA125093C2/uk unknown
- 2018-03-12 CN CN201880016390.8A patent/CN110603256B/zh active Active
- 2018-03-12 RS RS20211277A patent/RS62464B1/sr unknown
- 2018-03-12 PT PT187116660T patent/PT3592745T/pt unknown
- 2018-03-12 DK DK18711666.0T patent/DK3592745T3/da active
-
2019
- 2019-09-02 IL IL269063A patent/IL269063B/en unknown
- 2019-09-06 CL CL2019002557A patent/CL2019002557A1/es unknown
- 2019-09-09 PH PH12019502049A patent/PH12019502049A1/en unknown
- 2019-09-10 SA SA519410093A patent/SA519410093B1/ar unknown
-
2021
- 2021-10-20 CY CY20211100913T patent/CY1124613T1/el unknown
- 2021-12-03 US US17/541,362 patent/US20220194947A1/en active Pending
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