MA22798A1 - Procede de preparation de benzoylguanidines. - Google Patents

Procede de preparation de benzoylguanidines.

Info

Publication number: MA22798A1
Authority: MA; Morocco
Prior art keywords: phenyl; alkyl; equal; treatment; case
Prior art date: 1992-02-15

Application number

MA23090A

Other languages

English (en)

Inventor

Mania Dieter

Albus Udo

Linz Wolfgang

Jochen Lang Hans

Englert Heinrich

Scholz Wolfgang

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-15

Filing date

1993-02-12

Publication date

1993-10-01

1993-02-12 Application filed by Hoechst Ag filed Critical Hoechst Ag

1993-10-01 Publication of MA22798A1 publication Critical patent/MA22798A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MA23090A 1992-02-15 1993-02-12 Procede de preparation de benzoylguanidines. MA22798A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4204577		1992-02-15

Publications (1)

Publication Number	Publication Date
MA22798A1 true MA22798A1 (fr)	1993-10-01

Family

ID=6451809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA23090A MA22798A1 (fr)	1992-02-15	1993-02-12	Procede de preparation de benzoylguanidines.

Country Status (24)

Country	Link
US (1)	US5364868A (fr)
EP (1)	EP0556672B1 (fr)
JP (1)	JP3321473B2 (fr)
KR (1)	KR100275603B1 (fr)
AT (1)	ATE156485T1 (fr)
AU (1)	AU658261B2 (fr)
CA (1)	CA2089442C (fr)
CZ (1)	CZ284456B6 (fr)
DE (1)	DE59307039D1 (fr)
DK (1)	DK0556672T3 (fr)
ES (1)	ES2104971T3 (fr)
FI (1)	FI930603A7 (fr)
GR (1)	GR3024731T3 (fr)
HU (1)	HU215851B (fr)
IL (1)	IL104715A (fr)
MA (1)	MA22798A1 (fr)
MX (1)	MX9300784A (fr)
NO (1)	NO302029B1 (fr)
NZ (1)	NZ245896A (fr)
PH (1)	PH30940A (fr)
RO (1)	RO114131B1 (fr)
RU (1)	RU2085555C1 (fr)
TW (1)	TW224455B (fr)
ZA (1)	ZA93986B (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW250479B (fr) *	1992-12-15	1995-07-01	Hoechst Ag
DK0612723T3 (da) *	1993-02-20	1998-03-30	Hoechst Ag	Substituerede benzoylguanidiner, fremgangsmåde til fremstilling, deres anvendelse som lægemiddel, som inhibitor af den cellulære Na+/H+-udbytning eller som diagnostikum samt lægemiddel med indhold deraf
US6190894B1 (en)	1993-03-19	2001-02-20	The Regents Of The University Of California	Method and compositions for disrupting the epithelial barrier function
US6169107B1 (en)	1993-04-28	2001-01-02	Sumitomo Pharmaceutical Co., Ltd.	Indoloylguanidine derivatives
IL109570A0 (en) *	1993-05-17	1994-08-26	Fujisawa Pharmaceutical Co	Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4318658A1 (de) *	1993-06-04	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4318756A1 (de) *	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4325822A1 (de) *	1993-07-31	1995-02-02	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4337611A1 (de) *	1993-11-04	1995-05-11	Boehringer Ingelheim Kg	Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln
TW415937B (en) *	1994-01-25	2000-12-21	Hoechst Ag	Phenyl-substituted alkylcarboxylic acid guanidides bearing perfluoroalkyl groups, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
DE4404183A1 (de) *	1994-02-10	1995-08-17	Merck Patent Gmbh	4-Amino-1-piperidylbenzoylguanidine
DE4412334A1 (de) *	1994-04-11	1995-10-19	Hoechst Ag	Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4415873A1 (de) *	1994-05-05	1995-11-09	Hoechst Ag	Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4421495A1 (de) *	1994-06-20	1995-12-21	Merck Patent Gmbh	Heterocyclyloxy-benzoylguanidine
IL114670A0 (en) *	1994-08-05	1995-11-27	Fujisawa Pharmaceutical Co	Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
DE4430213A1 (de) *	1994-08-28	1996-02-29	Merck Patent Gmbh	Arylbenzoylguanidine
DE4430861A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Heterocyclyl-benzoylguanidine
DE4430916A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Alkyl-benzoylguanidin-Derivate
DE4432105A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Fluoro-alkyl/alkenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4432101A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4432106A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung
DE4441880A1 (de) *	1994-11-24	1996-05-30	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
TW372967B (en) *	1994-12-27	1999-11-01	Kanebo Ltd	1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof
DE19502644A1 (de) *	1995-01-28	1996-08-01	Merck Patent Gmbh	4-Amino-benzoylguanidin-Derivate
DE19502795A1 (de) *	1995-01-30	1996-08-01	Hoechst Ag	Benzolsulfonamid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19502895A1 (de) *	1995-01-31	1996-08-01	Merck Patent Gmbh	4-Mercapto-benzoylguanidin-Derivate
DE19517848A1 (de) *	1995-05-16	1996-11-21	Merck Patent Gmbh	Fluorhaltige Benzoylguanidine
DE19526381A1 (de) *	1995-07-19	1997-01-23	Hoechst Ag	4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19527305A1 (de) *	1995-07-26	1997-01-30	Hoechst Ag	Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0765868A1 (fr) *	1995-09-27	1997-04-02	Hoechst Aktiengesellschaft	Benzoylguanidines substituées, procédé de leur préparation, leur utilisation comme agent antiarythmique ou diagnostique ainsi le médicament les contenant
EP0765867A1 (fr) *	1995-09-27	1997-04-02	Hoechst Aktiengesellschaft	Benzoylguanidines substituées, procédé de leur préparation, leur utilisation comme agent antiarythmique ou diagnostique ainsi que le médicament les contenant
DE19540995A1 (de) *	1995-11-03	1997-05-07	Hoechst Ag	Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) *	1995-11-14	1997-05-15	Hoechst Ag	Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) *	1995-11-20	1997-05-26	Hoechst Ag	Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) *	1995-12-14	1997-06-19	Hoechst Ag	Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19606509A1 (de) *	1996-02-22	1997-08-28	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19608161A1 (de) *	1996-03-04	1997-09-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19622370A1 (de) *	1996-06-04	1997-12-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO1998039300A1 (fr) *	1997-03-06	1998-09-11	Toa Eiyo Ltd.	DERIVES DE CYCLOALCA[b]PYRIDINE-3-CARBONYLGUANIDINE, LEUR PROCEDE DE PRODUCTION ET MEDICAMENTS LES CONTENANT
US6462043B1 (en) *	1997-08-18	2002-10-08	Syngenta Crop Protection, Inc.	Method for producing substituted-2-nitroguanidine derivatives
DE19737224A1 (de) *	1997-08-27	1999-03-18	Hoechst Marion Roussel De Gmbh	Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
DE19737463A1 (de) *	1997-08-28	1999-03-04	Hoechst Marion Roussel De Gmbh	Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden
DE19738604A1 (de) *	1997-09-04	1999-03-11	Hoechst Marion Roussel De Gmbh	Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe
DE19819548A1 (de) *	1998-04-30	1999-11-04	Merck Patent Gmbh	Biphenylderivate
DE19919349A1 (de) *	1999-04-28	2000-11-02	Merck Patent Gmbh	Verfahren zur Herstellung eines Benzoylguanidinderivates
FR2842804B1 (fr)	2002-07-29	2004-09-03	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr)	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2906251B1 (fr)	2006-09-22	2008-11-07	Sanofi Aventis Sa	Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique

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Publication number	Priority date	Publication date	Assignee	Title
US3006913A (en) *	1959-06-10	1961-10-31	Ciba Pharm Prod Inc	Process for preparing (n,n-alkylene-imino)-lower alkyl-guanidines
US3780027A (en) *	1970-04-29	1973-12-18	Merck & Co Inc	Anthranilic acid derivatives
US3968243A (en) *	1970-06-05	1976-07-06	Burroughs Wellcome Co.	Substituted guanidine compounds in the treating of arrythmias
DE2931735A1 (de) *	1979-08-04	1981-02-19	Beiersdorf Ag	Neue substituierte phenylacetylguanidine und verfahren zu ihrer herstellung
DE3360148D1 (en) *	1982-02-10	1985-06-05	Beecham Group Plc	Guanidine derivatives
US5190976A (en) *	1986-07-10	1993-03-02	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And University Of Oregon	N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
US5006523A (en) *	1989-10-26	1991-04-09	E. R. Squibb & Sons, Inc.	Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
ES2089600T3 (es) *	1992-02-15	1996-10-01	Hoechst Ag	Benzoilguanidina sustituida en 3,5, con efecto antiarritmico y efecto inhibidor de la proliferacion de celulas.
DK0556673T3 (da) *	1992-02-15	1998-04-14	Hoechst Ag	o-Substituerede benzoylguanidiner til behandling og profylakse af hjerterytmeforstyrrelser og iskæmisk inducerede skader samt til inhiberering af celleproliferation
ES2100435T3 (es) *	1992-12-16	1997-06-16	Hoechst Ag	Aminobenzoilguanidinas 3,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.

1992
- 1992-12-31 CZ CS924033A patent/CZ284456B6/cs unknown
1993
- 1993-02-05 DK DK93101840.2T patent/DK0556672T3/da active
- 1993-02-05 DE DE59307039T patent/DE59307039D1/de not_active Expired - Lifetime
- 1993-02-05 EP EP93101840A patent/EP0556672B1/fr not_active Expired - Lifetime
- 1993-02-05 TW TW082100767A patent/TW224455B/zh active
- 1993-02-05 ES ES93101840T patent/ES2104971T3/es not_active Expired - Lifetime
- 1993-02-05 AT AT93101840T patent/ATE156485T1/de not_active IP Right Cessation
- 1993-02-11 FI FI930603A patent/FI930603A7/fi unknown
- 1993-02-11 RO RO93-00173A patent/RO114131B1/ro unknown
- 1993-02-11 US US08/016,535 patent/US5364868A/en not_active Expired - Lifetime
- 1993-02-12 MX MX9300784A patent/MX9300784A/es unknown
- 1993-02-12 AU AU33013/93A patent/AU658261B2/en not_active Ceased
- 1993-02-12 IL IL104715A patent/IL104715A/en not_active IP Right Cessation
- 1993-02-12 CA CA002089442A patent/CA2089442C/fr not_active Expired - Fee Related
- 1993-02-12 NO NO930512A patent/NO302029B1/no not_active IP Right Cessation
- 1993-02-12 HU HU9300368A patent/HU215851B/hu not_active IP Right Cessation
- 1993-02-12 PH PH45720A patent/PH30940A/en unknown
- 1993-02-12 JP JP02310993A patent/JP3321473B2/ja not_active Expired - Lifetime
- 1993-02-12 RU RU93004698/04A patent/RU2085555C1/ru not_active IP Right Cessation
- 1993-02-12 NZ NZ245896A patent/NZ245896A/en unknown
- 1993-02-12 ZA ZA93986A patent/ZA93986B/xx unknown
- 1993-02-12 MA MA23090A patent/MA22798A1/fr unknown
- 1993-02-15 KR KR1019930002037A patent/KR100275603B1/ko not_active Expired - Fee Related
1997
- 1997-09-16 GR GR970402375T patent/GR3024731T3/el unknown

Also Published As

Publication number	Publication date
NO930512L (no)	1993-08-16
CA2089442C (fr)	2005-08-23
CA2089442A1 (fr)	1993-08-16
ES2104971T3 (es)	1997-10-16
EP0556672A1 (fr)	1993-08-25
DE59307039D1 (de)	1997-09-11
NO930512D0 (no)	1993-02-12
IL104715A (en)	1998-02-08
MX9300784A (es)	1993-09-01
ZA93986B (en)	1993-09-20
HU215851B (hu)	2000-06-28
AU3301393A (en)	1993-08-19
TW224455B (fr)	1994-06-01
ATE156485T1 (de)	1997-08-15
HU9300368D0 (en)	1993-04-28
FI930603L (fi)	1993-08-16
NO302029B1 (no)	1998-01-12
FI930603A7 (fi)	1993-08-16
IL104715A0 (en)	1993-06-10
CZ403392A3 (en)	1993-12-15
KR100275603B1 (ko)	2000-12-15
RO114131B1 (ro)	1999-01-29
JPH0641049A (ja)	1994-02-15
FI930603A0 (fi)	1993-02-11
KR930017868A (ko)	1993-09-20
RU2085555C1 (ru)	1997-07-27
EP0556672B1 (fr)	1997-08-06
DK0556672T3 (da)	1998-03-02
CZ284456B6 (cs)	1998-12-16
HUT63379A (en)	1993-08-30
JP3321473B2 (ja)	2002-09-03
US5364868A (en)	1994-11-15
AU658261B2 (en)	1995-04-06
PH30940A (en)	1997-12-23
GR3024731T3 (en)	1997-12-31
NZ245896A (en)	1995-04-27

Publication	Publication Date	Title
MA22798A1 (fr)	1993-10-01	Procede de preparation de benzoylguanidines.
RU93004698A (ru)	1995-09-27	Аминозамещенные бензоилгуанидины, способ их получения и применение
AU6881194A (en)	1995-02-09	Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
GR3024927T3 (en)	1998-01-30	Substituted benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them.
CA2089439A1 (fr)	1993-08-16	Benzoylguanidines a substituant en 3,5, procede d'obtention et emploi comme medicament ou diagnostique, et medicament qui les contient
TW250479B (fr)	1995-07-01
IE811680L (en)	1982-01-25	Tri-substituted imidazole derivatives
NO306720B1 (no)	1999-12-13	Sykliske ureaer og analoger som er anvendbare som retrovirale proteaseinhibitorer, farmasöytiske preparater omfattende disse og anvendelse av forbindelsene for fremstilling av farmasöytiske preparater
AU542481B2 (en)	1985-02-21	Substituted phenyl ethers
FI943716A0 (fi)	1994-08-11	Ureasubstituoidut, bentsoyyliguanidiinit, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeinä tai diagnostisena aineena ja niitä sisältävä lääke
TW429243B (en)	2001-04-11	Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
IL86846A (en)	1992-03-29	Pharmaceutical compositions for preventing and treating heart failure containing indane or naphthalene carboxylic acids
MX9605538A (es)	1997-05-31	Benzoil-guanidinas sustituidas con sulfonilamino, procedimiento para su preparacion, su empleo como medicamento o para diagnostico, asi como el medicamento que las contiene.
CA2223574A1 (fr)	1996-12-19	Derives de biphenyl-2-acide carboxylique-tetrahydro-isoquinoleine-6-yl amides, preparation de ces amides et utilisation en tant qu'inhibiteurs de la proteine de transfert de triglyceride microsomal et/ou de la secretion d'apolipoproteines b (apo b)