MA24512A1 - Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose - Google Patents

Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose

Info

Publication number
MA24512A1
MA24512A1 MA24467A MA24467A MA24512A1 MA 24512 A1 MA24512 A1 MA 24512A1 MA 24467 A MA24467 A MA 24467A MA 24467 A MA24467 A MA 24467A MA 24512 A1 MA24512 A1 MA 24512A1
Authority
MA
Morocco
Prior art keywords
thrombosis
preparation
treatment
agents useful
anticoagulating agents
Prior art date
Application number
MA24467A
Other languages
English (en)
Inventor
Neal Blackburn Michael
Robert Church William
Zeev Feuerstein Giora
Stuart Gross Mitchell
John Nichols Andrew
Agustin Padlan Eduardo
Haribhai Patel Arunbhai
Robert Sylvester Daniel
Original Assignee
Univ Vermont And State Agrienl
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vermont And State Agrienl, Smithkline Beecham Corp filed Critical Univ Vermont And State Agrienl
Publication of MA24512A1 publication Critical patent/MA24512A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA24467A 1996-01-17 1997-01-15 Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose MA24512A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1010896P 1996-01-17 1996-01-17
US2911996P 1996-10-24 1996-10-24

Publications (1)

Publication Number Publication Date
MA24512A1 true MA24512A1 (fr) 1998-12-31

Family

ID=26680794

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24467A MA24512A1 (fr) 1996-01-17 1997-01-15 Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose

Country Status (25)

Country Link
US (5) US6005091A (fr)
EP (2) EP1832297A1 (fr)
JP (2) JP2000503210A (fr)
KR (1) KR100553629B1 (fr)
CN (1) CN1213312A (fr)
AR (1) AR005658A1 (fr)
AT (1) ATE330630T1 (fr)
AU (1) AU706397B2 (fr)
BR (1) BR9707049A (fr)
CZ (1) CZ299452B6 (fr)
DE (1) DE69736197T2 (fr)
DK (1) DK1007089T3 (fr)
ES (1) ES2267131T3 (fr)
HU (1) HU225903B1 (fr)
ID (1) ID17156A (fr)
IL (1) IL125380A0 (fr)
MA (1) MA24512A1 (fr)
MX (1) MX9805810A (fr)
NO (1) NO983284L (fr)
NZ (2) NZ331014A (fr)
PL (1) PL187274B1 (fr)
PT (1) PT1007089E (fr)
SI (1) SI1007089T1 (fr)
TR (1) TR199801390T2 (fr)
WO (1) WO1997026010A1 (fr)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA24512A1 (fr) * 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
US20040038898A1 (en) * 1996-05-16 2004-02-26 The Trustees Of Columbia University Method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal circulation
US6610293B1 (en) 1997-06-16 2003-08-26 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
EP1001991A4 (fr) * 1997-07-03 2005-01-26 Smithkline Beecham Corp Structures cristallines de fragments fab anti-facteur ix et procedes d'utilisation pour la conception de peptidomimetique
DE19802139C1 (de) 1998-01-22 1999-09-23 Centeon Pharma Gmbh Monoklonaler Antikörper spezifisch für aktivierten Gerinnungsfaktor VII und seine Verwendung
PT1095143E (pt) * 1998-05-08 2008-11-28 Sanquin Bloedvoorziening Inibidor para o diagnóstico e tratamento de doentes com hemofilia a
US7250494B2 (en) * 1998-06-15 2007-07-31 Biosynexus Incorporated Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
WO2000007626A1 (fr) * 1998-08-07 2000-02-17 Smithkline Beecham Corporation Utilisation d'anticorps de facteur anticoagulant comme agents protecteurs longue duree
DE69901569T2 (de) * 1998-08-28 2002-12-19 Genentech, Inc. Humane antikörper gegen faktor ix/ixa
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
JP4803879B2 (ja) * 1998-10-31 2011-10-26 アメリカ合衆国 ヒト化抗−癌腫モノクローナル抗体ｃｃ４９
US7067313B1 (en) 1999-07-14 2006-06-27 D. Collen Research Foundation Ligands for use in therapeutic compositions for the treatment of hemostasis disorders
ES2283308T3 (es) * 1999-07-14 2007-11-01 D. Collen Research Foundation Vzw Anticuerpo monoclonal para el factor viii, que incluso cuando esta presente en exceso molar inactiva el factor viii solo en parte y metodo para producir dicho anticuerpo.
US7829085B2 (en) * 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
AT411997B (de) 1999-09-14 2004-08-26 Baxter Ag Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
US6316259B1 (en) * 2000-01-21 2001-11-13 Isis Pharmaceuticals, Inc. Antisense inhibition of glycogen synthase kinase 3 alpha expression
CN100339132C (zh) * 2000-05-15 2007-09-26 史密丝克莱恩比彻姆公司 抗血栓剂
EP2351855A1 (fr) * 2000-09-26 2011-08-03 Duke University Aptamères d'ARN et leurs procédés d'identification
ES2346189T3 (es) 2001-01-11 2010-10-13 Life Sciences Research Partners Vzw Metodo y composicion farmaceutica para prevenir y/o tratar el sindrome de respuesta inflamatoria generalizada.
JP2005508838A (ja) * 2001-03-23 2005-04-07 アフトン コーポレーション 膵癌の組合せ治療
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
DE60230037D1 (de) * 2001-06-12 2009-01-08 Chemo Sero Therapeut Res Inst Humanantikörper gegen blutgerinnungsfaktor viii
AU2002326356A1 (en) * 2001-07-09 2003-01-29 Aphton Corporation Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
WO2003013423A2 (fr) * 2001-08-05 2003-02-20 Gvg, Inc. Agent antithrombotique
US20040052779A1 (en) * 2001-12-21 2004-03-18 Stinson Jeffrey R. Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
EP1532162B1 (fr) 2002-06-28 2013-08-07 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Les cc49, anti-tag-72 humanises servant au diagnostic et au traitement de tumeurs chez l'homme
US6928528B1 (en) 2002-10-07 2005-08-09 Advanced Micro Devices, Inc. Guaranteed data synchronization
US20060020119A1 (en) * 2004-03-29 2006-01-26 Stephen Grimes Monoclonal antibodies to gastrin hormone
WO2004088326A2 (fr) * 2003-03-28 2004-10-14 Aphton Corporation Dosages immunologiques pour la detection de l'hormone gastrine
JP4422430B2 (ja) 2003-05-14 2010-02-24 帝國製薬株式会社 エストロゲン及び／又はプロゲストゲン含有外用貼付剤
JP4934796B2 (ja) 2003-08-14 2012-05-16 トロンボジェニクス・ナムローゼ・フエンノートシャップ 可変抗体
US7589181B2 (en) 2003-08-29 2009-09-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Minimally immunogenic variants of SDR-grafted humanized antibody CC49 and their use
US7297336B2 (en) 2003-09-12 2007-11-20 Baxter International Inc. Factor IXa specific antibodies displaying factor VIIIa like activity
AU2003271174A1 (en) * 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
WO2005035754A1 (fr) * 2003-10-14 2005-04-21 Chugai Seiyaku Kabushiki Kaisha Anticorps a double specificite de substitution de proteine fonctionnelle
EP1794586B1 (fr) 2004-09-22 2013-01-30 Cancer Advances, Inc., Anticorps monoclonaux de progastrine
CN101198698B (zh) 2005-03-31 2014-03-19 中外制药株式会社 通过调节多肽缔合制备多肽的方法
CN104761637B (zh) 2006-03-31 2021-10-15 中外制药株式会社 调控抗体血液动力学的方法
EP2009101B1 (fr) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Procede de modification d'anticorps pour purifier un anticorps bispecifique
US20100322921A1 (en) * 2006-10-16 2010-12-23 Rekha Bansal METHOD OF INHIBITING COAGULATION ACTIVATION WITH HUMAN ANTI-FACTOR Va ANTIBODIES AND USE THEREOF
CN101842388B (zh) 2007-09-13 2013-09-04 德勒尼克斯治疗股份公司 针对β淀粉样肽的人源化抗体
US20100239570A1 (en) * 2007-09-13 2010-09-23 Roger Nitsch Moncolonal amyloid beta (abeta) - specific antibody and uses thereof
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
WO2009049234A2 (fr) * 2007-10-11 2009-04-16 Regents Of The University Of California Procédés de traitement d'une coagulopathie
WO2009154461A1 (fr) * 2008-06-19 2009-12-23 Prothix Bv Utilisation d’anticorps anti-facteurs xi pour prévenir la formation de thrombus
KR101962483B1 (ko) 2010-11-17 2019-03-29 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
CA2893977C (fr) 2012-12-21 2024-02-13 Seattle Genetics, Inc. Anticorps anti-ntb-a et compositions et procedes associes
WO2014160088A2 (fr) * 2013-03-14 2014-10-02 Rhode Island Hospital, A Lifespan-Partner Traitement d'infections par le virus de l'hépatite b
CN105764922B (zh) 2013-09-27 2020-07-17 中外制药株式会社 多肽异源多聚体的制备方法
SG10201805646WA (en) 2014-08-07 2018-08-30 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
WO2016020882A2 (fr) 2014-08-07 2016-02-11 Novartis Ag Anticorps de type angiopoétine 4 (angptl4) et procédés d'utilisation
TWI700300B (zh) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體
TWI701435B (zh) 2014-09-26 2020-08-11 日商中外製藥股份有限公司 測定ｆｖｉｉｉ的反應性之方法
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
US11142587B2 (en) 2015-04-01 2021-10-12 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
UY36751A (es) 2015-06-26 2017-01-31 Novartis Ag Anticuerpos de factor xi y métodos de uso
JP7068160B2 (ja) * 2015-07-21 2022-05-16 武田薬品工業株式会社 第ＸＩＩａ因子のモノクローナル抗体阻害剤
WO2017110980A1 (fr) 2015-12-25 2017-06-29 中外製薬株式会社 Anticorps présentant une activité accrue et son procédé de modification
SG11201803989WA (en) 2015-12-28 2018-06-28 Chugai Pharmaceutical Co Ltd Method for promoting efficiency of purification of fc region-containing polypeptide
RU2021129189A (ru) * 2016-01-22 2021-11-15 Мерк Шарп И Доум Корп. Антитела против фактора свертывания xi
ES3055961T3 (en) 2016-04-28 2026-02-17 Chugai Pharmaceutical Co Ltd Antibody-containing preparation
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
MY201852A (en) 2016-06-14 2024-03-20 Merck Sharp & Dohme Llc Anti-coagulation factor xi antibodies
CN109415444B (zh) 2016-07-29 2024-03-01 中外制药株式会社 显示增加的备选fviii辅因子功能活性的双特异性抗体
EP3509637B1 (fr) 2016-09-06 2024-11-27 Chugai Seiyaku Kabushiki Kaisha Procédés d'utilisation d'un anticorps bispécifique qui reconnaît le facteur de coagulation ix et/ou le facteur de coagulation ix activé et le facteur de coagulation x et/ou le facteur de coagulation x activé
CN110662770A (zh) * 2016-11-23 2020-01-07 比奥维拉迪维治疗股份有限公司 结合凝血因子ix和凝血因子x的双特异性抗体
BR112019012667A2 (pt) 2016-12-23 2020-02-11 Novartis Ag Anticorpos do fator xi e métodos de uso
US20200231701A1 (en) * 2016-12-23 2020-07-23 Novartis Ag Methods of treatment with anti-factor xi/xia antibodies
EP3603670A4 (fr) 2017-03-31 2021-03-10 Public University Corporation Nara Medical University Composition médicinale utilisable pour prévenir et/ou traiter une anomalie du facteur ix de la coagulation sanguine, comprenant une molécule de liaison d'antigène multispécifique remplaçant la fonction du facteur viii de la coagulation sanguine
US12150978B2 (en) 2017-06-15 2024-11-26 Cancer Advances Inc. Compositions and methods for preventing tumors and cancer
KR102772810B1 (ko) 2017-06-15 2025-02-28 캔서 어드밴시스 아이엔씨 종양 및 암에 대한 체액성 및 세포 면역을 유도하기 위한 조성물 및 방법
GB201709970D0 (en) * 2017-06-22 2017-08-09 Kymab Ltd Bispecific antigen-binding molecules
JP6496095B1 (ja) 2017-09-29 2019-04-03 中外製薬株式会社 血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）補因子機能代替活性を有する多重特異性抗原結合分子および当該分子を有効成分として含有する薬学的製剤
TW202600611A (zh) 2017-11-01 2026-01-01 日商中外製藥股份有限公司 生物活性降低之抗體變異體與同功型
US20220064327A1 (en) 2018-12-21 2022-03-03 Kymab Limited Fixaxfx bispecific antibody with common light chain
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3909799A1 (de) * 1989-03-24 1990-09-27 Behringwerke Ag Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
CA2049655C (fr) * 1990-09-17 1996-11-12 Akio Odawara Composition pharmaceutique pour inhiber l'aggregation des plaquettes
WO1993009804A1 (fr) * 1991-11-18 1993-05-27 The Scripps Research Institute Polypeptides derives de la serine protease et anticorps anti-peptidiques, systemes et procedes therapeutiques empechant la coagulation du sang
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
DK0658168T3 (da) * 1992-08-27 2001-01-22 Sanquin Bloedvoorziening Antistoffer, som er specifikke for et hæmostatisk protein, anvendelse heraf til isolering af intakt protein, hæmostatiske p
US5397581A (en) * 1993-02-05 1995-03-14 Lerman; Russell E. Means for continuous confectionery coating of edible centers
MA24512A1 (fr) * 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
US20070190059A1 (en) * 1996-01-17 2007-08-16 Smithkline Beecham Corporation Antithrombotic agents

Also Published As

Publication number Publication date
AU1830897A (en) 1997-08-11
IL125380A0 (en) 1999-03-12
US6391299B1 (en) 2002-05-21
EP1007089A4 (fr) 2003-04-16
PL187274B1 (pl) 2004-06-30
JP2000503210A (ja) 2000-03-21
EP1007089B1 (fr) 2006-06-21
WO1997026010A1 (fr) 1997-07-24
US20070003553A1 (en) 2007-01-04
KR100553629B1 (ko) 2006-10-04
DE69736197D1 (de) 2006-08-03
NZ501215A (en) 2001-04-27
KR19990077329A (ko) 1999-10-25
ES2267131T3 (es) 2007-03-01
US6005091A (en) 1999-12-21
NZ331014A (en) 2000-01-28
ATE330630T1 (de) 2006-07-15
CZ299452B6 (cs) 2008-07-30
HUP9900396A3 (en) 2001-10-29
NO983284D0 (no) 1998-07-16
SI1007089T1 (sl) 2006-12-31
MX9805810A (es) 1998-11-30
HUP9900396A2 (hu) 1999-05-28
AU706397B2 (en) 1999-06-17
DK1007089T3 (da) 2006-10-09
EP1007089A1 (fr) 2000-06-14
DE69736197T2 (de) 2007-06-21
NO983284L (no) 1998-09-16
AR005658A1 (es) 1999-07-14
HU225903B1 (en) 2007-12-28
BR9707049A (pt) 2000-10-24
TR199801390T2 (xx) 1998-12-21
JP2007325602A (ja) 2007-12-20
ID17156A (id) 1997-12-04
HK1029513A1 (en) 2001-04-06
EP1832297A1 (fr) 2007-09-12
CZ222598A3 (cs) 2000-01-12
PL327929A1 (en) 1999-01-04
PT1007089E (pt) 2006-11-30
US20020146411A1 (en) 2002-10-10
US20070224198A1 (en) 2007-09-27
CN1213312A (zh) 1999-04-07

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