MA26462A1 - Composes nouveaux a noyau dibenzocycloheptene, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Composes nouveaux a noyau dibenzocycloheptene, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number: MA26462A1
Authority: MA; Morocco
Prior art keywords: dibenzocycloheptened; novel; preparation; pharmaceutical compositions; compositions containing
Prior art date: 1997-01-08

Application number

MA24917A

Other languages

English (en)

Inventor

H Miller William

E Bondinell William

Wen Fu Ku Thomas

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-08

Filing date

1998-01-02

Publication date

2004-12-20

1998-01-02 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2004-12-20 Publication of MA26462A1 publication Critical patent/MA26462A1/fr

Links

150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MA24917A 1997-01-08 1998-01-02 Composes nouveaux a noyau dibenzocycloheptene, procede pour leur preparation et compositions pharmaceutiques les contenant MA26462A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3402697P	1997-01-08	1997-01-08

Publications (1)

Publication Number	Publication Date
MA26462A1 true MA26462A1 (fr)	2004-12-20

Family

ID=21873846

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA24917A MA26462A1 (fr)	1997-01-08	1998-01-02	Composes nouveaux a noyau dibenzocycloheptene, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (30)

Country	Link
US (2)	US6069158A (fr)
EP (1)	EP0977735B1 (fr)
JP (1)	JP2001508067A (fr)
KR (1)	KR20000069941A (fr)
CN (1)	CN1249745A (fr)
AP (1)	AP9901597A0 (fr)
AR (1)	AR010873A1 (fr)
AT (1)	ATE235467T1 (fr)
AU (1)	AU729641B2 (fr)
BG (1)	BG103548A (fr)
BR (1)	BR9806852A (fr)
CA (1)	CA2276738A1 (fr)
CO (1)	CO4920232A1 (fr)
DE (1)	DE69812602T2 (fr)
DZ (1)	DZ2395A1 (fr)
EA (1)	EA199900630A1 (fr)
ES (1)	ES2196534T3 (fr)
HU (1)	HUP0001945A3 (fr)
ID (1)	ID23168A (fr)
IL (1)	IL130760A0 (fr)
MA (1)	MA26462A1 (fr)
NO (1)	NO993350L (fr)
NZ (1)	NZ336560A (fr)
OA (1)	OA11076A (fr)
PE (1)	PE44799A1 (fr)
PL (1)	PL334499A1 (fr)
SK (1)	SK92799A3 (fr)
TR (1)	TR199901575T2 (fr)
WO (1)	WO1998030542A1 (fr)
ZA (1)	ZA9896B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1027337A4 (fr) *	1997-09-04	2002-04-03	Smithkline Beecham Corp	Antagonistes des recepteurs d'integrines
PE122699A1 (es) *	1997-09-19	2000-02-12	Smithkline Beecham Corp	Antagonistas de receptores de vitronectina
US6576643B2 (en)	1997-09-19	2003-06-10	Smithkline Beecham Corporation	Vitronectin receptor antagonists
KR20010042587A (ko)	1998-04-09	2001-05-25	기따자또 이찌로	인테그린 알파브이베타3 길항제로서 아미노피페리딘 유도체
JP4240424B2 (ja) *	1998-10-23	2009-03-18	エルジーディスプレイカンパニーリミテッド	エッチング剤及びこれを用いた電子機器用基板の製造方法
US6339083B1 (en)	1998-12-14	2002-01-15	Bayer Aktiengesellschaft	Multiheterocyclic pharmAceuticals
EP1150965A4 (fr)	1999-02-03	2002-05-15	Merck & Co Inc	Derives de la benzazepine utilises comme antagonistes du recepteur alpha-v de l'integrine
DE19916837A1 (de) *	1999-04-14	2000-10-19	Merck Patent Gmbh	Dibenzoazulenderivate
EP1209152A4 (fr)	1999-08-05	2003-03-12	Meiji Seika Kaisha	Derives d'acide omega-amino-alpha-hydroxycarboxylique possedant un antagonisme alpha v beta 3 d'integrine
DE19936780A1 (de)	1999-08-09	2001-02-15	Basf Ag	Neue Antagonisten von Integrinrezeptoren
FR2806082B1 (fr) *	2000-03-07	2002-05-17	Adir	Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU3943502A (en) *	2000-10-24	2002-05-27	Merck & Co Inc	Dibenzoxazepine alpha v integrin receptor antagonist
ES2366775T3 (es)	2001-04-24	2011-10-25	Merck Patent Gmbh	POLITERAPIA UTILIZANDO AGENTES ANTIANGIOGÉNICOS Y TNF(alfa).
WO2003059251A2 (fr)	2001-10-22	2003-07-24	The Scripps Research Institute	Composes de ciblage d'anticorps
GB0215867D0 (en) *	2002-07-09	2002-08-14	Glaxosmithkline Spa	Novel method and compounds
PL1734996T3 (pl) *	2004-04-02	2013-09-30	Univ California	Sposoby i kompozycje do leczenia i profilaktyki choroby związanej z integryną alfa v beta 5
AU2012216372B2 (en) *	2004-04-02	2015-01-22	The Regents Of The University Of California	Methods and compositions for treating and preventing disease associated with alphaVbeta5 integrin
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
US8282943B2 (en)	2005-05-31	2012-10-09	Ralf Jochem	Therapeutic composition for use in the prevention and treatment of bone metastases
WO2007048127A2 (fr) *	2005-10-20	2007-04-26	The Scripps Research Institute	MARQUAGE DE PARTIES Fc POUR L'IMMUNOCOLORATION ET L'IMMUNOCIBLAGE
AU2007207465B2 (en)	2006-01-18	2012-12-06	Merck Patent Gmbh	Specific therapy using integrin ligands for treating cancer
BRPI0806596A2 (pt)	2007-01-18	2013-07-23	Merck Patent Ges Mit Berchraenkter Haftung	medicamento e terapia especÍfica usando-se ligantes de integrina para o tratamento de cÂncer
JP5539221B2 (ja)	2007-12-21	2014-07-02	リガンド・ファーマシューティカルズ・インコーポレイテッド	選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）およびその使用
WO2010093706A2 (fr)	2009-02-10	2010-08-19	The Scripps Research Institute	Vaccination programmée chimiquement
EP2445534A2 (fr)	2009-05-25	2012-05-02	Merck Patent GmbH	Administration continue du cilengitide dans des traitements du cancer
CA2767409C (fr)	2009-07-24	2018-10-30	The Regents Of The University Of California	Procedes et compositions destines a traiter et a prevenir des maladies associees a l'integrine ?v?5
ES2864079T3 (es)	2014-05-30	2021-10-13	Pfizer	Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
KR20220003554A (ko)	2019-04-19	2022-01-10	리간드 파마슈티칼스 인코포레이티드	화합물의 결정질 형태 및 결정질 형태를 제조하는 방법
WO2023275715A1 (fr)	2021-06-30	2023-01-05	Pfizer Inc.	Métabolites de modulateurs sélectifs du récepteur des androgènes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE794424A (fr) *	1972-01-24	1973-07-23	Science Union & Cie	Nouveaux dibenzocycloheptenes, leur procede d'obtention et leur application comme medicament
US3906032A (en) *	1972-11-10	1975-09-16	Squibb & Sons Inc	Dihydroxy-tetrahydronaphthyoxyisobutyric acids and alkyl esters and salts thereof
IT1222986B (it) *	1987-10-23	1990-09-12	Texcontor Ets	Derivati dell'efedrina esterificata aventi attivita' antiulcera prolungata nel tempo
AU612437B2 (en) *	1987-12-14	1991-07-11	Kyowa Hakko Kogyo Co. Ltd.	Tricyclic compounds
ES2197950T3 (es) *	1995-06-29	2004-01-16	Smithkline Beecham Corporation	Antagonistas del receptor de la integrina.
KR19990076877A (ko) *	1995-12-29	1999-10-25	스티븐 베네티아너	비트로넥틴 수용체 길항제
EP1000031A4 (fr) *	1997-07-25	2001-08-16	Smithkline Beecham Corp	Antagonistes du recepteur de vitronectine
PE122699A1 (es) *	1997-09-19	2000-02-12	Smithkline Beecham Corp	Antagonistas de receptores de vitronectina

1997
- 1997-12-30 CO CO97075531A patent/CO4920232A1/es unknown
1998
- 1998-01-02 MA MA24917A patent/MA26462A1/fr unknown
- 1998-01-05 AR ARP980100031A patent/AR010873A1/es not_active Application Discontinuation
- 1998-01-07 PE PE1998000013A patent/PE44799A1/es not_active Application Discontinuation
- 1998-01-07 ZA ZA9896A patent/ZA9896B/xx unknown
- 1998-01-08 AT AT98902477T patent/ATE235467T1/de not_active IP Right Cessation
- 1998-01-08 EP EP98902477A patent/EP0977735B1/fr not_active Expired - Lifetime
- 1998-01-08 CA CA002276738A patent/CA2276738A1/fr not_active Abandoned
- 1998-01-08 TR TR1999/01575T patent/TR199901575T2/xx unknown
- 1998-01-08 ID IDW990650D patent/ID23168A/id unknown
- 1998-01-08 SK SK927-99A patent/SK92799A3/sk unknown
- 1998-01-08 BR BR9806852-0A patent/BR9806852A/pt not_active Application Discontinuation
- 1998-01-08 NZ NZ336560A patent/NZ336560A/xx unknown
- 1998-01-08 US US09/331,914 patent/US6069158A/en not_active Expired - Lifetime
- 1998-01-08 DE DE69812602T patent/DE69812602T2/de not_active Expired - Lifetime
- 1998-01-08 KR KR1019997006154A patent/KR20000069941A/ko not_active Ceased
- 1998-01-08 HU HU0001945A patent/HUP0001945A3/hu unknown
- 1998-01-08 EA EA199900630A patent/EA199900630A1/ru unknown
- 1998-01-08 PL PL98334499A patent/PL334499A1/xx unknown
- 1998-01-08 AP APAP/P/1999/001597A patent/AP9901597A0/en unknown
- 1998-01-08 ES ES98902477T patent/ES2196534T3/es not_active Expired - Lifetime
- 1998-01-08 JP JP53117598A patent/JP2001508067A/ja active Pending
- 1998-01-08 CN CN98802983A patent/CN1249745A/zh active Pending
- 1998-01-08 AU AU59127/98A patent/AU729641B2/en not_active Ceased
- 1998-01-08 IL IL13076098A patent/IL130760A0/xx unknown
- 1998-01-08 WO PCT/US1998/000490 patent/WO1998030542A1/fr not_active Ceased
- 1998-06-07 DZ DZ980005A patent/DZ2395A1/fr active
1999
- 1999-07-01 BG BG103548A patent/BG103548A/xx unknown
- 1999-07-07 NO NO993350A patent/NO993350L/no not_active Application Discontinuation
- 1999-07-08 OA OA9900155A patent/OA11076A/en unknown
2000
- 2000-04-18 US US09/551,743 patent/US6191304B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL130760A0 (en)	2001-01-28
US6069158A (en)	2000-05-30
BR9806852A (pt)	2001-08-07
CA2276738A1 (fr)	1998-07-16
DE69812602D1 (de)	2003-04-30
EP0977735A4 (fr)	2000-04-05
DZ2395A1 (fr)	2003-06-04
ID23168A (id)	2000-03-23
EP0977735A1 (fr)	2000-02-09
PE44799A1 (es)	1999-06-10
BG103548A (en)	2000-11-30
DE69812602T2 (de)	2004-02-19
EA199900630A1 (ru)	2000-02-28
ES2196534T3 (es)	2003-12-16
KR20000069941A (ko)	2000-11-25
HUP0001945A3 (en)	2001-12-28
US6191304B1 (en)	2001-02-20
NZ336560A (en)	2000-11-24
OA11076A (en)	2003-03-13
SK92799A3 (en)	1999-12-10
AR010873A1 (es)	2000-07-12
ZA9896B (en)	1998-10-14
ATE235467T1 (de)	2003-04-15
NO993350L (no)	1999-09-06
AP9901597A0 (en)	1999-09-30
CN1249745A (zh)	2000-04-05
HUP0001945A2 (hu)	2000-10-28
AU5912798A (en)	1998-08-03
TR199901575T2 (xx)	1999-11-22
WO1998030542A1 (fr)	1998-07-16
NO993350D0 (no)	1999-07-07
CO4920232A1 (es)	2000-05-29
EP0977735B1 (fr)	2003-03-26
JP2001508067A (ja)	2001-06-19
PL334499A1 (en)	2000-02-28
AU729641B2 (en)	2001-02-08

Publication	Publication Date	Title
MA26680A1 (fr)	2004-12-20	Derives de quinoleine-2-one a substituant alcynyle nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
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DZ2395A1 (fr)	2003-06-04	Composés nouveaux a noyau dibenzocycloheptène procédé pour leur préparation et compositions pharmaceutiques les contenant.
FR2794742B1 (fr)	2005-06-03	Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
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