NO993350L - Vitronectin-reseptor-antagonister - Google Patents

Vitronectin-reseptor-antagonister

Info

Publication number
NO993350L
NO993350L NO993350A NO993350A NO993350L NO 993350 L NO993350 L NO 993350L NO 993350 A NO993350 A NO 993350A NO 993350 A NO993350 A NO 993350A NO 993350 L NO993350 L NO 993350L
Authority
NO
Norway
Prior art keywords
receptor antagonists
vitronectin receptor
vitronectin
relates
present
Prior art date
Application number
NO993350A
Other languages
English (en)
Other versions
NO993350D0 (no
Inventor
William H Miller
William E Bondinell
Thomas Wenfu Ku
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO993350D0 publication Critical patent/NO993350D0/no
Publication of NO993350L publication Critical patent/NO993350L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår visse tricykliske forbindelser som er integrin- réseptor-antagonister.
NO993350A 1997-01-08 1999-07-07 Vitronectin-reseptor-antagonister NO993350L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3402697P 1997-01-08 1997-01-08
PCT/US1998/000490 WO1998030542A1 (en) 1997-01-08 1998-01-08 Vitronectin receptor antagonists

Publications (2)

Publication Number Publication Date
NO993350D0 NO993350D0 (no) 1999-07-07
NO993350L true NO993350L (no) 1999-09-06

Family

ID=21873846

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993350A NO993350L (no) 1997-01-08 1999-07-07 Vitronectin-reseptor-antagonister

Country Status (30)

Country Link
US (2) US6069158A (no)
EP (1) EP0977735B1 (no)
JP (1) JP2001508067A (no)
KR (1) KR20000069941A (no)
CN (1) CN1249745A (no)
AP (1) AP9901597A0 (no)
AR (1) AR010873A1 (no)
AT (1) ATE235467T1 (no)
AU (1) AU729641B2 (no)
BG (1) BG103548A (no)
BR (1) BR9806852A (no)
CA (1) CA2276738A1 (no)
CO (1) CO4920232A1 (no)
DE (1) DE69812602T2 (no)
DZ (1) DZ2395A1 (no)
EA (1) EA199900630A1 (no)
ES (1) ES2196534T3 (no)
HU (1) HUP0001945A3 (no)
ID (1) ID23168A (no)
IL (1) IL130760A0 (no)
MA (1) MA26462A1 (no)
NO (1) NO993350L (no)
NZ (1) NZ336560A (no)
OA (1) OA11076A (no)
PE (1) PE44799A1 (no)
PL (1) PL334499A1 (no)
SK (1) SK92799A3 (no)
TR (1) TR199901575T2 (no)
WO (1) WO1998030542A1 (no)
ZA (1) ZA9896B (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1027337A4 (en) * 1997-09-04 2002-04-03 Smithkline Beecham Corp Integrin receptor Antagonist
PE122699A1 (es) * 1997-09-19 2000-02-12 Smithkline Beecham Corp Antagonistas de receptores de vitronectina
US6576643B2 (en) 1997-09-19 2003-06-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
KR20010042587A (ko) 1998-04-09 2001-05-25 기따자또 이찌로 인테그린 알파브이베타3 길항제로서 아미노피페리딘 유도체
JP4240424B2 (ja) * 1998-10-23 2009-03-18 エルジー ディスプレイ カンパニー リミテッド エッチング剤及びこれを用いた電子機器用基板の製造方法
US6339083B1 (en) 1998-12-14 2002-01-15 Bayer Aktiengesellschaft Multiheterocyclic pharmAceuticals
EP1150965A4 (en) 1999-02-03 2002-05-15 Merck & Co Inc BENZAZEPINE DERIVATIVES AS ALPHA-V INTGRIN RECEPTOR ANTAGONISTS
DE19916837A1 (de) * 1999-04-14 2000-10-19 Merck Patent Gmbh Dibenzoazulenderivate
EP1209152A4 (en) 1999-08-05 2003-03-12 Meiji Seika Kaisha OMEGA-AMINO-ALPHA-HYDROXY-CARBONIC ACID DERIVATIVES WITH AN INTEGRIN ALPHA V BETA ANTAGONISM
DE19936780A1 (de) 1999-08-09 2001-02-15 Basf Ag Neue Antagonisten von Integrinrezeptoren
FR2806082B1 (fr) * 2000-03-07 2002-05-17 Adir Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU3943502A (en) * 2000-10-24 2002-05-27 Merck & Co Inc Dibenzoxazepine alpha v integrin receptor antagonist
ES2366775T3 (es) 2001-04-24 2011-10-25 Merck Patent Gmbh POLITERAPIA UTILIZANDO AGENTES ANTIANGIOGÉNICOS Y TNF(alfa).
WO2003059251A2 (en) 2001-10-22 2003-07-24 The Scripps Research Institute Antibody targeting compounds
GB0215867D0 (en) * 2002-07-09 2002-08-14 Glaxosmithkline Spa Novel method and compounds
PL1734996T3 (pl) * 2004-04-02 2013-09-30 Univ California Sposoby i kompozycje do leczenia i profilaktyki choroby związanej z integryną alfa v beta 5
AU2012216372B2 (en) * 2004-04-02 2015-01-22 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with alphaVbeta5 integrin
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
US8282943B2 (en) 2005-05-31 2012-10-09 Ralf Jochem Therapeutic composition for use in the prevention and treatment of bone metastases
WO2007048127A2 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
AU2007207465B2 (en) 2006-01-18 2012-12-06 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
BRPI0806596A2 (pt) 2007-01-18 2013-07-23 Merck Patent Ges Mit Berchraenkter Haftung medicamento e terapia especÍfica usando-se ligantes de integrina para o tratamento de cÂncer
JP5539221B2 (ja) 2007-12-21 2014-07-02 リガンド・ファーマシューティカルズ・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）およびその使用
WO2010093706A2 (en) 2009-02-10 2010-08-19 The Scripps Research Institute Chemically programmed vaccination
EP2445534A2 (en) 2009-05-25 2012-05-02 Merck Patent GmbH Continuous administration of cilengitide in cancer treatments
CA2767409C (en) 2009-07-24 2018-10-30 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with .alpha.v.beta.5 integrin
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
KR20220003554A (ko) 2019-04-19 2022-01-10 리간드 파마슈티칼스 인코포레이티드 화합물의 결정질 형태 및 결정질 형태를 제조하는 방법
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794424A (fr) * 1972-01-24 1973-07-23 Science Union & Cie Nouveaux dibenzocycloheptenes, leur procede d'obtention et leur application comme medicament
US3906032A (en) * 1972-11-10 1975-09-16 Squibb & Sons Inc Dihydroxy-tetrahydronaphthyoxyisobutyric acids and alkyl esters and salts thereof
IT1222986B (it) * 1987-10-23 1990-09-12 Texcontor Ets Derivati dell'efedrina esterificata aventi attivita' antiulcera prolungata nel tempo
AU612437B2 (en) * 1987-12-14 1991-07-11 Kyowa Hakko Kogyo Co. Ltd. Tricyclic compounds
ES2197950T3 (es) * 1995-06-29 2004-01-16 Smithkline Beecham Corporation Antagonistas del receptor de la integrina.
KR19990076877A (ko) * 1995-12-29 1999-10-25 스티븐 베네티아너 비트로넥틴 수용체 길항제
EP1000031A4 (en) * 1997-07-25 2001-08-16 Smithkline Beecham Corp VITRONECTIN RECEPTOR ANTAGONISTS
PE122699A1 (es) * 1997-09-19 2000-02-12 Smithkline Beecham Corp Antagonistas de receptores de vitronectina

Also Published As

Publication number Publication date
IL130760A0 (en) 2001-01-28
US6069158A (en) 2000-05-30
BR9806852A (pt) 2001-08-07
CA2276738A1 (en) 1998-07-16
DE69812602D1 (de) 2003-04-30
EP0977735A4 (en) 2000-04-05
DZ2395A1 (fr) 2003-06-04
ID23168A (id) 2000-03-23
EP0977735A1 (en) 2000-02-09
PE44799A1 (es) 1999-06-10
BG103548A (en) 2000-11-30
DE69812602T2 (de) 2004-02-19
EA199900630A1 (ru) 2000-02-28
ES2196534T3 (es) 2003-12-16
KR20000069941A (ko) 2000-11-25
HUP0001945A3 (en) 2001-12-28
US6191304B1 (en) 2001-02-20
NZ336560A (en) 2000-11-24
OA11076A (en) 2003-03-13
SK92799A3 (en) 1999-12-10
AR010873A1 (es) 2000-07-12
ZA9896B (en) 1998-10-14
ATE235467T1 (de) 2003-04-15
AP9901597A0 (en) 1999-09-30
CN1249745A (zh) 2000-04-05
HUP0001945A2 (hu) 2000-10-28
AU5912798A (en) 1998-08-03
TR199901575T2 (xx) 1999-11-22
WO1998030542A1 (en) 1998-07-16
MA26462A1 (fr) 2004-12-20
NO993350D0 (no) 1999-07-07
CO4920232A1 (es) 2000-05-29
EP0977735B1 (en) 2003-03-26
JP2001508067A (ja) 2001-06-19
PL334499A1 (en) 2000-02-28
AU729641B2 (en) 2001-02-08

Similar Documents

Publication Publication Date Title
TR199901575T2 (xx) Vitronektin resept�r antagonistleri.
DK1147115T5 (da) Tricycliske benzodiazepiner som vasopressinreceptorantagonister
BR9712248B1 (pt) antagonistas receptores de vitronectina.
TR199902986A3 (tr) Sentetik liften halatlarin ikamesi için tespit vasitasi.
DK1337518T3 (da) Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren
TR200000782T2 (tr) Resorsinol türevleri.
TR199801594A3 (tr) CCR-3 reseptör antagonistleri.
SE9702773D0 (sv) Novel compounds
DZ2769A1 (fr) Composés tricycliques substitués.
TR200002896T2 (tr) Kalsilitik Bileşimler
SE9901077D0 (sv) Novel use
NO20004503D0 (no) Vitronectin-reseptor-antagonister
TR200100885T2 (tr) 2-Metil-tieno-benzodiazepin formülasyonu
NO20001407D0 (no) Vitronectin-reseptor-antagonister
SE9801494D0 (sv) Novel use
TR200201459T2 (tr) Okzkarbazepin içeren süspansiyon
NO994106D0 (no) Oksazolidiner som 5-HT2A-antagonister
ATE198202T1 (de) Fibrinogen receptor antagonisten
DZ2322A1 (fr) Antagonistes de récepteurs de vitronectine.
HRP20041224A2 (en) Cck-1 receptor modulators
EA200100854A1 (ru) Кальций-литические соединения
SE9702794D0 (sv) New compounds
DE60016769D1 (de) Antagonisten des vitronectin-receptors
ES2166045T3 (es) Procedimiento para la preparacion de compuestos de 4,6-bis(ariloxi)pirimidina asimetricos.
TR200001622T2 (tr) Asilatlı Hetero-Alisiklik Türevleri

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application