MA26674A1 - Derives d'hydroxamides heterocycliques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives d'hydroxamides heterocycliques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number: MA26674A1
Authority: MA; Morocco
Prior art keywords: sup; preparation; pharmaceutical compositions; compositions containing; new heterocyclic
Prior art date: 1998-08-12

Application number

MA25729A

Other languages

English (en)

Inventor

Stanley Chupak Louis

Francis Mcclure Kim

Anthony Letavic Michael

Carl Noe Mark

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-12

Filing date

1999-08-11

Publication date

2004-12-20

1999-08-11 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2004-12-20 Publication of MA26674A1 publication Critical patent/MA26674A1/fr

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 2
201000011510 cancer Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 1
102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
229940009456 adriamycin Drugs 0.000 abstract 1
229930013930 alkaloid Natural products 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
206010003246 arthritis Diseases 0.000 abstract 1
238000002648 combination therapy Methods 0.000 abstract 1
229940111134 coxibs Drugs 0.000 abstract 1
239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
231100000433 cytotoxic Toxicity 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
229960005420 etoposide Drugs 0.000 abstract 1
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
229910052697 platinum Inorganic materials 0.000 abstract 1
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
229940063683 taxotere Drugs 0.000 abstract 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 1
229960004528 vincristine Drugs 0.000 abstract 1
-1 vincristine Natural products 0.000 abstract 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)

MA25729A 1998-08-12 1999-08-11 Derives d'hydroxamides heterocycliques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant MA26674A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9625698P	1998-08-12	1998-08-12

Publications (1)

Publication Number	Publication Date
MA26674A1 true MA26674A1 (fr)	2004-12-20

Family

ID=22256553

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA25729A MA26674A1 (fr)	1998-08-12	1999-08-11	Derives d'hydroxamides heterocycliques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (15)

Country	Link
US (2)	US20030181441A1 (fr)
EP (1)	EP1104412B1 (fr)
JP (1)	JP3623448B2 (fr)
AT (1)	ATE297908T1 (fr)
AU (1)	AU4925099A (fr)
BR (1)	BR9912944A (fr)
CA (1)	CA2340182A1 (fr)
DE (1)	DE69925840T2 (fr)
ES (1)	ES2242402T3 (fr)
GT (1)	GT199900132A (fr)
MA (1)	MA26674A1 (fr)
PA (1)	PA8479901A1 (fr)
TN (1)	TNSN99157A1 (fr)
UY (1)	UY25992A1 (fr)
WO (1)	WO2000009492A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6406901B1 (en)	1995-06-08	2002-06-18	Immunex Corporation	TNF-a converting enzyme
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP1081137A1 (fr)	1999-08-12	2001-03-07	Pfizer Products Inc.	Inhibiteurs sélectifs de l'aggrécanase pour le traitement de l'ostéoarthrite
GB9922825D0 (en) *	1999-09-25	1999-11-24	Smithkline Beecham Biolog	Medical use
GB0004531D0 (en) *	2000-02-25	2000-04-19	Richards Andrew J M	The treatment of respiratory diseases
US6458822B2 (en)	2000-03-13	2002-10-01	Pfizer Inc.	2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
EP1138680A1 (fr) *	2000-03-29	2001-10-04	Pfizer Products Inc.	Acides gem-substitués alpha-sulfonylamino hydroxamiques comme inhibiteurs de métalloprotease
MXPA01013326A (es)	2001-02-14	2002-08-26	Warner Lambert Co	Bifenil sulfonamidas utiles como inhibisdores de metaloproteinasa de matriz.
US7655658B2 (en)	2001-08-10	2010-02-02	Palatin Technologies, Inc.	Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7456184B2 (en) *	2003-05-01	2008-11-25	Palatin Technologies Inc.	Melanocortin receptor-specific compounds
US7354923B2 (en) *	2001-08-10	2008-04-08	Palatin Technologies, Inc.	Piperazine melanocortin-specific compounds
CA2462200A1 (fr)	2001-08-10	2003-02-20	Palatin Technologies, Inc.	Peptidomimetiques de metallopeptides biologiquement actifs
US7732451B2 (en)	2001-08-10	2010-06-08	Palatin Technologies, Inc.	Naphthalene-containing melanocortin receptor-specific small molecule
US7718802B2 (en)	2001-08-10	2010-05-18	Palatin Technologies, Inc.	Substituted melanocortin receptor-specific piperazine compounds
AUPR726201A0 (en) *	2001-08-24	2001-09-20	Fujisawa Pharmaceutical Co., Ltd.	New use of a cyclic compound
CA2485346C (fr)	2002-06-12	2013-05-28	Exelixis, Inc.	Inhibiteurs humains d'adam 10
WO2005021489A2 (fr)	2002-12-23	2005-03-10	Wyeth Holdings Corporation	Tace d'acide hydroxamique sulfonate aryle acetylene et inhibiteurs de metalloproteinase matricielle
MXPA05010793A (es) *	2003-04-09	2005-12-05	Millennium Pharm Inc	Beta-carbolinas utiles para tratar enfermedades inflamatorias.
US7727991B2 (en)	2003-05-01	2010-06-01	Palatin Technologies, Inc.	Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en)	2003-05-01	2010-06-01	Palatin Technologies, Inc.	Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7968548B2 (en)	2003-05-01	2011-06-28	Palatin Technologies, Inc.	Melanocortin receptor-specific piperazine compounds with diamine groups
JP2007532582A (ja)	2004-04-09	2007-11-15	ミレニアム・ファーマシューティカルズ・インコーポレイテッド	炎症性疾患の処置に有用なβ−カルボリン
US7709484B1 (en)	2004-04-19	2010-05-04	Palatin Technologies, Inc.	Substituted melanocortin receptor-specific piperazine compounds
WO2007016597A2 (fr) *	2005-07-29	2007-02-08	The Regents Of The University Of California	Ciblage de secretion de facteur de croissance dependant d'enzyme de conversion de tnf-alpha (tace) dans une therapie anticancereuse
EP2041181B1 (fr) *	2006-06-08	2011-05-18	Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)	Inhibiteurs spécifiques de protéase et leur utilisation pour le traitement du cancer
US7834017B2 (en)	2006-08-11	2010-11-16	Palatin Technologies, Inc.	Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
IT1404729B1 (it) *	2011-01-27	2013-11-29	Univ Pisa	Inibitori altamente selettivi dell'attivita' di adams
EP2763972A1 (fr) *	2011-10-04	2014-08-13	Institut National de la Santé et de la Recherche Médicale (INSERM)	Nouveaux composés induisant l'apoptose
CN111500721B (zh) *	2020-04-20	2022-11-29	青岛大学附属医院	Tace在腹主动脉瘤腔内修复术后内漏诊断中的应用

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69633947T2 (de) *	1995-12-08	2005-12-01	Agouron Pharmaceuticals, Inc., San Diego	Zwischenprodukte zur Herstellung von Metallproteinasehemmern
US5753653A (en) *	1995-12-08	1998-05-19	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
WO1998008827A1 (fr) *	1996-08-28	1998-03-05	The Procter & Gamble Company	Inhibiteurs heterocycliques de metalloproteases
EP0948489A1 (fr) *	1996-12-17	1999-10-13	Fujisawa Pharmaceutical Co., Ltd.	Composes de piperazine inhibiteurs de metalloprotease matricielle (mmp) ou de tnf
WO1998034918A1 (fr) *	1997-02-11	1998-08-13	Pfizer Inc.	Derives de l'acide arylsulfonylhydroxamique
EP1081137A1 (fr) *	1999-08-12	2001-03-07	Pfizer Products Inc.	Inhibiteurs sélectifs de l'aggrécanase pour le traitement de l'ostéoarthrite

1999
- 1999-08-05 AU AU49250/99A patent/AU4925099A/en not_active Abandoned
- 1999-08-05 WO PCT/IB1999/001392 patent/WO2000009492A1/fr not_active Ceased
- 1999-08-05 BR BR9912944-2A patent/BR9912944A/pt not_active IP Right Cessation
- 1999-08-05 CA CA002340182A patent/CA2340182A1/fr not_active Abandoned
- 1999-08-05 EP EP99933079A patent/EP1104412B1/fr not_active Expired - Lifetime
- 1999-08-05 JP JP2000564944A patent/JP3623448B2/ja not_active Expired - Fee Related
- 1999-08-05 DE DE69925840T patent/DE69925840T2/de not_active Expired - Fee Related
- 1999-08-05 ES ES99933079T patent/ES2242402T3/es not_active Expired - Lifetime
- 1999-08-05 AT AT99933079T patent/ATE297908T1/de not_active IP Right Cessation
- 1999-08-06 PA PA19998479901A patent/PA8479901A1/es unknown
- 1999-08-11 TN TNTNSN99157A patent/TNSN99157A1/fr unknown
- 1999-08-11 MA MA25729A patent/MA26674A1/fr unknown
- 1999-08-12 GT GT199900132A patent/GT199900132A/es unknown
- 1999-08-12 US US09/373,182 patent/US20030181441A1/en not_active Abandoned
2000
- 2000-01-28 UY UY25992A patent/UY25992A1/es not_active Application Discontinuation
2005
- 2005-05-03 US US11/120,846 patent/US20050215549A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2003526604A (ja)	2003-09-09
GT199900132A (es)	2001-02-02
WO2000009492A1 (fr)	2000-02-24
EP1104412B1 (fr)	2005-06-15
AU4925099A (en)	2000-03-06
EP1104412A1 (fr)	2001-06-06
UY25992A1 (es)	2000-03-31
CA2340182A1 (fr)	2000-02-24
ES2242402T3 (es)	2005-11-01
JP3623448B2 (ja)	2005-02-23
DE69925840D1 (de)	2005-07-21
BR9912944A (pt)	2001-05-08
DE69925840T2 (de)	2006-05-04
ATE297908T1 (de)	2005-07-15
US20050215549A1 (en)	2005-09-29
US20030181441A1 (en)	2003-09-25
PA8479901A1 (es)	2000-05-24
TNSN99157A1 (fr)	2005-11-10

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