MA26744A1 - Polymorphes d'un chlorhydrate d'azo-bicyclo-2,2,2-oct-3-ylamine cristallins et compositions pharmaceutiques les contenant - Google Patents

Polymorphes d'un chlorhydrate d'azo-bicyclo-2,2,2-oct-3-ylamine cristallins et compositions pharmaceutiques les contenant

Info

Publication number
MA26744A1
MA26744A1 MA26007A MA26007A MA26744A1 MA 26744 A1 MA26744 A1 MA 26744A1 MA 26007 A MA26007 A MA 26007A MA 26007 A MA26007 A MA 26007A MA 26744 A1 MA26744 A1 MA 26744A1
Authority
MA
Morocco
Prior art keywords
polymorphs
bicyclo
oct
chlorhydrate
ylamine
Prior art date
Application number
MA26007A
Other languages
English (en)
Inventor
John Meldrum Allen Douglas
Anthony Appleton Troy
Jon Gumkowski Michael
Joseph Muehlbauer David
Norris Timothy
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA26744A1 publication Critical patent/MA26744A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DEUX FORMES POLYMORPHES CRISTALLINES DU DICHLORHYDRATE DIHYDRATÉ DE LA (2 - BENZHYDRYL - 1- AZO - BICYCLO [ 2 , 2 , 2 ] OCT - 3 - YL ) - ( 5 -ISOPROPYL - 2 - MÉTHOXYBENZYL ) - AMINE SONT LA FORME I ET LA FORME II. LA COMPOSITION PHARMACEUTIQUE COMPRENANT AU MOINS L'UN DE CES POLYMORPHES PRÉSENTE UNE STABILKITÉ AVANTAGEUSE POUR LA FORMULAYION EN VUE DU TRAITEMENT DE L'ÉMèSE CHEZ DES PATIENTS SOUMIS à UNE CHIMIOTHARAPIE. L'ADMINISTRATION DE CETTE COMPOSITION PHARMACEUTIQUE S'EFFECTUE DE FAÇON CLASSIQUE PAR VOIE ORALE, AVANTAGESEMENT SOUS FORMES DE COMPRIMÉS OU GÉLULES, OU PAR VOIE INTRAVEINEUSES. UN PROCÉDÉ DE PRODUCTION DES FORMES I ET II EST ÉGALEMENT PROPOSÉ.
MA26007A 1999-06-22 2000-06-21 Polymorphes d'un chlorhydrate d'azo-bicyclo-2,2,2-oct-3-ylamine cristallins et compositions pharmaceutiques les contenant MA26744A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14023399P 1999-06-22 1999-06-22

Publications (1)

Publication Number Publication Date
MA26744A1 true MA26744A1 (fr) 2004-12-20

Family

ID=22490317

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26007A MA26744A1 (fr) 1999-06-22 2000-06-21 Polymorphes d'un chlorhydrate d'azo-bicyclo-2,2,2-oct-3-ylamine cristallins et compositions pharmaceutiques les contenant

Country Status (35)

Country Link
US (1) US6262067B1 (fr)
EP (1) EP1187834A1 (fr)
JP (1) JP2003502425A (fr)
KR (1) KR20020030280A (fr)
CN (1) CN1390216A (fr)
AP (1) AP2001002367A0 (fr)
AR (1) AR024411A1 (fr)
AU (1) AU767336B2 (fr)
BG (1) BG106205A (fr)
BR (1) BR0011835A (fr)
CA (1) CA2375265A1 (fr)
CO (1) CO5190663A1 (fr)
CZ (1) CZ20014458A3 (fr)
DZ (1) DZ3055A1 (fr)
EA (1) EA004264B1 (fr)
EC (1) ECSP003538A (fr)
EE (1) EE200100698A (fr)
HR (1) HRP20010920A2 (fr)
HU (1) HUP0201694A3 (fr)
IL (1) IL146410A0 (fr)
IS (1) IS6161A (fr)
MA (1) MA26744A1 (fr)
MX (1) MXPA02000033A (fr)
NO (1) NO20016187D0 (fr)
NZ (1) NZ515348A (fr)
OA (1) OA11952A (fr)
PA (1) PA8496701A1 (fr)
PE (1) PE20010322A1 (fr)
PL (1) PL352899A1 (fr)
SK (1) SK18672001A3 (fr)
TN (1) TNSN00137A1 (fr)
TR (1) TR200103688T2 (fr)
UY (1) UY26211A1 (fr)
WO (1) WO2000078759A1 (fr)
ZA (1) ZA200110387B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387925B1 (en) * 1999-06-01 2002-05-14 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions
US6939873B2 (en) * 2000-07-26 2005-09-06 Taro Pharmaceuticals Industries Limited Non-sedating barbituric acid derivatives
US7683071B2 (en) * 2000-07-26 2010-03-23 Taro Pharmaceuticals Industries Ltd. Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
US6756379B2 (en) * 2001-07-26 2004-06-29 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents
JP2006503859A (ja) * 2002-10-04 2006-02-02 メルク シャープ エンド ドーム リミテッド 受容体拮抗薬としてのアザ二環式スピロエーテル誘導体
ES2315569T3 (es) * 2002-12-11 2009-04-01 Taro Pharmaceutical Industries Ltd. Procedimiento de tratamiento de trastornos del movimiento usando derivados de acido barbiturico.
CA2572797A1 (fr) * 2004-07-02 2006-01-12 Daniella Gutman Procede de preparation d'acide 1-methoxymethyl-5,5-diphenylbarbiturique
EP2081576A4 (fr) * 2006-11-14 2010-06-30 Taro Pharmaceuticals North Ame Procédé d'amélioration de la biodisponibilité pour les barbituriques non sédatifs
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
BR112021024330A2 (pt) * 2019-06-03 2022-01-11 Biotheryx Inc Sais cristalinos não higroscópicos de um composto de pirazol, e composições farmacêuticas e uso dos mesmos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
UA27776C2 (uk) * 1991-05-31 2000-10-16 Пфайзер Інк. Похідні хінуклідину та їх фармацевтично прийнятні солі, що є антагоністами речовини р у ссавців, фармацевтична композиція, що має антагоністичну дію на речовину р у ссавців
DK0668863T3 (da) * 1992-11-12 1997-06-30 Pfizer Quinuclidinderivat som substans P-antagonist
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis

Also Published As

Publication number Publication date
IS6161A (is) 2001-11-13
EP1187834A1 (fr) 2002-03-20
ZA200110387B (en) 2002-12-19
EA004264B1 (ru) 2004-02-26
DZ3055A1 (fr) 2004-03-27
BG106205A (bg) 2002-07-31
EE200100698A (et) 2003-02-17
PL352899A1 (en) 2003-09-22
CA2375265A1 (fr) 2000-12-28
AP2001002367A0 (en) 2001-12-31
ECSP003538A (es) 2002-01-25
UY26211A1 (es) 2001-01-31
HUP0201694A3 (en) 2002-10-28
NO20016187L (no) 2001-12-18
TR200103688T2 (tr) 2002-12-23
PE20010322A1 (es) 2001-03-14
HRP20010920A2 (en) 2003-02-28
NO20016187D0 (no) 2001-12-18
CO5190663A1 (es) 2002-08-29
US6262067B1 (en) 2001-07-17
AR024411A1 (es) 2002-10-02
AU4774500A (en) 2001-01-09
AU767336B2 (en) 2003-11-06
MXPA02000033A (es) 2002-07-02
KR20020030280A (ko) 2002-04-24
OA11952A (en) 2006-04-13
CN1390216A (zh) 2003-01-08
WO2000078759A1 (fr) 2000-12-28
BR0011835A (pt) 2002-03-05
PA8496701A1 (es) 2002-07-30
IL146410A0 (en) 2002-07-25
SK18672001A3 (sk) 2002-08-06
JP2003502425A (ja) 2003-01-21
TNSN00137A1 (fr) 2002-05-30
EA200101179A1 (ru) 2002-06-27
HUP0201694A2 (en) 2002-09-28
CZ20014458A3 (cs) 2002-03-13
NZ515348A (en) 2003-07-25

Similar Documents

Publication Publication Date Title
KR910011894A (ko) 아미노산 유도체
HUT47217A (en) Process for producing pharmaceutical compositions containing indol derivatives as active components
TNSN00104A1 (fr) Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
UA41446C2 (uk) Застосування фумагілолу та його похідних для одержання ліків, призначених для боротьби з кишковими інфекціями, та фармацевтична композиція на їх основі
NO20022264D0 (no) Farmasöytisk blanding inneholdende tolterodin, samt anvendelse derav
ATE202076T1 (de) Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie
HUP9902121A2 (hu) Gonadotropin-leadó hormon antagonista hatású indolszármazékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
HUP9802339A2 (hu) Darifenacint tartalmazó gyógyászati készítmények
KR890009383A (ko) 지방산 합성물
KR960701049A (ko) 헤테로사이클릭 화합물, 이의 제조방법 및 이의 용도(Heterocyclic compounds and their preparation and use)
MA26744A1 (fr) Polymorphes d'un chlorhydrate d'azo-bicyclo-2,2,2-oct-3-ylamine cristallins et compositions pharmaceutiques les contenant
BE900564A (fr) Composition pharmaceutique pour le traitement d'arteriopathies peripheriques.
RU94046141A (ru) Замещенные производные /арилалкоксибензил/ аминопропанамида, способы их получения, фармацевтическая композиция
BR9503572A (pt) Composto composiçao farmaceutica e método de tratamento ou prevençao de uma doença
EP1027053A4 (fr) Procede pour prevenir la nephrotoxicite resultant de l'administration de cyclosporine et de tacrolimus
DZ1324A1 (fr) Dérivés de céphalosporine, procédé pour leur préparation compositions pharmaceutiques les contenant et leur utilisation dans le traitement d'infections bactériennes.
RU2222538C2 (ru) Оптически активное производное пиридил-4н-1,2,4-оксадиазина и фармацевтическая композиция
KR930007252B1 (ko) 우울증 치료용 약학조성물
RU95110110A (ru) Производные бензофурана, способ их получения, фармкомпозиция и способ лечения
KR890004705A (ko) 항바이러스성 제제
US6399650B2 (en) Method for improving disturbancies of activities of daily living after stroke
YU81101A (sh) Polimorfni oblici kristalnog citrata azabiciklo (2,2,2) oktan-3-amina i njihovih farmaceutskih kompozicija
GEP20043377B (en) Pharmaceutical Complex
KR930017579A (ko) 신경 보호제
CA2173839A1 (fr) Compositions a base de transferrine destinees a attenuer les effets secondaires de medicaments cytotoxiques