MA26769A1 - Derives de thioamide. - Google Patents

Derives de thioamide.

Info

Publication number: MA26769A1
Authority: MA; Morocco
Prior art keywords: thioamide derivatives; vcam; vla; asthma; discovered
Prior art date: 1999-02-18

Application number

MA26290A

Other languages

English (en)

Inventor

Kenneth Gregory Hull

Jefferson Wright Tilley

Achytharao Sidduri

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-18

Filing date

2001-08-08

Publication date

2004-12-20

2001-08-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA26769A1 publication Critical patent/MA26769A1/fr

Links

150000003556 thioamides Chemical class 0.000 title 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 2
206010061218 Inflammation Diseases 0.000 abstract 1
208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000037976 chronic inflammation Diseases 0.000 abstract 1
208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/46—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Liquid Crystal Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Gyroscopes (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

MA26290A 1999-02-18 2001-08-08 Derives de thioamide. MA26769A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12047599P	1999-02-18	1999-02-18

Publications (1)

Publication Number	Publication Date
MA26769A1 true MA26769A1 (fr)	2004-12-20

Family

ID=22390545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA26290A MA26769A1 (fr)	1999-02-18	2001-08-08	Derives de thioamide.

Country Status (28)

Country	Link
US (6)	US6288267B1 (fr)
EP (1)	EP1154993B1 (fr)
JP (1)	JP2002537286A (fr)
KR (1)	KR100649819B1 (fr)
CN (1)	CN1213025C (fr)
AT (1)	ATE278664T1 (fr)
AU (1)	AU773388B2 (fr)
BR (1)	BR0008280A (fr)
CA (1)	CA2362831C (fr)
CZ (1)	CZ20012980A3 (fr)
DE (1)	DE60014588T2 (fr)
DK (1)	DK1154993T3 (fr)
ES (1)	ES2228458T3 (fr)
HR (1)	HRP20010595B1 (fr)
HU (1)	HUP0200155A3 (fr)
ID (1)	ID30129A (fr)
IL (2)	IL144636A0 (fr)
MA (1)	MA26769A1 (fr)
NO (1)	NO20014018L (fr)
NZ (1)	NZ513254A (fr)
PL (1)	PL349461A1 (fr)
PT (1)	PT1154993E (fr)
RU (1)	RU2245874C2 (fr)
SI (1)	SI1154993T1 (fr)
TR (1)	TR200102399T2 (fr)
WO (1)	WO2000048994A1 (fr)
YU (1)	YU58701A (fr)
ZA (1)	ZA200106180B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6939855B2 (en) *	1997-07-31	2005-09-06	Elan Pharmaceuticals, Inc.	Anti-inflammatory compositions and method
US6680195B1 (en) *	1997-11-26	2004-01-20	Inhibitex, Inc.	Extracellular matrix-binding proteins from staphylococcus aureus
US6521626B1 (en) *	1998-03-24	2003-02-18	Celltech R&D Limited	Thiocarboxamide derivatives
US6380387B1 (en)	1999-12-06	2002-04-30	Hoffmann-La Roche Inc.	4-Pyrimidinyl-n-acyl-l phenylalanines
US6388084B1 (en)	1999-12-06	2002-05-14	Hoffmann-La Roche Inc.	4-pyridinyl-n-acyl-l-phenylalanines
KR100854012B1 (ko) *	2000-01-26	2008-08-26	미쓰이 가가쿠 가부시키가이샤	올레핀 중합체
AU2001242743A1 (en)	2000-03-23	2001-10-03	Ajinomoto Co. Inc.	Novel phenylalanine derivative
US6960597B2 (en) *	2000-06-30	2005-11-01	Orth-Mcneil Pharmaceutical, Inc.	Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
ES2252310T3 (es) *	2000-09-14	2006-05-16	Grunenthal Gmbh	Beta-tioaminoacidos.
US20090297611A1 (en) *	2003-07-31	2009-12-03	Robinson Cynthia B	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050069227A1 (en) *	2003-09-29	2005-03-31	Mark Steele	Flexible package having integrated slit member
US20050176755A1 (en) *	2003-10-31	2005-08-11	Dyatkin Alexey B.	Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
DE602005002251D1 (de) *	2004-02-10	2007-10-11	Janssen Pharmaceutica Nv	Pyridazinonharnstoffe als antagonisten von a4-integrinen
WO2005077915A1 (fr) *	2004-02-10	2005-08-25	Janssen Pharmaceutica, N.V.	Pyridazinones en tant qu'antagonistes d'intégrines $g(a)4
WO2005087760A1 (fr) *	2004-03-10	2005-09-22	Merck & Co., Inc.	Antagonistes de vla-4
CN101006097B (zh) *	2004-08-16	2012-07-11	默沙东公司	Vla-4拮抗剂
US7641325B2 (en) *	2004-10-04	2010-01-05	Kodak Graphic Communications Group Canada	Non-conductive fluid droplet characterizing apparatus and method
WO2006081986A1 (fr) *	2005-02-07	2006-08-10	F.Hoffmann-La Roche Ag	Combinaison de bambuterol et d'inhibiteur d'integrine
WO2006094640A2 (fr) *	2005-03-04	2006-09-14	F.Hoffmann-La Roche Ag	Association de roflumilast et d'un inhibiteur de l'integrine, et procede de traitement
CZ297581B6 (cs) *	2005-05-26	2007-01-10	Universita Karlova v Praze, Farmaceutická fakulta v Hradci Králové	Antimykotické a antimykobakteriální thiosalicylanilidy a způsob jejich přípravy
EA019879B1 (ru)	2005-12-29	2014-07-30	Лексикон Фармасьютикалз, Инк.	Полициклические производные аминокислот, содержащая их фармацевтическая композиция и способ лечения, использующий эти производные
EP2510941A3 (fr)	2007-02-20	2013-01-23	Merrimack Pharmaceuticals, Inc.	Procédés de traitement de la sclérose en plaques par administration d'une alpha-foetoprotéine combinée à un antagoniste de l'intégrine
KR101811965B1 (ko) *	2007-11-07	2017-12-22	셀덱스 쎄라퓨틱스, 인크.	인간 수지상 및 상피 세포 205(ｄｅｃ-205)에 결합하는 항체
BRPI0911652A2 (pt)	2008-04-11	2015-08-04	Merrimack Pharmaceuticals Inc	Ligantes de albumina sérica humana e seus conjugados
CN102282168A (zh)	2008-11-18	2011-12-14	梅里麦克制药股份有限公司	人血清白蛋白接头以及其结合物
US8343706B2 (en) *	2010-01-25	2013-01-01	International Business Machines Corporation	Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
MX2014004025A (es)	2011-10-17	2014-08-01	Univ Muenster Wilhelms	Metodos de valoracion de riesgo de lmp y aparatos relacionados.
WO2014036520A1 (fr)	2012-08-30	2014-03-06	Merrimack Pharmaceuticals, Inc.	Polythérapies comprenant des agents anti-erbb3
AU2019373242B2 (en)	2018-10-30	2023-07-13	Gilead Sciences, Inc.	Compounds for inhibition of alpha 4 beta 7 integrin
KR102630416B1 (ko)	2018-10-30	2024-02-01	길리애드 사이언시즈, 인코포레이티드	알파4베타7 인테그린 억제제로서의 퀴놀린 유도체
ES3013256T3 (en)	2018-10-30	2025-04-11	Gilead Sciences Inc	Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
US11179383B2 (en)	2018-10-30	2021-11-23	Gilead Sciences, Inc.	Compounds for inhibition of α4β7 integrin
CN114222730B (zh)	2019-08-14	2024-09-10	吉利德科学公司	用于抑制α4β7整合素的化合物
CN113683499B (zh) *	2021-09-10	2024-01-30	上海皓鸿生物医药科技有限公司	一种制备杜韦利西布中间体的方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE584914A (fr)	1958-11-24
US3527793A (en)	1967-08-18	1970-09-08	Bristol Myers Co	Phenylglycine derivatives
US4604406A (en) *	1984-11-16	1986-08-05	Ayerst, Mckenna & Harrison, Inc.	N-[6-methoxy-5-(perfluoroalkyl)-1-naphtholyl]-N-methylglycines and their thionaphthoyl analogs
IT1190378B (it)	1985-06-21	1988-02-16	Isf Spa	Derivati pirrolidonici
US5039805A (en)	1988-12-08	1991-08-13	Hoffmann-La Roche Inc.	Novel benzoic and phenylacetic acid derivatives
US5463116A (en)	1991-07-30	1995-10-31	Ajinomoto Co., Inc.	Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
AU2682695A (en)	1994-06-20	1996-01-15	Takeda Chemical Industries Ltd.	Condensed imidazole compounds, their production and use
US6306840B1 (en)	1995-01-23	2001-10-23	Biogen, Inc.	Cell adhesion inhibitors
US5804595A (en)	1995-12-05	1998-09-08	Regents Of The University Of Minnesota	Kappa opioid receptor agonists
DE19548709A1 (de)	1995-12-23	1997-07-03	Merck Patent Gmbh	Tyrosinderivate
PT891325E (pt) *	1996-03-29	2002-07-31	Searle & Co	Derivados do acido fenilpropanoico para-substituido como antagonistas de integrina
WO1997036862A1 (fr)	1996-03-29	1997-10-09	G.D. Searle & Co.	DERIVES DE PHENYLENE META-SUBSTITUES, UTILISES COMME ANTAGONISTES OU INHIBITEURS DE L'INTEGRINE ALPHAvBETA¿3?
DE19654483A1 (de)	1996-06-28	1998-01-02	Merck Patent Gmbh	Phenylalanin-Derivate
EP1001764A4 (fr) *	1997-05-29	2005-08-24	Merck & Co Inc	Composes d'amide heterocycliques utilises en tant qu'inhibiteurs de l'adhesion cellulaire
DK0991619T3 (da) *	1997-06-23	2003-12-29	Tanabe Seiyaku Co	Inhibitorer af alfa 4-beta 1-medieret celleadhæsion
HUP0003921A3 (en) *	1997-07-31	2001-03-28	Wyeth Corp	Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use
EP1001974B1 (fr) *	1997-07-31	2006-05-24	Elan Pharmaceuticals, Inc.	Composes de type 4-amino-phenylalanine inhibant une adhesion de leucocytes regulee par vla-4
KR20010022412A (ko) *	1997-07-31	2001-03-15	진 엠. 듀발	Ｖｌａ-4에 의해 매개되는 백혈구 유착을 억제하는디펩티드 화합물
DE69821950T2 (de)	1997-08-22	2004-12-16	F. Hoffmann-La Roche Ag	N-aroylphenylalaninderivate
US6229011B1 (en) *	1997-08-22	2001-05-08	Hoffman-La Roche Inc.	N-aroylphenylalanine derivative VCAM-1 inhibitors
ATE267801T1 (de) *	1997-08-22	2004-06-15	Hoffmann La Roche	N-alkanoylphenylalaninderivate
BR9814376A (pt) *	1997-12-23	2000-10-10	Aventis Pharma Ltd	Composto ou um pró-medicamento correspondente, ou um sal farmaceuticamente aceitável ou solvato de um tal composto ou um pró-medicamento deste, uso destes, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano sofrendo de, ou sujeito a, condições que podem ser melhoradas pela admnistração de um inibidor da adesão celular mediada por &4ß1, e, resina
ATE273273T1 (de)	1998-02-26	2004-08-15	Celltech Therapeutics Ltd	Phenylalaninderivate als inhibitoren von alpha4 integrinen
US6521626B1 (en)	1998-03-24	2003-02-18	Celltech R&D Limited	Thiocarboxamide derivatives
GB9811159D0 (en)	1998-05-22	1998-07-22	Celltech Therapeutics Ltd	Chemical compounds

2000
- 2000-02-10 KR KR1020017010495A patent/KR100649819B1/ko not_active Expired - Fee Related
- 2000-02-10 DK DK00903680T patent/DK1154993T3/da active
- 2000-02-10 TR TR2001/02399T patent/TR200102399T2/xx unknown
- 2000-02-10 HU HU0200155A patent/HUP0200155A3/hu unknown
- 2000-02-10 AT AT00903680T patent/ATE278664T1/de not_active IP Right Cessation
- 2000-02-10 CA CA002362831A patent/CA2362831C/fr not_active Expired - Fee Related
- 2000-02-10 ID IDW00200101770A patent/ID30129A/id unknown
- 2000-02-10 NZ NZ513254A patent/NZ513254A/en unknown
- 2000-02-10 YU YU58701A patent/YU58701A/sh unknown
- 2000-02-10 CN CNB008043973A patent/CN1213025C/zh not_active Expired - Fee Related
- 2000-02-10 AU AU25475/00A patent/AU773388B2/en not_active Ceased
- 2000-02-10 BR BR0008280-5A patent/BR0008280A/pt not_active Application Discontinuation
- 2000-02-10 ES ES00903680T patent/ES2228458T3/es not_active Expired - Lifetime
- 2000-02-10 HR HR20010595A patent/HRP20010595B1/xx not_active IP Right Cessation
- 2000-02-10 RU RU2001124596/04A patent/RU2245874C2/ru not_active IP Right Cessation
- 2000-02-10 CZ CZ20012980A patent/CZ20012980A3/cs unknown
- 2000-02-10 PL PL00349461A patent/PL349461A1/xx not_active Application Discontinuation
- 2000-02-10 DE DE60014588T patent/DE60014588T2/de not_active Expired - Lifetime
- 2000-02-10 SI SI200030513T patent/SI1154993T1/xx unknown
- 2000-02-10 PT PT00903680T patent/PT1154993E/pt unknown
- 2000-02-10 EP EP00903680A patent/EP1154993B1/fr not_active Expired - Lifetime
- 2000-02-10 IL IL14463600A patent/IL144636A0/xx active IP Right Grant
- 2000-02-10 JP JP2000599735A patent/JP2002537286A/ja active Pending
- 2000-02-10 WO PCT/EP2000/001058 patent/WO2000048994A1/fr not_active Ceased
- 2000-02-17 US US09/505,903 patent/US6288267B1/en not_active Expired - Fee Related
2001
- 2001-03-20 US US09/812,325 patent/US20020028933A1/en not_active Abandoned
- 2001-05-23 US US09/864,032 patent/US6426348B1/en not_active Expired - Fee Related
- 2001-05-23 US US09/864,104 patent/US6423728B1/en not_active Expired - Fee Related
- 2001-05-23 US US09/863,567 patent/US6479666B2/en not_active Expired - Fee Related
- 2001-05-23 US US09/863,579 patent/US6458844B2/en not_active Expired - Fee Related
- 2001-07-26 ZA ZA200106180A patent/ZA200106180B/en unknown
- 2001-07-30 IL IL144636A patent/IL144636A/en not_active IP Right Cessation
- 2001-08-08 MA MA26290A patent/MA26769A1/fr unknown
- 2001-08-17 NO NO20014018A patent/NO20014018L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATE278664T1 (de)	2004-10-15
NZ513254A (en)	2003-10-31
US20020052508A1 (en)	2002-05-02
DE60014588D1 (en)	2004-11-11
JP2002537286A (ja)	2002-11-05
ZA200106180B (en)	2002-10-28
CN1213025C (zh)	2005-08-03
CZ20012980A3 (cs)	2002-04-17
US6423728B1 (en)	2002-07-23
US6479666B2 (en)	2002-11-12
DK1154993T3 (da)	2005-02-14
NO20014018D0 (no)	2001-08-17
PL349461A1 (en)	2002-07-29
CA2362831A1 (fr)	2000-08-24
CA2362831C (fr)	2008-10-07
KR100649819B1 (ko)	2007-02-28
RU2245874C2 (ru)	2005-02-10
PT1154993E (pt)	2005-01-31
BR0008280A (pt)	2001-11-06
SI1154993T1 (en)	2004-12-31
ID30129A (id)	2001-11-08
HUP0200155A3 (en)	2005-04-28
AU773388B2 (en)	2004-05-27
TR200102399T2 (tr)	2002-01-21
ES2228458T3 (es)	2005-04-16
US20020028933A1 (en)	2002-03-07
NO20014018L (no)	2001-08-17
EP1154993A1 (fr)	2001-11-21
YU58701A (sh)	2004-05-12
DE60014588T2 (de)	2006-02-23
AU2547500A (en)	2000-09-04
HK1044330A1 (en)	2002-10-18
US6288267B1 (en)	2001-09-11
EP1154993B1 (fr)	2004-10-06
KR20010102243A (ko)	2001-11-15
US20010041799A1 (en)	2001-11-15
US6458844B2 (en)	2002-10-01
HUP0200155A2 (en)	2002-06-29
HRP20010595B1 (en)	2006-02-28
US20020040148A1 (en)	2002-04-04
WO2000048994A1 (fr)	2000-08-24
IL144636A (en)	2007-06-17
HRP20010595A2 (en)	2002-08-31
IL144636A0 (en)	2002-05-23
CN1342140A (zh)	2002-03-27
US20020010338A1 (en)	2002-01-24
US6426348B1 (en)	2002-07-30

Publication	Publication Date	Title
PT1154993E (pt)	2005-01-31	Derivados de tioamida
BG108806A (en)	2005-04-30	IIb/IIIa CELL ADHESION INHIIBITORS, METHOD FOR THE PRODUCTION, PHARMACEUTCIAL COMPOSITION AND ADMINISTRATION THEREOF
UA84175C2 (ru)	2008-09-25	Гетероциклические ингибиторы мэк и их применение
TW200716648A (en)	2007-05-01	Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
DE60118003D1 (de)	2006-05-11	Harnstoffderivate und ihre verwendung
FI950156A0 (fi)	1995-01-13	Dihydropyratsolopyrroleja
EA200501009A1 (ru)	2005-12-29	Замещённые пирролопиразольные производные в качестве ингибиторов киназы
WO2006124692A3 (fr)	2007-04-12	Inhibiteurs 3-cyanoquinoline de la tpl2 kinase et procedes de production et d'utilisation associes
YU40502A (sh)	2005-03-15	4-piridinil-n-acil-l-fenilalanini
DE60045508D1 (de)	2011-02-24	Dalda-analoge und ihre verwendung
AP1564A (en)	2006-02-02	Piperazinyl sulfonic acid derivatives, their pharmaceutical compositions and methods of use.
AU2003224923A1 (en)	2003-10-27	Heterocyclic amide derivatives as cytokine inhibitors
SE0302756D0 (sv)	2003-10-17	Novel Compounds
DE60016181D1 (de)	2004-12-30	C-16 ungesätigte fp-selektive prostaglandin analoge
CA2362833A1 (fr)	2000-08-24	Derives de phenylalaninol
PL1716147T3 (pl)	2008-03-31	Pochodne diazaspiropiperydyny jako inhibitory transportera 1 glicyny i transportera 2 glicyny
EP1619184A3 (fr)	2006-02-01	Composés d'urées comme inhibiteurs de kinase
WO2004042342A3 (fr)	2005-01-06	Proteine de pore nucleaire nup88 en tant que nouvelle cible