MA26976A1 - Derives du tetrahydropyridine, leur preparation et leur utilisation comme inhibiteur de proliferation de cellules - Google Patents

Derives du tetrahydropyridine, leur preparation et leur utilisation comme inhibiteur de proliferation de cellules

Info

Publication number
MA26976A1
MA26976A1 MA27207A MA27207A MA26976A1 MA 26976 A1 MA26976 A1 MA 26976A1 MA 27207 A MA27207 A MA 27207A MA 27207 A MA27207 A MA 27207A MA 26976 A1 MA26976 A1 MA 26976A1
Authority
MA
Morocco
Prior art keywords
preparation
cell proliferation
proliferation inhibitors
tetrahydropyridine derivatives
tetrahydropyridine
Prior art date
Application number
MA27207A
Other languages
English (en)
Inventor
Guy Georges
Adelbert Grossmann
Olaf Mundigl
Der Saal Wolfgang Von
Tim Sattelkau
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26976A1 publication Critical patent/MA26976A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
MA27207A 2000-12-23 2003-06-20 Derives du tetrahydropyridine, leur preparation et leur utilisation comme inhibiteur de proliferation de cellules MA26976A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00128487 2000-12-23

Publications (1)

Publication Number Publication Date
MA26976A1 true MA26976A1 (fr) 2004-12-20

Family

ID=8170814

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27207A MA26976A1 (fr) 2000-12-23 2003-06-20 Derives du tetrahydropyridine, leur preparation et leur utilisation comme inhibiteur de proliferation de cellules

Country Status (27)

Country Link
US (1) US6800638B2 (fr)
EP (1) EP1353921B1 (fr)
JP (1) JP2004516325A (fr)
KR (1) KR100836545B1 (fr)
CN (1) CN1213046C (fr)
AR (1) AR035513A1 (fr)
AT (1) ATE323700T1 (fr)
AU (1) AU2002226397B2 (fr)
BG (1) BG107935A (fr)
BR (1) BR0116402A (fr)
CA (1) CA2431471A1 (fr)
CZ (1) CZ20031940A3 (fr)
DE (1) DE60118975T2 (fr)
EC (1) ECSP034664A (fr)
ES (1) ES2261519T3 (fr)
HU (1) HUP0400554A2 (fr)
IL (1) IL156131A0 (fr)
MA (1) MA26976A1 (fr)
MX (1) MXPA03005713A (fr)
NO (1) NO20032830L (fr)
NZ (1) NZ526189A (fr)
PL (1) PL365531A1 (fr)
RU (1) RU2276140C2 (fr)
SK (1) SK9122003A3 (fr)
WO (1) WO2002051842A1 (fr)
YU (1) YU48803A (fr)
ZA (1) ZA200304264B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
CA2463552C (fr) 2001-10-16 2011-05-17 Sloan-Kettering Institute For Cancer Research Traitement des maladies neurodegeneratives et du cancer du cerveau
WO2003083323A1 (fr) 2002-04-01 2003-10-09 Ranko Rakanovic Élément élastique en caoutchouc
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2003900608A0 (en) * 2003-02-11 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Hdac inhibitor
JP2006520796A (ja) 2003-03-17 2006-09-14 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼインヒビター
WO2004113336A1 (fr) * 2003-06-16 2004-12-29 Chroma Therapeutics Limited Derives de carboline et de betacarboline inhibiteurs de l'enzyme hdac
EP1694329A4 (fr) * 2003-11-26 2009-06-03 Aton Pharma Inc Derives d'acide hydroxamique a base d'acide diamine et iminodiacetique
US20050159470A1 (en) * 2003-12-19 2005-07-21 Syrrx, Inc. Histone deacetylase inhibitors
WO2005066151A2 (fr) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
WO2006066133A2 (fr) * 2004-12-16 2006-06-22 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
US7772245B2 (en) 2005-02-14 2010-08-10 Miikana Therapeutics, Inc. Inhibitors of histone deacetylase
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
US7642253B2 (en) * 2005-05-11 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
KR20080032188A (ko) * 2005-07-14 2008-04-14 다케다 샌디에고, 인코포레이티드 히스톤 탈아세틸화 효소 억제제
EP2258359A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (fr) 2005-10-31 2011-04-27 Braincells, Inc. Modulation de la neurogenese dont la médiation est assurée par récepteur gaba
EP1976835A2 (fr) * 2006-01-13 2008-10-08 Takeda San Diego, Inc. Inhibiteurs des histone desacetylases
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenese induite par le recepteur 5ht
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (fr) 2006-09-08 2008-03-13 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TWI425945B (zh) * 2007-05-28 2014-02-11 Seldar Pharma Inc 四氫異喹啉－１－酮衍生物或其鹽
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CA2768466C (fr) * 2009-07-22 2018-08-14 The Board Of Trustees Of The University Of Illinois Inhibiteurs de hdac et procedes therapeutiques les utilisant
CN102153549B (zh) * 2010-12-14 2012-11-14 华东理工大学 γ咔啉化合物、制备方法和用途
PL2991982T3 (pl) 2013-04-29 2019-03-29 Chong Kun Dang Pharmaceutical Corp. Nowe związki dla selektywnych inhibitorów deacetylazy histonowej i zawierające je kompozycja farmaceutyczna
WO2015051035A1 (fr) 2013-10-01 2015-04-09 The J. David Gladstone Institutes Compositions, systèmes et procédés pour le criblage de médicament de bruit d'expression génétique et leurs utilisations
CN108084178B (zh) * 2018-01-04 2020-09-01 济南大学 一类含有四氢-β-咔碄结构的异羟肟酸类化合物的用途
CN108558653A (zh) * 2018-05-14 2018-09-21 湖南华腾制药有限公司 赛乐西帕中间体及赛乐西帕的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196758B (en) * 1986-05-21 1989-01-30 Gyogyszerkutato Intezet Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
WO1990002119A1 (fr) * 1988-08-18 1990-03-08 Banyu Pharmaceutical Co., Ltd. Derives de 1,2,3,4-tetrahydro-isoquinoline
US5369108A (en) * 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US6429212B1 (en) * 1996-08-16 2002-08-06 Ishihara Sangyo Kaisha Ltd. Medicinal composition
WO1998015525A1 (fr) 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Acides hydroxamiques
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
US6465468B1 (en) * 1999-03-22 2002-10-15 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives

Also Published As

Publication number Publication date
SK9122003A3 (en) 2004-02-03
CA2431471A1 (fr) 2002-07-04
ECSP034664A (es) 2003-07-25
NO20032830D0 (no) 2003-06-20
US20040053960A1 (en) 2004-03-18
EP1353921A1 (fr) 2003-10-22
CN1213046C (zh) 2005-08-03
KR20030063424A (ko) 2003-07-28
ES2261519T3 (es) 2006-11-16
BR0116402A (pt) 2003-11-11
AU2002226397B2 (en) 2006-10-05
RU2003122190A (ru) 2005-02-27
AR035513A1 (es) 2004-06-02
PL365531A1 (en) 2005-01-10
ATE323700T1 (de) 2006-05-15
CN1483033A (zh) 2004-03-17
YU48803A (sh) 2006-05-25
DE60118975T2 (de) 2006-12-21
RU2276140C2 (ru) 2006-05-10
WO2002051842A1 (fr) 2002-07-04
IL156131A0 (en) 2003-12-23
NO20032830L (no) 2003-08-04
CZ20031940A3 (cs) 2003-10-15
US6800638B2 (en) 2004-10-05
ZA200304264B (en) 2004-08-30
NZ526189A (en) 2004-10-29
MXPA03005713A (es) 2003-10-06
BG107935A (bg) 2004-08-31
EP1353921B1 (fr) 2006-04-19
JP2004516325A (ja) 2004-06-03
DE60118975D1 (de) 2006-05-24
KR100836545B1 (ko) 2008-06-10
HUP0400554A2 (hu) 2004-06-28

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