MA26985A1 - Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4 - Google Patents

Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4

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Publication number
MA26985A1
MA26985A1 MA27243A MA27243A MA26985A1 MA 26985 A1 MA26985 A1 MA 26985A1 MA 27243 A MA27243 A MA 27243A MA 27243 A MA27243 A MA 27243A MA 26985 A1 MA26985 A1 MA 26985A1
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MA
Morocco
Prior art keywords
group
inhibitors
alkyl
represent
groups
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MA27243A
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English (en)
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Anthony Marfat
Michael William Mckechney
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Pfizer Prod Inc
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Publication of MA26985A1 publication Critical patent/MA26985A1/fr

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Abstract

DEPOSANT Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 31 Janvier 2001 60/265,486 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés d'amides de thiazolyl-, oxazolyl-, pyrrolyl- et imidazolyl-acides utiles comme inhibiteurs d'isozymes PDE4 Composés utiles comme inhibiteurs de PDE4 dans le traitement de maladies, régulées par l'activation et la dégranulation des cellules éosinophiles, notamment l'asthme, la bronchite chronique, et une maladie pulmonaire obstructive chronique, de formule (I), dans laquelle j est égal à 0 ou 1 ; k est égal à 0 ou 1 ; m est égal à 0, 1, 2 ou 3 ; n est égal à 1 ou 2 ; W1 représente un groupe -O- ; ou -S(=O)t-, dans lequel t est égal à 0, 1 ou 2 ; ou -N(R3)- ; W2 représente un groupe -O-CRARB-ou est absent ; Y représente un groupe =C(R1a) ou - [N(flèche) (O) k] -, dans lequel k est égal à 0 ou 1 ; RA et RB représentent des groupes -H ; -F ; -CF3 ; -(alkyle en C1 à C4) ; - (cycloalkyle en C3 à C7), phényle ; ou benzyle substitué avec 0 à 3 substituants R10 ; ou bien RA et RB sont pris conjointement, mais seulement dans le cas oé m est égal à 1, pour former un groupement spiro ; Rc et RD répondent aux définitions de RA et RB, sauf qu'un d'entre eux doit représenter -H ; R1 et R2 représentent des groupes -H ; -F ; -Cl ; -CN ; -NO2 ; -(alkyle en C1 à C4) ; -(alcynyle en C2 à C4) ; - (fluoralkyle en C1 à C3) ; -OR16 ; ou -C (=O) NR22aR22b ; R3 représente -H ; un groupe -(alkyle en C1 à C3) ; phényle ; benzyle ; ou -OR16; R4, R5 et R6, en plus d'autres définitions, peuvent être pris conjointement pour former la formule (II) ; G1 représente un système de noyau carboné saturé ou insaturé ; dans lequel, facultativement, un atome de carbone peut être remplacé par un hétéroatome choisi entre N, O et S ; G2 représente un système de noyau carboné saturé ou insaturé ; dans lequel un atome de carbone peut être remplacé par un hétéroatome choisi entre N, O et S ; et E est choisi parmi les groupes de formule (III).
MA27243A 2001-01-31 2003-07-21 Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4 MA26985A1 (fr)

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US26548601P 2001-01-31 2001-01-31

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MA26985A1 true MA26985A1 (fr) 2004-12-20

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US (3) US6559168B2 (fr)
EP (1) EP1355907A1 (fr)
JP (1) JP2004518691A (fr)
KR (1) KR20030072614A (fr)
CN (1) CN1489588A (fr)
BG (1) BG108039A (fr)
BR (1) BR0116850A (fr)
CA (1) CA2436551A1 (fr)
CR (1) CR7038A (fr)
CZ (1) CZ20031903A3 (fr)
EA (1) EA200300622A1 (fr)
EC (1) ECSP034683A (fr)
EE (1) EE200300362A (fr)
HU (1) HUP0401305A2 (fr)
IL (1) IL156412A0 (fr)
IS (1) IS6844A (fr)
MA (1) MA26985A1 (fr)
MX (1) MXPA03006886A (fr)
NO (1) NO20033398L (fr)
OA (1) OA12542A (fr)
PL (1) PL365443A1 (fr)
TN (1) TNSN03050A1 (fr)
WO (1) WO2002060898A1 (fr)
ZA (1) ZA200305769B (fr)

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US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
WO2002094321A1 (fr) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Compositions favorisant la guérison d'une fracture osseuse
KR20040007583A (ko) * 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 연골 질환의 재생치료용 조성물
JPWO2003020313A1 (ja) * 2001-09-04 2004-12-16 小野薬品工業株式会社 スフィンゴシン−１−リン酸受容体調節剤からなる呼吸器疾患治療剤
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