MA27062A1 - Compositions pour inhalation, comprenant des 5, 6-dihydro-9h-pyrazolo [3, 4-c]-1, 2, 4-triazolo [4, 3- ] pyridines tricycliques - Google Patents

Compositions pour inhalation, comprenant des 5, 6-dihydro-9h-pyrazolo [3, 4-c]-1, 2, 4-triazolo [4, 3- ] pyridines tricycliques

Info

Publication number
MA27062A1
MA27062A1 MA27550A MA27550A MA27062A1 MA 27062 A1 MA27062 A1 MA 27062A1 MA 27550 A MA27550 A MA 27550A MA 27550 A MA27550 A MA 27550A MA 27062 A1 MA27062 A1 MA 27062A1
Authority
MA
Morocco
Prior art keywords
pyrazolo
dihydro
triazolo
pyridines
inhalation
Prior art date
Application number
MA27550A
Other languages
English (en)
Inventor
Michael John Humphrey
Michael Trevor Shepherd
Paul Robert Miller
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA27062A1 publication Critical patent/MA27062A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

DEPOSANT Société dite: PFIZER INC. REVENDICATION DE PRIORITES GB 12 Septembre 2001 0122031.8 Voir en annexe le titre de l'invention et le texte de l'abrégé Compositions pour inhalation, comprenant des 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4-triazolo[4, 3-(alpha)]pyridines tricycliques La présente invention concerne une formulation à inhaler comprenant un composé choisi dans une catégorie particulière de 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-(alpha)]pyridines, qui est capable de délivrer le composé sous forme de fines particules solides au poumon, et l'utilisation d'une telle formulation dans le traitement de certaines maladies telles que des maladies respiratoires. Au moyen de telles formulations, il est possible de supprimer la réponse de toux indésirable associée à l'utilisation de ces composés dans des inhalateurs à doses mesurées de solution, réponse qui peut empêcher l'administration d'une dose therapeutiquement efficace et, à long terme, entraver l'observance du patient.
MA27550A 2001-09-12 2004-02-26 Compositions pour inhalation, comprenant des 5, 6-dihydro-9h-pyrazolo [3, 4-c]-1, 2, 4-triazolo [4, 3- ] pyridines tricycliques MA27062A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0122031.8A GB0122031D0 (en) 2001-09-12 2001-09-12 Use of pde4 inhibitors in a dry powder inhaler

Publications (1)

Publication Number Publication Date
MA27062A1 true MA27062A1 (fr) 2004-12-20

Family

ID=9921954

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27550A MA27062A1 (fr) 2001-09-12 2004-02-26 Compositions pour inhalation, comprenant des 5, 6-dihydro-9h-pyrazolo [3, 4-c]-1, 2, 4-triazolo [4, 3- ] pyridines tricycliques

Country Status (35)

Country Link
US (3) US20030064034A1 (fr)
EP (1) EP1427414A1 (fr)
JP (1) JP2005505560A (fr)
KR (1) KR20040036940A (fr)
CN (1) CN1553801A (fr)
AP (2) AP2002002623A0 (fr)
AR (2) AR036474A1 (fr)
BG (1) BG108569A (fr)
BR (1) BR0212449A (fr)
CA (1) CA2457717A1 (fr)
CZ (1) CZ2004310A3 (fr)
EA (1) EA006742B1 (fr)
EC (1) ECSP045018A (fr)
EE (1) EE200400078A (fr)
GB (1) GB0122031D0 (fr)
HN (2) HN2002000253A (fr)
HR (1) HRP20040162A2 (fr)
HU (1) HUP0401890A3 (fr)
IL (1) IL160380A0 (fr)
IS (1) IS7151A (fr)
MA (1) MA27062A1 (fr)
MX (1) MXPA04002354A (fr)
NO (1) NO20041011L (fr)
NZ (1) NZ530929A (fr)
OA (1) OA12660A (fr)
PA (2) PA8554701A1 (fr)
PE (2) PE20030509A1 (fr)
PL (1) PL368736A1 (fr)
PY (2) PY0221503A (fr)
SK (1) SK1272004A3 (fr)
SV (2) SV2004001226A (fr)
TN (1) TNSN04040A1 (fr)
TW (1) TW200602054A (fr)
WO (2) WO2003022275A1 (fr)
ZA (1) ZA200401002B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7931022B2 (en) 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
EP1581182A2 (fr) * 2002-12-31 2005-10-05 Nektar Therapeutics Formulation pharmaceutique administree en aerosol dans une therapie destinee a traiter une infection fongique
GB0315889D0 (en) * 2003-07-08 2003-08-13 Aventis Pharma Ltd Stable pharmaceutical products
US20060009435A1 (en) * 2004-06-23 2006-01-12 Joseph Kaspi Synthesis and powder preparation of fluticasone propionate
JP2009509980A (ja) * 2005-09-28 2009-03-12 メルク フロスト カナダ リミテツド 篩分けされたラクトースを含むエアゾール粉末製剤
GB0801876D0 (en) * 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
TR200909788A2 (tr) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum içeren inhalasyona uygun kuru toz formülasyonu
AP2015008663A0 (en) 2013-02-19 2015-08-31 Pfizer Azabenzimidazole compounds as inhibitors of PDE4 isozymes for the treatment of cns and other disorders
KR20150076005A (ko) 2013-12-26 2015-07-06 삼성디스플레이 주식회사 액정 표시 장치
EP3172210B1 (fr) 2014-07-24 2020-01-15 Pfizer Inc Composés de pyrazolopyrimidine
SG11201700243YA (en) 2014-08-06 2017-02-27 Pfizer Imidazopyridazine compounds
PT3332767T (pt) * 2014-09-15 2019-06-27 Verona Pharma Plc Formulação por inalação líquida compreendendo rpl554

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69525978T2 (de) * 1995-06-06 2002-12-19 Pfizer Trizyclische 5,6-dihydro-9h-pyrazolo(3,4-c)-1,2,4-triazolo(4,3-alpha)pyridine
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren

Also Published As

Publication number Publication date
BG108569A (bg) 2005-02-28
TW200602054A (en) 2006-01-16
EA200400301A1 (ru) 2004-06-24
CN1553801A (zh) 2004-12-08
EE200400078A (et) 2004-06-15
US20030064034A1 (en) 2003-04-03
HN2002000253A (es) 2003-04-07
PE20030443A1 (es) 2003-05-17
US20050232871A1 (en) 2005-10-20
HUP0401890A3 (en) 2008-03-28
PY0221504A (es) 2004-04-01
NO20041011L (no) 2004-03-10
EP1427414A1 (fr) 2004-06-16
AP2002002624A0 (en) 2002-09-30
SV2004001226A (es) 2004-02-24
WO2003022279A1 (fr) 2003-03-20
AR036473A1 (es) 2004-09-08
OA12660A (en) 2006-06-19
SK1272004A3 (sk) 2005-03-04
WO2003022275A1 (fr) 2003-03-20
CA2457717A1 (fr) 2003-03-20
AP2002002623A0 (en) 2002-09-30
NZ530929A (en) 2006-08-31
PY0221503A (es) 2004-04-01
SV2004001227A (es) 2004-02-24
CZ2004310A3 (cs) 2005-02-16
IS7151A (is) 2004-02-13
BR0212449A (pt) 2004-08-17
IL160380A0 (en) 2004-07-25
JP2005505560A (ja) 2005-02-24
GB0122031D0 (en) 2001-10-31
HRP20040162A2 (en) 2004-08-31
TNSN04040A1 (fr) 2006-06-01
HN2002000254A (es) 2003-04-07
US20030064031A1 (en) 2003-04-03
PA8554701A1 (es) 2003-09-17
PE20030509A1 (es) 2003-06-23
EA006742B1 (ru) 2006-04-28
ECSP045018A (es) 2004-04-28
HUP0401890A2 (hu) 2004-12-28
ZA200401002B (en) 2005-02-07
KR20040036940A (ko) 2004-05-03
PA8554601A1 (es) 2003-09-17
MXPA04002354A (es) 2004-06-29
PL368736A1 (pl) 2005-04-04
AR036474A1 (es) 2004-09-08

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