MA27119A1 - Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine - Google Patents

Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine

Info

Publication number
MA27119A1
MA27119A1 MA27955A MA27955A MA27119A1 MA 27119 A1 MA27119 A1 MA 27119A1 MA 27955 A MA27955 A MA 27955A MA 27955 A MA27955 A MA 27955A MA 27119 A1 MA27119 A1 MA 27119A1
Authority
MA
Morocco
Prior art keywords
modulators
activity
receptor
tetrahydropyranyle
chimiokin
Prior art date
Application number
MA27955A
Other languages
English (en)
Inventor
Jiao Richard
Moyes Christopher
Yang Lihu
Morriello Gregori
Original Assignee
Merck Sharp & Dohme
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Merck & Co Inc filed Critical Merck Sharp & Dohme
Publication of MA27119A1 publication Critical patent/MA27119A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (I): (dans laquelle R3 et R4 sont définis ici) qui sont utiles comme modulateurs de l'activité d'un récepteur de chimiokine. En particulier, ces composés sont utiles comme modulateurs du récepteur de chimiokine CCR-2.
MA27955A 2002-04-29 2004-11-17 Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine MA27119A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
MA27119A1 true MA27119A1 (fr) 2004-12-20

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27955A MA27119A1 (fr) 2002-04-29 2004-11-17 Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine

Country Status (22)

Country Link
US (1) US7786305B2 (fr)
KR (1) KR100754760B1 (fr)
CN (1) CN1310917C (fr)
AR (1) AR039489A1 (fr)
AU (1) AU2003234251A1 (fr)
BR (1) BR0309650A (fr)
DO (1) DOP2003000638A (fr)
EC (1) ECSP045392A (fr)
HR (1) HRP20041023A2 (fr)
IL (1) IL164909A (fr)
IS (1) IS7512A (fr)
JO (1) JO2479B1 (fr)
MA (1) MA27119A1 (fr)
MX (1) MXPA04010702A (fr)
MY (1) MY129850A (fr)
NO (1) NO20045235L (fr)
PE (1) PE20040598A1 (fr)
PL (1) PL373401A1 (fr)
RU (1) RU2285004C2 (fr)
TW (1) TWI262077B (fr)
UA (1) UA75828C2 (fr)
WO (1) WO2003093266A1 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
CA2483752C (fr) * 2002-04-29 2011-03-29 Merck & Co., Inc. Modulateurs tetrahydropyranyl cyclopentyl tetrahydropyridopyridine de l'activite des recepteurs de chimiokine
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
PL376925A1 (pl) 2002-11-27 2006-01-09 Incyte Corporation Pochodne 3-aminopirolidyny jako modulatory receptorów chemokiny
US7393844B2 (en) * 2003-03-18 2008-07-01 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity
US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
AU2004287416C1 (en) 2003-10-27 2010-09-09 Merck Sharp & Dohme Corp. CCR-2 antagonist salt
BRPI0417605B8 (pt) 2003-12-18 2021-05-25 Incyte Corp “n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende”.
CA2551869A1 (fr) * 2004-01-02 2005-07-28 Merck & Co., Inc. Modulateurs d'amide cyclopentyle d'alkylamino, arylamino et sulfonamido de l'activite des recepteurs de la chimiokine
EP1742919A4 (fr) * 2004-04-26 2010-04-28 Merck Sharp & Dohme Modulateurs tetrahydropyranyle cyclopentyle de tetrahydroisoquinoline 1 substituee et 1,1-disubstituee de l'activite des recepteurs de chimiokine
CN101103027A (zh) * 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂
JP2007537264A (ja) 2004-05-11 2007-12-20 インサイト コーポレイション ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド
GEP20094843B (en) 2004-06-28 2009-11-25 Incyte Corp 3-aminocyclopentane carboxamides as modulators of chemokine receptors
EP1763347A4 (fr) 2004-06-28 2009-05-20 Incyte Corp 3-aminocyclopentanecarboxamides utilises en tant que modulateurs des recepteurs des chimiokines
WO2007053499A2 (fr) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Composés pouvant être employés en tant qu'antagonistes de ccr2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
CA2743030C (fr) 2008-11-26 2013-10-22 Pfizer Inc. 3-aminocyclopentanecarboxamides en tant que modulateurs des recepteurs de chimiokines
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
EP2515883A4 (fr) * 2009-12-22 2013-07-17 Abbvie Inc Capsule de abt-263
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
SG10201801794WA (en) 2010-10-29 2018-04-27 Abbvie Inc Solid dispersions containing an apoptosis-inducing agent
MY165884A (en) 2010-11-23 2018-05-18 Abbvie Ireland Unlimited Co Methods of treatment using selective bcl-2 inhibitors
KR101923364B1 (ko) 2010-11-23 2018-11-30 애브비 인코포레이티드 아폽토시스­유도제의 염 및 결정형
US8987268B2 (en) 2011-03-17 2015-03-24 Bristol-Myers Squibb Company Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
US20130345254A1 (en) * 2011-03-17 2013-12-26 Anilkumar G. Nair Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
US9024017B2 (en) 2012-07-19 2015-05-05 Janssen Pharmaceutica Nv Octahydro-cyclopentapyrrolyl antagonists of CCR2
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
PT3297438T (pt) 2015-05-21 2022-01-25 Chemocentryx Inc Moduladores de ccr2
MA50665A (fr) 2017-09-25 2020-08-05 Chemocentryx Inc Polythérapie utilisant un antagoniste du récepteur 2 de la chimiokine (ccr2) et un inhibiteur pd-1/pd-l1
IL275898B2 (en) 2018-01-08 2025-05-01 Chemocentryx Inc Methods for treating solid tumors with CCR2 antagonists
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647804A (en) 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
US3772308A (en) 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
CA2143143A1 (fr) 1994-03-08 1995-09-09 Toshihiko Tanaka Derives de la 3-phenylpyrrolidine
JPH09291034A (ja) 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
RU2174123C2 (ru) * 1996-10-28 2001-09-27 Новартис Аг Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
GB9812037D0 (en) 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
US6312689B1 (en) * 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US6500844B1 (en) 1999-06-11 2002-12-31 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
JP2004506013A (ja) 2000-08-17 2004-02-26 メルク　エンド　カムパニー　インコーポレーテッド シクロペンチル系ケモカイン受容体活性調節剤
MXPA03008109A (es) * 2001-03-07 2003-12-12 Pfizer Prod Inc Moduladores de la actividad de receptores de quimiocinas.
CA2483752C (fr) 2002-04-29 2011-03-29 Merck & Co., Inc. Modulateurs tetrahydropyranyl cyclopentyl tetrahydropyridopyridine de l'activite des recepteurs de chimiokine
JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
WO2003093231A2 (fr) 2002-04-29 2003-11-13 Merck & Co., Inc. Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline
JP2006514003A (ja) 2002-10-30 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルベンジルアミド調節剤
AU2004287416C1 (en) 2003-10-27 2010-09-09 Merck Sharp & Dohme Corp. CCR-2 antagonist salt
CN101103027A (zh) 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂

Also Published As

Publication number Publication date
PE20040598A1 (es) 2004-10-05
JO2479B1 (en) 2009-01-20
HRP20041023A2 (en) 2005-02-28
AU2003234251A8 (en) 2003-11-17
WO2003093266A1 (fr) 2003-11-13
MXPA04010702A (es) 2005-02-17
US7786305B2 (en) 2010-08-31
CN1662532A (zh) 2005-08-31
UA75828C2 (en) 2006-05-15
US20050101628A1 (en) 2005-05-12
RU2004134604A (ru) 2005-05-27
AR039489A1 (es) 2005-02-23
TW200307543A (en) 2003-12-16
TWI262077B (en) 2006-09-21
ECSP045392A (es) 2005-01-03
KR20050000413A (ko) 2005-01-03
IL164909A0 (en) 2005-12-18
IL164909A (en) 2010-04-15
RU2285004C2 (ru) 2006-10-10
PL373401A1 (en) 2005-08-22
CN1310917C (zh) 2007-04-18
AU2003234251A1 (en) 2003-11-17
MY129850A (en) 2007-05-31
NO20045235L (no) 2004-11-29
BR0309650A (pt) 2005-04-26
KR100754760B1 (ko) 2007-09-04
DOP2003000638A (es) 2003-11-30
HK1081967A1 (en) 2006-05-26
IS7512A (is) 2004-10-18

Similar Documents

Publication Publication Date Title
EP1501507A4 (fr) Modulateurs tetrahydropyranyl cyclopentyl tetrahydropyridopyridine de l'activite des recepteurs de chimiokine
EP1318811A4 (fr) Modulateurs cyclopentyles de l'activite du recepteur de la chimiokine
EP1501803A4 (fr) Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline
MY129850A (en) Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
MXPA02012712A (es) N-ureidoheterocicloalquil-piperidinas como moduladores de la actividad del receptor de quimiocinas.
MA28681B1 (fr) 3-aminocyclopentanecarboxamides utiles comme modulateurs de récepteurs de chimiokines
DE69936998D1 (de) Pyrazolotriazinderivate als gaba-rezeptorliganden
ATE302005T1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
ATE302606T1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
MA27452A1 (fr) Derives d'indole servant d'agonistes beta-2
AP2001002088A0 (en) 4,4-Biarylpiperidine derivatives with opiod receptor activity.
MA28680B1 (fr) 3-aminocyclopentanecarboxamides utiles comme modulateurs de récepteurs de chimiokines
MA30077B1 (fr) 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de chimiokines
TNSN04194A1 (fr) Derives de tropane servant de modulateurs de ccr5
WO2004042351A3 (fr) Modulateur piperidinyl-alpha-aminoamide de l'activite de recepteurs de la chimiokine
MA27448A1 (fr) Derives de pyridine modulateurs du recepteur cb2
WO2004041777A3 (fr) Modulateurs d'heteroarylpiperidine de l'activite des recepteurs de la chimiokine
WO2004094371A3 (fr) Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine
MA27501A1 (fr) Derives d'imidazoquinoline en tant que ligands recepteurs de l'adenosine a3
EP1599206A4 (fr) Modulateurs d'heterotricylicamide fusionne avec un aminocyclopentyl de l'activite des recepteurs de la chimiokine
MY120237A (en) Method for the synthesis of quinoline derivatives
DE60031676D1 (en) N-cyclopentylmodulatoren der chemokine rezeptoraktivität
MA28286A1 (fr) Dérivés de 1-N-phenyl-amino-1H-imidazole et compositions pharmaceutiques les contenant
WO2003103666A3 (fr) Nouvelles 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones
CA2345724A1 (fr) Compositions pharmaceutiques possedant une activite antitumorale