MA27119A1 - Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine - Google Patents

Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine

Info

Publication number
MA27119A1
MA27119A1 MA27955A MA27955A MA27119A1 MA 27119 A1 MA27119 A1 MA 27119A1 MA 27955 A MA27955 A MA 27955A MA 27955 A MA27955 A MA 27955A MA 27119 A1 MA27119 A1 MA 27119A1
Authority
MA
Morocco
Prior art keywords
modulators
activity
receptor
tetrahydropyranyle
chimiokin
Prior art date
Application number
MA27955A
Other languages
English (en)
Inventor
Jiao Richard
Moyes Christopher
Yang Lihu
Morriello Gregori
Original Assignee
Merck Sharp & Dohme
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Merck & Co Inc filed Critical Merck Sharp & Dohme
Publication of MA27119A1 publication Critical patent/MA27119A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (I): (dans laquelle R3 et R4 sont définis ici) qui sont utiles comme modulateurs de l'activité d'un récepteur de chimiokine. En particulier, ces composés sont utiles comme modulateurs du récepteur de chimiokine CCR-2.
MA27955A 2002-04-29 2004-11-17 Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine MA27119A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
MA27119A1 true MA27119A1 (fr) 2004-12-20

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27955A MA27119A1 (fr) 2002-04-29 2004-11-17 Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine

Country Status (22)

Country Link
US (1) US7786305B2 (fr)
KR (1) KR100754760B1 (fr)
CN (1) CN1310917C (fr)
AR (1) AR039489A1 (fr)
AU (1) AU2003234251A1 (fr)
BR (1) BR0309650A (fr)
DO (1) DOP2003000638A (fr)
EC (1) ECSP045392A (fr)
HR (1) HRP20041023A2 (fr)
IL (1) IL164909A (fr)
IS (1) IS7512A (fr)
JO (1) JO2479B1 (fr)
MA (1) MA27119A1 (fr)
MX (1) MXPA04010702A (fr)
MY (1) MY129850A (fr)
NO (1) NO20045235L (fr)
PE (1) PE20040598A1 (fr)
PL (1) PL373401A1 (fr)
RU (1) RU2285004C2 (fr)
TW (1) TWI262077B (fr)
UA (1) UA75828C2 (fr)
WO (1) WO2003093266A1 (fr)

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WO2004050024A2 (fr) 2002-11-27 2004-06-17 Incyte Corporation Derives de la 3-aminopyrrolidine modulateurs des recepteurs de la chemoquine
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WO2004110376A2 (fr) * 2003-06-06 2004-12-23 Merck & Co., Inc. Antagonistes de ccr-2 permettant de traiter une douleur neuropathique
RU2317295C1 (ru) * 2003-10-27 2008-02-20 Мерк Энд Ко., Инк. Соль антагониста ccr-2
CA2550596C (fr) 2003-12-18 2011-03-15 Incyte Corporation Derives 3-cycloalkylaminopyrrolidine utilises en tant que modulateurs des recepteurs de chimiokine
JP2007519633A (ja) * 2004-01-02 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド アルキルアミノ、アリールアミノおよびスルホンアミドシクロペンチルアミド系のケモカイン受容体活性調節剤
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WO2005105092A2 (fr) * 2004-04-28 2005-11-10 Merck & Co., Inc. Modulateurs de l'activité de récepteurs de chimiokines en tétrahydropyranylcyclopentylamide disubstitué en position 3,3
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AP2006003849A0 (en) 2004-06-28 2006-12-31 Incyte Corp 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
AU2005259983B2 (en) * 2004-06-28 2011-07-28 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
PL2370442T3 (pl) * 2008-11-26 2013-08-30 Pfizer 3-Aminocyklopentanokarboksamidy jako modulatory receptora chemokiny
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
US8927009B2 (en) * 2009-12-22 2015-01-06 Abbvie Inc. ABT-263 capsule
KR20180059560A (ko) 2010-10-29 2018-06-04 애브비 인코포레이티드 아폽토시스―유도제를 포함하는 고체 분산체
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
WO2012071336A1 (fr) 2010-11-23 2012-05-31 Abbott Laboratories Sels et formes cristallines d'un agent inducteur d'apoptose
RU2593231C2 (ru) 2010-11-23 2016-08-10 ЭббВи Айэленд Анлимитед Компани Способы лечения с использованием селективных ингибиторов bcl-2
TW201249846A (en) 2011-03-17 2012-12-16 Bristol Myers Squibb Co Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
WO2012125663A2 (fr) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Dérivés d'amino cyclopentane substitués par cyclohexane en tant qu'antagonistes utiles de ccr2
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
ES2627010T3 (es) 2012-07-19 2017-07-26 Janssen Pharmaceutica, N.V. Antagonistas de octahidro-ciclopentapirrolilo de CCR2
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2726206C2 (ru) 2015-05-21 2020-07-09 Кемосентрикс, Инк. Модуляторы ccr2
EP3687525B1 (fr) 2017-09-25 2025-10-29 ChemoCentryx, Inc. Polythérapie utilisant un antagoniste du récepteur 2 de la chimiokine (ccr2) et un inhibiteur pd-1/pd-l1
CN112105353B (zh) 2018-01-08 2024-04-19 凯莫森特里克斯股份有限公司 Ccr2拮抗剂治疗实体瘤的方法
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JP3780291B2 (ja) 2002-04-29 2006-05-31 メルク エンド カムパニー インコーポレーテッド テトラヒドロピラニルシクロペンチルテトラヒドロピリドピリジン系のケモカイン受容体活性調節剤
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Also Published As

Publication number Publication date
NO20045235L (no) 2004-11-29
TW200307543A (en) 2003-12-16
CN1310917C (zh) 2007-04-18
PL373401A1 (en) 2005-08-22
JO2479B1 (en) 2009-01-20
UA75828C2 (en) 2006-05-15
AR039489A1 (es) 2005-02-23
IS7512A (is) 2004-10-18
ECSP045392A (es) 2005-01-03
US7786305B2 (en) 2010-08-31
MXPA04010702A (es) 2005-02-17
IL164909A (en) 2010-04-15
US20050101628A1 (en) 2005-05-12
HK1081967A1 (en) 2006-05-26
RU2285004C2 (ru) 2006-10-10
DOP2003000638A (es) 2003-11-30
TWI262077B (en) 2006-09-21
BR0309650A (pt) 2005-04-26
AU2003234251A1 (en) 2003-11-17
MY129850A (en) 2007-05-31
KR100754760B1 (ko) 2007-09-04
HRP20041023A2 (en) 2005-02-28
WO2003093266A1 (fr) 2003-11-13
KR20050000413A (ko) 2005-01-03
PE20040598A1 (es) 2004-10-05
RU2004134604A (ru) 2005-05-27
AU2003234251A8 (en) 2003-11-17
CN1662532A (zh) 2005-08-31
IL164909A0 (en) 2005-12-18

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