MA27123A1 - Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer - Google Patents

Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer

Info

Publication number
MA27123A1
MA27123A1 MA25808A MA25808A MA27123A1 MA 27123 A1 MA27123 A1 MA 27123A1 MA 25808 A MA25808 A MA 25808A MA 25808 A MA25808 A MA 25808A MA 27123 A1 MA27123 A1 MA 27123A1
Authority
MA
Morocco
Prior art keywords
administration
lubricant
salt
acid
preparing
Prior art date
Application number
MA25808A
Other languages
English (en)
Inventor
Gabel Rolf-Dieter
Woog Heinrich
Preis Walter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8232769&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27123(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA27123A1 publication Critical patent/MA27123A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

FORME SOLIDE D'ADMINISTRATION D'ACIDE DIPHOSPHONIQUE OU DE SEL DE CELUI-CI, UTILISANT L'ACIDE STÉARIQUE COMME LUBRIFIANT, ET PROCÉDÉ POUR LA PRÉPARER F. HOFFMANN-LA ROCHE AG L'invention a trait à une forme pharmaceutique solide d'administration contenant un acide diphosphonique ou un sel de celui-ci compatible sur le plan physioloqique en tant que principe actif, dans laquelle le principe actif est présent sous forme de granulé, éventuellement conjointement avec des adjuvants pharmaceutiques, dans la phase interne, et la phase externe contient un lubrifiant sous la forme de moins de 5% en poids d'acide stéarique par rapport au poids total de la forme d'administration.
MA25808A 1998-10-09 1999-10-06 Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer MA27123A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98119102A EP0998932A1 (fr) 1998-10-09 1998-10-09 Forme d'administration pharmaceutique contenant des diphosphonates ou leurs sels et méthode pour la fabriquer

Publications (1)

Publication Number Publication Date
MA27123A1 true MA27123A1 (fr) 2005-01-03

Family

ID=8232769

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25808A MA27123A1 (fr) 1998-10-09 1999-10-06 Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer

Country Status (35)

Country Link
US (2) US6294196B1 (fr)
EP (2) EP0998932A1 (fr)
JP (2) JP4471498B2 (fr)
KR (1) KR100522505B1 (fr)
CN (1) CN1150000C (fr)
AR (3) AR014081A1 (fr)
AT (1) ATE311887T1 (fr)
AU (1) AU752532B2 (fr)
BR (1) BR9914367A (fr)
CA (1) CA2346662C (fr)
CO (1) CO5050325A1 (fr)
CY (1) CY1105437T1 (fr)
CZ (1) CZ299008B6 (fr)
DE (1) DE69928819T2 (fr)
DK (1) DK1117412T3 (fr)
ES (1) ES2253919T3 (fr)
HK (1) HK1040914B (fr)
HR (1) HRP20010243B1 (fr)
HU (1) HU226457B1 (fr)
ID (1) ID29876A (fr)
IL (3) IL141912A0 (fr)
MA (1) MA27123A1 (fr)
ME (1) ME00637B (fr)
MY (1) MY126625A (fr)
NO (1) NO327447B1 (fr)
NZ (1) NZ510433A (fr)
PE (1) PE20001082A1 (fr)
PL (1) PL194552B1 (fr)
RS (1) RS49809B (fr)
RU (1) RU2207860C2 (fr)
SI (1) SI1117412T1 (fr)
TR (1) TR200100889T2 (fr)
TW (1) TW576742B (fr)
WO (1) WO2000021540A1 (fr)
ZA (1) ZA200102276B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008645B2 (en) 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
US6984400B2 (en) 1998-07-14 2006-01-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating restenosis using bisphosphonate nanoparticles
IL125336A0 (en) 1998-07-14 1999-03-12 Yissum Res Dev Co Compositions for inhibition and treatment of restinosis
EP0998932A1 (fr) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Forme d'administration pharmaceutique contenant des diphosphonates ou leurs sels et méthode pour la fabriquer
RU2294203C2 (ru) * 2001-12-21 2007-02-27 Дзе Проктер Энд Гэмбл Компани Способ лечения костных нарушений
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
KR100897837B1 (ko) * 2001-12-24 2009-05-15 테바 파마슈티컬 인더스트리즈 리미티드 분말 또는 과립 물질의 압착된 환상체 내에 싸인 활성성분의 코어 정제를 갖는 제형과, 이의 제조 방법 및 툴링
RU2387451C2 (ru) 2002-05-10 2010-04-27 Ф.Хоффманн-Ля Рош Аг Бисфосфоновые кислоты, предназначенные для лечения и профилактики остеопороза
HRP20041013B1 (hr) † 2002-12-20 2013-10-25 F. Hoffmann - La Roche Ag Formulacija visoke doze ibandronata
AU2006222690B2 (en) * 2002-12-20 2009-04-23 F. Hoffmann-La Roche Ag High dose ibandronate formulation
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US20070191311A1 (en) * 2004-01-30 2007-08-16 Shuichiro Kakimoto P2x receptor inhibitor
EP1930011B1 (fr) * 2004-08-23 2011-08-17 Teva Pharmaceutical Industries Ltd Forme cristalline de ibandronate de sodium
US7687482B2 (en) * 2006-03-17 2010-03-30 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
US7358361B2 (en) * 2004-10-08 2008-04-15 The Board Of Trustees Of The University Of Illinois Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
WO2008128056A1 (fr) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Composés bisphosphonates et procédés présentant un potentiel amélioré pour cibles multiples incluant fpps, ggpps, et dpps
RU2368617C2 (ru) * 2005-02-01 2009-09-27 Ф.Хоффманн-Ля Рош Аг Полиморфная модификация а ибандроната
EP2363401A1 (fr) * 2005-02-01 2011-09-07 F. Hoffmann-La Roche AG Polymorphe B d'ibandronate
US20070049557A1 (en) * 2005-08-24 2007-03-01 Hashim Ahmed Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
US20070191315A1 (en) * 2006-02-16 2007-08-16 Bengt Bergstrom Method for administering ibandronate
GB0616794D0 (en) 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
US20080139514A1 (en) * 2006-11-29 2008-06-12 Subhash Pandurang Gore Diphosphonic acid pharmaceutical compositions
CA2570949A1 (fr) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Solvate d'ibandronate sodique et de propyleneglycol et methodes de preparation connexes
AU2007335156A1 (en) * 2006-12-20 2008-06-26 Mylan Pharmaceuticals Ulc Pharmaceutical composition comprising a hot-melt granulated lubricant
ES2623328T3 (es) * 2009-09-18 2017-07-11 Sitec Pharmabio Sl Procedimiento para la deshidratación de productos en polvo
KR101244414B1 (ko) * 2010-11-05 2013-03-18 주식회사 바이오파마티스 고함량 이반드론산 함유 골다공증 예방 또는 치료용 조성물 및 이의 제조방법
EP2661262B1 (fr) 2011-01-06 2017-11-15 Mahmut Bilgic Formulations améliorées de bisphosphonates
JP5874545B2 (ja) * 2011-06-20 2016-03-02 アステラス製薬株式会社 経口投与用医薬組成物
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture

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US4639338A (en) 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
US4798725A (en) 1986-06-16 1989-01-17 Norwich Eaton Pharmaceuticals, Inc. Sustained release capsule
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
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ATE60711T1 (de) * 1986-12-20 1991-02-15 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
FR2629716B1 (fr) 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
HU227530B1 (en) * 1991-11-22 2011-07-28 Warner Chilcott Company Delayed-release compositions containing risedronate and process for their production
WO1993013756A1 (fr) 1992-01-10 1993-07-22 Obschestvo S Ogranichennoy Otvetstvennostyu Meditsinsky Nauchno-Proizvodstvennoy Komplex 'biotiki' Composition pharmaceutique granulee et son procede de production
SE501389C2 (sv) * 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
DE4228552A1 (de) 1992-08-27 1994-03-03 Boehringer Mannheim Gmbh Diphosphonsäuren und deren Salze enthaltende Arzneimittel
US5358941A (en) 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
NZ254765A (en) 1993-05-15 1997-02-24 Boehringer Mannheim Gmbh Tablet medicament; comprises dichloromethylene diphosphonic acid (clodronic acid) or a pharmaceutically acceptable salt thereof as active ingredient and microcrystalline cellulose as auxiliary
TW390813B (en) 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US5656288A (en) * 1995-06-08 1997-08-12 Sanofi Winthrop, Inc. Stable pharmaceutical compositions containing tiludronate hydrates and process for producing the pharmaceutical compositions
IL120265A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis - polyphosphonates or progestins and estrogen agonists
DE19615812A1 (de) 1996-04-20 1997-10-23 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
EP0998933A1 (fr) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Procédé pour la préparation de compositions pharmaucetiques contenant des diphosphonates pour administration orale
EP0998932A1 (fr) * 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Forme d'administration pharmaceutique contenant des diphosphonates ou leurs sels et méthode pour la fabriquer

Also Published As

Publication number Publication date
ZA200102276B (en) 2002-06-19
MY126625A (en) 2006-10-31
NO327447B1 (no) 2009-06-29
DK1117412T3 (da) 2006-04-03
CY1105437T1 (el) 2010-04-28
JP2010116408A (ja) 2010-05-27
DE69928819D1 (de) 2006-01-12
ES2253919T3 (es) 2006-06-01
DE69928819T2 (de) 2006-07-20
HU226457B1 (en) 2008-12-29
KR100522505B1 (ko) 2005-10-18
IL141912A (en) 2006-12-10
ID29876A (id) 2001-10-18
JP4471498B2 (ja) 2010-06-02
YU20501A (sh) 2003-02-28
HUP0103931A2 (en) 2002-06-29
AU752532B2 (en) 2002-09-19
PL347243A1 (en) 2002-03-25
HUP0103931A3 (en) 2003-01-28
EP1117412A1 (fr) 2001-07-25
CN1319015A (zh) 2001-10-24
IL141912A0 (en) 2002-03-10
EP1117412B1 (fr) 2005-12-07
HRP20010243B1 (hr) 2011-02-28
IL177940A0 (en) 2006-12-31
CO5050325A1 (es) 2001-06-27
EP0998932A1 (fr) 2000-05-10
HK1040914B (zh) 2004-12-10
HK1040914A1 (en) 2002-06-28
BR9914367A (pt) 2001-06-26
CA2346662A1 (fr) 2000-04-20
NZ510433A (en) 2003-08-29
CN1150000C (zh) 2004-05-19
CA2346662C (fr) 2006-05-09
AR047815A2 (es) 2006-02-22
KR20010073203A (ko) 2001-07-31
ME00637B (fr) 2008-08-07
AR069942A2 (es) 2010-03-03
SI1117412T1 (sl) 2006-04-30
PE20001082A1 (es) 2000-10-18
RS49809B (sr) 2008-08-07
IL177940A (en) 2012-05-31
AR014081A1 (es) 2001-01-31
US20020006441A1 (en) 2002-01-17
HRP20010243A2 (en) 2002-04-30
RU2207860C2 (ru) 2003-07-10
TR200100889T2 (tr) 2001-07-23
NO20011714D0 (no) 2001-04-05
PL194552B1 (pl) 2007-06-29
CZ20011233A3 (cs) 2001-09-12
TW576742B (en) 2004-02-21
US6627221B2 (en) 2003-09-30
US6294196B1 (en) 2001-09-25
CZ299008B6 (cs) 2008-04-02
NO20011714L (no) 2001-04-05
WO2000021540A1 (fr) 2000-04-20
AU6467599A (en) 2000-05-01
JP2002527398A (ja) 2002-08-27
ATE311887T1 (de) 2005-12-15

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