MA27123A1 - Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer - Google Patents

Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer

Info

Publication number
MA27123A1
MA27123A1 MA25808A MA25808A MA27123A1 MA 27123 A1 MA27123 A1 MA 27123A1 MA 25808 A MA25808 A MA 25808A MA 25808 A MA25808 A MA 25808A MA 27123 A1 MA27123 A1 MA 27123A1
Authority
MA
Morocco
Prior art keywords
administration
lubricant
salt
acid
preparing
Prior art date
Application number
MA25808A
Other languages
English (en)
Inventor
Gabel Rolf-Dieter
Woog Heinrich
Preis Walter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8232769&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27123(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA27123A1 publication Critical patent/MA27123A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

FORME SOLIDE D'ADMINISTRATION D'ACIDE DIPHOSPHONIQUE OU DE SEL DE CELUI-CI, UTILISANT L'ACIDE STÉARIQUE COMME LUBRIFIANT, ET PROCÉDÉ POUR LA PRÉPARER F. HOFFMANN-LA ROCHE AG L'invention a trait à une forme pharmaceutique solide d'administration contenant un acide diphosphonique ou un sel de celui-ci compatible sur le plan physioloqique en tant que principe actif, dans laquelle le principe actif est présent sous forme de granulé, éventuellement conjointement avec des adjuvants pharmaceutiques, dans la phase interne, et la phase externe contient un lubrifiant sous la forme de moins de 5% en poids d'acide stéarique par rapport au poids total de la forme d'administration.
MA25808A 1998-10-09 1999-10-06 Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer MA27123A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98119102A EP0998932A1 (fr) 1998-10-09 1998-10-09 Forme d'administration pharmaceutique contenant des diphosphonates ou leurs sels et méthode pour la fabriquer

Publications (1)

Publication Number Publication Date
MA27123A1 true MA27123A1 (fr) 2005-01-03

Family

ID=8232769

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25808A MA27123A1 (fr) 1998-10-09 1999-10-06 Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer

Country Status (35)

Country Link
US (2) US6294196B1 (fr)
EP (2) EP0998932A1 (fr)
JP (2) JP4471498B2 (fr)
KR (1) KR100522505B1 (fr)
CN (1) CN1150000C (fr)
AR (3) AR014081A1 (fr)
AT (1) ATE311887T1 (fr)
AU (1) AU752532B2 (fr)
BR (1) BR9914367A (fr)
CA (1) CA2346662C (fr)
CO (1) CO5050325A1 (fr)
CY (1) CY1105437T1 (fr)
CZ (1) CZ299008B6 (fr)
DE (1) DE69928819T2 (fr)
DK (1) DK1117412T3 (fr)
ES (1) ES2253919T3 (fr)
HK (1) HK1040914B (fr)
HR (1) HRP20010243B1 (fr)
HU (1) HU226457B1 (fr)
ID (1) ID29876A (fr)
IL (3) IL141912A0 (fr)
MA (1) MA27123A1 (fr)
ME (1) ME00637B (fr)
MY (1) MY126625A (fr)
NO (1) NO327447B1 (fr)
NZ (1) NZ510433A (fr)
PE (1) PE20001082A1 (fr)
PL (1) PL194552B1 (fr)
RS (1) RS49809B (fr)
RU (1) RU2207860C2 (fr)
SI (1) SI1117412T1 (fr)
TR (1) TR200100889T2 (fr)
TW (1) TW576742B (fr)
WO (1) WO2000021540A1 (fr)
ZA (1) ZA200102276B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL125336A0 (en) 1998-07-14 1999-03-12 Yissum Res Dev Co Compositions for inhibition and treatment of restinosis
US6984400B2 (en) 1998-07-14 2006-01-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating restenosis using bisphosphonate nanoparticles
US7008645B2 (en) 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
EP0998932A1 (fr) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Forme d'administration pharmaceutique contenant des diphosphonates ou leurs sels et méthode pour la fabriquer
HUP0402267A3 (en) * 2001-12-21 2007-05-29 Procter & Gamble Method for treatment of bone disorders
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
NZ552514A (en) * 2001-12-24 2008-08-29 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
KR20140021045A (ko) * 2002-05-10 2014-02-19 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
NZ536273A (en) * 2002-12-20 2007-08-31 Hoffmann La Roche High dose ibandronate formulation
AU2006222690B2 (en) * 2002-12-20 2009-04-23 F. Hoffmann-La Roche Ag High dose ibandronate formulation
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
JPWO2005072746A1 (ja) * 2004-01-30 2007-10-11 アステラス製薬株式会社 Ｐ２ｘ受容体阻害剤
DE602005025977D1 (de) * 2004-08-23 2011-03-03 Teva Pharma Kristalline form des ibandronat-natriums und herstellungsverfahren dafür
US7687482B2 (en) * 2006-03-17 2010-03-30 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
EP1802641B8 (fr) * 2004-10-08 2012-03-07 The Board Of Trustees Of The University Of Illinois Composes de bisphosphonate et methodes de traitement de maladies de resorption osseuse, de cancers, de douleurs osseuses, de troubles immunitaires et de maladies infectieuses
US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
KR100908529B1 (ko) * 2005-02-01 2009-07-20 에프. 호프만-라 로슈 아게 이반드로네이트 다형체 에이
JP5828607B2 (ja) * 2005-02-01 2015-12-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ イバンドロネート多形ｂ
US20070049557A1 (en) * 2005-08-24 2007-03-01 Hashim Ahmed Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
US20070191315A1 (en) * 2006-02-16 2007-08-16 Bengt Bergstrom Method for administering ibandronate
GB0616794D0 (en) 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
US20080139514A1 (en) * 2006-11-29 2008-06-12 Subhash Pandurang Gore Diphosphonic acid pharmaceutical compositions
CA2570949A1 (fr) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Solvate d'ibandronate sodique et de propyleneglycol et methodes de preparation connexes
US20100120723A1 (en) * 2006-12-20 2010-05-13 Mostafa Akbarieh Pharmaceutical composition comprising a hot-melt granulated lubricant
ES2623328T3 (es) * 2009-09-18 2017-07-11 Sitec Pharmabio Sl Procedimiento para la deshidratación de productos en polvo
KR101244414B1 (ko) * 2010-11-05 2013-03-18 주식회사 바이오파마티스 고함량 이반드론산 함유 골다공증 예방 또는 치료용 조성물 및 이의 제조방법
EP2661262B1 (fr) 2011-01-06 2017-11-15 Mahmut Bilgic Formulations améliorées de bisphosphonates
JP5874545B2 (ja) * 2011-06-20 2016-03-02 アステラス製薬株式会社 経口投与用医薬組成物
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture

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US4639338A (en) 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
US4798725A (en) 1986-06-16 1989-01-17 Norwich Eaton Pharmaceuticals, Inc. Sustained release capsule
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE10199052I1 (de) 1986-11-21 2002-01-10 Novartis Ag Neue substituierte Alkandiphosphonsaeuren
DE3767998D1 (de) * 1986-12-20 1991-03-14 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
FR2629716B1 (fr) 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
AU661080B2 (en) 1991-11-22 1995-07-13 Warner Chilcott Company, Llc Risedronate delayed-release compositions
AU1193092A (en) 1992-01-10 1993-08-03 Obschestvo S Ogranichennoi Otvetstvennostju Meditsinsky Nauchno-Proizvodstvenny Komplex Biotiki Granulated pharmaceutical composition and method of obtaining it
SE501389C2 (sv) 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
DE4228552A1 (de) 1992-08-27 1994-03-03 Boehringer Mannheim Gmbh Diphosphonsäuren und deren Salze enthaltende Arzneimittel
US5358941A (en) 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
BR9307859A (pt) 1993-05-15 1996-01-09 Boehringer Mannheim Gmbh Comprimido com biodisponibilidade aperfeiçoada que contérn ácido
TW390813B (en) 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US5656288A (en) * 1995-06-08 1997-08-12 Sanofi Winthrop, Inc. Stable pharmaceutical compositions containing tiludronate hydrates and process for producing the pharmaceutical compositions
IL120265A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis - polyphosphonates or progestins and estrogen agonists
DE19615812A1 (de) 1996-04-20 1997-10-23 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
EP0998932A1 (fr) * 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Forme d'administration pharmaceutique contenant des diphosphonates ou leurs sels et méthode pour la fabriquer
EP0998933A1 (fr) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Procédé pour la préparation de compositions pharmaucetiques contenant des diphosphonates pour administration orale

Also Published As

Publication number Publication date
KR100522505B1 (ko) 2005-10-18
AU752532B2 (en) 2002-09-19
IL141912A (en) 2006-12-10
RU2207860C2 (ru) 2003-07-10
MY126625A (en) 2006-10-31
AR047815A2 (es) 2006-02-22
AR069942A2 (es) 2010-03-03
ATE311887T1 (de) 2005-12-15
WO2000021540A1 (fr) 2000-04-20
CO5050325A1 (es) 2001-06-27
PE20001082A1 (es) 2000-10-18
CZ20011233A3 (cs) 2001-09-12
PL347243A1 (en) 2002-03-25
EP1117412B1 (fr) 2005-12-07
ME00637B (fr) 2008-08-07
JP4471498B2 (ja) 2010-06-02
US20020006441A1 (en) 2002-01-17
CZ299008B6 (cs) 2008-04-02
HUP0103931A3 (en) 2003-01-28
EP1117412A1 (fr) 2001-07-25
HU226457B1 (en) 2008-12-29
NO20011714D0 (no) 2001-04-05
CN1319015A (zh) 2001-10-24
ES2253919T3 (es) 2006-06-01
NO327447B1 (no) 2009-06-29
DK1117412T3 (da) 2006-04-03
TW576742B (en) 2004-02-21
DE69928819D1 (de) 2006-01-12
HUP0103931A2 (en) 2002-06-29
US6627221B2 (en) 2003-09-30
HRP20010243A2 (en) 2002-04-30
HK1040914B (zh) 2004-12-10
HRP20010243B1 (hr) 2011-02-28
CN1150000C (zh) 2004-05-19
EP0998932A1 (fr) 2000-05-10
CA2346662C (fr) 2006-05-09
KR20010073203A (ko) 2001-07-31
ID29876A (id) 2001-10-18
ZA200102276B (en) 2002-06-19
NO20011714L (no) 2001-04-05
RS49809B (sr) 2008-08-07
AU6467599A (en) 2000-05-01
HK1040914A1 (en) 2002-06-28
AR014081A1 (es) 2001-01-31
SI1117412T1 (sl) 2006-04-30
IL177940A (en) 2012-05-31
IL141912A0 (en) 2002-03-10
BR9914367A (pt) 2001-06-26
YU20501A (sh) 2003-02-28
PL194552B1 (pl) 2007-06-29
DE69928819T2 (de) 2006-07-20
JP2002527398A (ja) 2002-08-27
TR200100889T2 (tr) 2001-07-23
CA2346662A1 (fr) 2000-04-20
US6294196B1 (en) 2001-09-25
IL177940A0 (en) 2006-12-31
JP2010116408A (ja) 2010-05-27
CY1105437T1 (el) 2010-04-28
NZ510433A (en) 2003-08-29

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