MA27144A1 - Benzamide et heteroarylamide servant d'antagonistes du recepteur p2x7 - Google Patents

Benzamide et heteroarylamide servant d'antagonistes du recepteur p2x7

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Publication number
MA27144A1
MA27144A1 MA27660A MA27660A MA27144A1 MA 27144 A1 MA27144 A1 MA 27144A1 MA 27660 A MA27660 A MA 27660A MA 27660 A MA27660 A MA 27660A MA 27144 A1 MA27144 A1 MA 27144A1
Authority
MA
Morocco
Prior art keywords
heteroarylamide
benzamide
preparation
present
inhibitors
Prior art date
Application number
MA27660A
Other languages
English (en)
Inventor
Allen Jacob Duplantier
Chakrapani Subramanyam
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA27144A1 publication Critical patent/MA27144A1/fr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
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Abstract

DEPOSANT Société dite: PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 12 Novembre 2001 60/336,781 Voir en annexe le titre de l'invention et le texte de l'abrégé Benzamide et heteroarylamide servant d'antagonistes du récepteur P2X7 La présente invention concerne des inhibiteurs de P2X7 nouveaux répondant à la formule (I) et des procédés pour leur préparation, des intermédiaires utiles dans leur préparation, des compositions pharmaceutiques les contenant, et leur utilisation en thérapeutique. Les composés actifs de la présente invention sont de puissants inhibiteurs de P2X7 et, en tant que tels, sont utiles dans le traitement de l'inflammation, de l'ostéoarthrite, de la polyarthrite rhumatoïde, du cancer, d'une lésion de reperfusion ou ischémie dans le cas d'un ictus ou d'une attaque cardiaque, de maladies auto-immunes et d'autres affections.
MA27660A 2001-11-12 2004-04-28 Benzamide et heteroarylamide servant d'antagonistes du recepteur p2x7 MA27144A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33678101P 2001-11-12 2001-11-12

Publications (1)

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MA27144A1 true MA27144A1 (fr) 2005-01-03

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Family Applications (1)

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MA27660A MA27144A1 (fr) 2001-11-12 2004-04-28 Benzamide et heteroarylamide servant d'antagonistes du recepteur p2x7

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US (2) US7214677B2 (fr)
EP (1) EP1448535B1 (fr)
JP (1) JP4365218B2 (fr)
KR (1) KR20050043785A (fr)
CN (1) CN1585755A (fr)
AP (1) AP2004003028A0 (fr)
AR (1) AR038365A1 (fr)
AT (1) ATE502020T1 (fr)
BR (1) BR0214044A (fr)
CA (1) CA2466724C (fr)
CY (1) CY1111405T1 (fr)
DE (1) DE60239485D1 (fr)
DK (1) DK1448535T3 (fr)
EA (1) EA200400488A1 (fr)
EC (1) ECSP045097A (fr)
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Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8557501A1 (es) * 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
AU2003288640A1 (en) * 2002-12-31 2004-07-22 Pfizer Products Inc. Benzamide inhibitors of the p2x7 receptor
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
US7071223B1 (en) * 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
SE0300480D0 (sv) 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
PL1469072T3 (pl) * 2003-04-17 2008-03-31 Affectis Pharmaceuticals Ag Środki i sposoby diagnozowania i leczenia chorób afektywnych
EP1626962B1 (fr) 2003-05-12 2007-02-28 Pfizer Products Inc. Inhibiteurs benzamidiques du recepteur p2x7
EP1837330B1 (fr) * 2003-05-12 2012-10-24 Pfizer Products Inc. Inhibiteurs benzamidiques du recepteur P2X7
EP1644042A1 (fr) * 2003-05-29 2006-04-12 AstraZeneca AB Composition pharmaceutique comprenant un antagoniste au recepteur p2x7 et du metotrexate
GB0312321D0 (en) * 2003-05-29 2003-07-02 Astrazeneca Ab New combination
WO2004105797A1 (fr) * 2003-05-29 2004-12-09 Astrazeneca Ab Nouvelle combinaison
MXPA05012705A (es) * 2003-05-29 2006-02-08 Astrazeneca Ab Una composicion farmaceutica que comprende un antagonista del receptor p2x7 y un factor alfa de necrosis tumoral.
WO2005015924A1 (fr) * 2003-07-11 2005-02-17 Thomson Licensing Structure de microcellules de recouvrement pour reseau de systeme universel de telecommunication mobile
WO2005019182A1 (fr) * 2003-08-20 2005-03-03 Bayer Healthcare Ag Derives de pyrazolylmethylbenzamide utilises comme antagonistes du recepteur p2xt
SE0302488D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab New combination
US7598412B2 (en) * 2003-10-08 2009-10-06 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
ITMI20040255A1 (it) * 2004-02-17 2004-05-17 Univ Degli Studi Milano Sostanze ad attivita' antiangiogenica
BRPI0512915A (pt) * 2004-06-29 2008-04-15 Warner Lambert Co terapias de combinação utilizando inibidores benzamida do receptor p2x7
CN1980902A (zh) * 2004-06-29 2007-06-13 辉瑞产品有限公司 通过对羟基保护前体去保护而制备5－4－(2－羟基－丙基)－3，5－二氧代－4，5－二氢－3h－[1，2，4]三嗪－2－基－苯甲酰胺衍生物的方法
CA2572118A1 (fr) * 2004-06-29 2006-01-12 Pfizer Products Inc. Procede de preparation de derives de 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3h-`1,2,4-triazin-2-yl-benzamide aant une activite inhibant p2x7 par reaction du derive non substitue en position 4 de triazine avec un oxyrane en presence d'un acide de lewis
WO2006083214A1 (fr) * 2005-02-02 2006-08-10 Astrazeneca Ab Composition pharmaceutique comprenant un antagoniste du recepteur p2x7 et un inhibiteur de hmg-coa reductase
US20090018121A1 (en) * 2005-03-29 2009-01-15 Kowa Co., Ltd. Preventive and/or therapeutic agent for rheumatoid arthritis
WO2007008157A1 (fr) * 2005-07-11 2007-01-18 Astrazeneca Ab Nouvelle combinaison 2
US20080207577A1 (en) * 2005-07-11 2008-08-28 Astrazeneca Ab Combination I
PT2404919E (pt) 2005-11-08 2013-10-22 Vertex Pharma Composto heterocíclico útil como um modulador de transportadores de cassete de ligação a atp
US20070117497A1 (en) * 2005-11-22 2007-05-24 Cabot Microelectronics Corporation Friction reducing aid for CMP
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
ES2596706T3 (es) * 2006-06-29 2017-01-11 F. Hoffmann-La Roche Ag Arilamidas con sustitución de tetrazol
US8828966B2 (en) * 2006-10-03 2014-09-09 Claire Mitchell Method for treatment of macular degeneration by modulating P2Y12 or P2X7 receptors
DE102006049618A1 (de) * 2006-10-20 2008-05-08 Tschesche, Harald, Prof. Dr. Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
EP2164840A2 (fr) 2007-05-09 2010-03-24 Vertex Pharmaceuticals Incorporated Modulateurs de cftr
NZ601866A (en) 2007-06-29 2013-12-20 Acucela Inc Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
CN101711245B (zh) 2007-07-19 2015-03-25 H.隆德贝克有限公司 5元杂环酰胺及相关的化合物
MX2010003667A (es) 2007-10-05 2010-09-28 Acucela Inc Compuestos alcoxi para el tratamiento de enfermedades.
WO2009053459A1 (fr) 2007-10-26 2009-04-30 Glaxo Group Limited Dérivés de 4-benzoyl-1-substitué-pipérazin-2-one comme modulateurs de p2x7
AR070950A1 (es) * 2007-11-01 2010-05-19 Acucela Inc Compuestos derivados de amina, composiciones farmaceuticas de ellos, compuestos inhibidores de produccion de 11-cis-retinol y metodos para tratar enfermedades y trastornos oftalmicos
HUE049642T2 (hu) 2007-12-07 2020-09-28 Vertex Pharma 3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)-ciklopropánkarboxamido)-3-metilpiridin-2-il)-benzoesav szilárd formái
CA2989620C (fr) 2007-12-07 2022-05-03 Vertex Pharmaceuticals Incorporated Procedes de fabrication d'acides cycloalkylcarboxamido-pyridine benzoiques
GB0724625D0 (en) * 2007-12-18 2008-01-30 Glaxo Group Ltd Novel compounds
CA2716109C (fr) 2008-02-28 2016-07-19 Vertex Pharmaceuticals Incorporated Derives heteroaryles convenant comme modulateurs du cftr
AU2009228649B2 (en) 2008-03-25 2014-05-22 Affectis Pharmaceuticals Ag Novel P2X7R antagonists and their use
KR101395952B1 (ko) * 2008-09-05 2014-05-21 어큐셀라 인코포레이티드 안과 질환 및 장애 치료를 위한 황-연결 화합물
BRPI0919920A2 (pt) * 2008-10-22 2016-02-16 Acucela Inc compostos para tratamento de doenças e desordens oftálmicas
DK2243772T3 (da) 2009-04-14 2012-02-13 Affectis Pharmaceuticals Ag Hidtil ukendte P2X7R-antagonister og deres anvendelse
ES2897527T3 (es) 2009-07-02 2022-03-01 Acucela Inc Farmacología de moduladores del ciclo visual
EP2322149A1 (fr) 2009-11-03 2011-05-18 Universidad del Pais Vasco Procédés et compositions de traitement de l'ischémie
JP2013516480A (ja) 2010-01-07 2013-05-13 セレクサゲン セラピューティクス，インク． ヘッジホッグ阻害剤
WO2011085261A1 (fr) * 2010-01-08 2011-07-14 Selexagen Therapeutics, Inc. Inhibiteurs de hedgehog
WO2011109833A2 (fr) 2010-03-05 2011-09-09 President And Fellows Of Harvard College Compositions de cellules dendritiques induites et utilisations associées
ES2900353T3 (es) 2010-04-07 2022-03-16 Vertex Pharma Composiciones farmacéuticas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiriidin-2-il)benzoico y administración de las mismas
EP2386541A1 (fr) 2010-05-14 2011-11-16 Affectis Pharmaceuticals AG Nouveaux procédés de préparation d'antagonistes de P2X7R
WO2012110190A1 (fr) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Nouveaux antagonistes p2x7r et leur utilisation
US20140073651A1 (en) 2011-02-22 2014-03-13 Actelion Pharmaceuticals Ltd. Benzamide derivatives as p2x7 receptor antagonists
WO2012163792A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
WO2012163456A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
MX2014000894A (es) 2011-07-22 2014-02-27 Actelion Pharmaceuticals Ltd Derivados de amidas heterociclicas como antagonistas de receptores p2x7.
US9707235B1 (en) 2012-01-13 2017-07-18 University Of Kentucky Research Foundation Protection of cells from degeneration and treatment of geographic atrophy
TWI576347B (zh) 2012-01-20 2017-04-01 艾克泰聯製藥有限公司 作為ｐ２ｘ受體拮抗劑之雜環醯胺衍生物
NZ727015A (en) 2012-01-25 2017-12-22 Vertex Pharma Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
TWI598325B (zh) * 2012-10-12 2017-09-11 Ｈ 朗德貝克公司 苯甲醯胺類
TW201427947A (zh) 2012-10-12 2014-07-16 Lundbeck & Co As H 環狀胺
KR102232742B1 (ko) 2012-12-12 2021-03-26 이도르시아 파마슈티컬스 리미티드 Ｐ２ｘ７ 수용체 길항제로서의 인돌 카르복사미드 유도체
WO2014097140A1 (fr) 2012-12-18 2014-06-26 Actelion Pharmaceuticals Ltd Dérivés d'indole carboxamide utilisés en tant qu'antagonistes du récepteur p2x7
JP6282016B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
JP6282017B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
BR112016000241B1 (pt) 2013-07-08 2021-06-22 Bayer Cropscience Aktiengesellschaft Compostos pesticidas derivados de sulfeto de arila e sulfóxido de arila, formulação, seus usos, método para controle de pragas e método de proteção de semente ou planta
CA2930199C (fr) 2013-11-12 2022-10-25 Vertex Pharmaceuticals Incorporated Procede de preparation de compositions pharmaceutiques pour le traitement de maladies a mediation assuree par le cftr
US9988373B2 (en) 2013-12-26 2018-06-05 Shionogi & Co., Ltd. Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same
HUE055423T2 (hu) 2014-11-18 2021-11-29 Vertex Pharma Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére
JP6358639B2 (ja) 2015-04-24 2018-07-18 塩野義製薬株式会社 ６員複素環誘導体およびそれらを含有する医薬組成物
EP3527568A4 (fr) 2016-10-17 2020-03-18 Shionogi & Co., Ltd Dérivé hétérocyclique azoté bicyclique et composition pharmaceutique le comprenant
CN106674098B (zh) * 2016-12-23 2019-07-02 中国医科大学 N-(3-氰基-4-烷氧基苯基)吡啶甲酰胺类化合物及其用途
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用
WO2026041663A1 (fr) 2024-08-22 2026-02-26 Breye Therapeutics Aps Antagonistes du récepteur p2x7

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US71529A (en) * 1867-11-26 John e
US142194A (en) * 1873-08-26 William w
US71509A (en) * 1867-11-26 mcclellan
US144170A (en) * 1873-10-28 Improvement in scarf-clasps
US158883A (en) * 1875-01-19 Improvement in wax-thread sewing-machines
US77018A (en) * 1868-04-21 Improvement in dove-tail mabkers
US123378A (en) * 1872-02-06 Improvement in time-locks
US128498A (en) * 1872-07-02 Improvement in tile-molds
US74576A (en) * 1868-02-18 Adam myers
US146200A (en) * 1874-01-06 Improvement in wind-wheels
US144213A (en) * 1873-11-04 Improvement in faucets
AU542544B2 (en) * 1980-03-12 1985-02-28 Nippon Kayaku Kabushiki Kaisha Tetrahydrophthalimide derivatives
EP0077938A3 (fr) * 1981-10-23 1983-08-24 Mitsubishi Kasei Corporation Tétrahydrophtalimides N-(3-substituées aminophényl) et compositions herbicides les contenant
US4766233A (en) * 1984-06-12 1988-08-23 Fmc Corporation Herbicidal 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones and sulfur analogs thereof
EP0185731A4 (fr) * 1984-06-12 1988-11-02 Fmc Corp 2-aryl-1,2,4-triazine-3,5(2h,4h)-diones herbicides et leurs analogues sulfures.
BR8807217A (pt) * 1987-09-23 1989-10-17 Hoffmann La Roche Compostos heterocilicos
US5128351A (en) * 1990-05-04 1992-07-07 American Cyanamid Company Bis-aryl amide and urea antagonists of platelet activating factor
US5077409A (en) * 1990-05-04 1991-12-31 American Cyanamid Company Method of preparing bis-aryl amide and urea antagonists of platelet activating factor
JP3089621B2 (ja) * 1990-12-17 2000-09-18 日産化学工業株式会社 ウラシル誘導体
KR930703259A (ko) 1990-12-17 1993-11-29 알베르투스 빌헬무스 요아네스 쩨스트라텐 살균성 이소퀴놀린 유도체
GB9110679D0 (en) * 1991-05-17 1991-07-10 Sandoz Ltd Improvements in or relating to organic compounds
GB9119467D0 (en) 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
US5691376A (en) 1994-02-17 1997-11-25 American Home Products Corporation Substituted biphenyl derivatives
DE4405614A1 (de) * 1994-02-22 1995-08-24 Bayer Ag Substituierte Triazolinone
US5686061A (en) 1994-04-11 1997-11-11 The Board Of Regents Of The University Of Texas System Particulate contrast media derived from non-ionic water soluble contrast agents for CT enhancement of hepatic tumors
GB9412603D0 (en) * 1994-06-23 1994-08-10 Sandoz Ltd Organic compounds
JP3144624B2 (ja) 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
JP3906935B2 (ja) 1995-12-18 2007-04-18 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
AU1335897A (en) 1995-12-21 1997-07-17 Du Pont Merck Pharmaceutical Company, The Isoxazoline, isothiazoline and pyrazoline factor xa inhibitors
DE69706407T2 (de) * 1996-03-29 2002-05-29 G.D. Searle & Co., Chicago META-SUBSTITUIERTE PHENYLENDERIVATE UND IHRE VERWENDUNG ALS ALPHAvBETA3 INTERGRIN-ANTAGONISTEN ODER INHIBITOREN
CA2275796A1 (fr) 1996-12-23 1998-07-02 Donald Joseph Phillip Pinto Composes heteroaromatiques contenant de l'azote, utilises en tant qu'inhibiteurs du facteur xa
US6187797B1 (en) * 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
DE19701287A1 (de) * 1997-01-16 1998-07-23 Wernicke & Co Gmbh Verfahren zum Erhöhen der Gebrauchsdauer von Schleifscheiben
EP1019375A1 (fr) 1997-03-25 2000-07-19 Astra Pharmaceuticals Limited Nouveaux derives de pyridine et compositions pharmaceutiques les renfermant
WO1998043973A1 (fr) 1997-03-27 1998-10-08 Novartis Ag Produits intermediaires et procede pour preparer des derives de pyrimidine
DE19719621A1 (de) 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
SE9704272D0 (sv) * 1997-11-21 1997-11-21 Astra Pharma Prod Novel Compounds
SE9704545D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704544D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704546D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
JPH11318492A (ja) * 1998-03-09 1999-11-24 Aisin Seiki Co Ltd 蛍光発生性基質を含有する組成物
US6320078B1 (en) 1998-07-24 2001-11-20 Mitsui Chemicals, Inc. Method of producing benzamide derivatives
FR2783519B1 (fr) 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
DE19851184A1 (de) 1998-11-06 2000-05-11 Aventis Pharma Gmbh N-Arylsulfonyl-aminosäure-omega-amide
CN1334801A (zh) 1998-12-16 2002-02-06 拜尔公司 作为整联蛋白拮抗剂的新的联苯基和类似联苯基的化合物
TR200102911T2 (tr) * 1999-04-09 2002-01-21 Astrazeneca Ab Adamantan türevleri.
AU5158100A (en) 1999-05-24 2000-12-12 Cor Therapeutics, Inc. Inhibitors of factor xa
SE9901875D0 (sv) * 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
EP1088821A1 (fr) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Derives des sulfamides pharmaceutiquement actifs
CA2387846A1 (fr) 1999-10-18 2001-04-26 University Of Connecticut Retro-anandamides, ligands des recepteurs des cannabinoides presentant une affinite et une stabilite elevees
SE9904505D0 (sv) * 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
SE9904738D0 (sv) 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
DE10005284A1 (de) 2000-02-07 2001-08-09 Bayer Ag Verfahren zur Herstellung von 1-Amino-3-aryl-uracilen
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
WO2003042190A1 (fr) * 2001-11-12 2003-05-22 Pfizer Products Inc. Derives de n-adamantylalkyle benzamide en tant qu'antagonistes du recepteur p2x7
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
EP1626962B1 (fr) * 2003-05-12 2007-02-28 Pfizer Products Inc. Inhibiteurs benzamidiques du recepteur p2x7
CA2572118A1 (fr) 2004-06-29 2006-01-12 Pfizer Products Inc. Procede de preparation de derives de 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3h-`1,2,4-triazin-2-yl-benzamide aant une activite inhibant p2x7 par reaction du derive non substitue en position 4 de triazine avec un oxyrane en presence d'un acide de lewis
BRPI0512915A (pt) * 2004-06-29 2008-04-15 Warner Lambert Co terapias de combinação utilizando inibidores benzamida do receptor p2x7
CN1980902A (zh) 2004-06-29 2007-06-13 辉瑞产品有限公司 通过对羟基保护前体去保护而制备5－4－(2－羟基－丙基)－3，5－二氧代－4，5－二氢－3h－[1，2，4]三嗪－2－基－苯甲酰胺衍生物的方法

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