MA27334A1 - Utilisation d'inhibiteurs de l'ikb kinase dans le traitement de la douleur - Google Patents

Utilisation d'inhibiteurs de l'ikb kinase dans le traitement de la douleur

Info

Publication number
MA27334A1
MA27334A1 MA28107A MA28107A MA27334A1 MA 27334 A1 MA27334 A1 MA 27334A1 MA 28107 A MA28107 A MA 28107A MA 28107 A MA28107 A MA 28107A MA 27334 A1 MA27334 A1 MA 27334A1
Authority
MA
Morocco
Prior art keywords
pain
treatment
kinase inhibitors
ikb kinase
ikb
Prior art date
Application number
MA28107A
Other languages
English (en)
Inventor
Martin Michaelis
Olaf Ritzeler
Gerhard Jaehne
Karl Rudolphi
Gerd Geisslinger
Hans-Georg Schaible
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of MA27334A1 publication Critical patent/MA27334A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Paper (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne l'utilisation d'inhibiteurs de l'IkB kinase pour produire des médicaments servant au traitement des douleurs. Les inhibiteurs appropriés proviennent des composés de formules (I) et (Ia).
MA28107A 2002-08-17 2005-02-15 Utilisation d'inhibiteurs de l'ikb kinase dans le traitement de la douleur MA27334A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10237723A DE10237723A1 (de) 2002-08-17 2002-08-17 Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie

Publications (1)

Publication Number Publication Date
MA27334A1 true MA27334A1 (fr) 2005-05-02

Family

ID=31968975

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28107A MA27334A1 (fr) 2002-08-17 2005-02-15 Utilisation d'inhibiteurs de l'ikb kinase dans le traitement de la douleur

Country Status (33)

Country Link
EP (1) EP1531819B1 (fr)
JP (1) JP4504811B2 (fr)
KR (2) KR101119845B1 (fr)
CN (1) CN100398107C (fr)
AR (1) AR043045A1 (fr)
AT (1) ATE418336T1 (fr)
AU (1) AU2003271555B2 (fr)
BR (1) BR0313555A (fr)
CA (1) CA2495455C (fr)
CO (1) CO5690585A2 (fr)
CR (1) CR7716A (fr)
CY (1) CY1108874T1 (fr)
DE (2) DE10237723A1 (fr)
DK (1) DK1531819T3 (fr)
EC (1) ECSP055609A (fr)
ES (1) ES2320118T3 (fr)
HR (1) HRP20050041B1 (fr)
IL (1) IL166780A (fr)
MA (1) MA27334A1 (fr)
MX (1) MXPA05001218A (fr)
MY (1) MY138059A (fr)
NO (1) NO334309B1 (fr)
OA (1) OA12907A (fr)
PL (1) PL212356B1 (fr)
PT (1) PT1531819E (fr)
RS (1) RS51878B (fr)
RU (1) RU2320338C2 (fr)
SI (1) SI1531819T1 (fr)
TN (1) TNSN05044A1 (fr)
TW (1) TWI325782B (fr)
UA (1) UA80837C2 (fr)
WO (1) WO2004022057A1 (fr)
ZA (1) ZA200500323B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
DE10237722A1 (de) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019831A1 (fr) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Procedes pour le traitement de l'hepatite c
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019832A1 (fr) 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines utilisees pour traiter l'hepatite c
DE102005025225A1 (de) 2005-06-01 2006-12-07 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
EP2582709B1 (fr) 2010-06-18 2018-01-24 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
JP5790440B2 (ja) 2010-12-01 2015-10-07 住友化学株式会社 ピリミジン化合物およびその有害生物防除用途
EP2766349B1 (fr) 2011-03-08 2016-06-01 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
EP2683704B1 (fr) 2011-03-08 2014-12-17 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
EP2683699B1 (fr) 2011-03-08 2015-06-24 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
EP2532755A1 (fr) * 2011-06-10 2012-12-12 Sanofi-Aventis Procédés et utilisations basés sur l'expression de Slfn2 et liés à l'identification et au profilage de composés pour une utilisation dans le traitement ou la prévention de la douleur
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
CA2856607C (fr) * 2011-12-06 2020-03-10 Sanofi Formes cristallines du [(s)-1-carbamoyl-2-(phenylpyrimidin-2-ylamino)ethyl]amide de l'acide 2-(2-methylaminopyrimidin-4-yl)-1h-indole-5-carboxylique
EP3184095A1 (fr) 2013-05-23 2017-06-28 IP Gesellschaft für Management mbH Unitées d'administration comprennante une polymorphe 1 de 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
JO3425B1 (ar) 2013-07-15 2019-10-20 Novartis Ag مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b
WO2016001197A1 (fr) * 2014-07-03 2016-01-07 Sanofi Acide 2-(2-méthylamino-pyrimidin-4-yl)-1 h-indole-5-carboxylique [(s)-1-carbamoyl-2-(phényl-pyrimidin-2-yl-amino)-éthyl]-amide utilisable dans le traitement de la douleur associée à l'arthrose
CN120118068A (zh) 2018-07-16 2025-06-10 诺华股份有限公司 用于制备苯基哌啶基吲哚衍生物的化学方法

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
DK1194425T3 (da) * 1999-06-23 2005-11-21 Aventis Pharma Gmbh Substituerede benzimidazoler
DE19951360A1 (de) * 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
DE10237722A1 (de) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase

Also Published As

Publication number Publication date
CR7716A (es) 2008-11-25
KR101119845B1 (ko) 2012-02-28
HK1079426A1 (en) 2006-04-07
RS51878B (sr) 2012-02-29
EP1531819B1 (fr) 2008-12-24
MXPA05001218A (es) 2005-05-16
IL166780A0 (en) 2006-01-15
PT1531819E (pt) 2009-02-18
CN100398107C (zh) 2008-07-02
ES2320118T3 (es) 2009-05-19
HRP20050041A2 (hr) 2006-04-30
CO5690585A2 (es) 2006-10-31
RU2005107419A (ru) 2005-08-10
MY138059A (en) 2009-04-30
AU2003271555B2 (en) 2009-03-26
SI1531819T1 (sl) 2009-06-30
ATE418336T1 (de) 2009-01-15
OA12907A (en) 2006-10-13
NO334309B1 (no) 2014-02-03
BR0313555A (pt) 2005-07-12
EP1531819A1 (fr) 2005-05-25
ECSP055609A (es) 2005-04-18
AR043045A1 (es) 2005-07-13
JP4504811B2 (ja) 2010-07-14
ZA200500323B (en) 2006-02-22
CY1108874T1 (el) 2014-07-02
RS20050070A (sr) 2007-06-04
AU2003271555A1 (en) 2004-03-29
RU2320338C2 (ru) 2008-03-27
DK1531819T3 (da) 2009-04-20
PL212356B1 (pl) 2012-09-28
CA2495455C (fr) 2011-01-11
PL373568A1 (en) 2005-09-05
KR20050058339A (ko) 2005-06-16
UA80837C2 (uk) 2007-11-12
HRP20050041B1 (hr) 2013-07-31
KR20110135428A (ko) 2011-12-16
WO2004022057A1 (fr) 2004-03-18
TW200417370A (en) 2004-09-16
CA2495455A1 (fr) 2004-03-18
CN1674899A (zh) 2005-09-28
TWI325782B (en) 2010-06-11
NO20051339L (no) 2005-05-03
DE50310980D1 (de) 2009-02-05
TNSN05044A1 (en) 2007-05-14
JP2005539053A (ja) 2005-12-22
IL166780A (en) 2011-11-30
DE10237723A1 (de) 2004-07-08

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