MA27860A1 - Derives de lincomycine nouveaux possedant une activite antimicrobienne - Google Patents

Derives de lincomycine nouveaux possedant une activite antimicrobienne

Info

Publication number
MA27860A1
MA27860A1 MA28672A MA28672A MA27860A1 MA 27860 A1 MA27860 A1 MA 27860A1 MA 28672 A MA28672 A MA 28672A MA 28672 A MA28672 A MA 28672A MA 27860 A1 MA27860 A1 MA 27860A1
Authority
MA
Morocco
Prior art keywords
new
lincomycin derivatives
antimicrobial activity
lincomycin
compounds
Prior art date
Application number
MA28672A
Other languages
English (en)
Inventor
Jason G Lewis
Sampath K Anandan
Hardwin O'dowd
Mikhail F Gordeev
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/642,807 external-priority patent/US7164011B2/en
Priority claimed from US10/777,455 external-priority patent/US7199105B2/en
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of MA27860A1 publication Critical patent/MA27860A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Dérivés de lincomycine nouveaux possédant une activité antimicrobienne Des dérivés de lincomycine nouveaux sont décrits. Ces dérivés de lincomycine présentent une activité antibactérienne. Les composés de la présente invention peuvent présenter de puissantes activités contre des bactéries, comprenant des organismes Gram-positifs, et peuvent être des agents antimicrobiens utiles. Des procédés de synthèse et méthodes d'utilisation des composés sont également décrits.
MA28672A 2003-06-17 2005-12-16 Derives de lincomycine nouveaux possedant une activite antimicrobienne MA27860A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47950203P 2003-06-17 2003-06-17
US47929603P 2003-06-17 2003-06-17
US10/642,807 US7164011B2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
US10/777,455 US7199105B2 (en) 2002-08-15 2004-02-11 Lincomycin derivatives possessing antibacterial activity

Publications (1)

Publication Number Publication Date
MA27860A1 true MA27860A1 (fr) 2006-04-03

Family

ID=40203032

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28672A MA27860A1 (fr) 2003-06-17 2005-12-16 Derives de lincomycine nouveaux possedant une activite antimicrobienne

Country Status (16)

Country Link
EP (1) EP1644393A2 (fr)
JP (1) JP2007516172A (fr)
KR (1) KR20060091050A (fr)
AU (1) AU2004261550A1 (fr)
BR (1) BRPI0411534A (fr)
CA (1) CA2528592A1 (fr)
EC (1) ECSP056233A (fr)
GE (1) GEP20084437B (fr)
IL (1) IL172183A0 (fr)
IS (1) IS8147A (fr)
MA (1) MA27860A1 (fr)
MX (1) MXPA05013915A (fr)
NO (1) NO20055893L (fr)
OA (1) OA13179A (fr)
RS (1) RS20050931A (fr)
WO (1) WO2005012320A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1529052A2 (fr) 2002-08-15 2005-05-11 Vicuron Pharmaceuticals, Inc. Derives de lincomycine presentant une activite antibacterienne
US7199105B2 (en) 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
EP1654268A2 (fr) * 2003-06-17 2006-05-10 Vicuron Pharmaceuticals, Inc. Derives de lincomycine a activite anti-bacterienne
US7361743B2 (en) 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
JP2009507793A (ja) * 2005-08-31 2009-02-26 ワイス グリシルサイクリンの９−アミノカルボニル置換誘導体
US7871982B2 (en) 2005-12-09 2011-01-18 Meiji Seika Kaisha, Ltd. Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient
US7879808B2 (en) 2007-05-31 2011-02-01 Meiji Seika Kaisha, Ltd. Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient
WO2008146919A1 (fr) 2007-05-31 2008-12-04 Meiji Seika Kaisha, Ltd. Dérivé de la lincosamide et agent antibactérien le comprenant en tant qu'ingrédient actif
US20130267699A1 (en) 2011-06-24 2013-10-10 California Institute Of Technology Quaternary heteroatom containing compounds
US8822679B2 (en) * 2011-06-24 2014-09-02 California Institute Of Technology Quaternary heteroatom containing compounds
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
CN107922373A (zh) 2015-03-27 2018-04-17 加利福尼亚技术学院 使用低催化剂浓度和稳定的预催化剂的不对称催化脱羧烷基烷基化
EP3426391A4 (fr) 2016-03-11 2019-08-28 California Institute of Technology Compositions et procédés d'acylation de lactames
EP3480190B1 (fr) 2017-11-01 2023-01-04 California Institute of Technology Procédés d'alkylation allylique énantiosélective d'esters, lactones et lactames avec des alcools allyliques inactivés
EP3699173A1 (fr) 2018-10-18 2020-08-26 California Institute of Technology Pyrrolidines, pipérazines et diazépanes disubstitués par gem, compositions et leurs procédés de fabrication
CN110357839A (zh) * 2019-08-29 2019-10-22 重庆经致制药技术开发有限公司 布瓦西坦手性中间体的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268556A (en) * 1964-04-13 1966-08-23 Upjohn Co Novel lincomycin derivatives
NL128232C (fr) * 1964-04-13
NL146501C (fr) * 1964-07-01
US3282917A (en) * 1964-08-17 1966-11-01 Upjohn Co Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor
NL140527B (nl) * 1965-02-08 1973-12-17 Upjohn Co Werkwijze ter bereiding van aan lincomycine verwante verbindingen.
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3555007A (en) * 1968-07-22 1971-01-12 Upjohn Co 7-deoxy-7-halo lincomycin d derivatives
US3549615A (en) * 1968-10-17 1970-12-22 Upjohn Co Lincomycin derivatives and process for producing the same
DE2118636A1 (de) * 1970-04-20 1971-11-04 The Upjohn Co., Kalamazoo, Mich. (V.StA.) 3-Nucleotide von Lincomycin und deren Analogen, Verfahren zu ihrer Herstellung und ihre Verwendung in therapeutischen Präparaten
US3787390A (en) * 1971-06-23 1974-01-22 Upjohn Co Analogs of lincomycin and process
US3849396A (en) * 1973-01-08 1974-11-19 Upjohn Co Lincomycin and clindamycin 1-o-ethers
US3923602A (en) * 1973-10-25 1975-12-02 Upjohn Co Composition of matter and process
JPS5641239A (en) * 1979-09-13 1981-04-17 Hitachi Cable Ltd Flame-retardant composition
US4278789A (en) * 1979-11-23 1981-07-14 The Upjohn Company Lincomycin compounds
EP1529052A2 (fr) * 2002-08-15 2005-05-11 Vicuron Pharmaceuticals, Inc. Derives de lincomycine presentant une activite antibacterienne
JP2007528360A (ja) * 2003-06-17 2007-10-11 ビキュロン・ファーマシューティカルズ・インコーポレイテッド 抗菌活性を有するリンコマイシン誘導体

Also Published As

Publication number Publication date
WO2005012320A3 (fr) 2005-10-20
WO2005012320A2 (fr) 2005-02-10
IL172183A0 (en) 2011-08-01
KR20060091050A (ko) 2006-08-17
BRPI0411534A (pt) 2006-08-22
JP2007516172A (ja) 2007-06-21
HK1090061A1 (zh) 2006-12-15
GEP20084437B (en) 2008-07-25
CA2528592A1 (fr) 2005-02-10
EP1644393A2 (fr) 2006-04-12
ECSP056233A (es) 2006-04-19
MXPA05013915A (es) 2006-07-03
OA13179A (en) 2006-12-13
NO20055893L (no) 2006-03-14
RS20050931A (sr) 2008-04-04
IS8147A (is) 2005-11-24
AU2004261550A1 (en) 2005-02-10

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