MA27880A1 - Derives de tetrahydrocarbazole et leur utilisation pharmaceutique - Google Patents

Derives de tetrahydrocarbazole et leur utilisation pharmaceutique

Info

Publication number
MA27880A1
MA27880A1 MA28646A MA28646A MA27880A1 MA 27880 A1 MA27880 A1 MA 27880A1 MA 28646 A MA28646 A MA 28646A MA 28646 A MA28646 A MA 28646A MA 27880 A1 MA27880 A1 MA 27880A1
Authority
MA
Morocco
Prior art keywords
pharmaceutical use
tetrahydrocarbazole derivatives
tetrahydrocarbazole
derivatives
compounds
Prior art date
Application number
MA28646A
Other languages
English (en)
Inventor
Sharon Davis Boggs
Kristjan S Gudmundsson
Leah D Aurora Richardson
Paul Richard Sebahar
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA27880A1 publication Critical patent/MA27880A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des nouveaux composés de formule (I) utiles dans le traitement de papillomavirus humains, ainsi que des méthodes de production et d'utilisation de ces composés
MA28646A 2003-06-10 2005-12-09 Derives de tetrahydrocarbazole et leur utilisation pharmaceutique MA27880A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47725103P 2003-06-10 2003-06-10
US49782303P 2003-08-26 2003-08-26

Publications (1)

Publication Number Publication Date
MA27880A1 true MA27880A1 (fr) 2006-05-02

Family

ID=33555453

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28646A MA27880A1 (fr) 2003-06-10 2005-12-09 Derives de tetrahydrocarbazole et leur utilisation pharmaceutique

Country Status (16)

Country Link
US (1) US7351733B2 (fr)
EP (1) EP1654228B1 (fr)
JP (1) JP2007501284A (fr)
KR (1) KR20060017545A (fr)
AT (1) ATE411981T1 (fr)
AU (1) AU2004247676A1 (fr)
BR (1) BRPI0411085A (fr)
CA (1) CA2528321A1 (fr)
CO (1) CO5660287A2 (fr)
DE (1) DE602004017326D1 (fr)
ES (1) ES2314446T3 (fr)
IL (1) IL171974A0 (fr)
MA (1) MA27880A1 (fr)
NO (1) NO20055741L (fr)
RU (1) RU2318810C2 (fr)
WO (1) WO2004110999A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2320663T3 (es) 2003-08-26 2009-05-27 Smithkline Beecham Corporation Nuevos indoles cicloalquil(b) condensados.
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
EA201200555A1 (ru) 2004-03-15 2013-01-30 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Производные карболина, полезные в ингибировании ангиогенеза
WO2006012310A2 (fr) * 2004-06-25 2006-02-02 Genzyme Corporation Derives de carbazole pour le traitement de la polykystose renale
EP1824476A2 (fr) * 2004-11-22 2007-08-29 SmithKline Beecham Corporation Derives de tetrahydrocarbazole pour le traitement des infections par les virus de la famille des flaviridae
JP2008520741A (ja) * 2004-11-23 2008-06-19 ピーティーシー セラピューティクス， インコーポレイテッド 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール
WO2007002051A1 (fr) * 2005-06-22 2007-01-04 Smithkline Beecham Corporation Derives de carboline et leur utilisation en tant qu'inhibiteurs d'infections a flaviridae
WO2013139929A1 (fr) * 2012-03-22 2013-09-26 Ludwig-Maximilians-Universität München Nouveaux moyens et méthodes pour le traitement de maladies du système nerveux central, de maladies cardiaques et métaboliques et du vieillissement
EP2887804B1 (fr) 2012-05-22 2021-01-27 Trustees of Dartmouth College Cycloalcanyl[b]indoles en tant que modulateurs de glp-1
EP2690091A1 (fr) 2012-07-25 2014-01-29 Studiengesellschaft Kohle mbH Procédé de préparation de dérivés d'indole substitués
KR101671484B1 (ko) 2016-07-21 2016-11-01 김정환 오셀타미비르(Oseltamivir)를 포함하는 인유두종 바이러스 치료용 약학적 조성물
US10882821B1 (en) 2017-09-26 2021-01-05 The Board Of Trustees Of The Leland Stanford Junior University Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes
WO2021183980A1 (fr) * 2020-03-13 2021-09-16 Fmc Corporation Pyrimidines et triazines substituées utilisées en tant qu'herbicides
CN113995758B (zh) * 2021-11-04 2023-06-02 中山大学 咔唑-嘧啶衍生物在制备治疗抗肿瘤药物中的应用
KR102907984B1 (ko) 2022-11-22 2026-01-06 이경엽 알칼로이드 함유 인유두종 바이러스 감염의 예방 또는 치료용 조성물
KR102907985B1 (ko) 2022-11-22 2026-01-06 이경엽 인유두종 바이러스 감염에 의한 후두유두종의 예방 또는 치료용 조성물
EP4725481A1 (fr) * 2024-10-10 2026-04-15 Leibniz-Institut für Virologie Dérivés de 1,2,3,4-tétrahydrocarbazole pour leur utilisation dans le traitement d'une infection adénovirale

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE507797C (de) * 1927-05-14 1930-09-20 I G Farbenindustrie Akt Ges Verfahren zur Herstellung von 1-Aminocarbazol und seinen Derivaten
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) * 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
US5100891A (en) 1991-01-18 1992-03-31 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
CA2106642C (fr) * 1992-10-14 2005-08-16 Peter Bod Derives de carbazolone et procede d'obtention
WO1997003473A1 (fr) * 1995-07-10 1997-01-30 International Business Machines Corporation Dispositif de boitier pour bloc batterie et bloc batterie
GB0015904D0 (en) * 2000-06-28 2000-08-23 Hoffmann La Roche Inhibitors of HPV E1 helicase enzyme
WO2003051837A2 (fr) * 2001-12-14 2003-06-26 Zentaris Gmbh Derives tetrahydrocarbazol servant de ligands de recepteurs couples aux proteines g (gpcr)
DE10164564B4 (de) * 2001-12-14 2007-05-16 Zentaris Gmbh Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)

Also Published As

Publication number Publication date
EP1654228A1 (fr) 2006-05-10
JP2007501284A (ja) 2007-01-25
CO5660287A2 (es) 2006-07-31
IL171974A0 (en) 2006-04-10
ATE411981T1 (de) 2008-11-15
AU2004247676A1 (en) 2004-12-23
NO20055741D0 (no) 2005-12-05
DE602004017326D1 (de) 2008-12-04
US7351733B2 (en) 2008-04-01
NO20055741L (no) 2006-01-06
KR20060017545A (ko) 2006-02-23
CA2528321A1 (fr) 2004-12-23
BRPI0411085A (pt) 2006-07-25
ES2314446T3 (es) 2009-03-16
WO2004110999A1 (fr) 2004-12-23
US20060161002A1 (en) 2006-07-20
RU2005138124A (ru) 2006-07-10
RU2318810C2 (ru) 2008-03-10
EP1654228B1 (fr) 2008-10-22

Similar Documents

Publication Publication Date Title
DK1654253T3 (da) Substituerede 3-pyrrolidinindolderivater
ATE451376T1 (de) Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
NO20055894L (no) Fremgangsmater og blandinger for behandling av amyloidrelatertere sykdommer
PT1206474E (pt) Compostos de sulfonilfenilpirazole uteis como inibidores de cox-2
EA200500169A1 (ru) Замещенные производные 1,3-дифенилпроп-2-ен-1-она, получение и применение
EA200900802A1 (ru) Способы и композиции для лечения амилоидных заболеваний
ATE433973T1 (de) Azolylaminoazine als inhibitoren von proteinkinasen
CY1110965T1 (el) Επιπροσθετες ετεροπολυκυκλικες ενωσεις και η χρηση τους ως ανταγωνιστες μεταβολοτροπικου υποδοχεα γλουταμικου
EA200602196A1 (ru) Производные пиразола, композиции, содержащие эти соединения, и способы применения
IL171974A0 (en) Tetrahydrocarbazole derivatives and their pharmaceutical use
DE60021381D1 (de) Chinonverbindungen zur behandlung von krankheiten
TW200510367A (en) Novel lapachone compounds, their preparation, and the use thereof
EA200501868A1 (ru) ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ
ATE389651T1 (de) Als inhibitoren von c-met geeignete pyrrolzusammensetzungen
EA200601217A1 (ru) Новые конденсированные пирролокарбазолы
EA200701930A1 (ru) Производные пиримидина для лечения гиперпролиферативных нарушений
DE60140871D1 (de) Arylmethylamin-derivate zur verwendung als inhibitoren von tryptase
EA200601219A1 (ru) Новые конденсированные пирролокарбазолы
EA200401319A1 (ru) Новые гетероциклические соединения, способы их получения и фармацевтические композиции, содержащие эти соединения, и их использование в медицине
EA200300727A1 (ru) Производные 2h-1-бензопирана, способы их получения и их фармацевтические композиции
DE602004019541D1 (de) Cycloalkyläbü kondensierte indole
TR200200278T2 (tr) Kalsilitik bileşimler
SE0300457D0 (sv) Novel compounds
ATE373644T1 (de) N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutika
DE60131968D1 (de) PYRANOÄ2,3-cÜIMIDAZOÄ1,2-aÜPYRIDIN-DERIVATE ZUR BEHANDLUNG VON GASTROINTESTINALEN ERKRANKUNGEN