ATE451376T1 - Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen - Google Patents

Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen

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Publication number
ATE451376T1
ATE451376T1 AT04794973T AT04794973T ATE451376T1 AT E451376 T1 ATE451376 T1 AT E451376T1 AT 04794973 T AT04794973 T AT 04794973T AT 04794973 T AT04794973 T AT 04794973T AT E451376 T1 ATE451376 T1 AT E451376T1
Authority
AT
Austria
Prior art keywords
inhibitors
protein kinases
compounds
compositions suitable
compositions
Prior art date
Application number
AT04794973T
Other languages
English (en)
Inventor
Juan-Miguel Jimenez
Jeremy Green
Huai Gao
Young-Choon Moon
Guy Brenchley
Ronald Knegtel
Francoise Pierard
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE451376T1 publication Critical patent/ATE451376T1/de

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Diabetes (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
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AT04794973T 2003-10-14 2004-10-14 Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen ATE451376T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51088103P 2003-10-14 2003-10-14
PCT/US2004/033749 WO2005037843A1 (en) 2003-10-14 2004-10-14 Compositions useful as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
ATE451376T1 true ATE451376T1 (de) 2009-12-15

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AT04794973T ATE451376T1 (de) 2003-10-14 2004-10-14 Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen

Country Status (11)

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US (3) US7700609B2 (de)
EP (1) EP1692140B1 (de)
JP (2) JP2007509848A (de)
CN (3) CN1897950A (de)
AT (1) ATE451376T1 (de)
AU (1) AU2004282172B2 (de)
CA (1) CA2542113A1 (de)
DE (1) DE602004024572D1 (de)
ES (1) ES2338234T3 (de)
TW (1) TW200530251A (de)
WO (1) WO2005037843A1 (de)

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CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
ES2410587T3 (es) 2004-01-22 2013-07-02 University Of Miami Formulaciones tópicas de coenzima Q10 y métodos de uso
US7772232B2 (en) * 2004-04-15 2010-08-10 Bristol-Myers Squibb Company Quinazolinyl compounds as inhibitors of potassium channel function
US8057815B2 (en) * 2004-04-19 2011-11-15 Portola Pharmaceuticals, Inc. Methods of treatment with Syk inhibitors
ATE381566T1 (de) 2004-05-14 2008-01-15 Millennium Pharm Inc Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
US7550598B2 (en) 2004-08-18 2009-06-23 Takeda Pharmaceutical Company Limited Kinase inhibitors
PE20060500A1 (es) * 2004-08-24 2006-07-13 Janssen Pharmaceutica Nv Derivados de heteroaril sulfamida benzo-fusionada como anticonvulsivantes
US20060276528A1 (en) * 2004-08-24 2006-12-07 Abdel-Magid Ahmed F Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents
EP1799684B1 (de) 2004-10-04 2014-12-03 Millennium Pharmaceuticals, Inc. Als proteinkinaseinhibotren geeignete lactamverbindungen
DE602005023333D1 (de) 2004-10-15 2010-10-14 Takeda Pharmaceutical Kinaseinhibitoren
BRPI0610864A2 (pt) * 2005-05-20 2010-08-03 Janssen Pharmaceutica Nv processo para preparação de derivados de sulfamida
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US8017619B2 (en) 2011-09-13
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DE602004024572D1 (de) 2010-01-21
US20100280026A1 (en) 2010-11-04
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