MA28279A1 - Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2 - Google Patents

Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2

Info

Publication number
MA28279A1
MA28279A1 MA29154A MA29154A MA28279A1 MA 28279 A1 MA28279 A1 MA 28279A1 MA 29154 A MA29154 A MA 29154A MA 29154 A MA29154 A MA 29154A MA 28279 A1 MA28279 A1 MA 28279A1
Authority
MA
Morocco
Prior art keywords
inhibitors
indole derivatives
kinase inhibitors
particular ikk2
kinase
Prior art date
Application number
MA29154A
Other languages
English (en)
Inventor
Ian Robert Baldwin
Paul Bamborough
John Andrew Christopher
Jeffrey K Kerns
Timothy Longstaff
David Drysdale Miller
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA28279A1 publication Critical patent/MA28279A1/fr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)

Abstract

La présente invention se rapporte à un dispositif d'économie quantifiée de l'eau pour les toilettes utilisant un mécanisme de double chasse avec un seul bouton-poussoir (11) qui actionne, en déplaçant vers le haut, un tuyau de trop-5 plein (3), muni d'un flotteur (5) capable de maintenir le dispositif ouvert jusqu'à la chasse complète s'il n'y a pas d'autres forces agissant sur ledit tuyau sauf son propre poids, et il a aussi un poids additionnel variable (6) placé à une hauteur intermédiaire qui, dans une première pression instantanée, agit avec le poids de l'ensemble, fermant la vanne d'évacuation (4) avant la vidange complète, un volume préétabli d'eau demeurant dans le réservoir, alors qu'en exerçant une deuxième pression pendant le remplissage de ce dernier, le tuyau (3) demeure en position soulevée et la vanne d'évacuation (4) ouverte jusqu'à la vidange complète du réservoir comme le poids additionnel variable (6) disparaît; il suffit que la deuxième pression soit instantanée pour réaliser une chasse complète.
MA29154A 2004-01-15 2006-07-03 Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2 MA28279A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0400895.9A GB0400895D0 (en) 2004-01-15 2004-01-15 Chemical compounds

Publications (1)

Publication Number Publication Date
MA28279A1 true MA28279A1 (fr) 2006-11-01

Family

ID=31726240

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29154A MA28279A1 (fr) 2004-01-15 2006-07-03 Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2

Country Status (23)

Country Link
US (1) US20080269200A1 (fr)
EP (1) EP1703905B1 (fr)
JP (2) JP4975447B2 (fr)
KR (1) KR20070026357A (fr)
CN (1) CN1933830A (fr)
AT (1) ATE413877T1 (fr)
AU (1) AU2005205090A1 (fr)
BR (1) BRPI0506802A (fr)
CA (1) CA2552953A1 (fr)
DE (1) DE602005010970D1 (fr)
DK (1) DK1703905T3 (fr)
ES (1) ES2317184T3 (fr)
GB (1) GB0400895D0 (fr)
HR (1) HRP20090071T3 (fr)
IL (1) IL176739A0 (fr)
MA (1) MA28279A1 (fr)
NO (1) NO20063676L (fr)
PL (1) PL1703905T3 (fr)
PT (1) PT1703905E (fr)
RU (1) RU2006129492A (fr)
SI (1) SI1703905T1 (fr)
WO (1) WO2005067923A1 (fr)
ZA (1) ZA200604855B (fr)

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PE20060748A1 (es) * 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
AR055343A1 (es) * 2005-06-30 2007-08-22 Smithkline Beecham Corp Derivados de indolcarboxamida inhibidores de quinasas ikk2
EP1940296A2 (fr) * 2005-10-25 2008-07-09 SmithKline Beecham Corporation Composés chimiques
US20080269291A1 (en) * 2005-11-18 2008-10-30 Kerns Jeffrey K Chemical Compounds
EP1959737A4 (fr) * 2005-12-16 2010-12-08 Glaxosmithkline Llc Composes chimiques
JP5070067B2 (ja) * 2007-01-15 2012-11-07 参天製薬株式会社 ＩκＢキナーゼβ阻害活性を有する新規インドール誘導体
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
CA2714181C (fr) * 2008-02-04 2013-12-24 Mercury Therapeutics, Inc. Modulateurs de l'ampk
WO2009107391A1 (fr) * 2008-02-27 2009-09-03 武田薬品工業株式会社 Composé contenant un cycle aromatique à 6 chaînons
CN102089281A (zh) * 2008-07-14 2011-06-08 参天制药株式会社 具有氨基甲酰基、脲基及取代氧基的新型吲哚衍生物
WO2010101299A1 (fr) * 2009-03-05 2010-09-10 住友化学株式会社 Procédé de production de benzène diméthanol à substitution halogène
WO2010102968A1 (fr) 2009-03-10 2010-09-16 Glaxo Group Limited Dérivés d'indole comme inhibiteurs de ikk2
EP2646020B1 (fr) * 2010-12-01 2016-09-21 Glaxosmithkline LLC Indoles
WO2014036268A2 (fr) * 2012-08-29 2014-03-06 Mount Sinai School Of Medicine Dérivés d'indole en tant qu'activateurs de la protéine sumo
FR3001219A1 (fr) * 2013-01-22 2014-07-25 Centre Nat Rech Scient Inhibiteurs de kinases
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
US9079866B2 (en) 2013-02-04 2015-07-14 Janssen Pharmaceutica Nv Flap modulators
WO2014210255A1 (fr) * 2013-06-26 2014-12-31 Abbvie Inc. Carboxamides primaires servant d'inhibiteurs de la btk
JP6644792B2 (ja) * 2014-12-18 2020-02-12 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ベンザゼピンスルホンアミド化合物
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EP1703905A1 (fr) 2006-09-27
PL1703905T3 (pl) 2009-04-30
EP1703905B1 (fr) 2008-11-12
DE602005010970D1 (de) 2008-12-24
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RU2006129492A (ru) 2008-02-27
ZA200604855B (en) 2007-11-28
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WO2005067923A1 (fr) 2005-07-28
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ATE413877T1 (de) 2008-11-15
DK1703905T3 (da) 2009-02-16
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