MA28279A1 - Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2 - Google Patents

Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2

Info

Publication number
MA28279A1
MA28279A1 MA29154A MA29154A MA28279A1 MA 28279 A1 MA28279 A1 MA 28279A1 MA 29154 A MA29154 A MA 29154A MA 29154 A MA29154 A MA 29154A MA 28279 A1 MA28279 A1 MA 28279A1
Authority
MA
Morocco
Prior art keywords
inhibitors
indole derivatives
kinase inhibitors
particular ikk2
kinase
Prior art date
Application number
MA29154A
Other languages
English (en)
Inventor
Ian Robert Baldwin
Paul Bamborough
John Andrew Christopher
Jeffrey K Kerns
Timothy Longstaff
David Drysdale Miller
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA28279A1 publication Critical patent/MA28279A1/fr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)

Abstract

La présente invention se rapporte à un dispositif d'économie quantifiée de l'eau pour les toilettes utilisant un mécanisme de double chasse avec un seul bouton-poussoir (11) qui actionne, en déplaçant vers le haut, un tuyau de trop-5 plein (3), muni d'un flotteur (5) capable de maintenir le dispositif ouvert jusqu'à la chasse complète s'il n'y a pas d'autres forces agissant sur ledit tuyau sauf son propre poids, et il a aussi un poids additionnel variable (6) placé à une hauteur intermédiaire qui, dans une première pression instantanée, agit avec le poids de l'ensemble, fermant la vanne d'évacuation (4) avant la vidange complète, un volume préétabli d'eau demeurant dans le réservoir, alors qu'en exerçant une deuxième pression pendant le remplissage de ce dernier, le tuyau (3) demeure en position soulevée et la vanne d'évacuation (4) ouverte jusqu'à la vidange complète du réservoir comme le poids additionnel variable (6) disparaît; il suffit que la deuxième pression soit instantanée pour réaliser une chasse complète.
MA29154A 2004-01-15 2006-07-03 Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2 MA28279A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0400895.9A GB0400895D0 (en) 2004-01-15 2004-01-15 Chemical compounds

Publications (1)

Publication Number Publication Date
MA28279A1 true MA28279A1 (fr) 2006-11-01

Family

ID=31726240

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29154A MA28279A1 (fr) 2004-01-15 2006-07-03 Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2

Country Status (23)

Country Link
US (1) US20080269200A1 (fr)
EP (1) EP1703905B1 (fr)
JP (2) JP4975447B2 (fr)
KR (1) KR20070026357A (fr)
CN (1) CN1933830A (fr)
AT (1) ATE413877T1 (fr)
AU (1) AU2005205090A1 (fr)
BR (1) BRPI0506802A (fr)
CA (1) CA2552953A1 (fr)
DE (1) DE602005010970D1 (fr)
DK (1) DK1703905T3 (fr)
ES (1) ES2317184T3 (fr)
GB (1) GB0400895D0 (fr)
HR (1) HRP20090071T3 (fr)
IL (1) IL176739A0 (fr)
MA (1) MA28279A1 (fr)
NO (1) NO20063676L (fr)
PL (1) PL1703905T3 (fr)
PT (1) PT1703905E (fr)
RU (1) RU2006129492A (fr)
SI (1) SI1703905T1 (fr)
WO (1) WO2005067923A1 (fr)
ZA (1) ZA200604855B (fr)

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US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
MX2007016541A (es) * 2005-06-30 2008-03-07 Smithkline Beecham Corp Compuestos quimicos.
EP1940296A2 (fr) * 2005-10-25 2008-07-09 SmithKline Beecham Corporation Composés chimiques
WO2007062318A2 (fr) * 2005-11-18 2007-05-31 Smithkline Beecham Corporation Composes chimiques
WO2007076286A2 (fr) * 2005-12-16 2007-07-05 Smithkline Beecham Corporation Composes chimiques
US8193237B2 (en) * 2007-01-15 2012-06-05 Santen Pharmaceutical Co., Ltd. Indole derivative having IκB kinase β inhibitory activity
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
KR20100115789A (ko) 2008-02-04 2010-10-28 머큐리 테라퓨틱스, 인코포레이티드 Ａｍｐｋ 조절자
US20110009421A1 (en) * 2008-02-27 2011-01-13 Takeda Pharmaceutical Company Limited Compound having 6-membered aromatic ring
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WO2010102968A1 (fr) 2009-03-10 2010-09-16 Glaxo Group Limited Dérivés d'indole comme inhibiteurs de ikk2
US8765792B2 (en) 2010-12-01 2014-07-01 Glaxosmithkline Llc Indoles
WO2014036268A2 (fr) * 2012-08-29 2014-03-06 Mount Sinai School Of Medicine Dérivés d'indole en tant qu'activateurs de la protéine sumo
FR3001219A1 (fr) * 2013-01-22 2014-07-25 Centre Nat Rech Scient Inhibiteurs de kinases
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US20080269200A1 (en) 2008-10-30
KR20070026357A (ko) 2007-03-08
NO20063676L (no) 2006-10-13
BRPI0506802A (pt) 2007-05-29
JP4975447B2 (ja) 2012-07-11
ZA200604855B (en) 2007-11-28
IL176739A0 (en) 2006-10-31
SI1703905T1 (sl) 2009-04-30
GB0400895D0 (en) 2004-02-18
RU2006129492A (ru) 2008-02-27
PL1703905T3 (pl) 2009-04-30
AU2005205090A1 (en) 2005-07-28
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ATE413877T1 (de) 2008-11-15
HK1098047A1 (en) 2007-07-13
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JP2007517848A (ja) 2007-07-05
PT1703905E (pt) 2009-02-04
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HRP20090071T3 (en) 2009-04-30
ES2317184T3 (es) 2009-04-16

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