DK1703905T3 - Indol-derivater og anvendelse deraf som kinaseinhibitorer, især IKK2-inhibitorer - Google Patents

Indol-derivater og anvendelse deraf som kinaseinhibitorer, især IKK2-inhibitorer

Info

Publication number: DK1703905T3
Authority: DK; Denmark
Prior art keywords: inhibitors; ikk2; indole derivatives; kinase inhibitors; kinase
Prior art date: 2004-01-15

Application number

DK05701855T

Other languages

English (en)

Inventor

Ian Robert Baldwin

Paul Bamborough

John Andrew Christopher

Jeffrey K Kerns

Timothy Longstaff

David Drysdale Miller

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-15

Filing date

2005-01-13

Publication date

2009-02-16

2005-01-13 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2009-02-16 Application granted granted Critical

2009-02-16 Publication of DK1703905T3 publication Critical patent/DK1703905T3/da

Links

102100021854 Inhibitor of nuclear factor kappa-B kinase subunit beta Human genes 0.000 title abstract 2
101710205525 Inhibitor of nuclear factor kappa-B kinase subunit beta Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
230000000694 effects Effects 0.000 abstract 2
VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1h-indole-2-carboxamide Chemical class C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 abstract 1
108091000080 Phosphotransferase Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
102000020233 phosphotransferase Human genes 0.000 abstract 1
230000017423 tissue regeneration Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
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Psychiatry (AREA)
AIDS & HIV (AREA)
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DK05701855T 2004-01-15 2005-01-13 Indol-derivater og anvendelse deraf som kinaseinhibitorer, især IKK2-inhibitorer DK1703905T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0400895.9A GB0400895D0 (en)	2004-01-15	2004-01-15	Chemical compounds
PCT/GB2005/000085 WO2005067923A1 (en)	2004-01-15	2005-01-13	Indole derivatives and use thereof as kinase inhibitors in particular ikk2 inhibitors

Publications (1)

Publication Number	Publication Date
DK1703905T3 true DK1703905T3 (da)	2009-02-16

Family

ID=31726240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05701855T DK1703905T3 (da)	2004-01-15	2005-01-13	Indol-derivater og anvendelse deraf som kinaseinhibitorer, især IKK2-inhibitorer

Country Status (23)

Country	Link
US (1)	US20080269200A1 (da)
EP (1)	EP1703905B1 (da)
JP (2)	JP4975447B2 (da)
KR (1)	KR20070026357A (da)
CN (1)	CN1933830A (da)
AT (1)	ATE413877T1 (da)
AU (1)	AU2005205090A1 (da)
BR (1)	BRPI0506802A (da)
CA (1)	CA2552953A1 (da)
DE (1)	DE602005010970D1 (da)
DK (1)	DK1703905T3 (da)
ES (1)	ES2317184T3 (da)
GB (1)	GB0400895D0 (da)
HR (1)	HRP20090071T3 (da)
IL (1)	IL176739A0 (da)
MA (1)	MA28279A1 (da)
NO (1)	NO20063676L (da)
PL (1)	PL1703905T3 (da)
PT (1)	PT1703905E (da)
RU (1)	RU2006129492A (da)
SI (1)	SI1703905T1 (da)
WO (1)	WO2005067923A1 (da)
ZA (1)	ZA200604855B (da)

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AR050253A1 (es) *	2004-06-24	2006-10-11	Smithkline Beecham Corp	Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
PE20060748A1 (es) *	2004-09-21	2006-10-01	Smithkline Beecham Corp	Derivados de indolcarboxamida como inhibidores de quinasa ikk2
US8063071B2 (en)	2007-10-31	2011-11-22	GlaxoSmithKline, LLC	Chemical compounds
AR055343A1 (es) *	2005-06-30	2007-08-22	Smithkline Beecham Corp	Derivados de indolcarboxamida inhibidores de quinasas ikk2
EP1940296A2 (en) *	2005-10-25	2008-07-09	SmithKline Beecham Corporation	Chemical compounds
US20080269291A1 (en) *	2005-11-18	2008-10-30	Kerns Jeffrey K	Chemical Compounds
EP1959737A4 (en) *	2005-12-16	2010-12-08	Glaxosmithkline Llc	CHEMICAL COMPOUNDS
JP5070067B2 (ja) *	2007-01-15	2012-11-07	参天製薬株式会社	ＩκＢキナーゼβ阻害活性を有する新規インドール誘導体
PE20081889A1 (es)	2007-03-23	2009-03-05	Smithkline Beecham Corp	Indol carboxamidas como inhibidores de ikk2
CA2714181C (en) *	2008-02-04	2013-12-24	Mercury Therapeutics, Inc.	Ampk modulators
WO2009107391A1 (ja) *	2008-02-27	2009-09-03	武田薬品工業株式会社	６員芳香環含有化合物
CN102089281A (zh) *	2008-07-14	2011-06-08	参天制药株式会社	具有氨基甲酰基、脲基及取代氧基的新型吲哚衍生物
WO2010101299A1 (ja) *	2009-03-05	2010-09-10	住友化学株式会社	ハロゲン置換ベンゼンジメタノールの製造方法
WO2010102968A1 (en)	2009-03-10	2010-09-16	Glaxo Group Limited	Indole derivatives as ikk2 inhibitors
EP2646020B1 (en) *	2010-12-01	2016-09-21	Glaxosmithkline LLC	Indoles
WO2014036268A2 (en) *	2012-08-29	2014-03-06	Mount Sinai School Of Medicine	Indole derivatives as sumo activators
FR3001219A1 (fr) *	2013-01-22	2014-07-25	Centre Nat Rech Scient	Inhibiteurs de kinases
TWI644899B (zh)	2013-02-04	2018-12-21	健生藥品公司	Ｆｌａｐ調節劑
US9079866B2 (en)	2013-02-04	2015-07-14	Janssen Pharmaceutica Nv	Flap modulators
WO2014210255A1 (en) *	2013-06-26	2014-12-31	Abbvie Inc.	Primary carboxamides as btk inhibitors
JP6644792B2 (ja) *	2014-12-18	2020-02-12	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	ベンザゼピンスルホンアミド化合物
WO2017096045A1 (en) *	2015-12-02	2017-06-08	Kyras Therapeutics, Inc.	Multivalent ras binding compounds
US11352328B2 (en)	2016-07-12	2022-06-07	Arisan Therapeutics Inc.	Heterocyclic compounds for the treatment of arenavirus
WO2018223819A1 (zh) *	2017-06-07	2018-12-13	中国中医科学院中药研究所	一种吲哚乙酸类衍生物及其制备方法和医药用途
US12419865B2 (en)	2018-12-06	2025-09-23	Arisan Therapeutics Inc.	Compounds for the treatment of arenavirus infection
WO2024059220A2 (en) *	2022-09-15	2024-03-21	Vanderbilt University	6,5 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same

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2004
- 2004-01-15 GB GBGB0400895.9A patent/GB0400895D0/en not_active Ceased
2005
- 2005-01-13 KR KR1020067014178A patent/KR20070026357A/ko not_active Withdrawn
- 2005-01-13 PT PT05701855T patent/PT1703905E/pt unknown
- 2005-01-13 EP EP05701855A patent/EP1703905B1/en not_active Expired - Lifetime
- 2005-01-13 CA CA002552953A patent/CA2552953A1/en not_active Abandoned
- 2005-01-13 RU RU2006129492/04A patent/RU2006129492A/ru not_active Application Discontinuation
- 2005-01-13 AT AT05701855T patent/ATE413877T1/de not_active IP Right Cessation
- 2005-01-13 JP JP2006548393A patent/JP4975447B2/ja not_active Expired - Fee Related
- 2005-01-13 PL PL05701855T patent/PL1703905T3/pl unknown
- 2005-01-13 WO PCT/GB2005/000085 patent/WO2005067923A1/en not_active Ceased
- 2005-01-13 ES ES05701855T patent/ES2317184T3/es not_active Expired - Lifetime
- 2005-01-13 HR HR20090071T patent/HRP20090071T3/xx unknown
- 2005-01-13 AU AU2005205090A patent/AU2005205090A1/en not_active Abandoned
- 2005-01-13 SI SI200530567T patent/SI1703905T1/sl unknown
- 2005-01-13 DK DK05701855T patent/DK1703905T3/da active
- 2005-01-13 DE DE602005010970T patent/DE602005010970D1/de not_active Expired - Lifetime
- 2005-01-13 CN CNA2005800083624A patent/CN1933830A/zh active Pending
- 2005-01-13 BR BRPI0506802-9A patent/BRPI0506802A/pt not_active IP Right Cessation
- 2005-01-13 US US10/597,154 patent/US20080269200A1/en not_active Abandoned
2006
- 2006-06-13 ZA ZA200604855A patent/ZA200604855B/xx unknown
- 2006-07-03 MA MA29154A patent/MA28279A1/fr unknown
- 2006-07-06 IL IL176739A patent/IL176739A0/en unknown
- 2006-08-15 NO NO20063676A patent/NO20063676L/no not_active Application Discontinuation
2011
- 2011-09-01 JP JP2011190903A patent/JP2012025761A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
CA2552953A1 (en)	2005-07-28
PT1703905E (pt)	2009-02-04
HRP20090071T3 (en)	2009-04-30
AU2005205090A1 (en)	2005-07-28
EP1703905A1 (en)	2006-09-27
PL1703905T3 (pl)	2009-04-30
EP1703905B1 (en)	2008-11-12
DE602005010970D1 (de)	2008-12-24
JP2012025761A (ja)	2012-02-09
KR20070026357A (ko)	2007-03-08
RU2006129492A (ru)	2008-02-27
ZA200604855B (en)	2007-11-28
US20080269200A1 (en)	2008-10-30
WO2005067923A1 (en)	2005-07-28
IL176739A0 (en)	2006-10-31
CN1933830A (zh)	2007-03-21
HK1098047A1 (en)	2007-07-13
JP4975447B2 (ja)	2012-07-11
NO20063676L (no)	2006-10-13
BRPI0506802A (pt)	2007-05-29
ATE413877T1 (de)	2008-11-15
JP2007517848A (ja)	2007-07-05
MA28279A1 (fr)	2006-11-01
SI1703905T1 (sl)	2009-04-30
ES2317184T3 (es)	2009-04-16
GB0400895D0 (en)	2004-02-18

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