MA28774B1 - Forme de dosage solide d'heparine mouillee - Google Patents

Forme de dosage solide d'heparine mouillee

Info

Publication number
MA28774B1
MA28774B1 MA29506A MA29506A MA28774B1 MA 28774 B1 MA28774 B1 MA 28774B1 MA 29506 A MA29506 A MA 29506A MA 29506 A MA29506 A MA 29506A MA 28774 B1 MA28774 B1 MA 28774B1
Authority
MA
Morocco
Prior art keywords
heparin
wet
dosing form
pharmaceutical composition
solid dosing
Prior art date
Application number
MA29506A
Other languages
English (en)
Inventor
Shingai Majuru
Brahma Singh
Nikhil Dhoot
Original Assignee
Emisphere Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emisphere Tech Inc filed Critical Emisphere Tech Inc
Publication of MA28774B1 publication Critical patent/MA28774B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/609—Amides, e.g. salicylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition pharmaceutique solide (telle qu'une forme de dosage solide) comprenant un agent d'administration et de l'héparine mouillée. L'inclusion d'héparine mouillée provoque, dans la composition pharmaceutique solide, beaucoup plus qu'une héparine non mouillée, une administration accrue de l'héparine. Sans aucun lien avec une théorie particulaire, les inventeurs estiment que du fait que la chaîne polymère d'héparine mouillée est déjà une forme « ouverte », alors que l'héparine non mouillée ne l'est pas, moins d'héparine mouillée est décomposée dans le tractus gastro-intestinal et est plus facilement absorbée dans l'estomac.
MA29506A 2004-05-06 2006-12-04 Forme de dosage solide d'heparine mouillee MA28774B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56947504P 2004-05-06 2004-05-06
US57267904P 2004-05-19 2004-05-19
US59897804P 2004-08-04 2004-08-04

Publications (1)

Publication Number Publication Date
MA28774B1 true MA28774B1 (fr) 2007-08-01

Family

ID=35320730

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29506A MA28774B1 (fr) 2004-05-06 2006-12-04 Forme de dosage solide d'heparine mouillee

Country Status (14)

Country Link
US (1) US8039018B2 (fr)
EP (1) EP1750729A2 (fr)
JP (1) JP2007536268A (fr)
KR (1) KR20070008720A (fr)
AU (1) AU2005240206B2 (fr)
BR (1) BRPI0510226A (fr)
CA (1) CA2564866A1 (fr)
EC (1) ECSP067050A (fr)
IL (1) IL178846A0 (fr)
MA (1) MA28774B1 (fr)
MX (1) MXPA06012841A (fr)
NZ (1) NZ550894A (fr)
RU (1) RU2006138703A (fr)
WO (1) WO2005107773A2 (fr)

Families Citing this family (14)

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JP2011500850A (ja) * 2007-10-24 2011-01-06 マンカインド コーポレイション Ｇｌｐ−１による副作用を防止する方法
JP5740689B2 (ja) 2008-08-18 2015-06-24 エンテラ バイオ エルティーディー． タンパク質の経口投与用の方法および組成物
AU2011213175A1 (en) * 2010-02-04 2014-02-20 Michael M. Goldberg Use of oral heparin preparations to treat urinary tract diseases and conditions
SI2651398T1 (en) 2010-12-16 2018-04-30 Novo Nordisk A/S SOLID COMPOSITIONS CONTAINING GLP-1 AGONIST AND SOL N- (8- (2-HYDROXYBENZOIL) AMINO) CAPRICULATE ACIDS
PL2696687T3 (pl) 2011-04-12 2017-06-30 Novo Nordisk A/S Pochodne podwójnie acylowanej GLP-1
PT2827845T (pt) 2012-03-22 2019-03-29 Novo Nordisk As Composições compreendendo um agente de entrega e sua preparação
HRP20181447T1 (hr) 2012-03-22 2018-11-02 Novo Nordisk A/S Pripravci glp-1 peptida i njihova priprava
ES2965469T3 (es) * 2012-03-22 2024-04-15 Novo Nordisk As Composiciones que comprenden un agente de suministro y preparación de estas
JP6517690B2 (ja) 2012-06-20 2019-05-22 ノヴォ ノルディスク アー／エス ペプチド及び送達剤を含む錠剤製剤
KR102272671B1 (ko) 2013-05-02 2021-07-06 노보 노르디스크 에이/에스 Glp-1 화합물의 경구 투여
JP6898518B2 (ja) 2018-02-02 2021-07-07 ノヴォ ノルディスク アー／エス Ｇｌｐ−１アゴニスト、ｎ−（８−（２−ヒドロキシベンゾイル）アミノ）カプリル酸の塩及び滑沢剤を含む固形組成物
TWI829687B (zh) * 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
CN118647386A (zh) * 2021-12-06 2024-09-13 广州大洲生物医药科技有限公司 肝素的口服递送

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Also Published As

Publication number Publication date
ECSP067050A (es) 2007-02-28
US20070224262A1 (en) 2007-09-27
MXPA06012841A (es) 2007-02-15
CA2564866A1 (fr) 2005-11-17
EP1750729A2 (fr) 2007-02-14
BRPI0510226A (pt) 2007-10-23
AU2005240206A1 (en) 2005-11-17
US8039018B2 (en) 2011-10-18
NZ550894A (en) 2011-02-25
JP2007536268A (ja) 2007-12-13
WO2005107773A8 (fr) 2006-12-21
IL178846A0 (en) 2007-05-15
RU2006138703A (ru) 2008-06-20
WO2005107773A2 (fr) 2005-11-17
WO2005107773A3 (fr) 2006-01-05
AU2005240206B2 (en) 2011-04-07
KR20070008720A (ko) 2007-01-17

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