MA28883B1 - Procede de preparation de 4-{4-[({[4-chloro-3-(trifluoromethyl) phenyl]amino}carbonyl) amino]phenoxy}-n-methylpyridine-2-carboxamide - Google Patents

Procede de preparation de 4-{4-[({[4-chloro-3-(trifluoromethyl) phenyl]amino}carbonyl) amino]phenoxy}-n-methylpyridine-2-carboxamide

Info

Publication number
MA28883B1
MA28883B1 MA29788A MA29788A MA28883B1 MA 28883 B1 MA28883 B1 MA 28883B1 MA 29788 A MA29788 A MA 29788A MA 29788 A MA29788 A MA 29788A MA 28883 B1 MA28883 B1 MA 28883B1
Authority
MA
Morocco
Prior art keywords
amino
methylpyridine
carboxamide
phenoxy
trifluoromethyl
Prior art date
Application number
MA29788A
Other languages
English (en)
Inventor
Michael Loegers
Reinhold Gehring
Oliver Kuhn
Mike Matthaeus
Klaus Mohrs
Matthias Mueller-Gliemann
Juergen Stiehl
Mathias Berwe
Jana Lenz
Werner Heilmann
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28883(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA28883B1 publication Critical patent/MA28883B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
MA29788A 2004-09-29 2007-03-30 Procede de preparation de 4-{4-[({[4-chloro-3-(trifluoromethyl) phenyl]amino}carbonyl) amino]phenoxy}-n-methylpyridine-2-carboxamide MA28883B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04023131 2004-09-29

Publications (1)

Publication Number Publication Date
MA28883B1 true MA28883B1 (fr) 2007-09-03

Family

ID=35457568

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29788A MA28883B1 (fr) 2004-09-29 2007-03-30 Procede de preparation de 4-{4-[({[4-chloro-3-(trifluoromethyl) phenyl]amino}carbonyl) amino]phenoxy}-n-methylpyridine-2-carboxamide

Country Status (34)

Country Link
US (1) US8124782B2 (fr)
EP (1) EP1797037B1 (fr)
JP (2) JP2008514657A (fr)
KR (1) KR101263032B1 (fr)
CN (1) CN101052619B (fr)
AR (1) AR053973A1 (fr)
AU (1) AU2005289099B2 (fr)
BR (1) BRPI0515944B1 (fr)
CA (1) CA2581835C (fr)
CU (1) CU23754B7 (fr)
CY (1) CY1116126T1 (fr)
DK (1) DK1797037T3 (fr)
DO (1) DOP2005000183A (fr)
EC (1) ECSP077357A (fr)
ES (1) ES2532377T3 (fr)
GT (1) GT200500269A (fr)
HN (1) HN2005000768A (fr)
HR (1) HRP20150295T1 (fr)
IL (1) IL182046A0 (fr)
MA (1) MA28883B1 (fr)
MY (1) MY149873A (fr)
NO (1) NO339647B1 (fr)
NZ (1) NZ554119A (fr)
PE (5) PE20091587A1 (fr)
PL (1) PL1797037T3 (fr)
PT (1) PT1797037E (fr)
SG (1) SG155997A1 (fr)
SI (1) SI1797037T1 (fr)
SV (1) SV2006002243A (fr)
TW (1) TWI382973B (fr)
UA (1) UA90691C2 (fr)
UY (1) UY29143A1 (fr)
WO (1) WO2006034796A1 (fr)
ZA (1) ZA200702511B (fr)

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US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP2324825A1 (fr) 2002-02-11 2011-05-25 Bayer Healthcare LLC Arylurées dotées d'une activité d'inhibition de l'angiogenèse
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DK1663978T3 (da) 2003-07-23 2008-04-07 Bayer Pharmaceuticals Corp Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser
SG155997A1 (en) 2004-09-29 2009-10-29 Bayer Schering Pharma Ag Process for the preparation of 4-{4-[({[4-chloro-3- (trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n- methylpyridine-2-carboxamide
WO2006034797A1 (fr) 2004-09-29 2006-04-06 Bayer Healthcare Ag Forme thermodynamiquement stable de tosylate de bay 43-9006
KR101335932B1 (ko) 2005-03-07 2013-12-04 바이엘 헬스케어 엘엘씨 암의 치료를 위한 오메가-카르복시아릴 치환된 디페닐우레아를 포함하는 제약 조성물
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KR101553211B1 (ko) * 2007-09-10 2015-09-15 씨아이피엘에이 엘티디. Raf 키나아제 저해제의 제조방법 및 상기 제조방법에 사용되는 중간체
WO2009054004A2 (fr) * 2007-10-22 2009-04-30 Natco Pharma Limited Nouveau procédé pour la préparation du sorafénib
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EP2142507A1 (fr) * 2008-03-06 2010-01-13 Sicor, Inc. Procédé de préparation du sorafénib et ses sels
CN103254126A (zh) * 2008-09-19 2013-08-21 苏州泽璟生物制药有限公司 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物
US8604208B2 (en) 2009-09-24 2013-12-10 Ranbaxy Laboratories Limited Polymorphs of sorafenib acid addition salts
EP2480534A1 (fr) * 2009-09-24 2012-08-01 Ranbaxy Laboratories Limited Procédé de préparation de tosylate de sorafénib
WO2011058522A1 (fr) 2009-11-12 2011-05-19 Ranbaxy Laboratories Limited Sel d'ethylsulfonate de sorafenib et son procede de preparation
WO2011076711A2 (fr) 2009-12-23 2011-06-30 Ratiopharm Gmbh Polymorphes de 4-[4-[[4-chloro-3-(trifluorométhyl)phényl]carbamoylamino]phénoxy]-n-méthylpyridine-2-carboxamide
EP2528899B1 (fr) 2010-01-29 2014-10-15 Ranbaxy Laboratories Limited Solvate de diméthylsulfoxyde du sorafenib
CN102190616B (zh) * 2010-03-18 2015-07-29 苏州泽璟生物制药有限公司 一种氘代的ω-二苯基脲的合成及生产的方法和工艺
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
CN102617458A (zh) * 2010-05-18 2012-08-01 张南 抗癌用化合物的制备方法
EP2595628A1 (fr) 2010-07-19 2013-05-29 Bayer HealthCare LLC Associations médicamenteuses contenant une oméga-carboxyaryl diphénylurée fluorosubstituée utilisées pour le traitement et la prévention de maladies et d'affections
EP2621486A1 (fr) 2010-10-01 2013-08-07 Bayer Intellectual Property GmbH Combinaisons contenant du n-(2-arylamino)arylsulfonamide substitué
WO2012071425A1 (fr) 2010-11-22 2012-05-31 Teva Pharmaceutical Industries Ltd. Formes à l'état solide de bésylate de sorafénib et procédés de préparation
EP2559431A1 (fr) 2011-08-17 2013-02-20 Ratiopharm GmbH Composition pharmaceutique comportant du 4-[4-[[4-Chloro-3-(trifluoromethyl)phényl]carbamoylamino]phénoxy]-N-méthyl-pyridine-2-carboxamide
CN103664771B (zh) * 2012-09-19 2016-03-30 齐鲁制药有限公司 索拉非尼的晶型a及其制备方法
WO2014118807A1 (fr) * 2013-02-04 2014-08-07 Intas Pharmaceuticals Limited Nouveau procédé de préparation de tosylate de sorafénib de forme iii
CN104710354A (zh) * 2013-12-13 2015-06-17 江苏豪森药业股份有限公司 高纯度索拉非尼的制备方法
CN104761492A (zh) * 2014-01-03 2015-07-08 正大天晴药业集团股份有限公司 对甲苯磺酸索拉非尼的晶型及其制备方法
CN104177292A (zh) * 2014-08-08 2014-12-03 亿腾药业(泰州)有限公司 一种工业化生产甲苯磺酸索拉非尼多晶型ⅰ的方法
CN110204483B (zh) * 2014-12-01 2021-06-29 石药集团中奇制药技术(石家庄)有限公司 一种甲苯磺酸索拉非尼新晶型及其制备方法
EP3109236B1 (fr) 2015-06-23 2017-08-09 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Procédé évolutif pour la préparation de solvate d'éthanol tosylate de sorafénibe et tosylate de sorafénibe forme iii
CN105181844A (zh) * 2015-09-11 2015-12-23 江苏嘉逸医药有限公司 一种高效液相色谱法测定甲苯磺酸索拉非尼含量和有关物质的方法
CN105585523A (zh) * 2015-12-29 2016-05-18 上海北卡医药技术有限公司 一种对甲苯磺酸索拉非尼的新晶型及其制备方法和用途
CN107840823B (zh) * 2016-09-20 2021-08-17 意大利合成制造有限公司 用于制备甲苯磺酸索拉非尼乙醇溶剂化物和iii型甲苯磺酸索拉非尼的可变规模的方法
CN107915676A (zh) * 2017-10-26 2018-04-17 魏海霞 索拉非尼的制备方法
CN109796400B (zh) * 2017-11-16 2022-07-29 四川科伦药物研究院有限公司 一种甲苯磺酸索拉菲尼晶型及其制备方法
CN113773249A (zh) * 2020-06-10 2021-12-10 杭州中美华东制药有限公司 索拉非尼游离碱晶型Form X及其制备方法

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Also Published As

Publication number Publication date
HN2005000768A (es) 2010-09-17
JP2008514657A (ja) 2008-05-08
CU20070069A7 (es) 2010-11-27
ZA200702511B (en) 2008-07-30
CA2581835C (fr) 2012-12-18
HRP20150295T1 (hr) 2015-05-22
NZ554119A (en) 2010-07-30
IL182046A0 (en) 2007-07-24
GT200500269A (es) 2006-05-11
KR101263032B1 (ko) 2013-05-09
TW200626551A (en) 2006-08-01
PE20091585A1 (es) 2009-10-31
SI1797037T1 (sl) 2015-06-30
CU23754B7 (es) 2012-01-31
UY29143A1 (es) 2006-04-28
DK1797037T3 (en) 2015-03-30
PT1797037E (pt) 2015-03-17
CY1116126T1 (el) 2017-02-08
KR20070058676A (ko) 2007-06-08
PE20091586A1 (es) 2009-10-31
PE20060825A1 (es) 2006-10-20
BRPI0515944B1 (pt) 2021-11-09
CN101052619A (zh) 2007-10-10
MY149873A (en) 2013-10-31
PL1797037T3 (pl) 2015-07-31
UA90691C2 (en) 2010-05-25
NO20072173L (no) 2007-06-14
TWI382973B (zh) 2013-01-21
ECSP077357A (es) 2007-04-26
AU2005289099B2 (en) 2012-07-19
EP1797037B1 (fr) 2014-12-17
JP5583190B2 (ja) 2014-09-03
US8124782B2 (en) 2012-02-28
HK1113484A1 (en) 2008-10-03
JP2013067625A (ja) 2013-04-18
EP1797037A1 (fr) 2007-06-20
ES2532377T3 (es) 2015-03-26
CA2581835A1 (fr) 2006-04-06
CN101052619B (zh) 2012-02-22
BRPI0515944A (pt) 2008-08-12
AU2005289099A1 (en) 2006-04-06
NO339647B1 (no) 2017-01-16
AR053973A1 (es) 2007-05-30
US20080262236A1 (en) 2008-10-23
SG155997A1 (en) 2009-10-29
PE20091584A1 (es) 2009-10-28
PE20091587A1 (es) 2009-11-05
WO2006034796A1 (fr) 2006-04-06
SV2006002243A (es) 2006-10-13
DOP2005000183A (es) 2006-03-31

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