CU23754B7 - Procedimiento para la preparación de 4-{4-[cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato. - Google Patents

Procedimiento para la preparación de 4-{4-[cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato.

Info

Publication number
CU23754B7
CU23754B7 CU20070069A CU20070069A CU23754B7 CU 23754 B7 CU23754 B7 CU 23754B7 CU 20070069 A CU20070069 A CU 20070069A CU 20070069 A CU20070069 A CU 20070069A CU 23754 B7 CU23754 B7 CU 23754B7
Authority
CU
Cuba
Prior art keywords
amino
formula
preparation
methylpiridine
phenoxi
Prior art date
Application number
CU20070069A
Other languages
English (en)
Other versions
CU20070069A7 (es
Inventor
Juergen Stiehl
Matthias Mueller-Gliemann
Mike Matthaeus
Oliver Kuhn
Jana Lenz
Mathias Berwe
Klaus Mohrs
Michael Loegers
Werner Heilmann
Reinhold Gehring
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23754(B7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CU20070069A7 publication Critical patent/CU20070069A7/es
Publication of CU23754B7 publication Critical patent/CU23754B7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

El objeto de la presente invención pertenece al campo de la industria farmacéutica, específicamente relacionado con un procedimiento para la preparación de los compuestos de fórmula (I) y fórmula (II) útiles en el tratamiento del cáncer: (ESPACIO PARA FÓRMULAS) que comprende hacer reaccionar el compuesto de fórmula (V) con isocianato de 4-cloro-3-trifluorometilfenilo en un disolvente orgánico no clorado, inerte hacia isocianatos, a temperatura superior a 15sC proporcionando el compuesto de fórmula II y una segunda etapa, mezclando el compuesto de fórmula II con ácido p-toluenosulfónico.
CU20070069A 2004-09-29 2007-03-26 Procedimiento para la preparación de 4-{4-[cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato. CU23754B7 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04023131 2004-09-29

Publications (2)

Publication Number Publication Date
CU20070069A7 CU20070069A7 (es) 2010-11-27
CU23754B7 true CU23754B7 (es) 2012-01-31

Family

ID=35457568

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20070069A CU23754B7 (es) 2004-09-29 2007-03-26 Procedimiento para la preparación de 4-{4-[cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato.

Country Status (34)

Country Link
US (1) US8124782B2 (es)
EP (1) EP1797037B1 (es)
JP (2) JP2008514657A (es)
KR (1) KR101263032B1 (es)
CN (1) CN101052619B (es)
AR (1) AR053973A1 (es)
AU (1) AU2005289099B2 (es)
BR (1) BRPI0515944B1 (es)
CA (1) CA2581835C (es)
CU (1) CU23754B7 (es)
CY (1) CY1116126T1 (es)
DK (1) DK1797037T3 (es)
DO (1) DOP2005000183A (es)
EC (1) ECSP077357A (es)
ES (1) ES2532377T3 (es)
GT (1) GT200500269A (es)
HN (1) HN2005000768A (es)
HR (1) HRP20150295T1 (es)
IL (1) IL182046A0 (es)
MA (1) MA28883B1 (es)
MY (1) MY149873A (es)
NO (1) NO339647B1 (es)
NZ (1) NZ554119A (es)
PE (5) PE20091586A1 (es)
PL (1) PL1797037T3 (es)
PT (1) PT1797037E (es)
SG (1) SG155997A1 (es)
SI (1) SI1797037T1 (es)
SV (1) SV2006002243A (es)
TW (1) TWI382973B (es)
UA (1) UA90691C2 (es)
UY (1) UY29143A1 (es)
WO (1) WO2006034796A1 (es)
ZA (1) ZA200702511B (es)

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WO2008058644A1 (en) * 2006-11-14 2008-05-22 Bayer Schering Pharma Aktiengesellschaft Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide
CA2698795C (en) 2007-09-10 2016-04-19 Cipla Limited Process for the preparation of a raf kinase inhibitor and intermediates for use in the process
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CN102190616B (zh) * 2010-03-18 2015-07-29 苏州泽璟生物制药有限公司 一种氘代的ω-二苯基脲的合成及生产的方法和工艺
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
CN102617458A (zh) * 2010-05-18 2012-08-01 张南 抗癌用化合物的制备方法
US20130183268A1 (en) 2010-07-19 2013-07-18 Bayer Healthcare Llc Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
EA201300420A1 (ru) 2010-10-01 2013-09-30 Байер Интеллектчуал Проперти Гмбх Комбинации, которые содержат замещенный n-(2-ариламино) арилсульфонамид
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CN103664771B (zh) * 2012-09-19 2016-03-30 齐鲁制药有限公司 索拉非尼的晶型a及其制备方法
WO2014118807A1 (en) * 2013-02-04 2014-08-07 Intas Pharmaceuticals Limited A novel process for the preparation of sorafenib tosylate form iii
CN104710354A (zh) * 2013-12-13 2015-06-17 江苏豪森药业股份有限公司 高纯度索拉非尼的制备方法
CN104761492A (zh) * 2014-01-03 2015-07-08 正大天晴药业集团股份有限公司 对甲苯磺酸索拉非尼的晶型及其制备方法
CN104177292A (zh) * 2014-08-08 2014-12-03 亿腾药业（泰州）有限公司 一种工业化生产甲苯磺酸索拉非尼多晶型ⅰ的方法
CN110204483B (zh) * 2014-12-01 2021-06-29 石药集团中奇制药技术（石家庄）有限公司 一种甲苯磺酸索拉非尼新晶型及其制备方法
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CN105181844A (zh) * 2015-09-11 2015-12-23 江苏嘉逸医药有限公司 一种高效液相色谱法测定甲苯磺酸索拉非尼含量和有关物质的方法
CN105585523A (zh) * 2015-12-29 2016-05-18 上海北卡医药技术有限公司 一种对甲苯磺酸索拉非尼的新晶型及其制备方法和用途
CN107840823B (zh) * 2016-09-20 2021-08-17 意大利合成制造有限公司 用于制备甲苯磺酸索拉非尼乙醇溶剂化物和iii型甲苯磺酸索拉非尼的可变规模的方法
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Also Published As

Publication number Publication date
UA90691C2 (en) 2010-05-25
PT1797037E (pt) 2015-03-17
PE20091585A1 (es) 2009-10-31
HRP20150295T1 (hr) 2015-05-22
PE20060825A1 (es) 2006-10-20
NO339647B1 (no) 2017-01-16
TWI382973B (zh) 2013-01-21
JP5583190B2 (ja) 2014-09-03
HN2005000768A (es) 2010-09-17
AR053973A1 (es) 2007-05-30
PE20091586A1 (es) 2009-10-31
MY149873A (en) 2013-10-31
AU2005289099A1 (en) 2006-04-06
JP2008514657A (ja) 2008-05-08
NZ554119A (en) 2010-07-30
UY29143A1 (es) 2006-04-28
IL182046A0 (en) 2007-07-24
AU2005289099B2 (en) 2012-07-19
EP1797037A1 (en) 2007-06-20
US8124782B2 (en) 2012-02-28
US20080262236A1 (en) 2008-10-23
DK1797037T3 (en) 2015-03-30
PE20091587A1 (es) 2009-11-05
CN101052619A (zh) 2007-10-10
BRPI0515944A (pt) 2008-08-12
ZA200702511B (en) 2008-07-30
WO2006034796A1 (en) 2006-04-06
SV2006002243A (es) 2006-10-13
KR101263032B1 (ko) 2013-05-09
CY1116126T1 (el) 2017-02-08
KR20070058676A (ko) 2007-06-08
DOP2005000183A (es) 2006-03-31
CN101052619B (zh) 2012-02-22
HK1113484A1 (en) 2008-10-03
SI1797037T1 (sl) 2015-06-30
SG155997A1 (en) 2009-10-29
ECSP077357A (es) 2007-04-26
CU20070069A7 (es) 2010-11-27
JP2013067625A (ja) 2013-04-18
CA2581835C (en) 2012-12-18
BRPI0515944B1 (pt) 2021-11-09
NO20072173L (no) 2007-06-14
MA28883B1 (fr) 2007-09-03
EP1797037B1 (en) 2014-12-17
TW200626551A (en) 2006-08-01
GT200500269A (es) 2006-05-11
PL1797037T3 (pl) 2015-07-31
PE20091584A1 (es) 2009-10-28
ES2532377T3 (es) 2015-03-26
CA2581835A1 (en) 2006-04-06

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