MA29148B1 - Derives de pyrazole condenses, et procedes pour traiter des troubles lies au metabolisme - Google Patents

Derives de pyrazole condenses, et procedes pour traiter des troubles lies au metabolisme

Info

Publication number
MA29148B1
MA29148B1 MA30071A MA30071A MA29148B1 MA 29148 B1 MA29148 B1 MA 29148B1 MA 30071 A MA30071 A MA 30071A MA 30071 A MA30071 A MA 30071A MA 29148 B1 MA29148 B1 MA 29148B1
Authority
MA
Morocco
Prior art keywords
inhibitors
compounds
derivatives
methods
related disorders
Prior art date
Application number
MA30071A
Other languages
English (en)
Inventor
Douglas P Boatman
Thomas O Schrader
Graeme Semple
Philip J Skinner
Jae-Kyu Jung
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of MA29148B1 publication Critical patent/MA29148B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'INVENTION CONCERNE CERTAINS DÉRIVÉS DE PYRAZOLE CONDENSÉS DE FORMULE (IA), ET DES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CES DÉRIVÉS, LESDITS DÉRIVÉS ET SELS PRÉSENTANT DES PROPRIÉTÉS PHARMACOLOGIQUES UTILES, PAR EXEMPLE, EN TANT QU'AGONISTES DU RÉCEPTEUR RUP25. CETTE INVENTION CONCERNE ÉGALEMENT DES COMPOSITIONS PHARMACEUTIQUES CONTENANT LES COMPOSÉS DE L'INVENTION, ET DES PROCÉDÉS D'UTILISATION DES COMPOSÉS ET COMPOSITIONS SELON L'INVENTION POUR TRAITER DES TROUBLES LIÉS AU MÉTABOLISME, Y COMPRIS LA DYSLIPIDEMIE, L'ATHÉROSCLÉROSE, LES MALADIES CORONARIENNES, LA RÉSISTANCE À L'INSULINE, LE DIABÈTE DE TYPE 2, LE SYNDROME X, ET ANALOGUE. DE PLUS, LA PRÉSENTE INVENTION CONCERNE L'UTILISATION DESDITS COMPOSÉS EN ASSOCIATION AVEC D'AUTRES AGENTS ACTIFS TELS QUE CEUX APPARTENANT À LA CLASSE DES INHIBITEURS DE L'$G(A)-GLUCOSIDASE, DES INHIBITEURS DE L'ALDOSE RÉDUCTASE, DES BIGUANIDES, DES INHIBITEURS DE LA HMG-COA RÉDUCTASE, DES INHIBITEURS DE LA SYNTHÈSE DE SQUALÈNE, DES FIBRATES, DES RENFORÇATEURS DU CATABOLISME DES LDL, DES INHIBITEURS DE L'ENZYME DE CONVERSION DE L'ANGIOTENSINE (ACE), DES RENFORÇATEURS DE LA SÉCRÉTION D'INSULINE, DES ANTAGONISTES DU RÉCEPTEUR DP, ET ANALOGUE.
MA30071A 2004-12-23 2007-07-12 Derives de pyrazole condenses, et procedes pour traiter des troubles lies au metabolisme MA29148B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63866804P 2004-12-23 2004-12-23
US67652105P 2005-04-29 2005-04-29

Publications (1)

Publication Number Publication Date
MA29148B1 true MA29148B1 (fr) 2008-01-02

Family

ID=36593187

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30071A MA29148B1 (fr) 2004-12-23 2007-07-12 Derives de pyrazole condenses, et procedes pour traiter des troubles lies au metabolisme

Country Status (24)

Country Link
US (3) US7241792B2 (fr)
EP (1) EP1831178A2 (fr)
JP (1) JP2008525476A (fr)
KR (1) KR20070088808A (fr)
CN (2) CN102321024A (fr)
AR (1) AR055015A1 (fr)
AU (1) AU2005319121A1 (fr)
BR (1) BRPI0519262A2 (fr)
CA (1) CA2589648A1 (fr)
CU (1) CU23691B7 (fr)
EA (1) EA013184B1 (fr)
GE (1) GEP20105126B (fr)
GT (1) GT200500379A (fr)
HN (1) HN2005036256A (fr)
IL (1) IL183654A0 (fr)
MA (1) MA29148B1 (fr)
NI (1) NI200700161A (fr)
NO (1) NO20073766L (fr)
NZ (1) NZ555721A (fr)
PA (1) PA8658301A1 (fr)
PE (1) PE20060949A1 (fr)
TN (1) TNSN07236A1 (fr)
TW (1) TW200635904A (fr)
WO (1) WO2006069242A2 (fr)

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Also Published As

Publication number Publication date
CA2589648A1 (fr) 2006-06-29
WO2006069242A2 (fr) 2006-06-29
CU23691B7 (es) 2011-09-21
GT200500379A (es) 2006-10-25
HN2005036256A (es) 2010-02-08
WO2006069242A3 (fr) 2006-08-31
NI200700161A (es) 2008-04-21
CN102311378A (zh) 2012-01-11
BRPI0519262A2 (pt) 2009-01-06
US20090258892A1 (en) 2009-10-15
AR055015A1 (es) 2007-08-01
US20060205955A1 (en) 2006-09-14
EA013184B1 (ru) 2010-02-26
TW200635904A (en) 2006-10-16
PA8658301A1 (es) 2006-10-13
US7241792B2 (en) 2007-07-10
EP1831178A2 (fr) 2007-09-12
NZ555721A (en) 2011-02-25
US20070073062A1 (en) 2007-03-29
NO20073766L (no) 2007-09-21
IL183654A0 (en) 2007-09-20
EA200701361A1 (ru) 2007-12-28
TNSN07236A1 (en) 2008-11-21
US7612106B2 (en) 2009-11-03
CN102321024A (zh) 2012-01-18
KR20070088808A (ko) 2007-08-29
PE20060949A1 (es) 2006-10-11
GEP20105126B (en) 2010-12-10
CU20070144A7 (es) 2010-01-22
AU2005319121A1 (en) 2006-06-29
JP2008525476A (ja) 2008-07-17

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MA27883A1 (fr) Derives de pyrido [2,1-a] isoquinoline utilises comme inhibiteurs de dpp-iv
MA27728A1 (fr) Antagonistes des recepteurs de cgrp
MA31087B1 (fr) Derives d'amide et d'ester d'indazolyle pour traiter des troubles medies par le recepteur de glucocorticoïde.
MA30333B1 (fr) Aminotetrahydropyranes utiles en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete.
MA27774A1 (fr) Inhibiteurs de phosphatidylinositol 3-kinase
MA29713B1 (fr) Derives de tetrahydroindolone et de tetrahydroindazolone
MA31763B1 (fr) Inhibiteurs de kinase de type polo
MA30652B1 (fr) Composes organiques
MA29799B1 (fr) Administration d'inhibiteurs de dipeptidyl peptidase
MA31373B1 (fr) Composes amino-heterocycliques
MA31766B1 (fr) Composés organiques
MA31761B1 (fr) Nouveaux inhibiteurs de seh et leur utilisation
MA28175A1 (fr) Composes organiques
MY140410A (en) Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
MA29170B1 (fr) Derives puriniques agissant comme des agonistes du recepteur a2a
MA31593B1 (fr) Derives de 2-aza-bicyclo[3.3.0]octane
MA31432B1 (fr) Metabolites de derives de (thio) carbamoyl-cyclohexane
MA30089B1 (fr) (arylsulfonyl)-pyrasolopiperidines
BR0005765A (pt) Combinação de inibidores de aldose redutase e agentes anti-hipertensivos para o tratamento de complicações diabéticas