MA29433B1 - COMPOSES IMIDAZO[1,2-a]PYRIDINYLE INHIBITEURS DU VEGF-R2. - Google Patents

COMPOSES IMIDAZO[1,2-a]PYRIDINYLE INHIBITEURS DU VEGF-R2.

Info

Publication number
MA29433B1
MA29433B1 MA30233A MA30233A MA29433B1 MA 29433 B1 MA29433 B1 MA 29433B1 MA 30233 A MA30233 A MA 30233A MA 30233 A MA30233 A MA 30233A MA 29433 B1 MA29433 B1 MA 29433B1
Authority
MA
Morocco
Prior art keywords
vegf
imidazo
inhibitors
pyridinyl compounds
compounds
Prior art date
Application number
MA30233A
Other languages
English (en)
Inventor
David Anthony Barda
Timothy Paul Burkholder
Joshua Ryan Clayton
Yan Hao
Perry Clark Heath
James Robert Henry
John Monte Knobeloch
David Mendel
Johnathan Alexander Mclean
David Michael Remick
Mark Edward Rempala
Zhao-Qing Wang
Yvonne Yee Mai Yip
Boyu Zhong
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA29433B1 publication Critical patent/MA29433B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE COMPOSÉS INHIBITEURS DU VEGF-R2 (RÉCEPTEUR 2 DU FACTEUR DE CROISSANCE DE L'ENDOTHÉLIUM VASCULAIRE) REPRÉSENTÉS PAR LA FORMULE (I). L'INVENTION CONCERNE ÉGALEMENT DES PROCÉDÉS D'UTILISATION DE CES COMPOSÉS.
MA30233A 2005-02-24 2007-09-24 COMPOSES IMIDAZO[1,2-a]PYRIDINYLE INHIBITEURS DU VEGF-R2. MA29433B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65598105P 2005-02-24 2005-02-24

Publications (1)

Publication Number Publication Date
MA29433B1 true MA29433B1 (fr) 2008-05-02

Family

ID=36587138

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30233A MA29433B1 (fr) 2005-02-24 2007-09-24 COMPOSES IMIDAZO[1,2-a]PYRIDINYLE INHIBITEURS DU VEGF-R2.

Country Status (33)

Country Link
US (1) US7666879B2 (fr)
EP (1) EP1904494B1 (fr)
JP (1) JP5055136B2 (fr)
KR (1) KR100904938B1 (fr)
CN (1) CN101128461B (fr)
AR (1) AR056186A1 (fr)
AT (1) ATE490254T1 (fr)
AU (1) AU2006216710B2 (fr)
BR (1) BRPI0609047A2 (fr)
CA (1) CA2599124C (fr)
CR (1) CR9331A (fr)
CY (1) CY1111154T1 (fr)
DE (1) DE602006018615D1 (fr)
DK (1) DK1904494T3 (fr)
DO (1) DOP2006000051A (fr)
EA (1) EA011691B1 (fr)
ES (1) ES2354716T3 (fr)
HR (1) HRP20100677T1 (fr)
IL (1) IL184717A (fr)
MA (1) MA29433B1 (fr)
MX (1) MX2007010326A (fr)
NO (1) NO20074666L (fr)
NZ (2) NZ584753A (fr)
PE (1) PE20061098A1 (fr)
PL (1) PL1904494T3 (fr)
PT (1) PT1904494E (fr)
RS (1) RS51590B (fr)
SI (1) SI1904494T1 (fr)
TN (1) TNSN07323A1 (fr)
TW (1) TW200640924A (fr)
UA (1) UA91535C2 (fr)
WO (1) WO2006091671A1 (fr)
ZA (1) ZA200707136B (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2114941B1 (fr) 2006-12-22 2015-03-25 Astex Therapeutics Limited Composés hétérocycliques bicycliques servant d'inhibiteurs des fgfr
US8131527B1 (en) 2006-12-22 2012-03-06 Astex Therapeutics Ltd. FGFR pharmacophore compounds
JP5442449B2 (ja) * 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド 新規化合物
WO2008112164A2 (fr) 2007-03-08 2008-09-18 The Board Of Trustees Of The Leland Stanford Junior University Modulateurs de l'aldéhyde déshydrogénase-2 mitochondrial, et leurs procédés d'utilisation
GB0720041D0 (en) * 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
MX2010004244A (es) * 2007-10-17 2010-04-30 Novartis Ag Derivados de imidazo [i,2-a]-piridina utiles como inhibidores de cinasa tipo activina (alk).
GB0810902D0 (en) * 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
EP2337563B1 (fr) 2008-09-08 2014-04-09 The Board of Trustees of The Leland Stanford Junior University Modulateurs de l'activité de l'aldéhyde déshydrogénase et leurs procédés d'utilisation
JP2012506856A (ja) 2008-10-28 2012-03-22 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アルデヒドデヒドロゲナーゼのモジュレーターおよびその使用方法
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
TW201124391A (en) 2009-10-20 2011-07-16 Lundbeck & Co As H 2-substituted-ethynylthiazole derivatives and uses of same
GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
UA109290C2 (uk) 2010-10-07 2015-08-10 Спільні кристали і солі інгібіторів ccr3
WO2012149106A1 (fr) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions et procédés d'augmentation de la prolifération de cellules souches salivaires adultes
AR090566A1 (es) * 2012-04-02 2014-11-19 Boehringer Ingelheim Int Proceso para la produccion de inhibidores de crr
US10213421B2 (en) 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
EP2900238B1 (fr) 2012-09-28 2017-12-06 Vanderbilt University Composés hétérocycliques condensés comme inhibiteurs sélectifs de bmp
CN104822679B (zh) * 2012-11-29 2016-10-19 霍夫曼-拉罗奇有限公司 咪唑并吡啶衍生物
WO2014160185A2 (fr) 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Modulateurs de l'aldéhyde déshydrogénase-2 mitochondriale et leurs procédés d'utilisation
WO2015095128A1 (fr) 2013-12-16 2015-06-25 Asana Biosciences, Llc Composés de p2x3 et/ou p2x2/3 et procédés
CN103772308B (zh) * 2013-12-31 2015-11-18 北京颖泰嘉和生物科技股份有限公司 5-氨基-3-(1-乙基-1-甲基丙基)异噁唑中间体的制备方法和异噁草胺的制备方法
EP3152194B8 (fr) * 2014-06-03 2019-10-09 Arizona Board of Regents on Behalf of the University of Arizona Dérivés de benzimidazole
CA2952083C (fr) 2014-07-17 2023-01-24 Sunshine Lake Pharma Co., Ltd. Derives d'uree substitues et utilisations pharmaceutiques de ceux-ci
CN104163790B (zh) * 2014-08-19 2016-02-10 贵州威顿晶磷电子材料股份有限公司 一种2-氨基-4-甲基-5溴吡啶的制备工艺
WO2017019804A2 (fr) 2015-07-28 2017-02-02 Plexxikon Inc. Composés et procédés de modulation des kinases, et indications associées
JP2018526452A (ja) * 2015-09-03 2018-09-13 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ Ｄｙｒｋ１ａの小分子抑制剤およびその使用
EP3430005B1 (fr) * 2016-03-16 2021-12-08 Plexxikon Inc. Composes et procedes de modulation des kinases, et indications associees
US12528810B2 (en) 2018-03-01 2026-01-20 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of DYRK/CLK and uses thereof
US10745400B2 (en) 2018-03-14 2020-08-18 Vanderbuilt University Inhibition of BMP signaling, compounds, compositions and uses thereof
US10239885B1 (en) 2018-06-18 2019-03-26 Avista Pharma Solutions, Inc. Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-α]pyrazin-3-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea as a prostaglandin EP4 receptor antagonist
US11174263B2 (en) 2018-12-31 2021-11-16 Biomea Fusion, Inc. Inhibitors of menin-MLL interaction
JP7536767B2 (ja) 2018-12-31 2024-08-20 バイオメア フュージョン，インコーポレイテッド メニン－ｍｌｌ相互作用の不可逆的阻害剤
CN113382990B (zh) 2019-01-11 2024-11-19 格吕伦塔尔有限公司 取代的吡咯烷酰胺iii
EP3917935A4 (fr) * 2019-01-30 2022-11-16 Avista Pharma Solutions, Inc. Procédé de synthèse et nouveaux intermédiaires
US11459331B2 (en) 2019-01-30 2022-10-04 Avista Pharma Solutions, Inc. Chemical compounds
CN111574521A (zh) * 2019-02-18 2020-08-25 深圳市塔吉瑞生物医药有限公司 取代的芳香稠合环衍生物及其组合物及用途
KR20220054286A (ko) * 2019-06-25 2022-05-02 시놉세 테라페우틱스 눈 장애의 치료를 위한 화합물
CN112778294A (zh) * 2021-01-07 2021-05-11 苏州安睿药业有限公司 5-氨基异噁唑衍生物及其在制备多激酶抑制剂中的应用
CA3228627A1 (fr) 2021-08-11 2023-02-16 Thomas Butler Inhibiteurs covalents de l'interaction menine-mll pour le diabete sucre
KR20240087693A (ko) 2021-08-20 2024-06-19 바이오메아 퓨전, 인크. 암 치료를 위한 비가역적 메닌-mll 억제제인 n-[4-[4-(4-모르폴리닐)-7h-피롤로[2,3-d]피리미딘-6-일]페닐]-4-[[3(r)-[(1-옥소-2-프로펜-1-일)아미노]-1-피페리디닐]메틸]-2-피리딘카르복스아미드의 결정질 형태
TW202430528A (zh) 2023-01-18 2024-08-01 美商拜歐米富士恩股份有限公司 Ｎ－［４－［４－（４－嗎啉基）－７ｈ－吡咯並［２，３－ｄ］嘧啶－６－基］苯基］－４－［［３（ｒ）－［（１－氧代－２－丙烯－１－基）氨基］－１－哌啶基］甲基］－２－吡啶甲醯胺的結晶形式作為ｍｅｎｉｎ－ｍｌｌ相互作用的共價抑制劑
WO2025038525A1 (fr) * 2023-08-11 2025-02-20 Bioventures, Llc Inhibiteurs de la fms-like tyrosine kinase 3 (flt3) pour le traitement de maladies ou d'affections de prolifération cellulaire

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000506880A (ja) 1996-03-15 2000-06-06 ゼネカ・リミテッド シンノリン誘導体及びその使用
JP2001518470A (ja) 1997-09-26 2001-10-16 メルク エンド カムパニー インコーポレーテッド 新規な血管形成阻害剤
MXPA02000314A (es) 1999-07-09 2004-06-22 Boehringer Ingelheim Pharma Proceso novedoso para la sintesis de compuestos de urea substituidos con heteroarilo.
US6492529B1 (en) 2000-01-18 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Bis pyrazole-1H-pyrazole intermediates and their synthesis
EP1408950B1 (fr) 2001-07-11 2007-04-25 Boehringer Ingelheim Pharmaceuticals Inc. Methodes permettant de traiter des maladies induites par les cytokines
JP2003313126A (ja) * 2002-04-23 2003-11-06 Sankyo Co Ltd イミダゾピリジン誘導体を有効成分とする医薬
EP1503757B1 (fr) * 2002-05-02 2007-12-19 Merck & Co., Inc. Inhibiteurs de la tyrosine kinase
AU2003299651A1 (en) * 2002-12-11 2004-06-30 Merck And Co., Inc. Tyrosine kinase inhibitors
US7262199B2 (en) * 2002-12-11 2007-08-28 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2004265189B2 (en) 2003-08-15 2010-03-04 Banyu Pharmaceutical Co., Ltd. Imidazopyridine derivatives

Also Published As

Publication number Publication date
NZ560402A (en) 2010-06-25
EP1904494A1 (fr) 2008-04-02
PT1904494E (pt) 2010-12-23
UA91535C2 (en) 2010-08-10
RS51590B (sr) 2011-08-31
CY1111154T1 (el) 2015-06-11
AR056186A1 (es) 2007-09-26
HK1118284A1 (en) 2009-02-06
AU2006216710B2 (en) 2011-08-11
ZA200707136B (en) 2008-11-26
ATE490254T1 (de) 2010-12-15
CN101128461A (zh) 2008-02-20
PL1904494T3 (pl) 2011-04-29
EA011691B1 (ru) 2009-04-28
PE20061098A1 (es) 2006-10-20
SI1904494T1 (sl) 2011-02-28
KR100904938B1 (ko) 2009-06-29
CA2599124A1 (fr) 2006-08-31
DE602006018615D1 (de) 2011-01-13
AU2006216710A1 (en) 2006-08-31
WO2006091671A1 (fr) 2006-08-31
US7666879B2 (en) 2010-02-23
NO20074666L (no) 2007-11-09
CN101128461B (zh) 2010-12-22
MX2007010326A (es) 2007-10-16
NZ584753A (en) 2011-06-30
CR9331A (es) 2008-03-31
DK1904494T3 (da) 2011-02-21
CA2599124C (fr) 2013-08-06
TNSN07323A1 (en) 2008-12-31
HRP20100677T1 (hr) 2011-01-31
EA200701802A1 (ru) 2008-02-28
JP2008531574A (ja) 2008-08-14
IL184717A (en) 2011-11-30
US20090227622A1 (en) 2009-09-10
IL184717A0 (en) 2007-12-03
KR20070099029A (ko) 2007-10-08
EP1904494B1 (fr) 2010-12-01
ES2354716T3 (es) 2011-03-17
JP5055136B2 (ja) 2012-10-24
BRPI0609047A2 (pt) 2010-11-16
TW200640924A (en) 2006-12-01
DOP2006000051A (es) 2006-08-31

Similar Documents

Publication Publication Date Title
TNSN07323A1 (en) Imidazo (1, 2-a) pyridine compounds as vegf-r2 inhibitors
TW200612958A (en) Substituted imidazole derivatives
MX2007004699A (es) Derivados de indol y bencimidazol.
MA30531B1 (fr) Anticorps anti-dll4 et leurs procedes d'utilisation
WO2006044687A3 (fr) Inhibiteurs de kinase
WO2008027812A3 (fr) Dérivés d'imidazopyridine et d'imidazopyrimidine
ZA200807274B (en) Novel pyridine derivatives
MXPA04008613A (es) N-aminoacetil-pirrolidina-2-carbonitrilos y su uso como inhibidores de ddp-iv.
EA200800727A1 (ru) Введение ингибиторов дипептидилпептидазы
WO2005021536A3 (fr) Nouveaux composes
TW200607801A (en) Pyrimidine derivatives for the treatment of abnormal cell growth
EP1675552A4 (fr) Preparation d'azabenzimidazoles 1,6-disubstitues comme inhibiteurs de kinases
WO2009079412A3 (fr) Inhibiteurs de transcriptase inverse
UA83875C2 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
WO2008086122A3 (fr) Dérivés cyclisés en tant qu'inhibiteurs d'eg-5
WO2007146124A3 (fr) Inhibiteurs de pde5 substitué
IL191751A0 (en) Pyrrolo[2,3-c]pyridine derivatives
MX2007005611A (es) Compuestos de imidazo[1,2-a]piridina, composiciones, usos y metodos relacionados.
MX2009005071A (es) Compuestos de pirazol y triazol sustituidos como inhibidores de ksp.
WO2006116733A3 (fr) Inhibiteurs des proteines kinases
TW200744593A (en) Thrombin receptor antagonists as prophylaxis to complications from cardiopulmonary surgery
IL189883A0 (en) Isoquinolines as igf-1r inhibitors
TNSN08209A1 (fr) Derives de pyrazolo [4,3-d] pyrimidine -5-yle utilises comme inhibiteurs de pde5
TW200800951A (en) Substituted imidazole compounds as KSP inhibitors
MA29910B1 (fr) Potentialisateurs des recepteurs ampa