MA29849B1 - Composes exercant une activite au niveau du recepteur m1 et leurs utilisations en medecine - Google Patents

Composes exercant une activite au niveau du recepteur m1 et leurs utilisations en medecine

Info

Publication number
MA29849B1
MA29849B1 MA30812A MA30812A MA29849B1 MA 29849 B1 MA29849 B1 MA 29849B1 MA 30812 A MA30812 A MA 30812A MA 30812 A MA30812 A MA 30812A MA 29849 B1 MA29849 B1 MA 29849B1
Authority
MA
Morocco
Prior art keywords
compounds
medicine
alkyl
activity
substituted
Prior art date
Application number
MA30812A
Other languages
English (en)
Inventor
Brian Budzik
David Gwyn Cooper
Ian Thomson Forbes
Vincenzo Garzya
Jian Jin
Dongchuan Shi
Paul William Smith
Graham Walker
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0519950.0A external-priority patent/GB0519950D0/en
Priority claimed from GB0602040A external-priority patent/GB0602040D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA29849B1 publication Critical patent/MA29849B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Composés ayant une activité au niveau du récepteur M1 et leurs utilisations en médecine Des composés qui présentent une activité au niveau du récepteur M1 et leurs utilisations en médecine. Il est proposé des composés de formule (I) et leurs sels et produits de solvatation : formule dans laquelle R4 représente un groupe fluoro, R5 est choisi entre un atome d'hydrogène et un atome d'halogène, des groupes cyano, alkyle en C1 à C6, alkyle en C1 à C6 substitué avec un ou plusieurs atomes de fluor, alkoxy en C1 à C6 et alkoxy en C1 à C6 substitué avec un ou plusieurs atomes de fluor ; et R6 est choisi entre un atome d'halogène, un groupe cyano, alkyle en C1 à C6, alkyle en C1 à C6 substitué avec un ou plusieurs atomes de fluor cycloalkyle en C3 à C6, cycloalkyle en C3 à C6 substitué avec un ou plusieurs atomes de fluor, alkoxy en C1 à C6 et alkoxy en C1 à C6 substitué avec un ou plusieurs atomes de fluor et Q représente un atome d'hydrogène ou un groupe alkyle en C1 à C6. Il est prévu que les composés soient utiles en thérapie, par exemple dans le traitement de troubles psychotiques et d'une altération cognitive.
MA30812A 2005-09-30 2008-04-04 Composes exercant une activite au niveau du recepteur m1 et leurs utilisations en medecine MA29849B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0519950.0A GB0519950D0 (en) 2005-09-30 2005-09-30 Compounds
GB0602040A GB0602040D0 (en) 2006-02-01 2006-02-01 Compounds

Publications (1)

Publication Number Publication Date
MA29849B1 true MA29849B1 (fr) 2008-10-03

Family

ID=37598231

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30812A MA29849B1 (fr) 2005-09-30 2008-04-04 Composes exercant une activite au niveau du recepteur m1 et leurs utilisations en medecine

Country Status (24)

Country Link
US (2) US8283364B2 (fr)
EP (1) EP1943230B1 (fr)
JP (1) JP5209480B2 (fr)
KR (2) KR101374458B1 (fr)
CN (1) CN101321736B (fr)
AR (1) AR056103A1 (fr)
AT (1) ATE492537T1 (fr)
AU (1) AU2006296369B2 (fr)
BR (1) BRPI0616609A2 (fr)
CA (1) CA2624504C (fr)
CR (1) CR9904A (fr)
DE (1) DE602006019119D1 (fr)
EA (1) EA016286B1 (fr)
IL (1) IL190219A (fr)
JO (1) JO2634B1 (fr)
MA (1) MA29849B1 (fr)
MY (1) MY148504A (fr)
NO (1) NO20081945L (fr)
NZ (1) NZ566508A (fr)
PE (1) PE20070490A1 (fr)
TW (1) TWI389905B (fr)
UA (1) UA101299C2 (fr)
WO (1) WO2007036715A2 (fr)
ZA (1) ZA200802167B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1960389B1 (fr) 2005-09-30 2012-08-15 Glaxo Group Limited Composes exerçant une activite au niveau du recepteur m1 et leurs utilisations en medecine
WO2007036711A1 (fr) 2005-09-30 2007-04-05 Glaxo Group Limited Benzimidazolones exerçant une activite au niveau du recepteur m1
EA016286B1 (ru) 2005-09-30 2012-03-30 Глэксо Груп Лимитед Соединения, которые обладают активностью по отношению к рецепторам м, и их применения в медицине
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GB0605785D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0706165D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706174D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706170D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706164D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0718415D0 (en) * 2007-09-20 2007-10-31 Glaxo Group Ltd Compounds
WO2009124882A1 (fr) * 2008-04-09 2009-10-15 H. Lundbeck A/S Nouvelles pipéridinyl-1,3-dihydrobenzoimidazol-2-ones comme agonistes de m1
GB0817982D0 (en) 2008-10-01 2008-11-05 Glaxo Group Ltd Compounds
CA2966594A1 (fr) * 2014-11-03 2016-05-12 William Beaumont Hospital Procede de traitement du syndrome de la vessie hypoactive
BR112017023200A2 (pt) * 2015-04-29 2018-08-07 Janssen Pharmaceutica Nv compostos de indolona e seu uso como moduladores do receptor de ampa
BR122023023802A2 (pt) 2015-04-29 2023-12-26 Janssen Pharmaceutica Nv Compostos azabenzimidazóis, seu uso como moduladores do receptor de ampa e composições farmacêuticas que os compreendem
WO2017044693A1 (fr) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Combinaison muscarinique et son utilisation pour lutter contre des troubles hypocholinergiques du système nerveux central
CN107673994A (zh) * 2017-04-27 2018-02-09 联化科技股份有限公司 一种芳基甲烷类化合物的制备方法
CN107739342B (zh) * 2017-11-29 2020-01-10 华南理工大学 一种一步合成5-二芳氨基苯并咪唑酮衍生物的方法
CN117049938B (zh) * 2023-06-20 2024-06-14 山东轩德医药科技有限公司 一种6-溴-2,3-二氟甲苯的制备方法

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EA016286B1 (ru) 2005-09-30 2012-03-30 Глэксо Груп Лимитед Соединения, которые обладают активностью по отношению к рецепторам м, и их применения в медицине
EP1960389B1 (fr) 2005-09-30 2012-08-15 Glaxo Group Limited Composes exerçant une activite au niveau du recepteur m1 et leurs utilisations en medecine
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GB0706173D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706188D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706164D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706174D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706189D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706165D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706187D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706168D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706167D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706170D0 (en) 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
EP1943230A2 (fr) 2008-07-16
ZA200802167B (en) 2009-08-26
US8481566B2 (en) 2013-07-09
TW200806657A (en) 2008-02-01
US20080255195A1 (en) 2008-10-16
MY148504A (en) 2013-04-30
JP2009512635A (ja) 2009-03-26
WO2007036715A2 (fr) 2007-04-05
JO2634B1 (en) 2012-06-17
JP5209480B2 (ja) 2013-06-12
EA200801001A1 (ru) 2008-08-29
KR20130091791A (ko) 2013-08-19
PE20070490A1 (es) 2007-05-30
TWI389905B (zh) 2013-03-21
EP1943230B1 (fr) 2010-12-22
NO20081945L (no) 2008-06-04
CR9904A (es) 2008-07-29
US8283364B2 (en) 2012-10-09
AR056103A1 (es) 2007-09-19
KR101374458B1 (ko) 2014-03-17
AU2006296369B2 (en) 2012-12-20
IL190219A (en) 2012-10-31
DE602006019119D1 (de) 2011-02-03
BRPI0616609A2 (pt) 2011-06-28
ATE492537T1 (de) 2011-01-15
CA2624504A1 (fr) 2007-04-05
KR20080049090A (ko) 2008-06-03
IL190219A0 (en) 2008-11-03
CN101321736B (zh) 2012-04-04
CA2624504C (fr) 2014-07-08
EA016286B1 (ru) 2012-03-30
NZ566508A (en) 2011-07-29
UA101299C2 (uk) 2013-03-25
AU2006296369A1 (en) 2007-04-05
CN101321736A (zh) 2008-12-10
US20080058378A1 (en) 2008-03-06
WO2007036715A3 (fr) 2007-05-18

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