MA29620B1 - Nouveau derive de 1,4-benzothiazepine-1,1-dioxyde presentant des proprietes ameliorees, procede pour sa preparation, medicaments contenant ce compose, et son utilisation - Google Patents
Nouveau derive de 1,4-benzothiazepine-1,1-dioxyde presentant des proprietes ameliorees, procede pour sa preparation, medicaments contenant ce compose, et son utilisationInfo
- Publication number
- MA29620B1 MA29620B1 MA30557A MA30557A MA29620B1 MA 29620 B1 MA29620 B1 MA 29620B1 MA 30557 A MA30557 A MA 30557A MA 30557 A MA30557 A MA 30557A MA 29620 B1 MA29620 B1 MA 29620B1
- Authority
- MA
- Morocco
- Prior art keywords
- same
- benzothiazepine
- novel
- improved properties
- medicaments containing
- Prior art date
Links
- IVGHNDNOFMTFMK-UHFFFAOYSA-N 1$l^{6},4-benzothiazepine 1,1-dioxide Chemical class O=S1(=O)C=CN=CC2=CC=CC=C12 IVGHNDNOFMTFMK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000003524 antilipemic agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
L'invention concerne un nouveau dérivé de 1,4-benzothiazépine-1,1-dioxyde présentant des propriétés améliorées, un procédé de fabrication de ce composé, des médicaments contenant ce composé et son utilisation. L'invention concerne le composé représenté par la formule (A) ainsi que ses sels physiologiquement compatibles. Le composé selon l'invention peut par exemple servent d'agent hypolipidémiant.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005033100A DE102005033100B3 (de) | 2005-07-15 | 2005-07-15 | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, diese Verbindung enthaltene Arzneimittel und Verfahren zu deren Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA29620B1 true MA29620B1 (fr) | 2008-07-01 |
Family
ID=37575930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA30557A MA29620B1 (fr) | 2005-07-15 | 2008-01-08 | Nouveau derive de 1,4-benzothiazepine-1,1-dioxyde presentant des proprietes ameliorees, procede pour sa preparation, medicaments contenant ce compose, et son utilisation |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20080207592A1 (fr) |
| EP (1) | EP1907370B1 (fr) |
| JP (1) | JP2009501178A (fr) |
| KR (1) | KR20080027841A (fr) |
| CN (1) | CN101218217A (fr) |
| AR (2) | AR055076A1 (fr) |
| AT (1) | ATE423774T1 (fr) |
| AU (1) | AU2006272043A1 (fr) |
| BR (1) | BRPI0613041A2 (fr) |
| CA (1) | CA2614697A1 (fr) |
| DE (2) | DE102005033100B3 (fr) |
| IL (1) | IL188606A0 (fr) |
| MA (1) | MA29620B1 (fr) |
| MX (1) | MX2008000355A (fr) |
| NO (1) | NO20080728L (fr) |
| NZ (1) | NZ565293A (fr) |
| RU (1) | RU2008105741A (fr) |
| TW (1) | TW200745070A (fr) |
| WO (1) | WO2007009656A2 (fr) |
| ZA (1) | ZA200710360B (fr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ566877A (en) | 2005-09-29 | 2010-05-28 | Sanofi Aventis | Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−2,4−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
| US7960564B2 (en) * | 2007-10-19 | 2011-06-14 | Abbott Laboratories | Crystalline chemotherapeutic |
| US7943782B2 (en) * | 2007-10-19 | 2011-05-17 | Abbott Laboratories | Crystalline chemotherapeutic |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| WO2010003624A2 (fr) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Composés hétérocycliques, leurs procédés de préparation, médicaments comprenant lesdits composés et leur utilisation |
| EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
| MX366925B (es) | 2010-11-04 | 2019-07-31 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepaticas. |
| US20130236541A1 (en) | 2010-11-08 | 2013-09-12 | Albireo Ab | Pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| EP2683704B1 (fr) | 2011-03-08 | 2014-12-17 | Sanofi | Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation |
| WO2012120054A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
| EP2683698B1 (fr) | 2011-03-08 | 2017-10-04 | Sanofi | Dérivés benzyl-oxathiazine substitués avec adamantane ou noradamantane, médicaments contenant ces composés et leur utilisation |
| WO2012120055A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| EP2766349B1 (fr) | 2011-03-08 | 2016-06-01 | Sanofi | Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation |
| EP2683703B1 (fr) | 2011-03-08 | 2015-05-27 | Sanofi | Nouveaux dérivés phényl-oxathiazine substitués, procédé pour leur préparation, agent pharmaceutique contenant ces composés et leur utilisation |
| US8846666B2 (en) | 2011-03-08 | 2014-09-30 | Sanofi | Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| WO2012120056A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
| EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CA2952406A1 (fr) | 2014-06-25 | 2015-12-30 | Ea Pharma Co., Ltd. | Preparation solide et procede d'inhibition ou d'attenuation de coloration de celle-ci |
| EP3012252A1 (fr) | 2014-10-24 | 2016-04-27 | Ferring BV | Formes crystallines d'Elobixibat |
| JP6954927B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| CN108601744B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| CA3011595C (fr) | 2016-02-09 | 2024-01-02 | Albireo Ab | Pastilles de cholestyramine et procedes de preparation associes |
| US11186558B2 (en) * | 2016-06-27 | 2021-11-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Synthetic methods |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| JP7328207B2 (ja) | 2017-08-09 | 2023-08-16 | アルビレオ・アクチボラグ | コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用 |
| JP7391048B2 (ja) | 2018-06-05 | 2023-12-04 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| KR20210024033A (ko) | 2018-06-20 | 2021-03-04 | 알비레오 에이비 | 오데빅시바트의 약학 제제 |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| BR112021002207A2 (pt) | 2018-08-10 | 2021-05-04 | Diapin Therapeutics, Llc | tri-peptídeos e tratamento de distúrbios metabólicos, cardiovasculares e inflamatórios |
| SG11202108566VA (en) | 2019-02-06 | 2021-09-29 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| CN113453753B (zh) | 2019-02-06 | 2024-07-23 | 阿尔比里奥公司 | 苯并硫氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| WO2021110885A1 (fr) | 2019-12-04 | 2021-06-10 | Albireo Ab | Composés de benzothiadiazépine et leur utilisation en tant que modulateurs de l'acide biliaire |
| JP7665621B2 (ja) | 2019-12-04 | 2025-04-21 | アルビレオ・アクチボラグ | ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| CA3158181A1 (fr) | 2019-12-04 | 2021-06-10 | Albireo Ab | Composes de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire |
| CA3158195A1 (fr) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Composes de benzothia(di)azepine et leur utilisation en tant que modulateurs de l'acide biliaire |
| CN114786772B (zh) | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| ES3002777T3 (en) | 2020-08-03 | 2025-03-07 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| AU2021379076A1 (en) | 2020-11-12 | 2023-06-08 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| CN117412955A (zh) | 2021-06-03 | 2024-01-16 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| CN119053330A (zh) | 2022-04-22 | 2024-11-29 | 阿尔比里奥公司 | 皮下给药asbt抑制剂 |
| EP4536232A1 (fr) | 2022-06-09 | 2025-04-16 | Albireo AB | Traitement de l'hépatite |
| CN119487013A (zh) | 2022-07-05 | 2025-02-18 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| EP4629997A1 (fr) | 2022-12-09 | 2025-10-15 | Albireo AB | Inhibiteurs d'asbt dans le traitement de maladies rénales |
| WO2025146508A1 (fr) | 2024-01-05 | 2025-07-10 | Albireo Ab | Composés de benzothia(di)azépine et leur utilisation en tant que modulateurs d'acide biliaire |
| WO2025146507A1 (fr) | 2024-01-05 | 2025-07-10 | Albireo Ab | Composés de benzothia(di)azépine et leur utilisation en tant que modulateurs d'acide biliaire |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| DE19916108C1 (de) * | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
-
2005
- 2005-07-15 DE DE102005033100A patent/DE102005033100B3/de not_active Expired - Fee Related
-
2006
- 2006-07-13 JP JP2008520795A patent/JP2009501178A/ja not_active Abandoned
- 2006-07-13 MX MX2008000355A patent/MX2008000355A/es not_active Application Discontinuation
- 2006-07-13 KR KR1020087001184A patent/KR20080027841A/ko not_active Withdrawn
- 2006-07-13 RU RU2008105741/04A patent/RU2008105741A/ru not_active Application Discontinuation
- 2006-07-13 AR ARP060103009A patent/AR055076A1/es unknown
- 2006-07-13 DE DE502006002956T patent/DE502006002956D1/de not_active Expired - Fee Related
- 2006-07-13 AR ARP060103010A patent/AR058433A1/es unknown
- 2006-07-13 CN CNA2006800250068A patent/CN101218217A/zh active Pending
- 2006-07-13 CA CA002614697A patent/CA2614697A1/fr not_active Abandoned
- 2006-07-13 WO PCT/EP2006/006849 patent/WO2007009656A2/fr not_active Ceased
- 2006-07-13 TW TW095125566A patent/TW200745070A/zh unknown
- 2006-07-13 EP EP06776212A patent/EP1907370B1/fr not_active Expired - Lifetime
- 2006-07-13 BR BRPI0613041-0A patent/BRPI0613041A2/pt not_active Application Discontinuation
- 2006-07-13 NZ NZ565293A patent/NZ565293A/en unknown
- 2006-07-13 AU AU2006272043A patent/AU2006272043A1/en not_active Abandoned
- 2006-07-13 AT AT06776212T patent/ATE423774T1/de not_active IP Right Cessation
-
2007
- 2007-11-29 ZA ZA200710360A patent/ZA200710360B/xx unknown
-
2008
- 2008-01-06 IL IL188606A patent/IL188606A0/en unknown
- 2008-01-07 US US11/970,293 patent/US20080207592A1/en not_active Abandoned
- 2008-01-08 MA MA30557A patent/MA29620B1/fr unknown
- 2008-02-08 NO NO20080728A patent/NO20080728L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE102005033100B3 (de) | 2007-01-25 |
| WO2007009656A3 (fr) | 2007-04-19 |
| CN101218217A (zh) | 2008-07-09 |
| IL188606A0 (en) | 2008-04-13 |
| MX2008000355A (es) | 2008-03-07 |
| JP2009501178A (ja) | 2009-01-15 |
| EP1907370A2 (fr) | 2008-04-09 |
| WO2007009656A2 (fr) | 2007-01-25 |
| RU2008105741A (ru) | 2009-08-20 |
| EP1907370B1 (fr) | 2009-02-25 |
| ATE423774T1 (de) | 2009-03-15 |
| AR058433A1 (es) | 2008-02-06 |
| US20080207592A1 (en) | 2008-08-28 |
| AR055076A1 (es) | 2007-08-01 |
| CA2614697A1 (fr) | 2007-01-25 |
| NZ565293A (en) | 2010-01-29 |
| AU2006272043A1 (en) | 2007-01-25 |
| KR20080027841A (ko) | 2008-03-28 |
| ZA200710360B (en) | 2008-11-26 |
| TW200745070A (en) | 2007-12-16 |
| BRPI0613041A2 (pt) | 2010-12-14 |
| DE502006002956D1 (de) | 2009-04-09 |
| NO20080728L (no) | 2008-02-08 |
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| MA29311B1 (fr) | Derives d'isoxazolines et son nouveau procede de production | |
| MA31832B1 (fr) | Dérivés de quinazolinedione, leur préparation et leurs applications thérapeutiques | |
| MA30351B1 (fr) | Composes de tetrahydropyridothienopyrimidine et leurs procedes d'utilisation | |
| MA38330B1 (fr) | Dérivés d'acide phosphonique butanoïque de bisphénol substitués en qualité d'inhibiteurs de nep (endopeptidase neutre) | |
| MA31116B1 (fr) | Procede de synthese de derives de l'acide 3-amino-tetrahydro-furan-3-carboxylique et utilisation de ceux-ci en tant que medicaments | |
| MA30959B1 (fr) | Composes de pyrazole et de triazole substitues comme inhibiteurs de ksp | |
| MA31325B1 (fr) | Nouveaux procedes |