MA30409B1 - Amino-pyrimidine 2,6-substituee-4-mono-substituee en tant qu'antagoniste du recepteur de la prostaglandine d2. - Google Patents

Amino-pyrimidine 2,6-substituee-4-mono-substituee en tant qu'antagoniste du recepteur de la prostaglandine d2.

Info

Publication number
MA30409B1
MA30409B1 MA31375A MA31375A MA30409B1 MA 30409 B1 MA30409 B1 MA 30409B1 MA 31375 A MA31375 A MA 31375A MA 31375 A MA31375 A MA 31375A MA 30409 B1 MA30409 B1 MA 30409B1
Authority
MA
Morocco
Prior art keywords
pharmaceutically
substituted
urticaria
hydrate
inflammation
Prior art date
Application number
MA31375A
Other languages
English (en)
Inventor
David Stefany
Keith John Harris
Timothy Alan Gillespy
Charles J Gardner
Joacy C Aguiar
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA30409B1 publication Critical patent/MA30409B1/fr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN COMPOSÉ DE FORMULE (I) DANS LAQUELLE R1 ET R2 SONT TELS QUE DÉFINIS DANS LA PRÉSENTE OU UN SEL, HYDRATE OU SOLVATE ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE DE CELUI-CI, UN PROMÉDICAMENT ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE DE CELUI-CI OU UN SEL, HYDRATE OU SOLVATE ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE DU PROMÉDICAMENT, UNE COMPOSITION PHARMACEUTIQUE COMPRENANT UNE QUANTITÉ EFFICACE DU POINT DE VUE PHARMACEUTIQUE D'UN OU PLUSIEURS COMPOSÉS DE L'INVENTION EN MÉLANGE AVEC UN VÉHICULE ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE, UN PROCÉDÉ DE TRAITEMENT D'UN PATIENT SOUFFRANT D'UN TROUBLE MÉDIÉ PAR LA PGD2 Y COMPRIS, MAIS SANS Y ÊTRE LIMITÉ, UNE MALADIE ALLERGIQUE (TELLE QUE LA RHINITE ALLERGIQUE, LA CONJONCTIVITE ALLERGIQUE, LA DERMATITE ATOPIQUE, L'ASTHME BRONCHIQUE ET UNE ALLERGIE ALIMENTAIRE), LA MASTOCYTOSE SYSTÉMIQUE, DES TROUBLES S'ACCOMPAGNANT D'UNE ACTIVATION SYSTÉMIQUE DES MASTOCYTES, LE CHOC ANAPHYLACTIQUE, LA BRONCHOCONSTRICTION, LA BRONCHITE, L'URTICAIRE, L'ECZÉMA, DES MALADIES S'ACCOMPAGNANT DE DÉMANGEAISONS (TELLES QUE LA DERMATITE ATOPIQUE ET L'URTICAIRE), DES MALADIES (TELLES QUE LA CATARACTE, LE DÉCOLLEMENT DE LA RÉTINE, UNE INFLAMMATION, UNE INFECTION ET DES TROUBLES DU SOMMEIL) LESQUELLES SONT GÉNÉRÉES DE FAÇON SECONDAIRE EN CONSÉQUENCE D'UN COMPORTEMENT ACCOMPAGNANT DES DÉMANGEAISONS (TEL QUE LE FAIT DE SE GRATTER OU DE SE FRAPPER), UNE INFLAMMATION, DES BRONCHOPNEUMOPATHIES OBSTRUCTIVES CHRONIQUES, UNE LÉSION D'ISCHÉMIE-REPERFUSION, UN ACCIDENT CÉRÉBROVASCULAIRE, LA POLYARTHRITE RHUMATOÏDE CHRONIQUE, LA PLEURÉSIE, LA RECTOCOLITE HÉMORRAGIQUE ET SIMILAIRES, EN ADMINISTRANT AUDIT PATIENT UNE QUANTITÉ EFFICACE DU POINT DE VUE PHARMACEUTIQUE D'UN COMPOSÉ DE L'INVENTION.
MA31375A 2006-04-12 2008-11-10 Amino-pyrimidine 2,6-substituee-4-mono-substituee en tant qu'antagoniste du recepteur de la prostaglandine d2. MA30409B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74467606P 2006-04-12 2006-04-12

Publications (1)

Publication Number Publication Date
MA30409B1 true MA30409B1 (fr) 2009-05-04

Family

ID=38294040

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31375A MA30409B1 (fr) 2006-04-12 2008-11-10 Amino-pyrimidine 2,6-substituee-4-mono-substituee en tant qu'antagoniste du recepteur de la prostaglandine d2.

Country Status (25)

Country Link
US (1) US20090036469A1 (fr)
EP (1) EP2010503A1 (fr)
JP (1) JP2009533473A (fr)
KR (1) KR20080108287A (fr)
CN (1) CN101421252B (fr)
AR (1) AR060403A1 (fr)
AU (1) AU2007238052B2 (fr)
BR (1) BRPI0710710A2 (fr)
CA (1) CA2649083C (fr)
CR (1) CR10249A (fr)
DO (1) DOP2007000068A (fr)
EC (1) ECSP088813A (fr)
HN (1) HN2008001530A (fr)
MA (1) MA30409B1 (fr)
MX (1) MX2008011369A (fr)
NO (1) NO20084291L (fr)
NZ (1) NZ571793A (fr)
PE (1) PE20080186A1 (fr)
RU (1) RU2431631C2 (fr)
TN (1) TNSN08339A1 (fr)
TW (1) TW200815395A (fr)
UA (1) UA95950C2 (fr)
UY (1) UY30283A1 (fr)
WO (1) WO2007121280A1 (fr)
ZA (1) ZA200807380B (fr)

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JP5039594B2 (ja) * 2008-02-08 2012-10-03 株式会社日立ハイテクノロジーズ レビュー装置,検査領域設定支援システム、および、欠陥の画像得方法
AR074776A1 (es) * 2008-12-18 2011-02-09 Sanofi Aventis Metodo para tratar la degeneracion macular; modulando el sistema inmunitario del paciente
AR080527A1 (es) * 2010-03-16 2012-04-11 Aventis Pharma Inc Una pirimidina sustituida como un antagonista del receptor de la postaglandina d2
MX2012010035A (es) * 2010-03-16 2012-10-01 Aventis Pharma Inc Pirimidinas sustituidas como antagonistas del receptor de la prostaglandina d2.
CN102958914B (zh) 2010-07-05 2015-05-27 埃科特莱茵药品有限公司 1-苯基取代的杂环衍生物及其作为前列腺素d2受体调节剂的用途
WO2012044561A2 (fr) * 2010-09-30 2012-04-05 Merck Sharp & Dohme Corp. Inhibiteurs de 2-alcoxy pyrimidine pde10
TW201331179A (zh) 2011-12-21 2013-08-01 Actelion Pharmaceuticals Ltd 雜環衍生物及其作為前列腺素d2受體調節劑之用途
CA2876808A1 (fr) 2012-07-05 2014-01-09 Actelion Pharmaceuticals Ltd Derives heterocyclyles 1-phenyl-substitues et leur utilisation en tant que modulateurs du recepteur de la prostaglandine d2
ES2690782T3 (es) 2012-10-24 2018-11-22 Nyu Winthrop Hospital Biomarcador no invasivo para identificar sujetos en riesgo de parto prematuro
CA2930008A1 (fr) * 2013-11-08 2015-05-14 Kissei Pharmaceutical Co., Ltd. Derive de carboxymethylpiperidine
CR20170077A (es) 2014-08-04 2017-06-26 Nuevolution As Derivados de heterociclilo opcionalmente condensados de pirimidina útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
TW201900179A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 作為pge2受體調節劑之苯并呋喃及苯并噻吩衍生物
US11839613B2 (en) 2017-05-18 2023-12-12 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
KR102612140B1 (ko) 2017-05-18 2023-12-08 이도르시아 파마슈티컬스 리미티드 피리미딘 유도체
PE20191814A1 (es) 2017-05-18 2019-12-27 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
CA3075688A1 (fr) 2017-09-13 2019-03-21 Progenity, Inc. Biomarqueurs de pre-eclampsie ainsi que systemes et procedes associes
AU2020347662A1 (en) * 2019-09-13 2022-03-31 Meiji Co., Ltd. Solid food and solid milk
EP4070113A4 (fr) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. Évaluation de la prééclampsie à l'aide de dosages du facteur de croissance placentaire libre et dissocié
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
UY38994A (es) 2019-12-20 2021-07-30 Nuevolution As Compuestos activos frente a receptores nucleares
WO2021198956A1 (fr) 2020-03-31 2021-10-07 Nuevolution A/S Composés actifs vis-à-vis des récepteurs nucléaires
AU2021245397A1 (en) 2020-03-31 2022-10-20 Nuevolution A/S Compounds active towards nuclear receptors

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DE3644799A1 (de) * 1986-06-04 1987-12-10 Hoechst Ag Neue pyrimidin-derivate, deren herstellung und verwendung
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
SE0200411D0 (sv) * 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
GT200500284A (es) * 2004-10-15 2006-03-27 Aventis Pharma Inc Pirimidinas como antagonistas del receptor de prostaglandina d2
GT200600457A (es) * 2005-10-13 2007-04-27 Aventis Pharma Inc Sal de fosfato dihidrogeno como antagonistas del receptor de prostaglandina d2

Also Published As

Publication number Publication date
UA95950C2 (en) 2011-09-26
NO20084291L (no) 2008-11-11
EP2010503A1 (fr) 2009-01-07
US20090036469A1 (en) 2009-02-05
CA2649083A1 (fr) 2007-10-25
JP2009533473A (ja) 2009-09-17
HN2008001530A (es) 2012-01-17
AU2007238052B2 (en) 2011-12-22
RU2008144578A (ru) 2010-05-20
AR060403A1 (es) 2008-06-11
HK1131975A1 (en) 2010-02-12
PE20080186A1 (es) 2008-04-15
CR10249A (es) 2008-11-26
WO2007121280A1 (fr) 2007-10-25
BRPI0710710A2 (pt) 2011-08-16
TW200815395A (en) 2008-04-01
CA2649083C (fr) 2011-06-28
UY30283A1 (es) 2007-11-30
KR20080108287A (ko) 2008-12-12
CN101421252A (zh) 2009-04-29
ZA200807380B (en) 2009-05-27
AU2007238052A1 (en) 2007-10-25
ECSP088813A (es) 2008-11-27
DOP2007000068A (es) 2007-10-31
RU2431631C2 (ru) 2011-10-20
MX2008011369A (es) 2008-09-18
TNSN08339A1 (en) 2009-12-29
CN101421252B (zh) 2011-10-12
NZ571793A (en) 2011-08-26

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