MA30511B1 - Polymorphes de n-hydroxy -3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2- propenamide - Google Patents

Polymorphes de n-hydroxy -3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2- propenamide

Info

Publication number
MA30511B1
MA30511B1 MA31470A MA31470A MA30511B1 MA 30511 B1 MA30511 B1 MA 30511B1 MA 31470 A MA31470 A MA 31470A MA 31470 A MA31470 A MA 31470A MA 30511 B1 MA30511 B1 MA 30511B1
Authority
MA
Morocco
Prior art keywords
methyl
propenamide
indol
hydroxy
phenyl
Prior art date
Application number
MA31470A
Other languages
English (en)
Inventor
Murat Acemoglu
Joginder S Bajwa
Piotr Karpinski
Dimitris Papoutsakis
Joel Slade
Frank Stowasser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832679&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30511(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30511B1 publication Critical patent/MA30511B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)

Abstract

Les formes polymorphes de la base libre de N-hydroxy-3-[4-[[[2-(2-méthyl-1H-indol-3-yl)éthyl]amino]méthyl]phényl]-2E-2-propénamide et les sels de ces composés, faisant l'objet de la présente invention, sont préparés au moyen de procédés variés.
MA31470A 2006-06-12 2008-12-12 Polymorphes de n-hydroxy -3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2- propenamide MA30511B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80451706P 2006-06-12 2006-06-12
US88322407P 2007-01-03 2007-01-03

Publications (1)

Publication Number Publication Date
MA30511B1 true MA30511B1 (fr) 2009-06-01

Family

ID=38832679

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31470A MA30511B1 (fr) 2006-06-12 2008-12-12 Polymorphes de n-hydroxy -3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2- propenamide

Country Status (29)

Country Link
US (1) US7989494B2 (fr)
EP (2) EP2086930A2 (fr)
JP (3) JP2009540006A (fr)
KR (4) KR20160032264A (fr)
CN (1) CN102584673B (fr)
AR (1) AR061297A1 (fr)
AU (1) AU2007257881B2 (fr)
BR (1) BRPI0712993A2 (fr)
CA (1) CA2650263A1 (fr)
CL (1) CL2007001689A1 (fr)
CR (1) CR10440A (fr)
EA (1) EA017984B1 (fr)
EC (1) ECSP088976A (fr)
GE (1) GEP20115175B (fr)
GT (1) GT200800280A (fr)
IL (1) IL195015A (fr)
MA (1) MA30511B1 (fr)
ME (1) ME00529B (fr)
MX (1) MX2008015900A (fr)
MY (1) MY149337A (fr)
NI (1) NI200800306A (fr)
NO (1) NO20090135L (fr)
PE (1) PE20080852A1 (fr)
PH (2) PH12012501724A1 (fr)
SM (1) SMP200900001B (fr)
TN (1) TNSN08495A1 (fr)
TW (2) TWI515179B (fr)
UY (1) UY30406A1 (fr)
WO (1) WO2007146716A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ572547A (en) * 2006-06-12 2011-06-30 Novartis Ag SALTS OF N-HYDROXY-3-[4-[[[2-(2-METHYL-1H-INDOL-3-yl)ETHYL]AMINO]METHYL]PHENYL]-2E-2-PROPENAMIDE
AU2008204928B2 (en) * 2007-01-10 2011-03-31 Novartis Ag Formulations of deacetylase inhibitors
WO2017032281A1 (fr) * 2015-08-21 2017-03-02 苏州晶云药物科技有限公司 Nouvelles formes cristallines de lactate de panobinostat
CN106866492B (zh) * 2015-12-10 2021-11-26 江苏豪森药业集团有限公司 帕比司他乳酸盐晶型ii及其制备方法和用途
CN106866491B (zh) * 2015-12-10 2021-12-10 江苏豪森药业集团有限公司 帕比司他乳酸盐晶型ⅰ及其制备方法和用途
WO2018092151A1 (fr) * 2016-11-21 2018-05-24 Msn Laboratories Private Limited, R&D Center Procédé de préparation de l'acide 2- (e)-n-hydroxy-3-[4- [[ [2- (2-méthyl -1 h-indol-3-yl) éthyl] amino] méthyl] phényl]-2-propénamide 2-hydroxypropanoïque (1 : 1) et ses polymorphes
WO2018163114A1 (fr) * 2017-03-10 2018-09-13 Shilpa Medicare Limited Panobinostat amorphe et son sel de lactate
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
MX2022001820A (es) * 2019-08-20 2022-03-17 Ono Pharmaceutical Co Sal y forma cristalina de un compuesto que tiene actividad agonista para el receptor 5 de esfingosina-1-fosfato [acido (2s,3r,4e)-2-amino-3-hidroxioctadeca-4-enil-1-fosforico (s1p5).
GB201913124D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913122D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913121D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
AU2021368107A1 (en) * 2020-10-28 2023-06-22 Viracta Subsidiary, Inc. Hdac inhibitor solid state forms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
ATE352319T1 (de) 2001-11-06 2007-02-15 Novartis Pharma Gmbh Kombination cyclooxygenase-2 inhibitor/ histone deacetylase inhibitor
AU2002361022A1 (en) 2001-12-07 2003-06-17 Novartis Ag Use of alpha-tubulin acetylation levels as a biomarker for protein deacetylase inhibitors
MXPA05012464A (es) 2003-05-21 2006-01-30 Novartis Ag Combinacion de inhibidores de deacetilasa de histona con agentes quimioterapeuticos.
JP2007501775A (ja) 2003-08-07 2007-02-01 ノバルティス アクチエンゲゼルシャフト 免疫抑制剤としてのヒストンデアセチラーゼ阻害剤
US20080085902A1 (en) 2003-09-23 2008-04-10 Guido Bold Combination Of A Vegf Receptor Inhibitor Or With A Chemotherapeutic Agent
NZ572547A (en) 2006-06-12 2011-06-30 Novartis Ag SALTS OF N-HYDROXY-3-[4-[[[2-(2-METHYL-1H-INDOL-3-yl)ETHYL]AMINO]METHYL]PHENYL]-2E-2-PROPENAMIDE

Also Published As

Publication number Publication date
KR20150082690A (ko) 2015-07-15
TNSN08495A1 (en) 2010-04-14
SMAP200900001A (it) 2009-01-14
CA2650263A1 (fr) 2007-12-21
EA017984B1 (ru) 2013-04-30
MX2008015900A (es) 2009-03-06
ECSP088976A (es) 2009-01-30
IL195015A0 (en) 2009-08-03
PH12012501724A1 (en) 2014-05-12
KR20090015968A (ko) 2009-02-12
WO2007146716A2 (fr) 2007-12-21
PE20080852A1 (es) 2008-08-19
CL2007001689A1 (es) 2008-05-16
BRPI0712993A2 (pt) 2012-04-17
ME00529B (fr) 2011-10-10
NO20090135L (no) 2009-03-12
US7989494B2 (en) 2011-08-02
MY149337A (en) 2013-08-30
AR061297A1 (es) 2008-08-20
JP2009540006A (ja) 2009-11-19
TW201441190A (zh) 2014-11-01
GEP20115175B (en) 2011-03-10
UY30406A1 (es) 2008-01-31
EA200802383A1 (ru) 2010-02-26
AU2007257881B2 (en) 2011-06-16
WO2007146716A3 (fr) 2009-07-30
EP2409967A1 (fr) 2012-01-25
JP2015164968A (ja) 2015-09-17
GT200800280A (es) 2015-11-24
CN102584673B (zh) 2014-08-06
NI200800306A (es) 2012-02-01
SMP200900001B (it) 2010-03-01
JP2013139476A (ja) 2013-07-18
CN102584673A (zh) 2012-07-18
US20090192210A1 (en) 2009-07-30
KR20160032264A (ko) 2016-03-23
TWI453196B (zh) 2014-09-21
TWI515179B (zh) 2016-01-01
CR10440A (es) 2011-08-22
KR20140142335A (ko) 2014-12-11
IL195015A (en) 2014-03-31
EP2086930A2 (fr) 2009-08-12
AU2007257881A1 (en) 2007-12-21
PH12012501725A1 (en) 2015-07-06
TW200815344A (en) 2008-04-01

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