MA30813B1 - Derives de 2-pyridinecarboxamide ayant un effet d'activation sur la gk. - Google Patents

Derives de 2-pyridinecarboxamide ayant un effet d'activation sur la gk.

Info

Publication number
MA30813B1
MA30813B1 MA31819A MA31819A MA30813B1 MA 30813 B1 MA30813 B1 MA 30813B1 MA 31819 A MA31819 A MA 31819A MA 31819 A MA31819 A MA 31819A MA 30813 B1 MA30813 B1 MA 30813B1
Authority
MA
Morocco
Prior art keywords
formula
aliphatic
cycle
atom
nitrogenic
Prior art date
Application number
MA31819A
Other languages
English (en)
Inventor
Noriaki Hashimoto
Yufu Sagara
Masanori Asai
Teruyuki Nishimura
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of MA30813B1 publication Critical patent/MA30813B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'INVENTION CONCERNE UN COMPOSÉ REPRÉSENTÉ PAR LA FORMULE (I) OU UN SEL ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE DE CELUI-CI, LEQUEL A UNE ACTIVITÉ D'ACTIVATION DE LA GLUCOKINASE ET EST PAR CONSÉQUENT UTILE POUR LE TRAITEMENT DU DIABÈTE OU DE L'OBÉSITÉ. (I) [DANS LA FORMULE R1 ET R2 REPRÉSENTENT CHACUN INDÉPENDAMMENT UN GROUPE ALKYLE INFÉRIEUR ; ET X1 REPRÉSENTE UN GROUPE REPRÉSENTÉ PAR LA FORMULE (II-1) : (II-1) OÙ R11 ET R12 REPRÉSENTENT CHACUN INDÉPENDAMMENT UN ATOME D'HYDROGÈNE OU UN GROUPE ALKYLE INFÉRIEUR OU BIEN R11 ET R12 PEUVENT FORMER AVEC UN ATOME D'AZOTE AUQUEL R11 ET R12 SONT LIÉS UN CYCLE ALIPHATIQUE AZOTÉ AYANT 4 À 7 CHAÎNONS (L'UN DES ATOMES DE CARBONE CONSTITUANT LE CYCLE ALIPHATIQUE AZOTÉ AYANT 4 À 7 CHAÎNONS POUVANT ÊTRE SUBSTITUÉ PAR UN ATOME D'OXYGÈNE) OU BIEN R11 ET R12 PEUVENT FORMER AVEC N'IMPORTE QUEL ATOME DE CARBONE PRÉSENT DANS LE GROUPE (CH2)M UN CYCLE ALIPHATIQUE AZOTÉ AYANT 4 À 7 CHAÎNONS OU SIMILAIRE ; ET M REPRÉSENTE UN NOMBRE ENTIER CHOISI 1 PARMI 3.]
MA31819A 2006-10-06 2009-04-24 Derives de 2-pyridinecarboxamide ayant un effet d'activation sur la gk. MA30813B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006275824 2006-10-06

Publications (1)

Publication Number Publication Date
MA30813B1 true MA30813B1 (fr) 2009-10-01

Family

ID=39282963

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31819A MA30813B1 (fr) 2006-10-06 2009-04-24 Derives de 2-pyridinecarboxamide ayant un effet d'activation sur la gk.

Country Status (22)

Country Link
US (1) US8338460B2 (fr)
EP (1) EP2077266B1 (fr)
JP (1) JP5292100B2 (fr)
KR (1) KR20090060426A (fr)
CN (1) CN101522673A (fr)
AR (1) AR063028A1 (fr)
AU (1) AU2007307560B2 (fr)
BR (1) BRPI0716590A2 (fr)
CA (1) CA2667068C (fr)
CL (1) CL2007002890A1 (fr)
CO (1) CO6180507A2 (fr)
CR (1) CR10673A (fr)
GT (1) GT200900065A (fr)
IL (1) IL197714A0 (fr)
MA (1) MA30813B1 (fr)
MX (1) MX2009003073A (fr)
NO (1) NO20091793L (fr)
PE (1) PE20081195A1 (fr)
RU (1) RU2009117209A (fr)
SV (1) SV2009003196A (fr)
TW (1) TW200831504A (fr)
WO (1) WO2008044777A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0407283A (pt) * 2003-02-13 2006-01-31 Banyu Pharma Co Ltd Composto, composição farmacêutica, e, agente ativador de glucoquinase, agentes terapêuticos e/ou agentes preventivos para diabetes melito e obesidade
AR063028A1 (es) 2006-10-06 2008-12-23 Banyu Pharma Co Ltd Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
AU2008321959B2 (en) 2007-11-12 2014-02-13 Msd K.K. Heteroaryloxy quinazoline derivative
JP2012500181A (ja) 2008-08-15 2012-01-05 Ｍｓｄ株式会社 アセチルピロリジニルインドール誘導体
CA2734981A1 (fr) * 2008-08-29 2010-03-04 Banyu Pharmaceutical Co., Ltd. Derive d'oxotetrahydrofurann-2-yl-benzimidazole
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
EP2582709B1 (fr) 2010-06-18 2018-01-24 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
EP2760862B1 (fr) 2011-09-27 2015-10-21 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
US9527838B2 (en) 2012-12-17 2016-12-27 Merck Sharp & Dohme Corp. 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment
CN113045546A (zh) * 2021-03-25 2021-06-29 浙江天宇药业股份有限公司 一种吡咯替尼杂质、其制备方法及用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3630200A (en) 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
GB2277930A (en) 1993-05-11 1994-11-16 Shell Int Research Herbicidal picolinamide derivatives
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
SE0102300D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
SE519859C2 (sv) 2001-08-17 2003-04-15 Novacast Ab Anordning för behandling av järnlegeringar i ett kärl
WO2003080585A1 (fr) * 2002-03-26 2003-10-02 Banyu Pharmaceutical Co., Ltd. Derive aminobenzamide
BRPI0407283A (pt) 2003-02-13 2006-01-31 Banyu Pharma Co Ltd Composto, composição farmacêutica, e, agente ativador de glucoquinase, agentes terapêuticos e/ou agentes preventivos para diabetes melito e obesidade
WO2004076420A1 (fr) 2003-02-26 2004-09-10 Banyu Pharmaceutical Co., Ltd. Derives d'heteroarylcarbamoylbenzene
EP2256106B1 (fr) 2003-07-22 2015-05-06 Astex Therapeutics Limited Composes 1H-pyrazole 3,4-disubstitues et leur utilisation en tant que kinases dependant des cyclines (CDK) et modulateurs de la glycogene synthase kinase-3 (GSK-3)
WO2005042524A1 (fr) 2003-10-30 2005-05-12 Virochem Pharma Inc. Carboxamide de pyridine et methodes permettant d'inhiber l'integrase du vih
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
GB0412468D0 (en) 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
KR100716891B1 (ko) 2005-11-01 2007-05-09 (주)아모레퍼시픽 피리딘 티아졸 카복사마이드 유도체, 이의 제조방법 및이를 함유하는 피부 미백용 조성물
US7951824B2 (en) 2006-02-17 2011-05-31 Hoffman-La Roche Inc. 4-aryl-pyridine-2-carboxyamide derivatives
EP1849785A1 (fr) 2006-04-28 2007-10-31 Neuropharma, S.A. Dérivés de N-(2-Thiazolyl)-amide en tant qu'inhibiteurs de GSK-3
AR063028A1 (es) 2006-10-06 2008-12-23 Banyu Pharma Co Ltd Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
JP5292100B2 (ja) 2013-09-18
IL197714A0 (en) 2009-12-24
NO20091793L (no) 2009-05-05
BRPI0716590A2 (pt) 2012-12-25
EP2077266A1 (fr) 2009-07-08
WO2008044777A1 (fr) 2008-04-17
CA2667068C (fr) 2012-03-27
AU2007307560B2 (en) 2012-10-04
GT200900065A (es) 2010-04-28
US8338460B2 (en) 2012-12-25
EP2077266B1 (fr) 2012-07-25
CL2007002890A1 (es) 2008-01-18
PE20081195A1 (es) 2008-09-04
CA2667068A1 (fr) 2008-04-17
RU2009117209A (ru) 2010-11-20
EP2077266A4 (fr) 2010-07-07
CN101522673A (zh) 2009-09-02
AU2007307560A1 (en) 2008-04-17
CO6180507A2 (es) 2010-07-19
KR20090060426A (ko) 2009-06-12
CR10673A (es) 2009-09-03
AR063028A1 (es) 2008-12-23
SV2009003196A (es) 2009-07-28
TW200831504A (en) 2008-08-01
US20080090799A1 (en) 2008-04-17
JPWO2008044777A1 (ja) 2010-02-18
MX2009003073A (es) 2009-04-02

Similar Documents

Publication Publication Date Title
MA27626A1 (fr) Nouveaux derives de 2-pyridinecarboxamide
MA32089B1 (fr) Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
MA29323B1 (fr) Composes de l'acide pyridylacetique
MA29250B1 (fr) Cyclohexylamides servant d'antagonistes des recepteurs de dopamine d3, d2 et de 5ht1a
EA200401609A1 (ru) Лекарственное средство для лечения диабета
MA28453B1 (fr) Nouveaux insecticides
MA28024A1 (fr) Derives de (thio) carbamoyl-cyclohexane utilises en tant qu'antagonistes des recepteurs d3/d2
MX2009003073A (es) Derivado de 2-piridincarboxamida que tiene efecto activador de gk.
MA32731B1 (fr) Céphalosporine possédant un groupe catéchol
MA31319B1 (fr) Dérivés de sulfonylamides destines au traitement d'une croissance cellulaire anormale
JP2004518723A5 (fr)
MXPA06001274A (es) Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio.
WO2005092858A3 (fr) Composes alpha-aryle ou heteroaryle methyle beta piperidino propanamide en tant qu'antagoniste du recepteur orl1
CA2662848C (fr) Derives de 2-aryl-6-phenyl-imidazo[1,2-.alpha.]pyridines, leur preparation et leur application en therapeutique
MA33851B1 (fr) Compose heterocyclique contenant de l'azote et fongicide agricole
MA29742B1 (fr) Derives de benzoquinazoline et utilisation de ceux-ci dans le traitement de maladies osseuses
TNSN08270A1 (fr) Dérivés pyrimidiques destinés à traiter une croissance cellulaire anormale
RU2006130466A (ru) Аминоспирт
MA29716B1 (fr) NOUVEAUX DERIVES D'IMIDAZO[1,5-a]PYRIDINES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT.
MA29698B1 (fr) Dérivés de n-(hétéroaryl)-1-hétéroarylalkyl-1h-indole-2-carboxamides, leur préparation et leur application en thérapeutique.
DK1740584T5 (da) Kondenseret chinolinderivat og anvendelse deraf
MA41790B1 (fr) Dérivé de morphinane
MA29343B1 (fr) Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine
TNSN07400A1 (fr) Derives d'aminoacides
MA30577B1 (fr) Molecules duales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques