MA31702B1 - Derive de 4-pyrimidinesulfamide - Google Patents

Derive de 4-pyrimidinesulfamide

Info

Publication number
MA31702B1
MA31702B1 MA32692A MA32692A MA31702B1 MA 31702 B1 MA31702 B1 MA 31702B1 MA 32692 A MA32692 A MA 32692A MA 32692 A MA32692 A MA 32692A MA 31702 B1 MA31702 B1 MA 31702B1
Authority
MA
Morocco
Prior art keywords
compound
pyrimidinesulfamide
derivative
pyrimidinesulfamide derivative
salts
Prior art date
Application number
MA32692A
Other languages
Arabic (ar)
English (en)
Inventor
Martin Bolli
Christoph Boss
Alexander Treiber
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40140023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31702(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA31702B1 publication Critical patent/MA31702B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)

Abstract

L'invention porte sur le composé représenté par la formule structurale (i) et sur les sels de celui-ci. Ledit composé est utile en tant qu'antagoniste du récepteur de l'endothéline. L'invention porte en outre sur un procédé pour préparer ledit composé.
MA32692A 2007-08-17 2010-03-12 Derive de 4-pyrimidinesulfamide MA31702B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2007053292 2007-08-17
IB2008052571 2008-06-26
PCT/IB2008/053282 WO2009024906A1 (fr) 2007-08-17 2008-08-15 Dérivé de 4-pyrimidinesulfamide

Publications (1)

Publication Number Publication Date
MA31702B1 true MA31702B1 (fr) 2010-09-01

Family

ID=40140023

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32692A MA31702B1 (fr) 2007-08-17 2010-03-12 Derive de 4-pyrimidinesulfamide

Country Status (31)

Country Link
US (1) US8324232B2 (fr)
EP (1) EP2190837B1 (fr)
JP (1) JP5323075B2 (fr)
KR (1) KR101528946B1 (fr)
CN (1) CN101772494B (fr)
AR (1) AR070018A1 (fr)
AU (1) AU2008290234B2 (fr)
BR (1) BRPI0815360B8 (fr)
CA (1) CA2695511C (fr)
CY (2) CY1113255T1 (fr)
DK (1) DK2190837T3 (fr)
ES (1) ES2394584T3 (fr)
FI (1) FIC20240041I1 (fr)
FR (1) FR24C1047I2 (fr)
HR (1) HRP20120878T1 (fr)
HU (1) HUS2400041I1 (fr)
IL (1) IL203936A (fr)
LT (1) LTC2190837I2 (fr)
MA (1) MA31702B1 (fr)
MX (1) MX2010001837A (fr)
MY (1) MY152281A (fr)
NL (1) NL301304I2 (fr)
NO (1) NO2024053I1 (fr)
NZ (1) NZ583990A (fr)
PL (1) PL2190837T3 (fr)
PT (1) PT2190837E (fr)
RU (1) RU2485116C2 (fr)
SI (1) SI2190837T1 (fr)
TW (1) TWI411437B (fr)
WO (1) WO2009024906A1 (fr)
ZA (1) ZA201001872B (fr)

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EP2907811A1 (fr) * 2014-02-14 2015-08-19 Actelion Pharmaceuticals Ltd. Procédé de fabrication de dérivés de sulfamide de pyrimidine
WO2017093903A1 (fr) * 2015-11-30 2017-06-08 Laurus Labs Private Limited Procédé amélioré de préparation de macitentane
WO2017191565A1 (fr) * 2016-05-04 2017-11-09 Shilpa Medicare Limited Procédé de préparation de macitentan
EP3658140B1 (fr) * 2017-02-27 2025-05-21 Idorsia Pharmaceuticals Ltd Combinaisons de l'aprocitentan avec des autres principes actifs pour le traitement de hypertension résistante
MY210547A (en) * 2017-11-30 2025-09-30 Idorsia Pharmaceuticals Ltd Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases
CN108997223B (zh) * 2018-08-09 2020-06-30 浙江先锋科技股份有限公司 5-(4-溴苯基)-4，6-二氯嘧啶的制备方法
SMT202400274T1 (it) 2018-12-21 2024-09-16 Actelion Pharmaceuticals Ltd Macitentan per il trattamento di ipertensione arteriosa polmonare
TW202042818A (zh) 2019-01-25 2020-12-01 瑞士商艾克泰聯製藥有限公司 用於治療慢性血栓性肺高血壓之醫藥組成物
CN114630668B (zh) * 2019-11-07 2024-02-27 苏州科睿思制药有限公司 一种Aprocitentan晶型及其制备方法和用途
WO2021237004A1 (fr) 2020-05-21 2021-11-25 Teva Pharmaceuticals International Gmbh Formes à l'état solide d'aprocitentan et leur procédé de préparation
CN114644595A (zh) * 2020-12-19 2022-06-21 普济生物科技（台州）有限公司 阿普昔腾坦的无定型态、其药物组合物和用途
WO2023111797A1 (fr) * 2021-12-17 2023-06-22 Janssen Biotech, Inc. Dérivés de pyrimidinsulfamides et procédé de fabrication associé
JP2025519101A (ja) 2022-05-22 2025-06-24 イドルシア・ファーマシューティカルズ・リミテッド 高血圧の治療のための４－ピリミジンスルファミド誘導体の使用
AU2023275935A1 (en) 2022-05-25 2025-01-09 Idorsia Pharmaceuticals Ltd Crystalline forms of sodium (5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)(sulfamoyl)amide
CN119330888B (zh) * 2024-10-25 2025-11-28 上海药坦药物研究开发有限公司 一种阿普昔腾坦的制备方法
CN119504609A (zh) * 2024-11-27 2025-02-25 成都启晟合研医药科技有限公司 一种阿普昔腾坦的中间体化合物、阿普昔腾坦及其制备方法
CN119528821B (zh) * 2024-11-29 2025-10-10 浙江国邦药业有限公司 一种阿普昔腾坦的制备方法
CN119528820B (zh) * 2024-11-29 2025-10-10 浙江国邦药业有限公司 一种阿普昔腾坦的合成方法

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ES2763176T3 (es) 2008-08-13 2020-05-27 Actelion Pharmaceuticals Ltd Composiciones terapéuticas que contienen macitentan

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Publication number Publication date
CA2695511A1 (fr) 2009-02-26
CN101772494B (zh) 2013-05-15
CA2695511C (fr) 2015-11-03
RU2485116C2 (ru) 2013-06-20
EP2190837A1 (fr) 2010-06-02
HK1144196A1 (en) 2011-02-02
SI2190837T1 (sl) 2012-11-30
BRPI0815360A8 (pt) 2017-12-26
CY1113255T1 (el) 2016-04-13
PT2190837E (pt) 2012-10-31
HUS2400041I1 (hu) 2024-12-28
LTPA2024534I1 (fr) 2024-12-27
TWI411437B (zh) 2013-10-11
NZ583990A (en) 2012-06-29
NO2024053I1 (no) 2024-12-03
PL2190837T3 (pl) 2013-01-31
RU2010109543A (ru) 2011-09-27
WO2009024906A1 (fr) 2009-02-26
DK2190837T3 (da) 2012-10-08
EP2190837B1 (fr) 2012-08-15
AR070018A1 (es) 2010-03-10
CN101772494A (zh) 2010-07-07
US8324232B2 (en) 2012-12-04
BRPI0815360A2 (pt) 2015-02-10
HRP20120878T1 (hr) 2012-11-30
ZA201001872B (en) 2011-05-25
AU2008290234B2 (en) 2013-11-21
JP2010536742A (ja) 2010-12-02
KR101528946B1 (ko) 2015-06-15
FR24C1047I1 (fr) 2025-01-10
FR24C1047I2 (fr) 2025-10-10
BRPI0815360B1 (pt) 2018-12-04
MY152281A (en) 2014-09-15
ES2394584T3 (es) 2013-02-04
KR20100052517A (ko) 2010-05-19
NL301304I2 (nl) 2024-12-19
MX2010001837A (es) 2010-03-10
US20120142716A1 (en) 2012-06-07
TW200927122A (en) 2009-07-01
IL203936A (en) 2016-03-31
FIC20240041I1 (fi) 2024-12-02
AU2008290234A1 (en) 2009-02-26
JP5323075B2 (ja) 2013-10-23
CY2024031I1 (el) 2026-02-25
BRPI0815360B8 (pt) 2021-05-25
LTC2190837I2 (fr) 2026-04-27
CY2024031I2 (el) 2026-02-25

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