MA31710B1 - (carboxylalkylenephenyl)phényloxamides, procédés pour la production de ceux-ci et utilisation de ceux-ci en tant que medicament - Google Patents

(carboxylalkylenephenyl)phényloxamides, procédés pour la production de ceux-ci et utilisation de ceux-ci en tant que medicament

Info

Publication number
MA31710B1
MA31710B1 MA32711A MA32711A MA31710B1 MA 31710 B1 MA31710 B1 MA 31710B1 MA 32711 A MA32711 A MA 32711A MA 32711 A MA32711 A MA 32711A MA 31710 B1 MA31710 B1 MA 31710B1
Authority
MA
Morocco
Prior art keywords
phenloxamide
carboxylalkylphenyl
drug
production processes
compounds
Prior art date
Application number
MA32711A
Other languages
Arabic (ar)
English (en)
Inventor
Elisabeth Defossa
Thomas Klabunde
Viktoria Dietrich
Siegfried Stengelin
Guido Haschke
Andreas Herling
Johanna Kuhlmann
Stefan Bartoschek
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA31710B1 publication Critical patent/MA31710B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des bis-phényl-oxalamides ainsi que leurs sels physiologiquement acceptables. La présente invention concerne des composés de la formule (i), dans laquelle rl, r2, r3, r4, r5, r6, r7, r8, m et x ont les significations indiquées, ainsi que les sels physiologiquement acceptables des composés de formule (i). Les composés sont par exemple appropriés pour le traitement du diabète.
MA32711A 2007-09-21 2010-03-19 (carboxylalkylenephenyl)phényloxamides, procédés pour la production de ceux-ci et utilisation de ceux-ci en tant que medicament MA31710B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291132 2007-09-21
PCT/EP2008/007218 WO2009039943A1 (fr) 2007-09-21 2008-09-04 (carboxyalkylène-phényl)-phényl-oxalamides, procédé pour leur fabrication et leur utilisation comme médicaments

Publications (1)

Publication Number Publication Date
MA31710B1 true MA31710B1 (fr) 2010-09-01

Family

ID=39111451

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32711A MA31710B1 (fr) 2007-09-21 2010-03-19 (carboxylalkylenephenyl)phényloxamides, procédés pour la production de ceux-ci et utilisation de ceux-ci en tant que medicament

Country Status (20)

Country Link
US (2) US8518875B2 (fr)
EP (1) EP2203416B1 (fr)
JP (1) JP5427784B2 (fr)
KR (1) KR20100061692A (fr)
CN (1) CN101796017A (fr)
AR (1) AR068479A1 (fr)
AU (1) AU2008303976B9 (fr)
CA (1) CA2700028A1 (fr)
CL (1) CL2008002742A1 (fr)
CO (1) CO6260062A2 (fr)
IL (1) IL204555A0 (fr)
MA (1) MA31710B1 (fr)
MX (1) MX2010002461A (fr)
MY (1) MY149648A (fr)
NZ (1) NZ584049A (fr)
RU (1) RU2488578C2 (fr)
TW (1) TWI439265B (fr)
UY (1) UY31350A1 (fr)
WO (1) WO2009039943A1 (fr)
ZA (1) ZA201001015B (fr)

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CN104710381A (zh) 2009-12-25 2015-06-17 持田制药株式会社 新的3-羟基-5-芳基异噻唑衍生物
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
EP2612669A4 (fr) 2010-08-31 2014-05-14 Snu R&Db Foundation Utilisation de la reprogrammation f tale d'un agoniste des ppar
JP5809157B2 (ja) 2010-10-08 2015-11-10 持田製薬株式会社 環状アミド誘導体
RU2013152631A (ru) 2011-04-27 2015-06-10 Мотида Фармасьютикал Ко., Лтд. Новое 3-гидроксиизотиазол-1-окидное производное
JPWO2012147516A1 (ja) 2011-04-28 2014-07-28 持田製薬株式会社 環状アミド誘導体
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
WO2013102626A1 (fr) * 2012-01-04 2013-07-11 Sanofi Acides 3-[4-(phénylamino oxalyl amino) phényl] hex-4-énoïques, leur procédé de préparation et leur utilisation comme médicament
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
WO2015046317A1 (fr) * 2013-09-30 2015-04-02 国立大学法人岡山大学 Nouveau dérivé d'acétylène-amide
EP3076959B1 (fr) 2013-12-04 2018-07-04 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
WO2015119899A1 (fr) 2014-02-06 2015-08-13 Merck Sharp & Dohme Corp. Composés antidiabétiques
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CR20200347A (es) 2018-02-13 2020-09-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
TWI712412B (zh) 2018-04-19 2020-12-11 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
SG11202012425QA (en) 2018-07-13 2021-01-28 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2020086556A1 (fr) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Inhibiteurs de pd-1/pd-l1
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제
CN114728917B (zh) * 2019-12-04 2023-12-08 深圳信立泰药业股份有限公司 草酰胺类衍生物、其制备方法及其在医药上的应用
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
WO2021236617A1 (fr) 2020-05-19 2021-11-25 Kallyope, Inc. Activateurs d'ampk
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂

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DE1618196B1 (de) * 1966-02-07 1971-12-09 Ciba Geigy Verwendung von asymmetrischen Oxalsäure-diarylamiden als Ultraviolettschutzmittel
FR2727114B1 (fr) * 1994-11-17 1996-12-27 Oreal Nouveaux filtres solaires, compositions cosmetiques photoprotectrices les contenant et utilisations
EP2583675A1 (fr) * 1998-02-02 2013-04-24 Trustees Of Tufts College Utilisation d'inhibiteurs de la dipeptidylpeptidase pour réguler le métabolisme du glucose
US6890568B2 (en) * 1999-05-24 2005-05-10 Grant Pierce Method for management of blood glucose levels
US6867299B2 (en) * 2000-02-24 2005-03-15 Hoffmann-La Roche Inc. Oxamide IMPDH inhibitors
HU227197B1 (en) 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
EP1395561A1 (fr) * 2001-05-25 2004-03-10 Boehringer Ingelheim Pharmaceuticals Inc. Composes de carbamate et d'oxamide inhibant la production de cytokine
ITRM20020016A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
JP4224979B2 (ja) * 2002-04-09 2009-02-18 大正製薬株式会社 インターロイキン１２抑制剤
AU2003243921B2 (en) * 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
US20050124667A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Oxamide inhibitors of plasminogen activator inhibitor-1

Also Published As

Publication number Publication date
ZA201001015B (en) 2010-10-27
WO2009039943A1 (fr) 2009-04-02
TWI439265B (zh) 2014-06-01
CN101796017A (zh) 2010-08-04
IL204555A0 (en) 2010-11-30
RU2010115748A (ru) 2011-10-27
KR20100061692A (ko) 2010-06-08
AU2008303976B2 (en) 2013-04-18
US8518875B2 (en) 2013-08-27
MX2010002461A (es) 2010-03-26
EP2203416A1 (fr) 2010-07-07
AU2008303976A1 (en) 2009-04-02
AR068479A1 (es) 2009-11-18
RU2488578C2 (ru) 2013-07-27
CA2700028A1 (fr) 2009-04-02
MY149648A (en) 2013-09-30
US20130231388A1 (en) 2013-09-05
JP2010539199A (ja) 2010-12-16
CL2008002742A1 (es) 2009-01-16
JP5427784B2 (ja) 2014-02-26
US20100261645A1 (en) 2010-10-14
EP2203416B1 (fr) 2016-10-26
UY31350A1 (es) 2009-04-30
TW200927088A (en) 2009-07-01
CO6260062A2 (es) 2011-03-22
AU2008303976B9 (en) 2013-09-12
NZ584049A (en) 2011-05-27

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