MA31979B1 - (cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament - Google Patents

(cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament

Info

Publication number
MA31979B1
MA31979B1 MA32712A MA32712A MA31979B1 MA 31979 B1 MA31979 B1 MA 31979B1 MA 32712 A MA32712 A MA 32712A MA 32712 A MA32712 A MA 32712A MA 31979 B1 MA31979 B1 MA 31979B1
Authority
MA
Morocco
Prior art keywords
phenoxamide
cyclopropylphenyl
drug
producing
compounds
Prior art date
Application number
MA32712A
Other languages
Arabic (ar)
English (en)
Inventor
Elisabeth Defossa
Thomas Klabunde
Viktoria Dietrich
Siegfried Stengelin
Guido Haschke
Andreas Herling
Johanna Kuhlmann
Stefan Bartoschek
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA31979B1 publication Critical patent/MA31979B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des (cyclopropyl-phényl)-phényl-oxalamides ainsi que leurs sels physiologiquement acceptables. Elle concerne des composés de la formule (i), dans laquelle r1, r2, r3, r4, r5, r6, r7, r8 et m ont les significations indiquées, ainsi que les sels physiologiquement acceptables desdits composés. Ces composés sont par exemple appropriés pour le traitement du diabète.
MA32712A 2007-09-21 2010-03-19 (cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament MA31979B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291131 2007-09-21
PCT/EP2008/007217 WO2009039942A1 (fr) 2007-09-21 2008-09-04 (cyclopropyl-phényl)-phényl-oxalamides, procédé pour leur fabrication et leur utilisation comme médicaments

Publications (1)

Publication Number Publication Date
MA31979B1 true MA31979B1 (fr) 2011-01-03

Family

ID=39111440

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32712A MA31979B1 (fr) 2007-09-21 2010-03-19 (cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament

Country Status (20)

Country Link
US (1) US8148375B2 (fr)
EP (1) EP2203415B1 (fr)
JP (1) JP2011509239A (fr)
KR (1) KR20100075444A (fr)
CN (1) CN101796018A (fr)
AR (1) AR070753A1 (fr)
AU (1) AU2008303975B2 (fr)
BR (1) BRPI0817198A2 (fr)
CA (1) CA2700025A1 (fr)
CL (1) CL2008002768A1 (fr)
CO (1) CO6260061A2 (fr)
IL (1) IL204556A (fr)
MA (1) MA31979B1 (fr)
MX (1) MX2010002419A (fr)
NZ (1) NZ584050A (fr)
RU (1) RU2010115747A (fr)
TW (1) TW200934751A (fr)
UY (1) UY31351A1 (fr)
WO (1) WO2009039942A1 (fr)
ZA (1) ZA201001014B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
EP2612669A4 (fr) 2010-08-31 2014-05-14 Snu R&Db Foundation Utilisation de la reprogrammation f tale d'un agoniste des ppar
AU2011304285B2 (en) * 2010-09-22 2015-01-29 Eisai R&D Management Co., Ltd. Cyclopropane compound
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
EP3076959B1 (fr) 2013-12-04 2018-07-04 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
WO2015119899A1 (fr) 2014-02-06 2015-08-13 Merck Sharp & Dohme Corp. Composés antidiabétiques
ES2843952T3 (es) 2014-10-23 2021-07-21 Eisai R&D Man Co Ltd Composiciones para tratar el insomnio
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CR20200347A (es) 2018-02-13 2020-09-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
TWI712412B (zh) 2018-04-19 2020-12-11 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
SG11202012425QA (en) 2018-07-13 2021-01-28 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2020086556A1 (fr) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Inhibiteurs de pd-1/pd-l1
CN109574920B (zh) * 2018-12-25 2022-03-04 药大制药有限公司 3-腈基-6环丙基吡啶类ido1抑制剂及其用途
WO2020149129A1 (fr) * 2019-01-15 2020-07-23 株式会社カネカ Procédé de production d'un composé asymétrique
MX2021014410A (es) 2019-05-31 2022-03-17 Avolynt Composiciones y métodos para tratar la enfermedad metabólica.
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
WO2021236617A1 (fr) 2020-05-19 2021-11-25 Kallyope, Inc. Activateurs d'ampk
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890568B2 (en) * 1999-05-24 2005-05-10 Grant Pierce Method for management of blood glucose levels
EP1395561A1 (fr) * 2001-05-25 2004-03-10 Boehringer Ingelheim Pharmaceuticals Inc. Composes de carbamate et d'oxamide inhibant la production de cytokine
US20050124667A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Oxamide inhibitors of plasminogen activator inhibitor-1

Also Published As

Publication number Publication date
RU2010115747A (ru) 2011-10-27
MX2010002419A (es) 2010-03-30
IL204556A (en) 2013-06-27
IL204556A0 (en) 2010-11-30
US8148375B2 (en) 2012-04-03
KR20100075444A (ko) 2010-07-02
AU2008303975B2 (en) 2013-05-16
JP2011509239A (ja) 2011-03-24
EP2203415A1 (fr) 2010-07-07
US20100261644A1 (en) 2010-10-14
CO6260061A2 (es) 2011-03-22
CL2008002768A1 (es) 2009-03-06
EP2203415B1 (fr) 2016-10-26
AU2008303975A1 (en) 2009-04-02
UY31351A1 (es) 2009-04-30
TW200934751A (en) 2009-08-16
AR070753A1 (es) 2010-05-05
CN101796018A (zh) 2010-08-04
CA2700025A1 (fr) 2009-04-02
BRPI0817198A2 (pt) 2015-03-17
NZ584050A (en) 2011-09-30
WO2009039942A1 (fr) 2009-04-02
ZA201001014B (en) 2010-10-27

Similar Documents

Publication Publication Date Title
MA31979B1 (fr) (cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament
MA31710B1 (fr) (carboxylalkylenephenyl)phényloxamides, procédés pour la production de ceux-ci et utilisation de ceux-ci en tant que medicament
MA30609B1 (fr) Imidazolidine-2,4-diones arylaminoaryl-alkyl-substituees, leur procede de synthese, les medicaments comprenant ces composes, et leurs applications.
TN2009000450A1 (fr) Derives de pyridine
TN2009000428A1 (fr) Derives de sulfonylamides destines au traitement d'une croissance cellulaire anormale
MA31574B1 (fr) Dérivés de pyrazole et leur utilisation comme inhibiteurs de raf
MA29926B1 (fr) Derives de pyrazine
TNSN07022A1 (fr) Derives de pyridine
MA40225A (fr) Composés dihydroisoquinolinone substitués
MA33275B1 (fr) Inhibiteurs de la replication du virus de l'immunodeficience humaine
MA34397B1 (fr) Dérivés d'acide napht-2-ylacétique dans le traitement du sida
EA201070186A1 (ru) Способы и соединения, предназначенные для получения ингибиторов котранспортера натрий-глюкозы 2 типа
MA30402B1 (fr) Acides carboxyliques substitues par des phenylamino-benzoxazoles, leur procede de production et leur utilisation comme medicaments
CY1107956T1 (el) Χρηση υποκατεστημενων 2-αμινοτετραλινιων για την προληπτικη αντιμετωπιση της νοσου του παρκινσον
MA31894B1 (fr) Composes organiques
MA30142B1 (fr) Agonistes du recepteur de neuropeptide-2
MA34965B1 (fr) Procédé de production de dérivé de dihydrobenzofurane optiquement actif
EA200601830A1 (ru) Ортозамещённые арильные или гетероарильные амидные соединения
EA200900023A1 (ru) Применение замещенных 2-аминотетралинов для изготовления лекарственного средства для предупреждения, облегчения и/или лечения разных видов боли
MA31906B1 (fr) Inhibiteurs de la replication du virus de limmunodeficience humaine
TN2011000316A1 (fr) Derives de sulfonamides
MA31690B1 (fr) Nouveaux fongicides
NZ600207A (en) Substituted 4-aminocyclohexane derivatives
EA200802329A1 (ru) Производные триазола ii
MA30162B1 (fr) Nouveaux derives de pyrrole a cycles fusionnes