MA31979B1 - (cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament - Google Patents

(cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament

Info

Publication number
MA31979B1
MA31979B1 MA32712A MA32712A MA31979B1 MA 31979 B1 MA31979 B1 MA 31979B1 MA 32712 A MA32712 A MA 32712A MA 32712 A MA32712 A MA 32712A MA 31979 B1 MA31979 B1 MA 31979B1
Authority
MA
Morocco
Prior art keywords
phenoxamide
cyclopropylphenyl
drug
producing
compounds
Prior art date
Application number
MA32712A
Other languages
Arabic (ar)
English (en)
Inventor
Elisabeth Defossa
Thomas Klabunde
Viktoria Dietrich
Siegfried Stengelin
Guido Haschke
Andreas Herling
Johanna Kuhlmann
Stefan Bartoschek
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA31979B1 publication Critical patent/MA31979B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La présente invention concerne des (cyclopropyl-phényl)-phényl-oxalamides ainsi que leurs sels physiologiquement acceptables. Elle concerne des composés de la formule (i), dans laquelle r1, r2, r3, r4, r5, r6, r7, r8 et m ont les significations indiquées, ainsi que les sels physiologiquement acceptables desdits composés. Ces composés sont par exemple appropriés pour le traitement du diabète.
MA32712A 2007-09-21 2010-03-19 (cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament MA31979B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291131 2007-09-21
PCT/EP2008/007217 WO2009039942A1 (fr) 2007-09-21 2008-09-04 (cyclopropyl-phényl)-phényl-oxalamides, procédé pour leur fabrication et leur utilisation comme médicaments

Publications (1)

Publication Number Publication Date
MA31979B1 true MA31979B1 (fr) 2011-01-03

Family

ID=39111440

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32712A MA31979B1 (fr) 2007-09-21 2010-03-19 (cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament

Country Status (20)

Country Link
US (1) US8148375B2 (fr)
EP (1) EP2203415B1 (fr)
JP (1) JP2011509239A (fr)
KR (1) KR20100075444A (fr)
CN (1) CN101796018A (fr)
AR (1) AR070753A1 (fr)
AU (1) AU2008303975B2 (fr)
BR (1) BRPI0817198A2 (fr)
CA (1) CA2700025A1 (fr)
CL (1) CL2008002768A1 (fr)
CO (1) CO6260061A2 (fr)
IL (1) IL204556A (fr)
MA (1) MA31979B1 (fr)
MX (1) MX2010002419A (fr)
NZ (1) NZ584050A (fr)
RU (1) RU2010115747A (fr)
TW (1) TW200934751A (fr)
UY (1) UY31351A1 (fr)
WO (1) WO2009039942A1 (fr)
ZA (1) ZA201001014B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
AU2011296737A1 (en) 2010-08-31 2013-04-11 Snu R&Db Foundation Use of the fetal reprogramming of a PPAR delta agonist
SI2626350T1 (sl) * 2010-09-22 2015-09-30 Eisai R&D Management Co., Ltd. Spojina ciklopropana
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
WO2014064215A1 (fr) 2012-10-24 2014-05-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibiteurs de la kinase tpl2 pour prévenir ou traiter le diabète et favoriser la survie de cellules β
EP3076959B1 (fr) 2013-12-04 2018-07-04 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
US10059667B2 (en) 2014-02-06 2018-08-28 Merck Sharp & Dohme Corp. Antidiabetic compounds
SG10202007759RA (en) 2014-10-23 2020-09-29 Eisai R&D Man Co Ltd Compositions and methods for treating insomnia
WO2016151018A1 (fr) 2015-03-24 2016-09-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthode et composition pharmaceutique destinées à être utilisées dans le traitement du diabète
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
KR102708681B1 (ko) 2018-02-13 2024-09-26 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
EP4600247A3 (fr) 2018-04-19 2025-11-19 Gilead Sciences, Inc. Inhibiteurs de pd-1/pd-l1
UA126421C2 (uk) 2018-07-13 2022-09-28 Гіліад Сайєнсіз, Інк. Інгібітори pd-1/pd-l1
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN109574920B (zh) * 2018-12-25 2022-03-04 药大制药有限公司 3-腈基-6环丙基吡啶类ido1抑制剂及其用途
WO2020149129A1 (fr) * 2019-01-15 2020-07-23 株式会社カネカ Procédé de production d'un composé asymétrique
CN114450011B (zh) 2019-05-31 2024-10-22 阿沃林特有限公司 用于治疗代谢性疾病的组合物和方法
BR112022006546A2 (pt) 2019-10-07 2022-08-30 Kallyope Inc Agonistas de gpr119
CA3173731A1 (fr) 2020-02-28 2021-09-02 Kallyope, Inc. Agonistes de gpr40
CN116323608A (zh) 2020-05-19 2023-06-23 卡尔优普公司 Ampk活化剂
EP4172162A4 (fr) 2020-06-26 2024-08-07 Kallyope, Inc. Activateurs d'ampk

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890568B2 (en) * 1999-05-24 2005-05-10 Grant Pierce Method for management of blood glucose levels
EP1395561A1 (fr) * 2001-05-25 2004-03-10 Boehringer Ingelheim Pharmaceuticals Inc. Composes de carbamate et d'oxamide inhibant la production de cytokine
US20050124667A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Oxamide inhibitors of plasminogen activator inhibitor-1

Also Published As

Publication number Publication date
WO2009039942A1 (fr) 2009-04-02
EP2203415B1 (fr) 2016-10-26
CA2700025A1 (fr) 2009-04-02
CL2008002768A1 (es) 2009-03-06
US20100261644A1 (en) 2010-10-14
CN101796018A (zh) 2010-08-04
IL204556A (en) 2013-06-27
RU2010115747A (ru) 2011-10-27
BRPI0817198A2 (pt) 2015-03-17
NZ584050A (en) 2011-09-30
EP2203415A1 (fr) 2010-07-07
CO6260061A2 (es) 2011-03-22
AU2008303975A1 (en) 2009-04-02
UY31351A1 (es) 2009-04-30
MX2010002419A (es) 2010-03-30
AU2008303975B2 (en) 2013-05-16
KR20100075444A (ko) 2010-07-02
AR070753A1 (es) 2010-05-05
US8148375B2 (en) 2012-04-03
JP2011509239A (ja) 2011-03-24
TW200934751A (en) 2009-08-16
ZA201001014B (en) 2010-10-27
IL204556A0 (en) 2010-11-30

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