ATE438622T1 - 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus - Google Patents

3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus

Info

Publication number
ATE438622T1
ATE438622T1 AT05723594T AT05723594T ATE438622T1 AT E438622 T1 ATE438622 T1 AT E438622T1 AT 05723594 T AT05723594 T AT 05723594T AT 05723594 T AT05723594 T AT 05723594T AT E438622 T1 ATE438622 T1 AT E438622T1
Authority
AT
Austria
Prior art keywords
hepatitis
cyclopentyl
virus
inhibitors
condensed
Prior art date
Application number
AT05723594T
Other languages
English (en)
Inventor
F Njoroge
Srikanth Venkatraman
Ashok Arasappan
Francisco Velazquez
Viyyoor Girijavallabhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE438622T1 publication Critical patent/ATE438622T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AT05723594T 2004-02-27 2005-02-24 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus ATE438622T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54865504P 2004-02-27 2004-02-27
PCT/US2005/005778 WO2005087730A1 (en) 2004-02-27 2005-02-24 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease

Publications (1)

Publication Number Publication Date
ATE438622T1 true ATE438622T1 (de) 2009-08-15

Family

ID=34961939

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05723594T ATE438622T1 (de) 2004-02-27 2005-02-24 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus

Country Status (11)

Country Link
US (1) US7342041B2 (de)
EP (1) EP1737821B1 (de)
JP (1) JP2007525512A (de)
CN (1) CN1946692A (de)
AR (1) AR048413A1 (de)
AT (1) ATE438622T1 (de)
CA (1) CA2557307A1 (de)
DE (1) DE602005015834D1 (de)
ES (1) ES2328589T3 (de)
TW (1) TWI302835B (de)
WO (1) WO2005087730A1 (de)

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Also Published As

Publication number Publication date
EP1737821A1 (de) 2007-01-03
AR048413A1 (es) 2006-04-26
JP2007525512A (ja) 2007-09-06
TW200536530A (en) 2005-11-16
CA2557307A1 (en) 2005-09-22
DE602005015834D1 (de) 2009-09-17
EP1737821B1 (de) 2009-08-05
ES2328589T3 (es) 2009-11-16
WO2005087730A1 (en) 2005-09-22
US7342041B2 (en) 2008-03-11
HK1095820A1 (en) 2007-05-18
US20050197301A1 (en) 2005-09-08
CN1946692A (zh) 2007-04-11
TWI302835B (en) 2008-11-11

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