MA32282B1 - Dérivés de 2-phényl-pyridine substitués - Google Patents

Dérivés de 2-phényl-pyridine substitués

Info

Publication number
MA32282B1
MA32282B1 MA33303A MA33303A MA32282B1 MA 32282 B1 MA32282 B1 MA 32282B1 MA 33303 A MA33303 A MA 33303A MA 33303 A MA33303 A MA 33303A MA 32282 B1 MA32282 B1 MA 32282B1
Authority
MA
Morocco
Prior art keywords
alternative
pyridine derivatives
phenyl pyridine
vascular
viscero
Prior art date
Application number
MA33303A
Other languages
Arabic (ar)
English (en)
Inventor
Eva Caroff
Kurt Hilpert
Francis Hubler
Emmanuel Meyer
Dorte Renneberg
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40756274&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32282(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA32282B1 publication Critical patent/MA32282B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (i) dans laquelle r1, r2, r4, r5, ra, rb, n, w et z sont tels que définis dans la demande, leur préparation et leur utilisation comme antagonistes du récepteur p2y12 dans le traitement et/ou la prévention des maladies vasculaires périphériques, viscéro-vasculaires, hépato-vasculaires et réno-vasculaires, cardiovasculaires et cérébrovasculaires ou des états associés à l'agrégation plaquettaire, y compris la thrombose chez les humains et les autres mammifères.
MA33303A 2008-04-11 2010-11-01 Dérivés de 2-phényl-pyridine substitués MA32282B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008051384 2008-04-11
PCT/IB2009/051499 WO2009125366A1 (fr) 2008-04-11 2009-04-09 Dérivés de 2-phényl-pyridine substitués

Publications (1)

Publication Number Publication Date
MA32282B1 true MA32282B1 (fr) 2011-05-02

Family

ID=40756274

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33303A MA32282B1 (fr) 2008-04-11 2010-11-01 Dérivés de 2-phényl-pyridine substitués

Country Status (17)

Country Link
US (1) US8058263B2 (fr)
EP (1) EP2279191B1 (fr)
JP (1) JP5404768B2 (fr)
KR (1) KR101702670B1 (fr)
CN (1) CN101998961B (fr)
AR (1) AR071652A1 (fr)
AU (1) AU2009235033A1 (fr)
CA (1) CA2719636A1 (fr)
ES (1) ES2476045T3 (fr)
IL (1) IL208547A0 (fr)
MA (1) MA32282B1 (fr)
MX (1) MX2010010933A (fr)
NZ (1) NZ589168A (fr)
RU (1) RU2010145463A (fr)
TW (1) TW200944536A (fr)
WO (1) WO2009125366A1 (fr)
ZA (1) ZA201008053B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200640877A (en) 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
CL2007002920A1 (es) 2006-10-13 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos.
CL2007003038A1 (es) 2006-10-25 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos.
BRPI0819696B1 (pt) * 2007-11-29 2018-10-23 Actelion Pharmaceuticals Ltd compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto
AR071653A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2-fenil-4-ciclopropil-pirimidina
AR071652A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2- fenil-piridina substituidos
WO2010116328A2 (fr) 2009-04-08 2010-10-14 Actelion Pharmaceuticals Ltd 6-(3-azabicyclo[3.1.0]hex-3-yl)-2-phénylpyrimidines
KR101728180B1 (ko) 2009-04-22 2017-04-18 액테리온 파마슈티칼 리미티드 티아졸 유도체들 및 ｐ2ｙ12 수용체 길항제로서 이들의 용도
EP2322514A1 (fr) * 2009-11-11 2011-05-18 Bayer Schering Pharma Aktiengesellschaft Acide homoglutamique et dérivés d'acide glutamique
US9539246B2 (en) 2011-08-30 2017-01-10 University Of Utah Research Foundation Methods and compositions for treating nephrogenic diabetes insipidus
HUE057772T2 (hu) 2016-09-22 2022-06-28 Idorsia Pharmaceuticals Ltd Kristályos formák
US11179390B2 (en) 2017-03-15 2021-11-23 Idorsia Pharmaceuticals Ltd Subcutaneous administration of a P2Y12 receptor antagonist

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5373586A (en) 1976-12-09 1978-06-30 Mitsubishi Chem Ind Ltd New penicillin derivatives
CA2020437A1 (fr) 1989-07-05 1991-01-06 Yoshihide Fuse Derive de cinnamamide
US6855715B1 (en) * 1999-06-14 2005-02-15 Eli Lilly And Company Serine protease inhibitors
US6861424B2 (en) * 2001-06-06 2005-03-01 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
CA2507657C (fr) * 2002-12-11 2011-05-31 Bayer Schering Pharma Aktiengesellschaft Composes de 2-aminocarbonyl-quinoline utilises en tant qu'antagonistes du recepteur de l'adenosine diphosphate des plaquettes
PT1611144E (pt) 2003-04-09 2010-11-12 Wyeth Llc Derivados do ácido 2-(8,9-dioxo-2,6-diazabiciclo(5.2.0)- non-1(7)-eno-2-il)-alquil-fosfónico e sua utilização como antagonistas do receptor n-metil-d-aspartato (nmda)
TW200640877A (en) * 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
ES2421448T3 (es) * 2005-10-21 2013-09-02 Actelion Pharmaceuticals Ltd Derivados de piperazina como agentes contra la malaria
CL2007002920A1 (es) 2006-10-13 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos.
CL2007003038A1 (es) 2006-10-25 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos.
BRPI0819696B1 (pt) * 2007-11-29 2018-10-23 Actelion Pharmaceuticals Ltd compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto
JP5560202B2 (ja) 2007-12-26 2014-07-23 サノフイ Ｐ２ｙ１２拮抗薬としてのピラゾール−カルボキサミド誘導体
JP5504171B2 (ja) 2007-12-26 2014-05-28 サノフイ Ｐ２ｙ１２アンタゴニストとしてのヘテロサイクリックピラゾール−カルボキサミド
AR071653A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2-fenil-4-ciclopropil-pirimidina
AR071652A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2- fenil-piridina substituidos
WO2010116328A2 (fr) 2009-04-08 2010-10-14 Actelion Pharmaceuticals Ltd 6-(3-azabicyclo[3.1.0]hex-3-yl)-2-phénylpyrimidines
KR101728180B1 (ko) 2009-04-22 2017-04-18 액테리온 파마슈티칼 리미티드 티아졸 유도체들 및 ｐ2ｙ12 수용체 길항제로서 이들의 용도

Also Published As

Publication number Publication date
TW200944536A (en) 2009-11-01
ES2476045T3 (es) 2014-07-11
CN101998961B (zh) 2014-06-25
NZ589168A (en) 2012-06-29
KR20100129788A (ko) 2010-12-09
JP5404768B2 (ja) 2014-02-05
MX2010010933A (es) 2010-11-05
JP2011516540A (ja) 2011-05-26
AR071652A1 (es) 2010-07-07
AU2009235033A1 (en) 2009-10-15
US20110046089A1 (en) 2011-02-24
EP2279191A1 (fr) 2011-02-02
CN101998961A (zh) 2011-03-30
US8058263B2 (en) 2011-11-15
ZA201008053B (en) 2014-04-30
KR101702670B1 (ko) 2017-02-06
WO2009125366A1 (fr) 2009-10-15
CA2719636A1 (fr) 2009-10-15
EP2279191B1 (fr) 2014-04-02
RU2010145463A (ru) 2012-05-20
IL208547A0 (en) 2010-12-30

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