MA32312B1 - Synthese de diols dihydrothieno [3,2-d] pyrimidiniques et de diols pyrimidiniques analogues. - Google Patents

Synthese de diols dihydrothieno [3,2-d] pyrimidiniques et de diols pyrimidiniques analogues.

Info

Publication number
MA32312B1
MA32312B1 MA33361A MA33361A MA32312B1 MA 32312 B1 MA32312 B1 MA 32312B1 MA 33361 A MA33361 A MA 33361A MA 33361 A MA33361 A MA 33361A MA 32312 B1 MA32312 B1 MA 32312B1
Authority
MA
Morocco
Prior art keywords
pyrimidine
dihydrothino
diphenylated
diploid
isotopes
Prior art date
Application number
MA33361A
Other languages
Arabic (ar)
English (en)
Inventor
Rogelio Perez Frutos
Thomas G Tampone
Jason Alan Mulder
Dhileepkumar Krishnamurthy
Chris Hugh Senanayake
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41319263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32312(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA32312B1 publication Critical patent/MA32312B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne un procédé amélioré de préparation de diols dihydrothiénol[3,2-d]pyrimidiniques et de diols pyrimidiniques analogues. Ce procédé est efficace, présente un rendement élevé et ne requiert pas de produits intermédiaires coûteux et potentiellement instables. Les diols sont utilisés comme produits intermédiaires dans la synthèse de composés pyrimidiniques inhibant la pde4, et sont donc utiles dans le traitement de maladies et de plaintes respiratoires ou gastro-intestinales, de maladies et de troubles du système nerveux central ou périphérique, d'affections inflammatoires et de cancers.
MA33361A 2008-05-13 2010-11-12 Synthese de diols dihydrothieno [3,2-d] pyrimidiniques et de diols pyrimidiniques analogues. MA32312B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5281608P 2008-05-13 2008-05-13
PCT/US2009/043068 WO2009140127A2 (fr) 2008-05-13 2009-05-07 SYNTHÈSE DE DIOLS DIHYDROTHIÉNO[3,2-d]PYRIMIDINIQUES ET DE DIOLS PYRIMIDINIQUES ANALOGUES

Publications (1)

Publication Number Publication Date
MA32312B1 true MA32312B1 (fr) 2011-05-02

Family

ID=41319263

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33361A MA32312B1 (fr) 2008-05-13 2010-11-12 Synthese de diols dihydrothieno [3,2-d] pyrimidiniques et de diols pyrimidiniques analogues.

Country Status (31)

Country Link
US (1) US8471010B2 (fr)
EP (1) EP2315755B1 (fr)
JP (1) JP5281153B2 (fr)
KR (1) KR20110021764A (fr)
CN (1) CN102026984B (fr)
AR (1) AR071720A1 (fr)
AU (1) AU2009246686B2 (fr)
BR (1) BRPI0912546A2 (fr)
CA (1) CA2722970A1 (fr)
CL (1) CL2009001149A1 (fr)
CO (1) CO6260135A2 (fr)
CY (1) CY1113577T1 (fr)
DK (1) DK2315755T3 (fr)
EA (1) EA019735B1 (fr)
EC (1) ECSP10010571A (fr)
ES (1) ES2392920T3 (fr)
HR (1) HRP20120860T1 (fr)
IL (1) IL208382A0 (fr)
MA (1) MA32312B1 (fr)
ME (1) ME01465B (fr)
MX (1) MX2010011025A (fr)
MY (1) MY152292A (fr)
NZ (1) NZ588484A (fr)
PL (1) PL2315755T3 (fr)
PT (1) PT2315755E (fr)
RS (1) RS52476B (fr)
SI (1) SI2315755T1 (fr)
TW (1) TWI421254B (fr)
UA (1) UA99964C2 (fr)
WO (1) WO2009140127A2 (fr)
ZA (1) ZA201006891B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
US9173884B2 (en) 2011-11-30 2015-11-03 Trustees Of Boston College Inhibitors of phosphodiesterase 11 (PDE11)
CN117820328A (zh) * 2023-11-21 2024-04-05 苏州楚凯药业有限公司 一种2,4-二氯-6,7-二氢呋喃并[3,2-d]嘧啶的合成方法
WO2025131986A1 (fr) 2023-12-19 2025-06-26 Boehringer Ingelheim International Gmbh Nouvelles étapes de synthèse pour procédé de fabrication de 1-({(5r)-2-[4-(5-chloropyrimidine-2-yl)pipéridine-1-yl]-5-oxydo-6,7-dihydrothiéno[3,2-d]pyrimidine-4-yl}amino)cyclobutyl]méthanol inhibiteur de pde4b

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470336A1 (de) * 1962-07-04 1969-03-20 Thomae Gmbh Dr K Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung
FR2029250A5 (fr) 1969-01-21 1970-10-16 Roussel Uclaf
AR044743A1 (es) 2002-09-26 2005-10-05 Nihon Nohyaku Co Ltd Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos,
CN101163706A (zh) * 2005-04-21 2008-04-16 贝林格尔·英格海姆国际有限公司 用于治疗炎性疾病的二氢噻吩并嘧啶
US7851468B2 (en) * 2006-05-15 2010-12-14 Cephalon, Inc. Substituted pyrazolo[3,4-d]pyrimidines

Also Published As

Publication number Publication date
CN102026984A (zh) 2011-04-20
CL2009001149A1 (es) 2010-07-23
AR071720A1 (es) 2010-07-07
MX2010011025A (es) 2010-11-05
AU2009246686B2 (en) 2014-02-13
JP5281153B2 (ja) 2013-09-04
EA201001775A1 (ru) 2011-06-30
US20110130563A1 (en) 2011-06-02
EP2315755B1 (fr) 2012-08-08
KR20110021764A (ko) 2011-03-04
TWI421254B (zh) 2014-01-01
ZA201006891B (en) 2011-06-29
ES2392920T3 (es) 2012-12-17
WO2009140127A3 (fr) 2010-01-28
MY152292A (en) 2014-09-15
UA99964C2 (en) 2012-10-25
ME01465B (me) 2014-04-20
RS52476B (sr) 2013-02-28
US8471010B2 (en) 2013-06-25
EA019735B1 (ru) 2014-05-30
TW201006841A (en) 2010-02-16
EP2315755A2 (fr) 2011-05-04
AU2009246686A1 (en) 2009-11-19
SI2315755T1 (sl) 2012-10-30
CA2722970A1 (fr) 2009-11-19
IL208382A0 (en) 2010-12-30
HK1151524A1 (en) 2012-02-03
NZ588484A (en) 2012-06-29
WO2009140127A2 (fr) 2009-11-19
PL2315755T3 (pl) 2013-01-31
CY1113577T1 (el) 2016-06-22
CN102026984B (zh) 2013-12-25
BRPI0912546A2 (pt) 2016-10-18
CO6260135A2 (es) 2011-03-22
JP2011520886A (ja) 2011-07-21
HRP20120860T1 (hr) 2012-11-30
ECSP10010571A (es) 2010-11-30
PT2315755E (pt) 2012-10-03
DK2315755T3 (da) 2012-10-15

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