MA32321B1 - Pregn-4-en-21, 17 carbolactones substitués sur le noyau c, et préparations pharmaceutiques contenant ces derniers - Google Patents

Pregn-4-en-21, 17 carbolactones substitués sur le noyau c, et préparations pharmaceutiques contenant ces derniers

Info

Publication number
MA32321B1
MA32321B1 MA33376A MA33376A MA32321B1 MA 32321 B1 MA32321 B1 MA 32321B1 MA 33376 A MA33376 A MA 33376A MA 33376 A MA33376 A MA 33376A MA 32321 B1 MA32321 B1 MA 32321B1
Authority
MA
Morocco
Prior art keywords
brin
ring
pharmaceutical preparations
lactone substituted
lactone
Prior art date
Application number
MA33376A
Other languages
Arabic (ar)
English (en)
Inventor
Rolf Bohlmann
Sven Ring
Joachim Kuhnke
Ludwig Zorn
Steffen Borden
Katja Prelle
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41061273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32321(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA32321B1 publication Critical patent/MA32321B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des pregn-4-en-21, 17 carbolactones substitués sur le noyau c de la formule générale i dans laquelle r6,7 représente un méthylène en position ? Ou ? Et r9 représente un atome d'hydrogène et r11 représente un atome de brome, de chlore ou de fluor ou r9 et r11 représentent ensemble une liaison. Les nouveaux composés sont des antiminéralocorticoïdes gestagènes.
MA33376A 2008-06-02 2010-11-30 Pregn-4-en-21, 17 carbolactones substitués sur le noyau c, et préparations pharmaceutiques contenant ces derniers MA32321B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008026793A DE102008026793A1 (de) 2008-06-02 2008-06-02 C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate
PCT/EP2009/003716 WO2009146811A1 (fr) 2008-06-02 2009-05-26 Pregn-4-en-21, 17 carbolactones substitués sur le noyau c, et préparations pharmaceutiques contenant ces derniers

Publications (1)

Publication Number Publication Date
MA32321B1 true MA32321B1 (fr) 2011-05-02

Family

ID=41061273

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33376A MA32321B1 (fr) 2008-06-02 2010-11-30 Pregn-4-en-21, 17 carbolactones substitués sur le noyau c, et préparations pharmaceutiques contenant ces derniers

Country Status (28)

Country Link
US (1) US20110130371A1 (fr)
EP (1) EP2297177B1 (fr)
JP (1) JP2012528075A (fr)
KR (1) KR20110020240A (fr)
CN (1) CN102046646B (fr)
AR (1) AR071984A1 (fr)
AU (1) AU2009254266A1 (fr)
BR (1) BRPI0913401A2 (fr)
CA (1) CA2726855A1 (fr)
CL (1) CL2009001342A1 (fr)
CO (1) CO6321132A2 (fr)
CR (1) CR11821A (fr)
DE (1) DE102008026793A1 (fr)
DO (1) DOP2010000372A (fr)
EA (1) EA017570B1 (fr)
EC (1) ECSP10010652A (fr)
ES (1) ES2389237T3 (fr)
HN (1) HN2010002548A (fr)
IL (1) IL209371A0 (fr)
MA (1) MA32321B1 (fr)
MX (1) MX2010013233A (fr)
NZ (1) NZ589593A (fr)
PE (1) PE20100154A1 (fr)
SV (1) SV2010003748A (fr)
TW (1) TW201000106A (fr)
UY (1) UY31859A (fr)
WO (1) WO2009146811A1 (fr)
ZA (1) ZA201009097B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012004248A1 (fr) 2010-07-08 2012-01-12 Bayer Pharma Aktiengesellschaft PROCÉDÉ MICROBIOLOGIQUE DE PRÉPARATION DE 11α-HYDROXY-DROSPIRÉNONE
WO2012059594A1 (fr) 2010-11-04 2012-05-10 Bayer Pharma Aktiengesellschaft Antagonistes de récepteur de minéralocorticoïde pour le traitement de l'obésité induite par corticoïde
CN102876582B (zh) * 2011-07-15 2015-01-07 复旦大学 金龟子绿僵菌突变株及其在甾体化合物羟化反应中的应用
WO2015055789A1 (fr) * 2013-10-17 2015-04-23 Bayer Pharma Aktiengesellschaft Utilisation intra-vaginale de 18-méthyl-15ss,16ss-méthylène-19-nor-20-spirox-4-en-3-ones, anneaux intra-vaginaux comprenant des 18-méthyl-15ss,16ss-méthylène-19-nor-20-spirox-4-en-3-ones, et utilisation de ceux-ci pour la contraception
CN105779555B (zh) * 2014-12-15 2021-02-02 天津金耀集团有限公司 犁头霉和节杆菌联合发酵制备11β-羟基-1,4-二烯-3,20-二酮甾体化合物
CN105779553B (zh) * 2014-12-15 2020-10-27 天津金耀集团有限公司 新月弯孢霉和节杆菌联合发酵制备11β-羟基-1,4-二烯-3,20-二酮甾体化合物
CN104862323B (zh) * 2015-06-02 2018-01-16 中国农业科学院生物技术研究所 修饰苯二酚类化合物的羟化酶基因

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3092628A (en) * 1959-05-29 1963-06-04 Merck & Co Inc Aldosterone antagonists
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
DE1183500B (de) 1962-10-12 1964-12-17 Schering Ag Verfahren zur Herstellung von alpha, beta-Methylenketonen der Steroidreihe
US3539558A (en) * 1968-08-09 1970-11-10 Searle & Co 3 - oxygenated 3 - (9alpha,11beta - dichloro-17beta- hydroxyandrosten - 17alpha-yl)propionic acid gamma-lactones and congeners
DE2453823C2 (de) * 1974-11-11 1984-08-09 Schering AG, 1000 Berlin und 4709 Bergkamen 11β,17α-Dihydroxy-15α,16α-methylen-1,4-pregnadien-3,20-dion
DE2922500A1 (de) 1979-05-31 1980-12-04 Schering Ag 6 beta .7 beta
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
DE102004063864A1 (de) 2004-12-30 2006-07-13 Schering Ag 18-Methyl-19-nor-17-pregn-4-en21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate
PT1746101E (pt) * 2005-07-21 2008-10-27 Bayer Schering Pharma Ag Processo para o fabrico de 3-oxo-pregn-4-eno-21,17-carbolactonas por meio de oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-di-hidroxiandrostanos
WO2007025780A2 (fr) * 2005-09-02 2007-03-08 Recordati Ireland Limited Antagonistes des recepteurs de l'aldosterone
DE102006030416A1 (de) 2006-06-29 2008-01-03 Bayer Schering Pharma Ag 18-Methyl-19-nor-androst-4-en-17,17-spiroether (18-Methyl-19-nor-20-spirox-4-en-3-one) sowie diese enthaltende pharmazeutische Präparate
ITMI20061802A1 (it) * 2006-09-22 2008-03-23 Antibioticos Spa Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio

Also Published As

Publication number Publication date
HK1156954A1 (en) 2012-06-22
SV2010003748A (es) 2011-04-06
AU2009254266A1 (en) 2009-12-10
KR20110020240A (ko) 2011-03-02
CN102046646B (zh) 2013-03-27
WO2009146811A1 (fr) 2009-12-10
ZA201009097B (en) 2012-05-01
CA2726855A1 (fr) 2009-12-10
CO6321132A2 (es) 2011-09-20
AR071984A1 (es) 2010-07-28
NZ589593A (en) 2012-04-27
CL2009001342A1 (es) 2010-05-28
DOP2010000372A (es) 2010-12-31
US20110130371A1 (en) 2011-06-02
EA201001861A1 (ru) 2011-08-30
TW201000106A (en) 2010-01-01
ECSP10010652A (es) 2011-01-31
UY31859A (es) 2010-01-05
CN102046646A (zh) 2011-05-04
MX2010013233A (es) 2010-12-21
CR11821A (es) 2011-02-04
PE20100154A1 (es) 2010-03-20
EP2297177A1 (fr) 2011-03-23
EA017570B1 (ru) 2013-01-30
EP2297177B1 (fr) 2012-06-20
IL209371A0 (en) 2011-01-31
JP2012528075A (ja) 2012-11-12
HN2010002548A (es) 2012-08-27
ES2389237T3 (es) 2012-10-24
BRPI0913401A2 (pt) 2015-11-24
DE102008026793A1 (de) 2009-12-03

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