ECSP10010652A - Pregn-4-en-21,17-carbolactonas sustituidas en el anillo c, así como preparados farmacéuticos que las contienen - Google Patents

Pregn-4-en-21,17-carbolactonas sustituidas en el anillo c, así como preparados farmacéuticos que las contienen

Info

Publication number
ECSP10010652A
ECSP10010652A EC2010010652A ECSP10010652A ECSP10010652A EC SP10010652 A ECSP10010652 A EC SP10010652A EC 2010010652 A EC2010010652 A EC 2010010652A EC SP10010652 A ECSP10010652 A EC SP10010652A EC SP10010652 A ECSP10010652 A EC SP10010652A
Authority
EC
Ecuador
Prior art keywords
carbolactones
pregn
substituted
ring
well
Prior art date
Application number
EC2010010652A
Other languages
English (en)
Inventor
Rolf Bohlmann
Ludwig Zorn
Joachim Kuhnke
Sven Ring
Katja Prelle
Steffen Borden
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41061273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP10010652(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of ECSP10010652A publication Critical patent/ECSP10010652A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a pregn-4-en-21,17-carbolactonas sustituidas en el anillo C de la fórmula general I en donde R6,7 es un metileno en posición ? o ? y R9 es un átomo de hidrógeno y R11 es un átomo de bromo, cloro o flúor, o R9 y R11 son juntos un enlace.Los nuevos compuestos son antimineralocorticoides gestagénicos.
EC2010010652A 2008-06-02 2010-12-02 Pregn-4-en-21,17-carbolactonas sustituidas en el anillo c, así como preparados farmacéuticos que las contienen ECSP10010652A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102008026793A DE102008026793A1 (de) 2008-06-02 2008-06-02 C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate

Publications (1)

Publication Number Publication Date
ECSP10010652A true ECSP10010652A (es) 2011-01-31

Family

ID=41061273

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010652A ECSP10010652A (es) 2008-06-02 2010-12-02 Pregn-4-en-21,17-carbolactonas sustituidas en el anillo c, así como preparados farmacéuticos que las contienen

Country Status (28)

Country Link
US (1) US20110130371A1 (es)
EP (1) EP2297177B1 (es)
JP (1) JP2012528075A (es)
KR (1) KR20110020240A (es)
CN (1) CN102046646B (es)
AR (1) AR071984A1 (es)
AU (1) AU2009254266A1 (es)
BR (1) BRPI0913401A2 (es)
CA (1) CA2726855A1 (es)
CL (1) CL2009001342A1 (es)
CO (1) CO6321132A2 (es)
CR (1) CR11821A (es)
DE (1) DE102008026793A1 (es)
DO (1) DOP2010000372A (es)
EA (1) EA017570B1 (es)
EC (1) ECSP10010652A (es)
ES (1) ES2389237T3 (es)
HN (1) HN2010002548A (es)
IL (1) IL209371A0 (es)
MA (1) MA32321B1 (es)
MX (1) MX2010013233A (es)
NZ (1) NZ589593A (es)
PE (1) PE20100154A1 (es)
SV (1) SV2010003748A (es)
TW (1) TW201000106A (es)
UY (1) UY31859A (es)
WO (1) WO2009146811A1 (es)
ZA (1) ZA201009097B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012004248A1 (de) 2010-07-08 2012-01-12 Bayer Pharma Aktiengesellschaft MIKROBIOLOGISCHES VERFAHREN ZUR HERSTELLUNG VON 11α-HYDROXY-DROSPIRENON
WO2012059594A1 (en) 2010-11-04 2012-05-10 Bayer Pharma Aktiengesellschaft Mineralcorticoid receptor antagonists for the treatment of corticoid-induced obesity
CN102876582B (zh) * 2011-07-15 2015-01-07 复旦大学 金龟子绿僵菌突变株及其在甾体化合物羟化反应中的应用
WO2015055789A1 (en) * 2013-10-17 2015-04-23 Bayer Pharma Aktiengesellschaft INTRAVAGINAL USE OF 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, INTRAVAGINAL RINGS COMPRISING 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, AND USE THEREOF IN CONTRACEPTION
CN105779555B (zh) * 2014-12-15 2021-02-02 天津金耀集团有限公司 犁头霉和节杆菌联合发酵制备11β-羟基-1,4-二烯-3,20-二酮甾体化合物
CN105779553B (zh) * 2014-12-15 2020-10-27 天津金耀集团有限公司 新月弯孢霉和节杆菌联合发酵制备11β-羟基-1,4-二烯-3,20-二酮甾体化合物
CN104862323B (zh) * 2015-06-02 2018-01-16 中国农业科学院生物技术研究所 修饰苯二酚类化合物的羟化酶基因

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3092628A (en) * 1959-05-29 1963-06-04 Merck & Co Inc Aldosterone antagonists
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
DE1183500B (de) 1962-10-12 1964-12-17 Schering Ag Verfahren zur Herstellung von alpha, beta-Methylenketonen der Steroidreihe
US3539558A (en) * 1968-08-09 1970-11-10 Searle & Co 3 - oxygenated 3 - (9alpha,11beta - dichloro-17beta- hydroxyandrosten - 17alpha-yl)propionic acid gamma-lactones and congeners
DE2453823C2 (de) * 1974-11-11 1984-08-09 Schering AG, 1000 Berlin und 4709 Bergkamen 11β,17α-Dihydroxy-15α,16α-methylen-1,4-pregnadien-3,20-dion
DE2922500A1 (de) 1979-05-31 1980-12-04 Schering Ag 6 beta .7 beta
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
DE102004063864A1 (de) 2004-12-30 2006-07-13 Schering Ag 18-Methyl-19-nor-17-pregn-4-en21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate
PT1746101E (pt) * 2005-07-21 2008-10-27 Bayer Schering Pharma Ag Processo para o fabrico de 3-oxo-pregn-4-eno-21,17-carbolactonas por meio de oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-di-hidroxiandrostanos
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
DE102006030416A1 (de) 2006-06-29 2008-01-03 Bayer Schering Pharma Ag 18-Methyl-19-nor-androst-4-en-17,17-spiroether (18-Methyl-19-nor-20-spirox-4-en-3-one) sowie diese enthaltende pharmazeutische Präparate
ITMI20061802A1 (it) * 2006-09-22 2008-03-23 Antibioticos Spa Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio

Also Published As

Publication number Publication date
HK1156954A1 (en) 2012-06-22
SV2010003748A (es) 2011-04-06
AU2009254266A1 (en) 2009-12-10
KR20110020240A (ko) 2011-03-02
CN102046646B (zh) 2013-03-27
WO2009146811A1 (de) 2009-12-10
ZA201009097B (en) 2012-05-01
CA2726855A1 (en) 2009-12-10
CO6321132A2 (es) 2011-09-20
AR071984A1 (es) 2010-07-28
NZ589593A (en) 2012-04-27
CL2009001342A1 (es) 2010-05-28
DOP2010000372A (es) 2010-12-31
US20110130371A1 (en) 2011-06-02
EA201001861A1 (ru) 2011-08-30
TW201000106A (en) 2010-01-01
UY31859A (es) 2010-01-05
CN102046646A (zh) 2011-05-04
MX2010013233A (es) 2010-12-21
CR11821A (es) 2011-02-04
PE20100154A1 (es) 2010-03-20
EP2297177A1 (de) 2011-03-23
EA017570B1 (ru) 2013-01-30
MA32321B1 (fr) 2011-05-02
EP2297177B1 (de) 2012-06-20
IL209371A0 (en) 2011-01-31
JP2012528075A (ja) 2012-11-12
HN2010002548A (es) 2012-08-27
ES2389237T3 (es) 2012-10-24
BRPI0913401A2 (pt) 2015-11-24
DE102008026793A1 (de) 2009-12-03

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