MA32502B1 - Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv) - Google Patents

Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv)

Info

Publication number
MA32502B1
MA32502B1 MA33556A MA33556A MA32502B1 MA 32502 B1 MA32502 B1 MA 32502B1 MA 33556 A MA33556 A MA 33556A MA 33556 A MA33556 A MA 33556A MA 32502 B1 MA32502 B1 MA 32502B1
Authority
MA
Morocco
Prior art keywords
hcv
hepatitis
virus
protease inhibitors
quinoxaline compounds
Prior art date
Application number
MA33556A
Other languages
Arabic (ar)
English (en)
Inventor
Vincenzo Summa
Nigel J Liverton
Johh A Mccauley
Steven Harper
Original Assignee
Angeletti P Ist Richerche Bio
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41130248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32502(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Angeletti P Ist Richerche Bio, Merck Sharp & Dohme filed Critical Angeletti P Ist Richerche Bio
Publication of MA32502B1 publication Critical patent/MA32502B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un composé macrocyclique de la formule (i), et son utilisation en tant qu'inhibiteurs de la protéase ns3 du virus de l'hépatite c (hcv), et dans le traitement ou la prévention d'infections par hcv.
MA33556A 2008-07-22 2011-01-25 Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv) MA32502B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13555908P 2008-07-22 2008-07-22
PCT/US2009/050915 WO2010011566A1 (fr) 2008-07-22 2009-07-17 Composés de quinoxaline macrocycliques en tant qu'inhibiteurs de protéase ns3 du virus de l'hépatite c (hcv)

Publications (1)

Publication Number Publication Date
MA32502B1 true MA32502B1 (fr) 2011-07-03

Family

ID=41130248

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33556A MA32502B1 (fr) 2008-07-22 2011-01-25 Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv)

Country Status (43)

Country Link
US (2) US7973040B2 (fr)
EP (3) EP2540349B1 (fr)
JP (1) JP4920797B2 (fr)
KR (1) KR101313675B1 (fr)
CN (1) CN102159285B (fr)
AR (1) AR072588A1 (fr)
AU (1) AU2009274190B2 (fr)
BR (1) BRPI0916235B8 (fr)
CA (1) CA2731177C (fr)
CL (1) CL2011000145A1 (fr)
CO (1) CO6351757A2 (fr)
CR (1) CR20110089A (fr)
CY (3) CY1113752T1 (fr)
DK (2) DK2540350T3 (fr)
DO (1) DOP2011000023A (fr)
EA (1) EA019327B1 (fr)
EC (1) ECSP11010777A (fr)
ES (2) ES2491090T3 (fr)
FR (1) FR16C1027I2 (fr)
HN (1) HN2011000209A (fr)
HR (2) HRP20120866T1 (fr)
HU (1) HUS1700001I1 (fr)
IL (1) IL210580A (fr)
LT (1) LTC2310095I2 (fr)
LU (1) LUC00002I2 (fr)
MA (1) MA32502B1 (fr)
ME (2) ME02024B (fr)
MX (1) MX2011000826A (fr)
MY (1) MY152070A (fr)
NI (1) NI201100023A (fr)
NL (1) NL300857I2 (fr)
NO (1) NO2017004I1 (fr)
NZ (1) NZ590638A (fr)
PE (1) PE20110212A1 (fr)
PL (2) PL2540350T3 (fr)
PT (2) PT2540350E (fr)
RS (2) RS53420B (fr)
SI (2) SI2540350T1 (fr)
SV (1) SV2011003813A (fr)
TN (1) TN2011000014A1 (fr)
TW (1) TWI441638B (fr)
UA (1) UA100436C2 (fr)
WO (1) WO2010011566A1 (fr)

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US20190127365A1 (en) 2017-11-01 2019-05-02 Merck Sharp & Dohme Corp. Inhibitors of hepatitis c virus replication
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