MA32723B1 - Derives d'anilino-pyrimidine a substitution sulfoximine en tant qu'inhibiteurs de cdk, leur preparation et leur utilisation comme medicaments - Google Patents

Derives d'anilino-pyrimidine a substitution sulfoximine en tant qu'inhibiteurs de cdk, leur preparation et leur utilisation comme medicaments

Info

Publication number
MA32723B1
MA32723B1 MA33786A MA33786A MA32723B1 MA 32723 B1 MA32723 B1 MA 32723B1 MA 33786 A MA33786 A MA 33786A MA 33786 A MA33786 A MA 33786A MA 32723 B1 MA32723 B1 MA 32723B1
Authority
MA
Morocco
Prior art keywords
anilino
drugs
preparation
sulfoximine
marked
Prior art date
Application number
MA33786A
Other languages
Arabic (ar)
English (en)
Inventor
Ulrich Lücking
Rolf Jautelat
Gerhard Siemeister
Julia Schulze
Philip Lienau
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA32723B1 publication Critical patent/MA32723B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION PORTE SUR DES DÉRIVÉS D'ANILINO-PYRIMIDINE À SUBSTITUTION SULFOXIMINE DE FORMULE (I), SUR DES PROCÉDÉS POUR LES PRÉPARER, AINSI QUE SUR LEUR UTILISATION EN TANT QUE MÉDICAMENTS POUR LE TRAITEMENT DE DIFFÉRENTES MALADIES.
MA33786A 2008-10-21 2011-04-20 Derives d'anilino-pyrimidine a substitution sulfoximine en tant qu'inhibiteurs de cdk, leur preparation et leur utilisation comme medicaments MA32723B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08167113A EP2179991A1 (fr) 2008-10-21 2008-10-21 Dérivés d'anilino-pyrimidine substitués par sulfoximine en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments
PCT/EP2009/007247 WO2010046035A1 (fr) 2008-10-21 2009-10-09 Dérivés d'anilino-pyrimidine à substitution sulfoximine en tant qu'inhibiteurs de cdk, leur préparation et leur utilisation comme médicaments

Publications (1)

Publication Number Publication Date
MA32723B1 true MA32723B1 (fr) 2011-10-02

Family

ID=40282208

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33786A MA32723B1 (fr) 2008-10-21 2011-04-20 Derives d'anilino-pyrimidine a substitution sulfoximine en tant qu'inhibiteurs de cdk, leur preparation et leur utilisation comme medicaments

Country Status (38)

Country Link
US (1) US8735412B2 (fr)
EP (2) EP2179991A1 (fr)
JP (1) JP5564054B2 (fr)
KR (1) KR20110069115A (fr)
CN (1) CN102197029B (fr)
AR (1) AR074053A1 (fr)
AU (1) AU2009306733C1 (fr)
BR (1) BRPI0920112A2 (fr)
CA (1) CA2739739C (fr)
CO (1) CO6361926A2 (fr)
CR (1) CR20110210A (fr)
CU (1) CU24052B1 (fr)
CY (1) CY1115590T1 (fr)
DK (1) DK2350026T3 (fr)
DO (1) DOP2011000107A (fr)
EA (1) EA019230B1 (fr)
EC (1) ECSP11010992A (fr)
ES (1) ES2499028T3 (fr)
HN (1) HN2011001019A (fr)
HR (1) HRP20140830T1 (fr)
IL (1) IL211713A (fr)
MA (1) MA32723B1 (fr)
MX (1) MX2011004238A (fr)
MY (1) MY155230A (fr)
NZ (1) NZ592314A (fr)
PA (1) PA8846201A1 (fr)
PE (1) PE20110546A1 (fr)
PL (1) PL2350026T3 (fr)
PT (1) PT2350026E (fr)
RS (1) RS53523B1 (fr)
SA (1) SA109300632B1 (fr)
SI (1) SI2350026T1 (fr)
TN (1) TN2011000199A1 (fr)
TW (2) TWI496774B (fr)
UA (1) UA103500C2 (fr)
UY (1) UY32190A (fr)
WO (1) WO2010046035A1 (fr)
ZA (1) ZA201103727B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8729265B2 (en) 2009-08-14 2014-05-20 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
DE102010014427A1 (de) 2010-04-01 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Kombinationen neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010014426A1 (de) * 2010-04-01 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010046720A1 (de) * 2010-09-23 2012-03-29 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von pan-CDK-Inhibitoren der Formel (l), sowie Intermediate der Herstellung
TW201636330A (zh) * 2011-05-24 2016-10-16 拜耳知識產權公司 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺
DE102011080991A1 (de) * 2011-08-16 2013-02-21 Bayer Pharma AG Verwendung von CCNE2 als Stratifikationsmarker bei der Behandlung von Brusttumoren mit neuen pan-CDK-Inhibitoren
DE102011080992A1 (de) * 2011-08-16 2013-02-21 Bayer Pharma AG Verwendung von MAD2L2 als Stratifikationsmarker bei der Behandlung von Brusttumoren mit neuen pan-CDK-Inhibitoren
CN103930399B (zh) 2011-09-16 2016-03-16 拜耳知识产权有限责任公司 包含亚氨基亚磺酰基的二取代的5-氟嘧啶衍生物
AU2013234451A1 (en) * 2012-03-21 2014-09-25 Bayer Intellectual Property Gmbh Use of (RS)-S-cyclopropyl-S-(4-{[4-{[1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl] amino}phenyl)sulfoximide for treating specific tumours
CN107001341B (zh) * 2014-10-16 2020-08-07 拜耳医药股份有限公司 含有磺亚胺基的氟化苯并呋喃基-嘧啶衍生物
SMT202500028T1 (it) 2018-09-10 2025-03-12 Mirati Therapeutics Inc Terapie combinate
WO2021138391A1 (fr) 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Composés d'indazole

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4029650A1 (de) 1990-09-19 1992-03-26 Hoechst Ag 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide
EP1017394B1 (fr) 1997-07-12 2005-12-07 Cancer Research Technology Limited Derives de purine inhibant la kinase dependant de la cycline
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
ATE336484T1 (de) 1998-08-29 2006-09-15 Astrazeneca Ab Pyrimidine verbindungen
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
IL159120A0 (en) 2001-05-29 2004-05-12 Schering Ag Cdk inhibiting pyrimidines, production thereof and their use as medicaments
JP2005526765A (ja) 2002-03-11 2005-09-08 シエーリング アクチエンゲゼルシャフト Ｃｄｋ−阻害性２−ヘテロアリール−ピリミジン類、それらの生成及び医薬としての使用
WO2004048343A1 (fr) 2002-11-28 2004-06-10 Schering Aktiengesellschaft Pyrimidines inhibitrices de chk-, pdk- et de akt, production et utilisation de ces composes comme agents pharmaceutiques
DE10349423A1 (de) * 2003-10-16 2005-06-16 Schering Ag Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
EP1794134A1 (fr) * 2004-09-29 2007-06-13 Bayer Schering Pharma Aktiengesellschaft 2-anilinopyrimidine substituee utilisee en tant que kinase a cycle cellulaire ou recepteur de la tyrosine kinase, leur production et leur utilisation en tant que medicament
DE102005062742A1 (de) * 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
DE102006027156A1 (de) 2006-06-08 2007-12-13 Bayer Schering Pharma Ag Sulfimide als Proteinkinaseinhibitoren
EP2179992A1 (fr) * 2008-10-21 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Dérivés d'anilino-pyrimidine substitués par sulfone en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments

Also Published As

Publication number Publication date
SA109300632B1 (ar) 2013-07-04
WO2010046035A1 (fr) 2010-04-29
PE20110546A1 (es) 2011-08-12
MX2011004238A (es) 2011-05-23
RS53523B1 (sr) 2015-02-27
US8735412B2 (en) 2014-05-27
JP5564054B2 (ja) 2014-07-30
TWI458716B (zh) 2014-11-01
EP2350026A1 (fr) 2011-08-03
CY1115590T1 (el) 2017-01-04
IL211713A0 (en) 2011-06-30
SI2350026T1 (sl) 2014-10-30
EP2179991A1 (fr) 2010-04-28
EA019230B1 (ru) 2014-02-28
PT2350026E (pt) 2014-09-12
AU2009306733A1 (en) 2010-04-29
UY32190A (es) 2010-05-31
CA2739739C (fr) 2016-12-20
TW201444803A (zh) 2014-12-01
UA103500C2 (uk) 2013-10-25
PL2350026T3 (pl) 2014-11-28
AR074053A1 (es) 2010-12-22
AU2009306733B2 (en) 2015-11-12
US20110294838A1 (en) 2011-12-01
ECSP11010992A (es) 2011-05-31
ES2499028T3 (es) 2014-09-26
IL211713A (en) 2015-04-30
PA8846201A1 (es) 2010-05-26
HN2011001019A (es) 2013-07-01
DK2350026T3 (da) 2014-09-15
HRP20140830T1 (hr) 2014-11-21
AU2009306733C1 (en) 2016-07-14
CU20110088A7 (es) 2011-12-28
TWI496774B (zh) 2015-08-21
TN2011000199A1 (en) 2012-12-17
TW201020237A (en) 2010-06-01
EP2350026B1 (fr) 2014-06-18
CU24052B1 (es) 2014-12-26
CN102197029B (zh) 2014-05-14
KR20110069115A (ko) 2011-06-22
CO6361926A2 (es) 2012-01-20
CR20110210A (es) 2011-06-08
EA201100623A1 (ru) 2011-12-30
CN102197029A (zh) 2011-09-21
ZA201103727B (en) 2014-11-26
JP2012506391A (ja) 2012-03-15
NZ592314A (en) 2013-02-22
DOP2011000107A (es) 2011-05-15
BRPI0920112A2 (pt) 2015-12-22
CA2739739A1 (fr) 2010-04-29
MY155230A (en) 2015-09-30

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