MA32748B1 - Traitement du cancer de l'utérus du cancer de l'ovaire avec un inhibiteur parp utilisé seul ou en combinaison avec des antitumoraux - Google Patents

Traitement du cancer de l'utérus du cancer de l'ovaire avec un inhibiteur parp utilisé seul ou en combinaison avec des antitumoraux

Info

Publication number
MA32748B1
MA32748B1 MA32905A MA32905A MA32748B1 MA 32748 B1 MA32748 B1 MA 32748B1 MA 32905 A MA32905 A MA 32905A MA 32905 A MA32905 A MA 32905A MA 32748 B1 MA32748 B1 MA 32748B1
Authority
MA
Morocco
Prior art keywords
cancer
treatment
combination
parp inhibitor
antitumor
Prior art date
Application number
MA32905A
Other languages
Arabic (ar)
English (en)
Inventor
Barry M Sherman
Charles Bradley
Valeria S Ossovskaya
Original Assignee
Bipar Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40623903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32748(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bipar Sciences Inc filed Critical Bipar Sciences Inc
Publication of MA32748B1 publication Critical patent/MA32748B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Selon un de ses aspects, la présente invention concerne un procédé pour traiter le cancer de l'utérus, le cancer de l'endomètre, ou le cancer de l'ovaire, comprenant l'administration à un sujet d'au moins un inhibiteur PARP. Selon un autre aspect, la présente invention concerne un procédé pour traiter le cancer de l'utérus, le cancer de l'endomètre, ou le cancer de l'ovaire, comprenant l'administration à un sujet d'au moins un inhibiteur PARP en combinaison avec au moins un antitumoral.
MA32905A 2007-11-12 2010-06-11 Traitement du cancer de l'utérus du cancer de l'ovaire avec un inhibiteur parp utilisé seul ou en combinaison avec des antitumoraux MA32748B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US98733507P 2007-11-12 2007-11-12
US1236407P 2007-12-07 2007-12-07
US5852808P 2008-06-03 2008-06-03
PCT/US2008/012757 WO2009064444A2 (fr) 2007-11-12 2008-11-12 Traitement du cancer de l'utérus et du cancer de l'ovaire avec un inhibiteur parp utilisé seul ou en combinaison avec des antitumoraux

Publications (1)

Publication Number Publication Date
MA32748B1 true MA32748B1 (fr) 2011-11-01

Family

ID=40623903

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32905A MA32748B1 (fr) 2007-11-12 2010-06-11 Traitement du cancer de l'utérus du cancer de l'ovaire avec un inhibiteur parp utilisé seul ou en combinaison avec des antitumoraux

Country Status (20)

Country Link
US (2) US20090123419A1 (fr)
EP (1) EP2217244A4 (fr)
JP (1) JP2011503071A (fr)
KR (1) KR20100102607A (fr)
CN (1) CN101918003A (fr)
AU (1) AU2008321382A1 (fr)
CA (1) CA2705417A1 (fr)
CO (1) CO6290649A2 (fr)
CR (1) CR11486A (fr)
DO (2) DOP2010000142A (fr)
EC (1) ECSP10010235A (fr)
GT (1) GT201000137A (fr)
IL (1) IL205633A0 (fr)
MA (1) MA32748B1 (fr)
MX (1) MX2010005221A (fr)
NI (1) NI201000084A (fr)
NZ (1) NZ586123A (fr)
SG (1) SG185954A1 (fr)
TN (1) TN2010000209A1 (fr)
WO (1) WO2009064444A2 (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615374A1 (fr) 2005-07-18 2007-01-25 Ernest Kun Kun Traitement du cancer
WO2008147418A1 (fr) * 2006-06-12 2008-12-04 Bipar Sciences, Inc. Procédé permettant de traiter des maladies avec des inhibiteurs de parp
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20100160442A1 (en) * 2006-07-18 2010-06-24 Ossovskaya Valeria S Formulations for cancer treatment
US7538252B2 (en) * 2006-09-05 2009-05-26 Bipar Sciences, Inc. Drug design for tubulin inhibitors, compositions, and methods of treatment thereof
CA2662337A1 (fr) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition de la synthese d'acides gras au moyen d'inhibiteurs parp et methodes de traitement associees
AU2007292302A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Methods for designing PARP inhibitors and uses thereof
JP2010502730A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド 癌の治療法
CN103169973A (zh) * 2007-11-12 2013-06-26 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌
KR20100102607A (ko) * 2007-11-12 2010-09-24 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 자궁암 및 난소암을 치료하는 방법
CA2708157A1 (fr) * 2007-12-07 2009-06-11 Bipar Sciences, Inc. Traitement du cancer avec des combinaisons d'inhibiteurs de topoisomerase et d'inhibiteurs de parp
WO2011060380A1 (fr) * 2009-11-14 2011-05-19 The Regents Of The University Of California L'état de mutation de pik3ca et l'expression de sash1 prédisent la synergie entre le lapatinib et un inhibiteur d'akt dans le cancer du sein her2 positif
US20130345164A1 (en) * 2010-04-21 2013-12-26 University Of Medicine And Dentistry Of New Jersey Treatments for cellular proliferative disorders and identification thereof
WO2011153383A1 (fr) * 2010-06-04 2011-12-08 Bipar Science, Inc. Procédés de traitement d'un cancer des ovaires récurrent et résistant au platine avec du 4-iodo-3-nitrobenzamide en combinaison avec un antimétabolite et un composé de platine.
WO2011153382A1 (fr) * 2010-06-04 2011-12-08 Bipar Sciences, Inc. Procédés de traitement d'un cancer des ovaires récurrent et sensible au platine avec du 4-iodo-3-nitrobenzamide en combinaison avec un antimétabolite et un composé de platine.
CA2805774A1 (fr) * 2010-07-19 2012-01-26 Charles Bradley Methodes de traitement du cancer du sein utilisant le 4-iodo-3-nitrobenzamide en association avec des agents anticancereux
BR112013011135A2 (pt) 2010-11-05 2016-08-02 Zhejiang Hisun Pharm Co Ltd ''composto,método para a preparação do composto,composição farmacêutica e uso do composto''
WO2013076295A1 (fr) * 2011-11-25 2013-05-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de recherche par criblage d'une perte de fonction du gène brca1 chez un sujet souffrant d'un cancer
FR2984750B1 (fr) * 2011-12-23 2014-01-10 Lfb Biotechnologies Nouvelles compositions pharmaceutiques comprenant un anticorps liant le recepteur humain de l'hormone anti-mullerienne de type ii
US20160011220A1 (en) * 2012-02-14 2016-01-14 Purdue Pharma L.P. Systems and Methods to Quantify Analytes in Keratinized Samples
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
TWI444358B (zh) * 2012-07-09 2014-07-11 Univ Chang Gung 一種含有５－硝基苯之衍生物，透過抑制腫瘤細胞誘發血小板凝集反應作為癌症轉移治療方式
US20140186293A1 (en) * 2012-12-31 2014-07-03 University Of Louisville Research Foundation, Inc. Immunoglobulin-bound extracellular vesicles and uses thereof
ES2684582T3 (es) * 2013-03-15 2018-10-03 Truckee Applied Genomics, Llc Métodos y reactivos para mantener la viabilidad de células cancerosas en tejido eliminado quirúrgicamente
KR102359214B1 (ko) 2014-04-04 2022-02-07 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
CN114927178A (zh) * 2015-06-12 2022-08-19 格尼亚Ip控股私人有限公司 患者和生物样本识别和追踪的方法和系统
EP3337467B1 (fr) 2015-08-20 2020-12-09 Ipsen Biopharm Ltd. Polythérapie utilisant l'irinotécan liposomal et un inhibiteur de parp pour le traitement du cancer
MX385425B (es) 2015-08-21 2025-03-18 Ipsen Biopharm Ltd Irinotecán liposomal y oxaliplatino, 5-fluoroacilo y leucovorina para usarse en el tratamiento de cáncer pancreático metastásico.
CN108697807B (zh) * 2016-01-11 2021-11-26 辛德弗雷克斯公司 代谢功能障碍引起的肿瘤的治疗
US11154538B2 (en) 2016-02-29 2021-10-26 Synta Pharmaceuticals Corporation Combination therapy for treatment of ovarian cancer
RU2760348C2 (ru) 2016-06-06 2021-11-24 Бейондспринг Фармасьютикалс, Инк. Способ уменьшения нейтропении
KR20230042136A (ko) 2016-06-29 2023-03-27 테사로, 인코포레이티드 난소암의 치료 방법
CN110087730B (zh) * 2016-09-27 2023-03-28 百济神州(苏州)生物科技有限公司 使用包含parp抑制剂的组合产品治疗癌症
EP3535026A1 (fr) 2016-11-02 2019-09-11 Ipsen Biopharm Limited Traitement du cancer gastrique au moyen de polythérapies comprenant de l'oxaliplatine, du 5-fluoruracile (et de la leucovorine) et de l'irinotécan sous forme liposomale
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
CN110475475A (zh) * 2017-02-06 2019-11-19 希望之城 癌症的治疗
US20200061054A1 (en) * 2017-02-28 2020-02-27 Del Mar Pharmaceuticals (Bc) Ltd. Use of dianhydrogalactitol or analogs and derivatives in combination with a p53 modulator or a parp inhibitor
TWI879716B (zh) 2017-05-09 2025-04-11 美商提薩羅有限公司 治療癌症的組合療法
AU2018270112A1 (en) 2017-05-18 2019-12-12 Tesaro, Inc. Combination therapies for treating cancer
US11433074B2 (en) 2017-06-22 2022-09-06 Triact Therapeutics, Inc. Methods of treating glioblastoma
US20200121703A1 (en) * 2017-06-26 2020-04-23 The Cleveland Clinic Foundation Cancer treatment
US11628144B2 (en) 2017-09-29 2023-04-18 Triact Therapeutics, Inc. Iniparib formulations and uses thereof
EP3697442A4 (fr) 2017-09-30 2021-07-07 Tesaro, Inc. Polythérapies pour le traitement du cancer
JP6915865B2 (ja) * 2017-10-03 2021-08-04 学校法人 愛知医科大学 Ｎｏ産生抑制剤及び固形腫瘍に対する転移・浸潤抑制剤
SG11202002499TA (en) * 2017-10-06 2020-04-29 Tesaro Inc Combination therapies and uses thereof
CA3095709A1 (fr) 2018-04-05 2019-10-10 Noviga Research Ab Nouvelles associations d'un inhibiteur de polymerisation de la tubuline et d'un inhibiteur de la poly(adp-ribose) polymerase (parp) destinees a etre utilisees dans le traitement du cancer
CN113454235A (zh) * 2019-02-21 2021-09-28 豪夫迈·罗氏有限公司 经改进的核酸靶标富集和相关方法
WO2020232133A1 (fr) * 2019-05-14 2020-11-19 Georgetown University Procédés de traitement de cancers gastro-intestinaux et de leurs tumeurs faisant intervenir une polythérapie
US11704494B2 (en) 2019-05-31 2023-07-18 Ab Initio Technology Llc Discovering a semantic meaning of data fields from profile data of the data fields
CN110600098A (zh) * 2019-08-09 2019-12-20 广州中医药大学第一附属医院 一种临床化学自动审核方法、系统、装置和存储介质
EP4090380A1 (fr) * 2020-01-13 2022-11-23 Gradalis, Inc. Procédés de traitement de cancers à l'aide de polynucléotide codant pour gm-csf et d'agents supplémentaires
US11886399B2 (en) 2020-02-26 2024-01-30 Ab Initio Technology Llc Generating rules for data processing values of data fields from semantic labels of the data fields
CN112316149A (zh) * 2020-11-11 2021-02-05 王海涛 一种治疗tp53突变的晚期难治性实体瘤的药物及应用
CA3215047A1 (fr) 2021-04-09 2022-10-13 Lan Huang Compositions therapeutiques et methodes de traitement de tumeurs
WO2024064705A1 (fr) 2022-09-20 2024-03-28 Ab Initio Technology Llc Techniques pour découvrir et mettre à jour une signification sémantique de champs de données
WO2024108231A1 (fr) * 2022-11-18 2024-05-23 University Of South Florida Modélisation physiologique d'angiographie par tomodensitométrie intra-artérielle multiphase pour une thérapie d'embolisation hépatique
WO2024191805A1 (fr) * 2023-03-10 2024-09-19 Beyondspring Pharmaceuticals, Inc. Polythérapie oncologique et méthodes d'utilisation
CN120496814B (zh) * 2025-07-09 2025-09-12 四川省肿瘤医院 基于多模态深度学习的卵巢附件肿瘤风险分级系统

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2669583A (en) * 1954-02-16 X-amroo-zralkoxbbenzamdjes
US2006735A (en) * 1932-11-17 1935-07-02 Gen Aniline Works Inc Nitro-aryl amino-aryl amines
NL247377A (fr) * 1957-11-25
US3228833A (en) * 1962-12-17 1966-01-11 Sterling Drug Inc Anticoccidial compositions and methods of using same
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US5215738A (en) * 1985-05-03 1993-06-01 Sri International Benzamide and nicotinamide radiosensitizers
US5032617A (en) * 1985-05-03 1991-07-16 Sri International Substituted benzamide radiosensitizers
US6407079B1 (en) * 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
JP2534631B2 (ja) * 1986-01-17 1996-09-18 プリベンティブ メディシン インスティテュート Ｄｎａが関連する病気にかかり易い体質または該病気に対する感受性を測定するための試験
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5177075A (en) * 1988-08-19 1993-01-05 Warner-Lambert Company Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
US5719151A (en) * 1990-05-04 1998-02-17 Shall; Sydney Substituted benzene compounds
US5633282A (en) * 1990-05-25 1997-05-27 British Technology Group Limited Inhibition of viral infection
US5631038A (en) * 1990-06-01 1997-05-20 Bioresearch, Inc. Specific eatable taste modifiers
US5637618A (en) * 1990-06-01 1997-06-10 Bioresearch, Inc. Specific eatable taste modifiers
SK283693B6 (sk) * 1990-09-28 2003-12-02 Smithkline Beecham Corporation Spôsob prípravy kamptotecínu alebo jeho farmaceuticky prijateľnej soli
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5200524A (en) * 1990-12-20 1993-04-06 North Carolina State University Camptothecin intermediates and method of making same
US5191082A (en) * 1990-12-20 1993-03-02 North Carolina State University Camptothecin intermediate and method of making camptothecin intermediates
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5516941A (en) * 1991-10-22 1996-05-14 Octamer, Inc. Specific inactivators of "retroviral" (asymmetric) zinc fingers
US5482975A (en) * 1991-10-22 1996-01-09 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5464871A (en) * 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5652260A (en) * 1991-10-22 1997-07-29 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compound useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5783599A (en) * 1993-02-24 1998-07-21 Octamer Inc Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones
JP3025602B2 (ja) * 1993-05-21 2000-03-27 デビオファーム エス．アー． 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法
US6015792A (en) * 1993-05-26 2000-01-18 Bioresearch, Inc. Specific eatable taste modifiers
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US5589483A (en) * 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5736576A (en) * 1996-06-04 1998-04-07 Octamer, Inc. Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
US6017958A (en) * 1996-06-04 2000-01-25 Octamer, Inc. Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
ZA982523B (en) * 1997-03-26 1999-10-04 Biosource Tech Inc Di-aryl ethers and their derivatives as anti-cancer agents.
US5908861A (en) * 1997-05-13 1999-06-01 Octamer, Inc. Methods for treating inflammation and inflammatory disease using pADPRT inhibitors
US6235748B1 (en) * 1997-09-03 2001-05-22 Guilford Pharmaceuticals Inc. Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
US6514983B1 (en) * 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6380193B1 (en) * 1998-05-15 2002-04-30 Guilford Pharmaceuticals Inc. Fused tricyclic compounds, methods and compositions for inhibiting PARP activity
US6395749B1 (en) * 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
CA2352554C (fr) * 1998-11-27 2006-10-10 Basf Aktiengesellschaft Benzimidazoles substitues et leur utilisation comme inhibiteurs de la parp
US6201020B1 (en) * 1998-12-31 2001-03-13 Guilford Pharmaceuticals, Inc. Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp
US6387902B1 (en) * 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6677333B1 (en) * 1999-01-26 2004-01-13 Ono Pharmaceutical Co., Ltd. 2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient
DE19921567A1 (de) * 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
ECSP003637A (es) * 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
US6723733B2 (en) * 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
ITMI20002358A1 (it) * 2000-10-31 2002-05-01 Flavio Moroni Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
US20050113283A1 (en) * 2002-01-18 2005-05-26 David Solow-Cordero Methods of treating conditions associated with an EDG-4 receptor
AUPS019702A0 (en) * 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds
US20040034078A1 (en) * 2002-06-14 2004-02-19 Agouron Pharmaceuticals, Inc. Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase
EP1585504A4 (fr) * 2002-11-06 2009-07-15 Azaya Therapeutics Inc Preparations liposomales d'agents pharmaceutiques stabilisees par des proteines
WO2005016970A2 (fr) * 2003-05-01 2005-02-24 Imclone Systems Incorporated Anticorps entierement humains diriges contre le recepteur du facteur de croissance 1 de type insuline
WO2004105700A2 (fr) * 2003-05-28 2004-12-09 Guildford Pharmaceuticals, Inc. Composes, procedes et compositions pharmaceutiques destines a l'inhibition de la parp
SI1660095T1 (sl) * 2003-07-25 2010-05-31 Cancer Rec Tech Ltd Triciklični parp inhibitorji
BRPI0413255A (pt) * 2003-08-01 2006-10-03 Wyeth Corp uso de uma combinação de um inibidor de quinase do receptor do fator de crescimento epidérmico e agentes citotóxicos para tratamento e inibição do cáncer
WO2005023246A1 (fr) * 2003-09-04 2005-03-17 Aventis Pharmaceuticals Inc. Indoles substitues comme inhibiteurs de polymerase de poly(adp-ribose) (parp)
WO2005023765A1 (fr) * 2003-09-11 2005-03-17 Pharmacia & Upjohn Company Llc Methode de catalyse de reactions d'amidation au moyen de co2
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
EP1793830A2 (fr) * 2004-09-22 2007-06-13 Pfizer, Inc. Combinaisons therapeutiques comprenant un inhibiteur des polymerases poly(adp-ribose)
EP1799685B1 (fr) * 2004-09-22 2012-03-28 Pfizer Inc. Formules polymorphes de sel de phosphate de 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
US20060094676A1 (en) * 2004-10-29 2006-05-04 Ronit Lahav Compositions and methods for treating cancer using compositions comprising an inhibitor of endothelin receptor activity
CA2612979A1 (fr) * 2005-06-10 2006-12-21 Bipar Sciences, Inc. Modulateurs de parp et traitement du cancer
CA2615374A1 (fr) * 2005-07-18 2007-01-25 Ernest Kun Kun Traitement du cancer
DE102006037399A1 (de) * 2006-08-10 2008-02-14 Archimica Gmbh Verfahren zur Herstellung von Arylaminen
JP2010502730A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド 癌の治療法
CA2662337A1 (fr) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition de la synthese d'acides gras au moyen d'inhibiteurs parp et methodes de traitement associees
US7538252B2 (en) * 2006-09-05 2009-05-26 Bipar Sciences, Inc. Drug design for tubulin inhibitors, compositions, and methods of treatment thereof
AU2007292302A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Methods for designing PARP inhibitors and uses thereof
WO2009051815A1 (fr) * 2007-10-19 2009-04-23 Bipar Sciences, Inc. Procédés et compositions pour le traitement du cancer au moyen d'inhibiteurs de parp de type benzopyrone
CN103169973A (zh) * 2007-11-12 2013-06-26 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌
KR20100102607A (ko) * 2007-11-12 2010-09-24 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 자궁암 및 난소암을 치료하는 방법
CA2708157A1 (fr) * 2007-12-07 2009-06-11 Bipar Sciences, Inc. Traitement du cancer avec des combinaisons d'inhibiteurs de topoisomerase et d'inhibiteurs de parp

Also Published As

Publication number Publication date
EP2217244A4 (fr) 2011-08-31
NZ586123A (en) 2012-12-21
KR20100102607A (ko) 2010-09-24
GT201000137A (es) 2012-04-23
CO6290649A2 (es) 2011-06-20
CN101918003A (zh) 2010-12-15
CA2705417A1 (fr) 2009-05-22
ECSP10010235A (es) 2010-07-30
WO2009064444A9 (fr) 2009-07-02
US20090123419A1 (en) 2009-05-14
CR11486A (es) 2013-08-09
DOP2010000142A (es) 2010-07-31
DOP2012000290A (es) 2013-03-31
SG185954A1 (en) 2012-12-28
TN2010000209A1 (en) 2011-11-11
US20100009930A1 (en) 2010-01-14
IL205633A0 (en) 2010-11-30
NI201000084A (es) 2011-04-27
AU2008321382A1 (en) 2009-05-22
WO2009064444A2 (fr) 2009-05-22
JP2011503071A (ja) 2011-01-27
EP2217244A2 (fr) 2010-08-18
MX2010005221A (es) 2010-09-28

Similar Documents

Publication Publication Date Title
MA32748B1 (fr) Traitement du cancer de l'utérus du cancer de l'ovaire avec un inhibiteur parp utilisé seul ou en combinaison avec des antitumoraux
MA31909B1 (fr) Traitement de cancer du sein avec un inhibiteur parp seul ou en combinaison avec des agents anti-tumoraux
MA32934B1 (fr) Combinaisons inhibitrices hsp90
MA33469B1 (fr) Polythérapie à base d'un anticorps afucosylé anti-cd20 et de bendamustine
EA201300242A1 (ru) Фармацевтические композиции, содержащие замещенные ациланилиды
ATE469895T1 (de) Cgrp-rezeptorantagonisten
CL2007002667A1 (es) Uso de trastuzumab para la prevencion o reduccion de la metastasis en un paciente que padece de cancer her2 positivo, que no responde a una monoterapia con trastuzumab ni a una monoterapia con pertuzumab.
CY1118523T1 (el) Πεπτιδικες ενωσεις για την θεραπεια του ανθεκτικου status epilepticus
MA38495A1 (fr) Compositions et méthodes pour le diagnostic et le traitement de cancers hépatiques
BR112015020466A2 (pt) inibidores de cdc7
MX360301B (es) Moleculas pequeñas que contienen boro como agentes antiinflamatorios.
EA200970737A1 (ru) Оксабициклогептаны и оксабициклогептены, их получение и применение
EP2154971A4 (fr) Combinaison pharmaceutique synergique pour le traitement du cancer
EA201170252A1 (ru) Амидофеноксиндазолы в качестве ингибиторов c-мет
BR112014028041A2 (pt) tratamento de obesidade hipotalâmica com inibidores de metap2
MX2010002732A (es) Inhibidores de f1f0-atpasa y metodos relacionados.
PA8851101A1 (es) Compuesto amino pirazol
GEP20135829B (en) C-met antagonist and aminoheteroaryl compound combination for cancer treatment
BRPI0908635A8 (pt) composto, composição farmacêutica e método de tratamento de câncer
TW200603828A (en) Treatment of disorders
TW200733976A (en) Method for the treatment of cognitive dysfunction
EP2522356A4 (fr) Fraction bioactive de petiveria alliacea, composition pharmaceutique contenant cette dernière et combinaison avec des agents immunostimulants pour le traitement du cancer
MA32933B1 (fr) Combinaison d'inhibiteurs de hspo90 et d'herceptine
EP2038248A4 (fr) Combinaison de céramide et d'oxaliplatine pour induire la mort cellulaire et ses utilisations dans le traitement du cancer
MY166063A (en) Intravenous antiviral treatments