MA33469B1 - Polythérapie à base d'un anticorps afucosylé anti-cd20 et de bendamustine - Google Patents

Polythérapie à base d'un anticorps afucosylé anti-cd20 et de bendamustine

Info

Publication number
MA33469B1
MA33469B1 MA34585A MA34585A MA33469B1 MA 33469 B1 MA33469 B1 MA 33469B1 MA 34585 A MA34585 A MA 34585A MA 34585 A MA34585 A MA 34585A MA 33469 B1 MA33469 B1 MA 33469B1
Authority
MA
Morocco
Prior art keywords
polytherapy
antibody
bendamustin
afucosylated anti
afucosylated
Prior art date
Application number
MA34585A
Other languages
Arabic (ar)
English (en)
Inventor
Frank Herting
Christian Klein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41351729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33469(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA33469B1 publication Critical patent/MA33469B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cette invention concerne une polythérapie à base d'un anticorps afucosylé anti-CD20 et de bendamustine pour le traitement du cancer, et notamment, la polythérapie des cancers exprimant CD20 à base d'un anticorps afucosylé anti-B-Ly1 humanisé et de bendamustine.
MA34585A 2009-08-14 2010-08-12 Polythérapie à base d'un anticorps afucosylé anti-cd20 et de bendamustine MA33469B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09010489 2009-08-14
PCT/EP2010/004939 WO2011018224A1 (fr) 2009-08-14 2010-08-12 Polythérapie à base d'un anticorps afucosylé anti-cd20 et de bendamustine

Publications (1)

Publication Number Publication Date
MA33469B1 true MA33469B1 (fr) 2012-07-03

Family

ID=41351729

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34585A MA33469B1 (fr) 2009-08-14 2010-08-12 Polythérapie à base d'un anticorps afucosylé anti-cd20 et de bendamustine

Country Status (34)

Country Link
US (4) US20110165151A1 (fr)
EP (1) EP2464382B1 (fr)
JP (3) JP5646626B2 (fr)
KR (1) KR101425736B1 (fr)
CN (2) CN102596245A (fr)
AR (1) AR077866A1 (fr)
AU (1) AU2010281866B2 (fr)
CA (1) CA2769674C (fr)
CL (1) CL2012000391A1 (fr)
CR (1) CR20120036A (fr)
CY (2) CY1119251T1 (fr)
DK (1) DK2464382T3 (fr)
ES (1) ES2630158T3 (fr)
HK (1) HK1245145A1 (fr)
HR (1) HRP20170972T1 (fr)
HU (2) HUE033531T2 (fr)
IL (1) IL217753A (fr)
LT (2) LT2464382T (fr)
LU (1) LUC00045I2 (fr)
MA (1) MA33469B1 (fr)
MX (2) MX355849B (fr)
MY (1) MY163003A (fr)
NO (1) NO2017054I1 (fr)
NZ (1) NZ597666A (fr)
PL (1) PL2464382T3 (fr)
PT (1) PT2464382T (fr)
RS (1) RS56146B1 (fr)
SG (1) SG178324A1 (fr)
SI (1) SI2464382T1 (fr)
SM (1) SMT201700329T1 (fr)
TW (1) TWI409079B (fr)
UA (1) UA110096C2 (fr)
WO (1) WO2011018224A1 (fr)
ZA (1) ZA201200830B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9296820B2 (en) 2003-11-05 2016-03-29 Roche Glycart Ag Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
EP2176295B1 (fr) 2007-07-16 2014-11-19 Genentech, Inc. Anticorps anti-cd79b humanisés, immunoconjugués, et procédés d'utilisation
PE20090943A1 (es) 2007-07-16 2009-08-05 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados
KR101607346B1 (ko) 2008-01-31 2016-03-29 제넨테크, 인크. 항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
TWI500617B (zh) 2010-05-31 2015-09-21 Ono Pharmaceutical Co Purine ketone derivatives
FR2976811A1 (fr) * 2011-06-22 2012-12-28 Lfb Biotechnologies Utilisation d'un anticorps anti-cd20 a haute adcc pour le traitement de la maladie de waldenstrom
KR20140064873A (ko) * 2011-08-16 2014-05-28 모르포시스 아게 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법
HRP20220224T1 (hr) * 2011-08-16 2022-04-29 Morphosys Ag Kombinacijska terapija s protutijelom anti-cd19 i dušičnim alkilirajućim agensom
FR2980110A1 (fr) * 2011-09-20 2013-03-22 Lfb Biotechnologies Combinaison d'anticorps anti-cd20 et de bendamustine
US9199997B2 (en) 2011-11-29 2015-12-01 Ono Pharmaceutical Co., Ltd. Purinone derivative hydrochloride
CN103375132A (zh) * 2012-04-24 2013-10-30 长江大学 井下旋转冲击式钻井工具
EP2762496A1 (fr) 2013-02-05 2014-08-06 EngMab AG Procédé pour la sélection d'anticorps contre BCMA
WO2014122143A1 (fr) 2013-02-05 2014-08-14 Engmab Ag Procédé de sélection d'anticorps anti-bcma
CA2911962A1 (fr) * 2013-06-07 2014-12-11 Roy H. Larsen Procede pour reguler a la hausse l'expression d'un antigene
WO2015146159A1 (fr) 2014-03-25 2015-10-01 Ono Pharmaceutical Co., Ltd. Agent prophylactique et/ou agent thérapeutique pour lymphome diffus à grandes cellules b
HUE049175T2 (hu) 2014-09-23 2020-09-28 Hoffmann La Roche Eljárás anti-CD79b immunkonjugátumok alkalmazására
ES2955554T3 (es) 2015-04-09 2023-12-04 Ono Pharmaceutical Co Proceso para producir un derivado de purinona
SI3331910T1 (sl) 2015-08-03 2020-07-31 Engmab Sarl Monoklonska protitelesa proti humani antigen dozorevanja limfocitov B (BCMA)
EP3257866A1 (fr) * 2016-06-17 2017-12-20 Academisch Medisch Centrum Anticorps anti-tnf modifiés et leur utilisation dans le traitement de la maladie intestinale inflammatoire
JP7267914B2 (ja) 2016-11-02 2023-05-02 エンクマフ エスアーエールエル Ｂｃｍａ及びｃｄ３に対する二重特異性抗体、及び多発性骨髄腫を治療するために併用して使用される免疫療法薬
WO2018106945A1 (fr) 2016-12-07 2018-06-14 Progenity Inc. Procédés, dispositifs et systèmes de détection du tractus gastro-intestinal
WO2018183929A1 (fr) 2017-03-30 2018-10-04 Progenity Inc. Traitement d'une maladie du tractus gastro-intestinal avec un agent immunomodulateur libéré à l'aide d'un dispositif ingérable
PL3796912T3 (pl) 2018-05-23 2023-09-11 Celgene Corporation Związki przeciwproliferacyjne i przeciwciało bispecyficzne przeciwko bcma i cd3 do zastosowania kombinowanego
WO2019246317A1 (fr) 2018-06-20 2019-12-26 Progenity, Inc. Traitement d'une maladie ou d'un état dans un tissu provenant de l'endoderme
WO2019246312A1 (fr) 2018-06-20 2019-12-26 Progenity, Inc. Traitement d'une maladie du tractus gastro-intestinal avec un immunomodulateur
EP3883635A1 (fr) 2018-11-19 2021-09-29 Progenity, Inc. Méthodes et dispositifs pour traiter une maladie au moyen d'une biothérapie
JP7287048B2 (ja) 2019-03-27 2023-06-06 セイコーエプソン株式会社 ロボット
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
TW202337494A (zh) 2021-11-16 2023-10-01 美商建南德克公司 用莫蘇妥珠單抗治療全身性紅斑狼瘡（ｓｌｅ）之方法及組成物

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US6750334B1 (en) 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
DK1071700T3 (da) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
KR20010071271A (ko) 1998-05-15 2001-07-28 존 비. 랜디스 방사선 및 성장 인자 수용체 티로신 키나아제 억제제에의한 사람 종양의 치료법
CA2704600C (fr) 1999-04-09 2016-10-25 Kyowa Kirin Co., Ltd. Methode de production d'anticorps avec activite adcc accrue
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
CA2463879C (fr) 2001-10-25 2012-12-04 Genentech, Inc. Compositions de glycoproteine
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
BRPI0315295C1 (pt) 2002-10-17 2021-05-25 Genmab As anticorpo monoclonal humano isolado, célula hospedeira procariótica, composição farmacêutica, molécula biespecífica, usos de um anticorpo, métodos in vitro de detectar a presença de antígeno de cd20 ou uma célula que expressa cd20 em uma amostra, kit, e, vetor de expressão
TWI335821B (en) 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
EP2248892B1 (fr) 2003-01-22 2015-04-22 Roche Glycart AG Constructions à fusion et utilisation associée pour produire des anticorps avec un récepteur FC liant l'affinité et fonction effectrice
MXPA05012421A (es) * 2003-05-16 2006-02-22 Hybridon Inc Tratamiento sinergistico de cancer usando inmunomeros junto con agentes quimioterapeuticos.
EP1648511A1 (fr) 2003-07-29 2006-04-26 Morphotek, Inc. Anticorps et procedes permettant de produire des anticorps genetiquement modifies presentant une fonction effectrice amelioree
AU2004266159A1 (en) 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Improved antibodies having altered effector function and methods for making the same
AU2004273791A1 (en) 2003-09-05 2005-03-31 Genentech, Inc. Antibodies with altered effector functions
US9296820B2 (en) * 2003-11-05 2016-03-29 Roche Glycart Ag Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
US7850962B2 (en) 2004-04-20 2010-12-14 Genmab A/S Human monoclonal antibodies against CD20
AU2005335714B2 (en) 2004-11-10 2012-07-26 Macrogenics, Inc. Engineering Fc antibody regions to confer effector function
US8008443B2 (en) 2005-04-26 2011-08-30 Medimmune, Llc Modulation of antibody effector function by hinge domain engineering
WO2006114700A2 (fr) 2005-04-26 2006-11-02 Bioren, Inc. Procede de production d'anticorps igg humains a fonctions effectrices renforcees
AU2006290433B2 (en) 2005-08-26 2012-06-07 Roche Glycart Ag Modified antigen binding molecules with altered cell signaling activity
KR20140133958A (ko) * 2005-10-21 2014-11-20 엘에프비 유에스에이, 인크. 항체 의존성 세포 독성 활성이 증강된 항체, 그 생산 및 사용 방법
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
US20090110688A1 (en) * 2007-10-24 2009-04-30 Georg Fertig Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor
WO2009083009A2 (fr) * 2008-01-03 2009-07-09 Genmab A/S Anticorps monoclonaux anti-cd32b
EA201170940A1 (ru) * 2009-01-16 2012-02-28 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Лечение рака с использованием комбинации бендамустина и анти-cd20-антитела
CN102395619B (zh) * 2009-04-15 2013-06-12 因温斯特技术公司 改进否则不溶混的化合物的溶混性

Also Published As

Publication number Publication date
JP2013501740A (ja) 2013-01-17
CN102596245A (zh) 2012-07-18
JP2015071611A (ja) 2015-04-16
IL217753A0 (en) 2012-03-29
MX355849B (es) 2018-05-02
PL2464382T3 (pl) 2017-09-29
US20160166688A9 (en) 2016-06-16
CY2017034I1 (el) 2018-02-14
ES2630158T3 (es) 2017-08-18
CY2017034I2 (el) 2018-02-14
DK2464382T3 (en) 2017-07-17
NZ597666A (en) 2013-10-25
CR20120036A (es) 2012-04-18
US20140044705A1 (en) 2014-02-13
NO2017054I1 (no) 2017-10-26
KR20120054068A (ko) 2012-05-29
AU2010281866A1 (en) 2012-02-02
CY1119251T1 (el) 2018-02-14
CA2769674A1 (fr) 2011-02-17
LUC00045I1 (fr) 2017-11-03
SMT201700329T1 (it) 2017-09-07
US20120315268A1 (en) 2012-12-13
MY163003A (en) 2017-07-31
AU2010281866B2 (en) 2016-05-12
EP2464382B1 (fr) 2017-05-03
AR077866A1 (es) 2011-09-28
LUC00045I2 (fr) 2018-02-26
WO2011018224A1 (fr) 2011-02-17
JP5646626B2 (ja) 2014-12-24
PT2464382T (pt) 2017-06-30
LT2464382T (lt) 2017-07-25
JP5963013B2 (ja) 2016-08-03
UA110096C2 (uk) 2015-11-25
HRP20170972T1 (hr) 2017-09-22
MX2012001782A (es) 2012-04-19
HUS1700041I1 (hu) 2017-11-28
JP2016222673A (ja) 2016-12-28
KR101425736B1 (ko) 2014-08-01
BR112012002855A2 (pt) 2016-11-01
LTPA2017035I1 (lt) 2017-11-27
CN107261138A (zh) 2017-10-20
SI2464382T1 (sl) 2017-08-31
US20110165151A1 (en) 2011-07-07
RU2012109445A (ru) 2013-09-27
ZA201200830B (en) 2012-10-31
CL2012000391A1 (es) 2012-08-24
TW201110980A (en) 2011-04-01
EP2464382A1 (fr) 2012-06-20
HK1245145A1 (zh) 2018-08-24
HUS000498I2 (hu) 2021-03-29
HUE033531T2 (hu) 2021-12-28
US20150093376A1 (en) 2015-04-02
CA2769674C (fr) 2018-01-23
RS56146B1 (sr) 2017-11-30
TWI409079B (zh) 2013-09-21
SG178324A1 (en) 2012-03-29
IL217753A (en) 2016-10-31

Similar Documents

Publication Publication Date Title
MA33469B1 (fr) Polythérapie à base d'un anticorps afucosylé anti-cd20 et de bendamustine
MA33470B1 (fr) Polythérapie à base d'un anticorps afucosylé anti-cd20 et de fludarabine et/ou mitoxantrone
MA40513A (fr) Conjugués médicament-anticorps anti-cdh6
MA44645B1 (fr) Traitement combiné d'un anticorps anti-cd20 avec un inhibiteur de bcl-2 et un inhibiteur de mdm2
MY163521A (en) ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
PA8851101A1 (es) Compuesto amino pirazol
MA32748B1 (fr) Traitement du cancer de l'utérus du cancer de l'ovaire avec un inhibiteur parp utilisé seul ou en combinaison avec des antitumoraux
UA106194C2 (ru) Диагностика и лечение рака с применением антитела к ereg
MX2020010639A (es) Anticuerpos humanizados a liv-1 y uso de los mismos para tratar cancer.
MX383886B (es) Anticuerpo anti-trop-2 humano que tiene una actividad antitumoral in vivo.
PY09043215A (es) Combinaciones antitumorales que contienen anticuerpos que reconocen específicamente cd38 y melfalan
ME03608B (fr) Anticorps monoclonaux contre la claudine-18 pour le traitement contre le cancer
MA39094A1 (fr) Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers
MA39909B1 (fr) Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer
MA37946A1 (fr) Traitement de la polyarthrite rhumatoïde
FR2975600B1 (fr) Agents pour le traitement de tumeurs
MA31265B1 (fr) Traitement du cancer au moyen de l'il-18 humaine combinee a un anticorps anti-cd20
MX2015014501A (es) Terapia de combinacion de un anticuerpo para cd20 afucosilado con un conjugado de anticuerpo para cd22-farmaco.
MA35281B1 (fr) Dosage et administration d'anticorps anti-erbb3 en combinaison avec le paclitaxel pour le traitement de cancers gynécologiques
EP3496754A4 (fr) Efficacité d'un conjugué anticorps-médicament anti-hla-dr (hl243-cl2a-sn -38) dans le traitement des cancers hla-dr positifs
AR081321A1 (es) N-cadherina: un blanco para el diagnostico y la terapia del cancer
PH12013500432A1 (en) Anti-vegfr-3 antibody compositions
MA33555B1 (fr) Procédés et compositions pour traiter la leucémie
TN2013000068A1 (en) Anti-vegfr-3 antibody compositions
TR201905240T4 (tr) LIV-1'e hümanize edilmiş antikorlar ve bunların kanserin tedavisinde kullanımı.